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The map label for this gene is coaX

Identifier: 108563270

GI number: 108563270

Start: 879837

End: 880508

Strand: Reverse

Name: coaX

Synonym: HPAG1_0845

Alternate gene names: 108563270

Gene position: 880508-879837 (Counterclockwise)

Preceding gene: 108563271

Following gene: 108563269

Centisome position: 55.16

GC content: 39.43

Gene sequence:

>672_bases
ATGCCAGCTAGGCAATCTTTTACAGATTTGAAAAACCTGGTTTTATGCGATATAGGCAATACGCACATCCATTTCGCGCA
AAATTATCAGCTCTTTTCAAGCGCTAAAGAAGATTTAAAGCGTTTGGGTATTCAAAAGGAAATTTTTTACATTAGCGTGA
ATGAAGAAAATGAAAAAGCCCTTTTGAATTGTTATCCTAACGCTAAAAATATTGCAGGATTTTTTCATTTAGAAACCGAC
TATATAGGGCTTGGGATAGACCGGCAAATGGCGTGTTTGGCGGTAAATAATGGCGTGGTGGTGGATGCGGGGAGCGCGAT
TACGATTGATTTAGTCAAAGAGGGCAAGCATTTAGGAGGGTGTATTTTACCCGGTTTAGCCCAATATATTCATGCGTATA
AAAAAAGCGCTAAAATCTTAGAGCAACCTTTCAAGACCTTAGACTCTTTAGAGATTTTACCTAAAAACACCAGAGACGCT
GTGAATTACGGCATGATTTTGAGCGTCATCTCTTGTATCCAGCATTTAGCCAAAAATCAAAAAATCTATCTTTGTGGGGG
CGATGCGAAGTATTTGAGCGCGTTTTTACCCCATTCTGTTTGCAAGGAGCGCTTGGTTTTTGATGGGATGGAAATCGCTC
TTAAAAAAGCAGGGATACTAGAATGCAAATGA

Upstream 100 bases:

>100_bases
GCTAGAGAATTTGAACAAAGAGCAAGAGAGCATCAAGAAAGAGATGAAAAAGAGCTTGAAGAAAGAAAAAAAGCTTTAGA
AATGAATAAGAAGTGAGTCT

Downstream 100 bases:

>100_bases
TGCACCATTTGAGTTTTTTGGGCATGTTTTTAGCCGCTTTGAGCATGTCTTTAGGTCATTGTGTGGGCATGTGTGGGGGG
ATTGTGAGCGCGTTCAGTCA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MPARQSFTDLKNLVLCDIGNTHIHFAQNYQLFSSAKEDLKRLGIQKEIFYISVNEENEKALLNCYPNAKNIAGFFHLETD
YIGLGIDRQMACLAVNNGVVVDAGSAITIDLVKEGKHLGGCILPGLAQYIHAYKKSAKILEQPFKTLDSLEILPKNTRDA
VNYGMILSVISCIQHLAKNQKIYLCGGDAKYLSAFLPHSVCKERLVFDGMEIALKKAGILECK

Sequences:

>Translated_223_residues
MPARQSFTDLKNLVLCDIGNTHIHFAQNYQLFSSAKEDLKRLGIQKEIFYISVNEENEKALLNCYPNAKNIAGFFHLETD
YIGLGIDRQMACLAVNNGVVVDAGSAITIDLVKEGKHLGGCILPGLAQYIHAYKKSAKILEQPFKTLDSLEILPKNTRDA
VNYGMILSVISCIQHLAKNQKIYLCGGDAKYLSAFLPHSVCKERLVFDGMEIALKKAGILECK
>Mature_222_residues
PARQSFTDLKNLVLCDIGNTHIHFAQNYQLFSSAKEDLKRLGIQKEIFYISVNEENEKALLNCYPNAKNIAGFFHLETDY
IGLGIDRQMACLAVNNGVVVDAGSAITIDLVKEGKHLGGCILPGLAQYIHAYKKSAKILEQPFKTLDSLEILPKNTRDAV
NYGMILSVISCIQHLAKNQKIYLCGGDAKYLSAFLPHSVCKERLVFDGMEIALKKAGILECK

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_HELPH (Q1CT10)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_627586.1
- ProteinModelPortal:   Q1CT10
- SMR:   Q1CT10
- STRING:   Q1CT10
- GeneID:   4097873
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_0845
- eggNOG:   COG1521
- HOGENOM:   HBG321208
- OMA:   LCDIGNT
- ProtClustDB:   PRK13333
- BioCyc:   HPYL357544:HPAG1_0845-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 24737; Mature: 24606

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: ACT_SITE 87-87 BINDING 81-81 BINDING 105-105 BINDING 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARQSFTDLKNLVLCDIGNTHIHFAQNYQLFSSAKEDLKRLGIQKEIFYISVNEENEKA
CCCCCHHHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCE
LLNCYPNAKNIAGFFHLETDYIGLGIDRQMACLAVNNGVVVDAGSAITIDLVKEGKHLGG
EEEECCCCCCCEEEEEEECCEEEECCCCCEEEEEECCCEEEECCCEEEEEEECCCCCCCC
CILPGLAQYIHAYKKSAKILEQPFKTLDSLEILPKNTRDAVNYGMILSVISCIQHLAKNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KIYLCGGDAKYLSAFLPHSVCKERLVFDGMEIALKKAGILECK
EEEEECCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
PARQSFTDLKNLVLCDIGNTHIHFAQNYQLFSSAKEDLKRLGIQKEIFYISVNEENEKA
CCCCHHHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCE
LLNCYPNAKNIAGFFHLETDYIGLGIDRQMACLAVNNGVVVDAGSAITIDLVKEGKHLGG
EEEECCCCCCCEEEEEEECCEEEECCCCCEEEEEECCCEEEECCCEEEEEEECCCCCCCC
CILPGLAQYIHAYKKSAKILEQPFKTLDSLEILPKNTRDAVNYGMILSVISCIQHLAKNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KIYLCGGDAKYLSAFLPHSVCKERLVFDGMEIALKKAGILECK
EEEEECCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA