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The map label for this gene is guaB [H]

Identifier: 108563240

GI number: 108563240

Start: 848804

End: 850249

Strand: Reverse

Name: guaB [H]

Synonym: HPAG1_0815

Alternate gene names: 108563240

Gene position: 850249-848804 (Counterclockwise)

Preceding gene: 108563241

Following gene: 108563239

Centisome position: 53.26

GC content: 44.26

Gene sequence:

>1446_bases
ATGAGAATTTTACAAAGGGCTTTGACTTTTGAAGACGTGTTGATGGTGCCTAGAAAGTCCAGCGTTTTACCTAAAGATGT
GAGCTTGAAGTCCCGCCTAACCAAAAACATTAGTTTGAATATCCCTTTTATTAGCGCGGCTATGGATACGGTTACAGAGC
ATAAAACCGCTATCGCTATGGCGCGCCTTGGGGGTATTGGCATCGTGCATAAAAACATGGATATTCAAACGCAACTCAAA
GAAATCACTAAAGTTAAAAAAAGCGAGAGTGGGGTGATTAATGATCCTATTTTTATCCATGCACACAGGACGCTAGCGGA
TGCTAAAGTCATAACGGATAATTACAAGATTTCAGGTGTACCTGTGGTAGATGATAAGGGGTTGTTGATTGGGATTTTAA
CCAACAGAGACGTGCGCTTTGAAACCGATTTGAGTAAAAAAGTGGGCGATGTGATGACTAAAATGCCTTTAGTTACCGCT
CATGTGGGTATCAGTTTGGAAGAGGCTAGGGATTTGATGCACAAGCATAAGATTGAAAAATTGCCCATTGTGGATAAAGA
TAATGTTTTAAAAGGCTTGATCACGATCAAAGACATTCAAAAACGCATTGAATACCCTGAGGCCAATAAAGATGATTTTG
GGAGGTTGAGAGTGGGGGCGGCTATTGGAGTGGGGCAACTAGATAGGGCTGAAATGTTAGTTAAAGCTGGGGTTGATGCG
TTGGTGCTAGACAGCGCGCATGGGCATTCAGCTAATATTTTACACACTTTAGAAGAGATTAAAAAAAGCTTGGTAGTGGA
TGTGATTGTGGGGAATGTGGTTACCAAAGAAGCCACAAGCGATTTGATTAGCGCGGGAGCGGACGCTGTTAAAGTGGGTA
TTGGGCCAGGAAGCATTTGCACCACTAGGATTGTGGCTGGGGTGGGAATGCCTCAAGTGAGCGCGATTGATAATTGCGTG
GAAGTGGCGTCTAAATTTGATATTCCTGTGATTGCAGATGGAGGGATCCGCTATTCAGGCGATGTGGCTAAGGCTTTAGC
TTTAGGGGCATCAAGCGTGATGATAGGCTCTTTACTCGCTGGCACAGAAGAATCGCCGGGGGATTTTATGATCTATCAAG
GGAGGCAATATAAAAGCTATAGGGGCATGGGCAGCATTGGGGCTATGACAAAAGGGAGTTCTGATCGGTATTTTCAAGAG
GGCGTGGCGAGTGAAAAATTAGTCCCAGAAGGCATTGAGGGGCGTGTGCCTTATCGTGGTAAGGTTTCGGATATGATTTT
CCAATTAGTAGGGGGCGTGCGTTCTTCTATGGGGTATCAGGGGGCGAAAAACATTTTGGAATTGTATCAAAACGCTGAAT
TTGTAGAAATCACTAGTGCGGGGCTGAAAGAAAGCCATGTGCATGGCGTGGATATTACTAAAGAAGCCCCTAATTATTAT
GGGTGA

Upstream 100 bases:

>100_bases
GATGCAATTCATTGCTAAGGCTTTTGATGAGCAAAGCCTTTTAGATGTTTCTTACGCTTTAGAGCAAGAATTAGATTTAA
AATTAGATTAAGGATAGAAA

Downstream 100 bases:

>100_bases
ATTGTAAAAGAAAACAAGACAAATCGTTAAAAAACTCGTTAAAAAGCTTGATTTAATGAGTTTTTAAAACTTAATTGCTA
CAATTAAGGAAATTTTCAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQLK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Sequences:

>Translated_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQLK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G
>Mature_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQLK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=40.9185803757829, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=39.5061728395062, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=39.0396659707724, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=37.160751565762, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=38.3720930232558, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=38.3720930232558, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=38.3720930232558, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=38.3720930232558, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.2113821138211, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=55.4865424430642, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.5565610859729, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=35.9243697478992, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=38.0952380952381, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17560440, Length=254, Percent_Identity=38.1889763779528, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=40.956340956341, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=40.3326403326403, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=41.7879417879418, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.9495548961424, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=42.3728813559322, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=39.375, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=39.375, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.7727272727273, Blast_Score=272, Evalue=5e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51817; Mature: 51817

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQLKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLEEARDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHCC
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQLKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLEEARDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHCC
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]