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The map label for this gene is cagE [H]

Identifier: 108562944

GI number: 108562944

Start: 541315

End: 542631

Strand: Reverse

Name: cagE [H]

Synonym: HPAG1_0519

Alternate gene names: 108562944

Gene position: 542631-541315 (Counterclockwise)

Preceding gene: 108562945

Following gene: 108562943

Centisome position: 33.99

GC content: 38.27

Gene sequence:

>1317_bases
ATGAGGGCTATGAGTTTTGATGGCAATCAAGAGAATAACGCTTGGGGCAATAGTGTGATGACGCTAAAAAGCGAAATCAA
TTCGCCTTTTTATCTGAATTTCCACATGCCCACTGATTTTGGTTCAGCTTCAGCAGGACACACTTTGATACTTGGCTCAA
CCGGTTCAGGTAAGACAGTGTTTATGTCCATGACTTTGAACGCTATGGGACAATTTGTTCACAATTTTCCTGCTAATGTC
AGCAAAGACAAGCAAAAGCTCACTATGGTTTATATGGATAAAGATTATGGCGCTTATGGGAATATTGTCGCAATGGGTGG
GGAGTATGTCAAGATTGAGCTAGGGACAGATACAGGATTAAATCCTTTTGCTTGGGCGGCTTGTGTGCAAAAAACAAATG
CAACAATGGAGCAAAAACAAACAGCTATTTCTGTTGTCAAAGAGCTTGTGAAAAACTTAGCAACCAAAAGCGATGAAAAA
GATGAAAATGGCAACAGCATCTCTTTTAGCCTAGCAGATTCTAATACGCTTGCAGCGGCAGTAACCAACCTTATCACAGG
AGATATGAATCTAGATTATCCCATCACTCAACTTATTAATGCTTTCGGAAAAGACCACAATGATCCTAATGGGCTTGTCG
CGCGATTAGCGCCTTTTTGCAAATCAACCAATGGTGAATTTCAATGGCTTTTTGATAATAAAGCAACAGATCGCTTAGAT
TTTTCAAAAACGATTATTGGCGTTGATGGGTCAAGTTTCTTAGACAATAATGATGTTTCGCCCTTTATTTGTTTTTACCT
TTTCGCTCGTATCCAAGAGGCAATGGATGGGCGTAGATTTGTCTTAGATATTGATGAAGCTTGGAAATATTTAGGCGATC
CAAAGGTCGCTTATTTTGTAAGAGACATGCTAAAAACTGCAAGGAAAAGAAACGCTATTGTCAGGCTTGCGACTCAAAGC
ATCACTGATCTTTTGGCTTGCCCCATTGCTGATACTATTAGAGAACAATGCCCTACAAAGATTTTTTTGAGAAACGATGG
GGGCAATCTTTCTGATTACCAAAGATTGGCTAATGTTACAGAAAAAGAATTTGAAATCATCACTAAGGGGCTAGATAGGA
AAATTCTCTACAAACAAGATGGAAGCCCTAGCGTTATCGCTAGTTTTAATTTGAGAGGCATTCCTAAAGAATATTTGAAA
ATTTTATCCACAGATACTGTATTTGTCAAAGAAATTGACAAGATTATCCAAAACCATAGTATCATAGATAAATATCAGGC
CTTGAGGCAAATGTATCAACAAATAGAGGAGTATTAA

Upstream 100 bases:

>100_bases
CTTTCTCTATGGAAAATTACTTTTTTGCCAACATTGCTCTTTTATCACGCTTCCTTTTATTTTTGATGTAACTTCTAATA
ATTTTGCTGATTTCATCGCT

Downstream 100 bases:

>100_bases
AATGAAACAAAATTTGCGCGAACAAAAATTATTGGAAATTTTAGAAAATGATGTCTTGACGATTTTGGATAGTTTTTCTA
ATTACCTTTTTGAACTGAGA

Product: cag pathogenicity island protein E

Products: NA

Alternate protein names: Protein picB [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFVHNFPANV
SKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEK
DENGNSISFSLADSNTLAAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLD
FSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQS
ITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLK
ILSTDTVFVKEIDKIIQNHSIIDKYQALRQMYQQIEEY

Sequences:

>Translated_438_residues
MRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFVHNFPANV
SKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEK
DENGNSISFSLADSNTLAAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLD
FSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQS
ITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLK
ILSTDTVFVKEIDKIIQNHSIIDKYQALRQMYQQIEEY
>Mature_438_residues
MRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFVHNFPANV
SKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEK
DENGNSISFSLADSNTLAAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLD
FSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQS
ITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLK
ILSTDTVFVKEIDKIIQNHSIIDKYQALRQMYQQIEEY

Specific function: Involved in DNA transfer. Required for induction of IL-8 in gastric epithelial cells [H]

COG id: COG3451

COG function: function code U; Type IV secretory pathway, VirB4 components

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To A.tumefaciens virB4 [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004346
- InterPro:   IPR018145 [H]

Pfam domain/function: PF03135 CagE_TrbE_VirB [H]

EC number: NA

Molecular weight: Translated: 48988; Mature: 48988

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTV
CCCCCCCCCCCCCCCCCCEEEEHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCEE
FMSMTLNAMGQFVHNFPANVSKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGL
EEEEEHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCEEEEEEECCCCCC
NPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEKDENGNSISFSLADSNTLAAA
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHH
VTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLD
HHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
FSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFV
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHH
RDMLKTARKRNAIVRLATQSITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVT
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
EKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLKILSTDTVFVKEIDKIIQNHS
HHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCH
IIDKYQALRQMYQQIEEY
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAMSFDGNQENNAWGNSVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTV
CCCCCCCCCCCCCCCCCCEEEEHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCEE
FMSMTLNAMGQFVHNFPANVSKDKQKLTMVYMDKDYGAYGNIVAMGGEYVKIELGTDTGL
EEEEEHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCEEEEEEECCCCCC
NPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEKDENGNSISFSLADSNTLAAA
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHH
VTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLD
HHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
FSKTIIGVDGSSFLDNNDVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFV
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHH
RDMLKTARKRNAIVRLATQSITDLLACPIADTIREQCPTKIFLRNDGGNLSDYQRLANVT
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
EKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLKILSTDTVFVKEIDKIIQNHS
HHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCH
IIDKYQALRQMYQQIEEY
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]