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The map label for this gene is gltX [H]

Identifier: 108562878

GI number: 108562878

Start: 464858

End: 466249

Strand: Reverse

Name: gltX [H]

Synonym: HPAG1_0453

Alternate gene names: 108562878

Gene position: 466249-464858 (Counterclockwise)

Preceding gene: 108562886

Following gene: 108562874

Centisome position: 29.21

GC content: 38.94

Gene sequence:

>1392_bases
ATGAGTTTGATCGTTACGCGCTTCGCTCCATCGCCCACTGGCTACCTCCACATAGGAGGCTTAAGAACAGCCATTTTCAA
TTATCTTTTTGCACGAGCCAATCAAGGAAAATTTTTTTTACGCATTGAAGACACGGATTTGAGCCGCAACTCTATAGAAG
CGGCTAACGCCATTATAGAGGCTTTCAAATGGGTAGGGCTAGAATACGATGGAGAAATCCTCTACCAATCCAAACGCTTT
GAGATTTATAAAGAATATATCCAAAAACTCTTAGATGAAGACAAAGCCTATTATTGCTACATGAGTAAAGATGAGTTGGA
CGCTTTGAGAGAAGAACAAAAGGCCAGGAAAGAAACCCCACGCTATGACAATCGTTATCGTGATTTTAAAGGCACGCCCC
CTAAAGGCATAGAGCCTGTGGTAAGGATTAAAGTCCCGCAAAATGAGGTGATTGTTTTTAATGATGGGGTTAAAGGCGAA
GTGAAAGTGAATACTAACGAATTAGACGATTTTATTATCGCCAGGAGCGATGGGACGCCCACTTATAATTTTGTGGTTAT
TGTTGATGACGCTTTAATGGGGATTACTGATGTGATTAGAGGCGATGATCACCTTTCTAACACCCCTAAACAAATCGTTC
TCTATAAGGCTTTGAATTTTAAAATCCCTAATTTTTTCCATGTGCCGATGATTTTGAATGAAGAAGGGCAAAAATTAAGC
AAACGCCATGGGGCCACTAATGTGATGGACTATCAAGAAAGGGGCTATCTTAAGGAAGCTTTAGTGAATTTTTTAGCGCG
TTTGGGGTGGAGCTATCAAGATAAAGAAATTTTTAGCATGCAAGAATTATTGGAATGTTTTGACCCTAAAGATTTGAATT
CTTCGCCCAGTTGCTTCAGCTGGCACAAACTTAATTGGCTCAACGCTCATTATTTAAAAAACCAAAGCGCACAAGAATTA
TTGGAGCTTTTAAAGCCTTTTAGTTTTAGCGATCTTTCTCATTTAAACCCCGCTCAATTGGATCGCTTGTTGGACGCTCT
CAAAGAAAGATCTCAAACCCTAAAAGAATTAGCCCTTAAAATAGATGAGGTTTTAACCGCTCCTATAGAGTATGAAAAAA
AGGTTTTTAAAAAACTCAATCAAGCGCTCGTCATGCCTTTGTTAGAAAAGTTTAAGCTGGAATTAAATAAGGTCAATTTC
AACGATGAAAACGCGCTAGAAAACGCCATGCACAAAATCATTGAAGAAGAAAAGATTAAAGCGGGTAGTTTTATGCAGCC
TTTAAGATTGGCCCTTTTGGGTAAGGGAGGCGGGATAGGCCTTAAAGAAGCGCTTTTTATTTTAGGCAAAACAGAGAGCC
TCAAAAGAATAGAAAAGTTTTTGAAAAACTAA

Upstream 100 bases:

>100_bases
AATAATCTCAATCATACACTAATTTTAATAGAAAAAAGTGAAACCATTTTTAAGCCATTTTTGAATACAATAAGAGTATT
TTATTTTTAAGGTTAGAATA

Downstream 100 bases:

>100_bases
AAAATTGGCTCTGTTTTCATTGAACGCTAATCATAAAAGAGCTTATTTTAGCGGTTGTTCTAAACAACTCCTTTTGAAAA
ATAAGAGGGTTTCAAGAGAA

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase 1; GluRS 1 [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIEAFKWVGLEYDGEILYQSKRF
EIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETPRYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIVFNDGVKGE
VKVNTNELDDFIIARSDGTPTYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLS
KRHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFSWHKLNWLNAHYLKNQSAQEL
LELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALKIDEVLTAPIEYEKKVFKKLNQALVMPLLEKFKLELNKVNF
NDENALENAMHKIIEEEKIKAGSFMQPLRLALLGKGGGIGLKEALFILGKTESLKRIEKFLKN

Sequences:

>Translated_463_residues
MSLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIEAFKWVGLEYDGEILYQSKRF
EIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETPRYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIVFNDGVKGE
VKVNTNELDDFIIARSDGTPTYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLS
KRHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFSWHKLNWLNAHYLKNQSAQEL
LELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALKIDEVLTAPIEYEKKVFKKLNQALVMPLLEKFKLELNKVNF
NDENALENAMHKIIEEEKIKAGSFMQPLRLALLGKGGGIGLKEALFILGKTESLKRIEKFLKN
>Mature_462_residues
SLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIEAFKWVGLEYDGEILYQSKRFE
IYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETPRYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIVFNDGVKGEV
KVNTNELDDFIIARSDGTPTYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLSK
RHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFSWHKLNWLNAHYLKNQSAQELL
ELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALKIDEVLTAPIEYEKKVFKKLNQALVMPLLEKFKLELNKVNFN
DENALENAMHKIIEEEKIKAGSFMQPLRLALLGKGGGIGLKEALFILGKTESLKRIEKFLKN

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=494, Percent_Identity=30.9716599190283, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788743, Length=459, Percent_Identity=43.1372549019608, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI226510925, Length=282, Percent_Identity=34.7517730496454, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786895, Length=327, Percent_Identity=25.6880733944954, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71993394, Length=475, Percent_Identity=32.2105263157895, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17511007, Length=258, Percent_Identity=23.6434108527132, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17543332, Length=363, Percent_Identity=23.9669421487603, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324540, Length=514, Percent_Identity=33.2684824902724, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6321192, Length=218, Percent_Identity=28.4403669724771, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324742, Length=128, Percent_Identity=29.6875, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665321, Length=492, Percent_Identity=34.1463414634146, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17864488, Length=289, Percent_Identity=25.6055363321799, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24649466, Length=251, Percent_Identity=24.7011952191235, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 53414; Mature: 53283

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIE
CCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AFKWVGLEYDGEILYQSKRFEIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETP
HHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCC
RYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIVFNDGVKGEVKVNTNELDDFIIARSDGTP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCEEEECCCCCCCEEEEECCCCC
TYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLS
CEEEEEEECCHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCEEECCEEECCCHHHHH
KRHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFS
HHCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCE
WHKLNWLNAHYLKNQSAQELLELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALK
EECCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDEVLTAPIEYEKKVFKKLNQALVMPLLEKFKLELNKVNFNDENALENAMHKIIEEEKIK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
AGSFMQPLRLALLGKGGGIGLKEALFILGKTESLKRIEKFLKN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLIVTRFAPSPTGYLHIGGLRTAIFNYLFARANQGKFFLRIEDTDLSRNSIEAANAIIE
CEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHH
AFKWVGLEYDGEILYQSKRFEIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKARKETP
HHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCC
RYDNRYRDFKGTPPKGIEPVVRIKVPQNEVIVFNDGVKGEVKVNTNELDDFIIARSDGTP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCEEEECCCCCCCEEEEECCCCC
TYNFVVIVDDALMGITDVIRGDDHLSNTPKQIVLYKALNFKIPNFFHVPMILNEEGQKLS
CEEEEEEECCHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCEEECCEEECCCHHHHH
KRHGATNVMDYQERGYLKEALVNFLARLGWSYQDKEIFSMQELLECFDPKDLNSSPSCFS
HHCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCE
WHKLNWLNAHYLKNQSAQELLELLKPFSFSDLSHLNPAQLDRLLDALKERSQTLKELALK
EECCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDEVLTAPIEYEKKVFKKLNQALVMPLLEKFKLELNKVNFNDENALENAMHKIIEEEKIK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
AGSFMQPLRLALLGKGGGIGLKEALFILGKTESLKRIEKFLKN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA