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The map label for this gene is rnc [H]

Identifier: 108563072

GI number: 108563072

Start: 674565

End: 675287

Strand: Direct

Name: rnc [H]

Synonym: HPAG1_0647

Alternate gene names: 108563072

Gene position: 674565-675287 (Clockwise)

Preceding gene: 108563071

Following gene: 108563073

Centisome position: 42.26

GC content: 40.8

Gene sequence:

>723_bases
ATGATGAAAAACAAACGCTCTCAAAACAGCCCTTATGTAACGCCTAATAACCCTTATACAACGCTAGAAAAAGCTTTGGG
GTATTCTTTTAAAGACAAGCGTTTATTGGAGCAAGCCTTAACGCATAAATCATGCAAGCTCGCTTTAAACAATGAGCGCT
TGGAATTTTTAGGCGATGCGGTGTTGGGTTTGGTGATAGGGGAGTTGCTATACCATAAATTCTACCAATACGATGAGGGC
AAACTCTCTAAATTAAGGGCTTCTATTGTGAGCGCGCATGGTTTTACGAAATTAGCGAAAGCGATCGCTTTGCAAGATTA
TTTGCGCGTTTCTTCTTCTGAAGAAATTTCTAATGGGAGAGAAAAACCCTCTATTTTATCAAGCGCTTTTGAGGCTTTAA
TGGCCGGGGTGTATTTAGAAGCGGGGTTAGCTAAGGTGCGCAAAATCATGCAAAATTTACTCAATCGCGCTTACAAGCGT
TTGGATTTGGAGCATTTGTTTATGGACTATAAAACCGCTTTGCAGGAATTAACCCAAGCGCAATTTTGCGTGATCCCCAC
TTACCAATTGCTCCAAGAAAAAGGCCCCGATCACCATAAAGAATTTGAAATGGCTCTATACATTCAAGATAAAATGTATG
CGACCGCTAAAGGCAAAAGCAAAAAAGAAGCCGAACAGCAATGCGCTTATTATGCGCTTCAAAAACTGAAGGAAGCCAAA
TGA

Upstream 100 bases:

>100_bases
GGATCAAGGGGCATAACGGGCATGCTGAGAATGAACGATGCGATAGCCTTGCTAAATTAGAGGCGCAAAAACGCACTAAA
ACGATCACTTAAAGGGAAAA

Downstream 100 bases:

>100_bases
ACACTTTGGGGTGTTTTTTAAGGCTCACGACTTTTGGGGAATCGCATGGGGATATGATAGGGGGGGTATTAGACGGCATG
CCTAGCGGGATTAAAATAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MMKNKRSQNSPYVTPNNPYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEG
KLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVRKIMQNLLNRAYKR
LDLEHLFMDYKTALQELTQAQFCVIPTYQLLQEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYYALQKLKEAK

Sequences:

>Translated_240_residues
MMKNKRSQNSPYVTPNNPYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEG
KLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVRKIMQNLLNRAYKR
LDLEHLFMDYKTALQELTQAQFCVIPTYQLLQEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYYALQKLKEAK
>Mature_240_residues
MMKNKRSQNSPYVTPNNPYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEG
KLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVRKIMQNLLNRAYKR
LDLEHLFMDYKTALQELTQAQFCVIPTYQLLQEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYYALQKLKEAK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=231, Percent_Identity=30.7359307359307, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI155030234, Length=231, Percent_Identity=30.7359307359307, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=37.0535714285714, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17506883, Length=246, Percent_Identity=26.0162601626016, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=246, Percent_Identity=26.0162601626016, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137682, Length=232, Percent_Identity=28.0172413793103, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27433; Mature: 27433

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKNKRSQNSPYVTPNNPYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDA
CCCCCCCCCCCEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLGLVIGELLYHKFYQYDEGKLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
EKPSILSSAFEALMAGVYLEAGLAKVRKIMQNLLNRAYKRLDLEHLFMDYKTALQELTQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFCVIPTYQLLQEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYYALQKLKEAK
HEHCCCCHHHHHCCCCCHHHHHHHHEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKNKRSQNSPYVTPNNPYTTLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDA
CCCCCCCCCCCEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLGLVIGELLYHKFYQYDEGKLSKLRASIVSAHGFTKLAKAIALQDYLRVSSSEEISNGR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
EKPSILSSAFEALMAGVYLEAGLAKVRKIMQNLLNRAYKRLDLEHLFMDYKTALQELTQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFCVIPTYQLLQEKGPDHHKEFEMALYIQDKMYATAKGKSKKEAEQQCAYYALQKLKEAK
HEHCCCCHHHHHCCCCCHHHHHHHHEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA