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The map label for this gene is hemE [H]

Identifier: 108563010

GI number: 108563010

Start: 602946

End: 603968

Strand: Direct

Name: hemE [H]

Synonym: HPAG1_0585

Alternate gene names: 108563010

Gene position: 602946-603968 (Clockwise)

Preceding gene: 108563009

Following gene: 108563011

Centisome position: 37.77

GC content: 40.86

Gene sequence:

>1023_bases
ATGATGATTTTCATTGATGCATGTTTTAGAAAGGAAACGCCTTACACGCCCATTTGGATGATGAGACAAGCCGGGCGTTA
CCTTAGAGAATACCAAGAGAGCCGTAAAAAAGCGGGGAGCTTCTTGGAATTGTGTAAAAATAGCGATTTAGCCACAGAAG
TTACCCTACAGCCGGTAGAGATTTTAGGCGTGGATGCGGCTATTTTGTTTAGCGATATTTTAGTAGTGCCTTTGGAAATG
GGCTTGAATTTGGAGTTTATCCCCAAAAAGGGGCCGCATTTTTTAGAGACGATTACGGATTTAAAAAGCGTGGAAAACCT
GAAAGTAGGGGCTTATAAACAACTGAATTATGTCTATGATACGATTTCTCAAACGCGCCAAAAGCTTTCTAAAGAGAAAG
CGTTAATCGGTTTTTGCGGATCGCCTTGGACTTTAGCGACTTACATGATAGAAGGCGAGGGGAGCAAATCGTATGCCAAA
AGCAAGAAAATGCTTTATAGCGAGCCTGAAGTTTTAAAAGCGCTTTTAGAAAAATTAAGCCTTGAATTGATAGAGTATTT
GAGCCTTCAAATCCAAGCAGGGGTCAATGCGGTGATGATCTTTGACTCATGGGCTAGCGCTTTAGAAAAAGAAGCGTATT
TGAAATTCAGTTGGGATTATTTGAAAAAAATCTCTAAAGAGCTTAAAAAACGCTATGCGCATATCCCAGTTATCCTTTTC
CCTAAAGGGATTGGCGCTTATTTGGATAGCATAGACGGGGAATTTGATGTGTTTGGCGTGGATTGGGGCACACCTTTAAC
TGCGGCAAAAAAGATTTTAGGCGGTAAGTATGTTTTGCAAGGGAATTTAGAACCCACCCGCCTTTATGATAAAAACGCTT
TAGAAGAAGGGGTTGAAGGGATTTTAAAAGTCATGGGCAATCAAGGGCATATTTTTAATTTAGGGCATGGGATGTTGCCG
GATCTGCCTAGAGAAAACGCAAAATATTTAGTGCAATTAGTGCATGCTAAAACCAGGCGATAG

Upstream 100 bases:

>100_bases
TCACTTTTTATGATTTTACGAGATTTTTAGGGTAAAATATTCATTTTAAAAGATGACTATAGAGTATAAAAACAATAATT
AGACAAACCTTTAAGGATTT

Downstream 100 bases:

>100_bases
GGGGGATTGATGAAAACGATTATAAGATATGCTAGTTTATGGGGCTTGTGTGCAGCTTTAACTCTAGCCCAAAGCCCCTC
TAAAACCCCAGATGAAATCA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MMIFIDACFRKETPYTPIWMMRQAGRYLREYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEM
GLNLEFIPKKGPHFLETITDLKSVENLKVGAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAK
SKKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILF
PKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVEGILKVMGNQGHIFNLGHGMLP
DLPRENAKYLVQLVHAKTRR

Sequences:

>Translated_340_residues
MMIFIDACFRKETPYTPIWMMRQAGRYLREYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEM
GLNLEFIPKKGPHFLETITDLKSVENLKVGAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAK
SKKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILF
PKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVEGILKVMGNQGHIFNLGHGMLP
DLPRENAKYLVQLVHAKTRR
>Mature_340_residues
MMIFIDACFRKETPYTPIWMMRQAGRYLREYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEM
GLNLEFIPKKGPHFLETITDLKSVENLKVGAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAK
SKKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILF
PKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVEGILKVMGNQGHIFNLGHGMLP
DLPRENAKYLVQLVHAKTRR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=39.367816091954, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI2367337, Length=338, Percent_Identity=46.1538461538462, Blast_Score=296, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6320252, Length=334, Percent_Identity=38.0239520958084, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI221330099, Length=328, Percent_Identity=40.2439024390244, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19921920, Length=328, Percent_Identity=40.2439024390244, Blast_Score=235, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38495; Mature: 38495

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIFIDACFRKETPYTPIWMMRQAGRYLREYQESRKKAGSFLELCKNSDLATEVTLQPVE
CEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHH
ILGVDAAILFSDILVVPLEMGLNLEFIPKKGPHFLETITDLKSVENLKVGAYKQLNYVYD
HHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKSKKMLYSEPEVLKALLEKLS
HHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHH
LELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILF
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEEECHHHHHHHHHHHHHHHCCCCEEEE
PKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVEG
CCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
ILKVMGNQGHIFNLGHGMLPDLPRENAKYLVQLVHAKTRR
HHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMIFIDACFRKETPYTPIWMMRQAGRYLREYQESRKKAGSFLELCKNSDLATEVTLQPVE
CEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHH
ILGVDAAILFSDILVVPLEMGLNLEFIPKKGPHFLETITDLKSVENLKVGAYKQLNYVYD
HHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKSKKMLYSEPEVLKALLEKLS
HHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHH
LELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILF
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEEECHHHHHHHHHHHHHHHCCCCEEEE
PKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVEG
CCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
ILKVMGNQGHIFNLGHGMLPDLPRENAKYLVQLVHAKTRR
HHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA