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The map label for this gene is cagE [H]

Identifier: 108562945

GI number: 108562945

Start: 542661

End: 544265

Strand: Reverse

Name: cagE [H]

Synonym: HPAG1_0520

Alternate gene names: 108562945

Gene position: 544265-542661 (Counterclockwise)

Preceding gene: 108562946

Following gene: 108562944

Centisome position: 34.09

GC content: 34.14

Gene sequence:

>1605_bases
GTGTTTGTGGCGAGCAAGCAGGCTGATGAACAAAAAAAGCTAATCATAGAGCAAGAGGTTCAAAAGCGCCAATTTCAAAA
AATAGAAGAACTTAAAACAGACATGCAAAAAGGTATTAATCCCTTTTTTAAAGTCTTGTTTGATGGGGGGAATAGGTTGT
TTGGTTTCCCTGAAACTTTTATTTATTCCTCTATATTTATATTGTTTGTAACAATTGTATTATCTGTTATTCTTTTTCAA
GCCTATGAACCTGTTTTGATTGTAGCGATTGTTATTGTGCTTGTAGCTCTTGGATTCAAGAAAGATTACAGGCTTTATCA
AAGAATGGAGCGAGCGATGAAATTTAAAAAACCTTTTTTGTTTAAGGGCGTGAAAAACAAAGCGTTCATGAGCATTTTTT
CCATGAAGCCTAGTAAAGAAATGGCTAATGACATCCACTTAAATCCAAACAGAGAAGACAGACTTGTGAGCGCTGCAAAT
TCCTATCTAGCGAATAACTATGAATGTTTTTTAGATGATGGGGTGATCCTTACTAACAACTATTCTCTTTTAGGCACAAT
CAAATTGGGGGGTATTGATTTTTTAACCACTTCCAAAAAAGATCTCATAGAGTTACACGCTTCTATTTATAGCGTTTTTA
GGAATTTTGTTACCCCTGAATTCAAATTTTATTTTCACACTATTAAAAAGAAAATCGTTATTGATGAAACCAATAGGGAC
TATGGTCTTATTTTTTCTAATGATTTCATGCGAGCCTATAATGAGAAGCAAAAGAGAGAAAGTTTTTATGATATTAGTTT
TTATCTCACCATAGAGCAAGATTTATTAGACACTCTCAATGAACCCGTTATGAATAAAAAGCATTTTGCAGACAATAATT
TTGAAGAGTTTCAAAGGATTATTAGAGCCAAGCTTGAAAACTTCAAGGATAGGATAGAGCTTATAGAAGAGCTACTGAGT
AAATACCACCCCACTAGATTGAAAGAATACACCAAAGATGGCATTATTTACTCCAAACAATGCGAGTTTTATAATTTTTT
GGTGGGAATGAATGAAGCCCCTTTTATTTGCAACCGCAAAGACTTGTATCTCAAAGAAAAAATGCATGGAGGGGTGAAAG
AAGTTTATTTTGCTAATAAGCATGGAAAAATCTTAAATGATGATTTGAGTGAAAAATATTTTAGTGCTATTGAGATTAGT
GAATACGCCCCTAAATCACAGAGCGATTTGTTTGACAAAATCAACGCTCTAGACAGCGAATTTATCTTTATGCATGCTTA
TTCGCCTAAAAACTCACAAGTTTTAAAGGACAAACTAGCTTTCACCTCTAGAAGGATTATTATTAGTGGAGGCTCTAAAG
AGCAAGGCATGACTTTGGGTTGCTTGAGCGAATTAGTGGGTAATGGTGATATTACGCTAGGTAGTTATGGTAATTCTTTA
GTGCTGTTTGCTGATAGCTTTGAAAAAATGAAACAAAGCGTTAAGGAATGCGTCTCTAGTCTTAACGCTAAAGGTTTTTT
AGCCAACGCAGCGACTTTCTCTATGGAAAATTACTTTTTTGCCAACATTGCTCTTTTATCACGCTTCCTTTTATTTTTGA
TGTAA

Upstream 100 bases:

>100_bases
ATGATCCTAATGATCTTTTGAAACATATTAGCACCGTAGAGTCTCTCAAAAAAATCTTTTATACGATTACATGTGAAGCG
GTATATCTATAAAGAGAGGG

Downstream 100 bases:

>100_bases
CTTCTAATAATTTTGCTGATTTCATCGCTATGAGGGCTATGAGTTTTGATGGCAATCAAGAGAATAACGCTTGGGGCAAT
AGTGTGATGACGCTAAAAAG

Product: cag pathogenicity island protein E

Products: NA

Alternate protein names: Protein picB [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MFVASKQADEQKKLIIEQEVQKRQFQKIEELKTDMQKGINPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQ
AYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAAN
SYLANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRD
YGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLS
KYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEIS
EYAPKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSL
VLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFANIALLSRFLLFLM

Sequences:

>Translated_534_residues
MFVASKQADEQKKLIIEQEVQKRQFQKIEELKTDMQKGINPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQ
AYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAAN
SYLANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRD
YGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLS
KYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEIS
EYAPKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSL
VLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFANIALLSRFLLFLM
>Mature_534_residues
MFVASKQADEQKKLIIEQEVQKRQFQKIEELKTDMQKGINPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQ
AYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAAN
SYLANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRD
YGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLS
KYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEIS
EYAPKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSL
VLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFANIALLSRFLLFLM

Specific function: Involved in DNA transfer. Required for induction of IL-8 in gastric epithelial cells [H]

COG id: COG3451

COG function: function code U; Type IV secretory pathway, VirB4 components

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To A.tumefaciens virB4 [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004346
- InterPro:   IPR018145 [H]

Pfam domain/function: PF03135 CagE_TrbE_VirB [H]

EC number: NA

Molecular weight: Translated: 61899; Mature: 61899

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVASKQADEQKKLIIEQEVQKRQFQKIEELKTDMQKGINPFFKVLFDGGNRLFGFPETF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCHHH
IYSSIFILFVTIVLSVILFQAYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHH
FKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAANSYLANNYECFLDDGVILTNN
HCCCCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEECC
YSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRD
CEEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCC
YGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRI
EEEEEECHHHHHHHHHHHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IRAKLENFKDRIELIEELLSKYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCEECCC
DLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEISEYAPKSQSDLFDKINALDSE
CHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
FIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSL
EEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCEE
VLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFANIALLSRFLLFLM
EEEEHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFVASKQADEQKKLIIEQEVQKRQFQKIEELKTDMQKGINPFFKVLFDGGNRLFGFPETF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCHHH
IYSSIFILFVTIVLSVILFQAYEPVLIVAIVIVLVALGFKKDYRLYQRMERAMKFKKPFL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHH
FKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAANSYLANNYECFLDDGVILTNN
HCCCCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEECC
YSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTIKKKIVIDETNRD
CEEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCC
YGLIFSNDFMRAYNEKQKRESFYDISFYLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRI
EEEEEECHHHHHHHHHHHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IRAKLENFKDRIELIEELLSKYHPTRLKEYTKDGIIYSKQCEFYNFLVGMNEAPFICNRK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCEECCC
DLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEISEYAPKSQSDLFDKINALDSE
CHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
FIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSL
EEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCEE
VLFADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFANIALLSRFLLFLM
EEEEHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]