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The map label for this gene is dus [H]

Identifier: 108563136

GI number: 108563136

Start: 749355

End: 750341

Strand: Reverse

Name: dus [H]

Synonym: HPAG1_0711

Alternate gene names: 108563136

Gene position: 750341-749355 (Counterclockwise)

Preceding gene: 108563137

Following gene: 108563135

Centisome position: 47.0

GC content: 40.73

Gene sequence:

>987_bases
ATGGACTTTAAGAATAAAAAATGGCTTTTTTTAGCCCCTCTAGCAGGCTATACGGATTTGCCTTTCAGGAGCGTGGTGAA
AAAATTTGGCGTGGATGTTACCACAAGCGAAATGGTGAGTTCGCATTCGTTGGTGTATGCGTTTGATAAAACTTCTAAAA
TGTTAGAAAAATCCCCTTTAGAAGATCATTTCATGGCGCAAATTTCAGGCTCTAAAGAGGGCGTAGTCAAAGAAGCGGTG
GAGAAAATCAACGCTTTAGAGCATGTGAGTGGGATTGATTTTAATTGCGGTTGTCCCGCTCCTAAAGTGGCTAATCATGG
TAATGGTAGCGGGCTATTAAAGGATTTAGACCACTTGGTGAAGCTTTTAAAAATCATCAGAGAAAACACCAATAAAAAGA
TCACAAGCGTGAAAGTGCGTTTAGGCTTTGAAAAGAAAATCCCTAAAGAAATCGCTCATGCCTTAAACGATGCGCCGGTG
GATTATGTGGTGGTGCATGGGAGGACACGAAGCGACAAATACCAAAAAGACAAAATAGATTATGAAAGCATCGCTTTAAT
GAAAAAGATTTTAAAAAAGCCTGTGATAGCCAATGGCGAAATTGACAGCGTGAAAAAGGCCTTTGAAGTTTTGCAAATCA
CGCAAGCTGATGGGCTAATGATAGGGCGAGCGGCCTTAAGAGCCCCATGGATATTTTGGCAAATCAGAAACAACACCACA
GAATTACCCGCAGTCGTGAAAAAAGATCTGGTTTTAGAACATTTTGATAAAATGGTGGAGTTTTATGGGGATAGGGGGGT
AATCATGTTTAGGAAAAATTTGCATGCTTACGCTAAGGGCGAGATGCAAGCGAGCGCGTTTCGCAACTGCGTCAATACCC
TTACAGAAATAAAGAGCATGCGAGAGGGTATAGAGGAATTTTTTAATCAAGAAATGTTGCAAAGTGAAGTACCGTTATGG
GTAGAATTGAATCAAAAAAGCGTTTGA

Upstream 100 bases:

>100_bases
TCTATAAAAGAGCTTCATTTCAATCAAGCGATAAGTTTTTAAAGCGCTTTTTAACCTTGATTGTGTCAAAATACAGCAAA
AAACTTTGATATGAGAGCGT

Downstream 100 bases:

>100_bases
AAGCGTTCATTTTTTTAGCGAGTTTGGGGGTGTTGTGGGGCAATGCGGCTGAAAAAACGCCTTTTTTTAAAACGAAAAAC
CACATTTATTTGGGTTTTAG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPLEDHFMAQISGSKEGVVKEAV
EKINALEHVSGIDFNCGCPAPKVANHGNGSGLLKDLDHLVKLLKIIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPV
DYVVVHGRTRSDKYQKDKIDYESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTT
ELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSMREGIEEFFNQEMLQSEVPLW
VELNQKSV

Sequences:

>Translated_328_residues
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPLEDHFMAQISGSKEGVVKEAV
EKINALEHVSGIDFNCGCPAPKVANHGNGSGLLKDLDHLVKLLKIIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPV
DYVVVHGRTRSDKYQKDKIDYESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTT
ELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSMREGIEEFFNQEMLQSEVPLW
VELNQKSV
>Mature_328_residues
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPLEDHFMAQISGSKEGVVKEAV
EKINALEHVSGIDFNCGCPAPKVANHGNGSGLLKDLDHLVKLLKIIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPV
DYVVVHGRTRSDKYQKDKIDYESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTT
ELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSMREGIEEFFNQEMLQSEVPLW
VELNQKSV

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family [H]

Homologues:

Organism=Homo sapiens, GI239788483, Length=243, Percent_Identity=30.4526748971193, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI239788462, Length=243, Percent_Identity=30.4526748971193, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI31742496, Length=224, Percent_Identity=27.6785714285714, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8923374, Length=250, Percent_Identity=26, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI40807366, Length=228, Percent_Identity=25.4385964912281, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789660, Length=315, Percent_Identity=33.6507936507937, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1788462, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17543114, Length=275, Percent_Identity=26.9090909090909, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25144369, Length=218, Percent_Identity=27.5229357798165, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17510279, Length=249, Percent_Identity=27.710843373494, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507177, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323437, Length=230, Percent_Identity=25.6521739130435, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323433, Length=264, Percent_Identity=25.3787878787879, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323560, Length=257, Percent_Identity=23.7354085603113, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585320, Length=282, Percent_Identity=29.0780141843972, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19921524, Length=229, Percent_Identity=28.3842794759825, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24580595, Length=244, Percent_Identity=25.8196721311475, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19920448, Length=244, Percent_Identity=25.8196721311475, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 37130; Mature: 37130

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00435 PEROXIDASE_1 ; PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPL
CCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEECHHHHHHHHCCC
EDHFMAQISGSKEGVVKEAVEKINALEHVSGIDFNCGCPAPKVANHGNGSGLLKDLDHLV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KLLKIIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPVDYVVVHGRTRSDKYQKDKID
HHHHHHHHCCCCEEEEEEEEECCHHCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCC
YESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHCCEEEEEECCCCC
ELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSM
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHH
REGIEEFFNQEMLQSEVPLWVELNQKSV
HHHHHHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPL
CCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEECHHHHHHHHCCC
EDHFMAQISGSKEGVVKEAVEKINALEHVSGIDFNCGCPAPKVANHGNGSGLLKDLDHLV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KLLKIIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPVDYVVVHGRTRSDKYQKDKID
HHHHHHHHCCCCEEEEEEEEECCHHCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCC
YESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRAALRAPWIFWQIRNNTT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHCCEEEEEECCCCC
ELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSM
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHH
REGIEEFFNQEMLQSEVPLWVELNQKSV
HHHHHHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]