Click here to switch to the map view.

The map label for this gene is kefBC [H]

Identifier: 108562872

GI number: 108562872

Start: 460159

End: 461409

Strand: Reverse

Name: kefBC [H]

Synonym: HPAG1_0447

Alternate gene names: 108562872

Gene position: 461409-460159 (Counterclockwise)

Preceding gene: 108562873

Following gene: 108562871

Centisome position: 28.9

GC content: 36.93

Gene sequence:

>1251_bases
ATGGAAAACAGCACACTTTATATTGTTATTGCTGGCTTATGGCTTGCTGTGGGCTTTGGAATCTTTTTAAAGAAATTAGA
CATGCCTGTTATCATTGGTTACATTTGCACAGGAACGGTCTTAGCGGCTTTTTTTAAAATTAATGATTTTGATTTGTTGT
CTGATATTGGTGAATTTGGTATCGTCTTTTTAATGTTTATGATAGGCATTGAGTTTAATTTTGACAAGCTCAAATCCATC
AAACAAGAAGTGCTGGTTTTTGGGCTTTTACAAGTCGTTTTATGCGCTTTAATCGCTTTTTTATTGGGGTATTTTGTTTT
GGGTCTTTCACCCATTTTTTCCCTTGTTTTAGGCATGGGGCTTTCGCTCTCTTCAACCGCTATTGTGTTGAAATTCTTTG
AAGATTCCAAACAGCTTAGCACGCCTATGGGAAAGAGCGCAGTGGGGATTTTGATTTTCCAAGATATTGCCGCCATTCCC
ATGCTTTTAATCCTCACTATTCTAGGCAGTAAAGATTCTAATGTCAATTTACTCATTCTTAAAACCCTTATTTCAGCAGG
GATTATTTTAGTTCTTTTGTTATTGCCTGGAAAAAAAGGGGCTAATCTCATCTTAGAGCAAGCAAAAGACACGCGCTTGC
CTGAAATTTTTATAGGCACGATTTTAGTGATTGTTTGTAGCGCAGCAGGGTTGAGCCATTTTTTTGGGTTTTCTATGTCT
TTAGGAGCGTTCATTGCGGGCATGGCCATTTCCAAATCGCGCTATAAAATCAATGTCCAAGAAGAATTCGCGCAATTAAA
AAACCTCTTCTTAGCCCTTTTTTTCATTACGATAGGGATGCAAATTAATGTGAGTTTCTTTATGGAGAAGTTCTTTGTTG
TCATCTTCTTACTCATTTTAGTGATGGGGTTTAAGACGGCTATCATTTATGCGCTCTTGCGTTTTTTTAGAGACGCTAAA
ACTGCCATAAAAACCGCTCTTTCTTTAGCGCAAATCGGGGAGTTTTCTTTCGTGATCTTTTTAAATTCAGGCTCGCACCA
GCTCTTTAATTTGCAAGAAAAAAAAGGGATTCTTGGTTTTTTGCACCAAAAAAATATCTTAAATATCGCTCAAAATGACA
TCCACCAGCTCCTTATTCTTATGGTGGTCTTTTCTATGTTGGCAACCCCTTTTATTTTAAAATACCTAGAATCTATCGCT
CAATTTATTTTGCACCAAAAGAGCCAAGAAAACGAGCCAGCTAAAAAATAA

Upstream 100 bases:

>100_bases
TATTATTTTATTTAATAGTGTTATTTAATGGCTCAATTTAATAGGATAGTTTCGCTTTTATTTCTTTAAAACAAATTGAT
TCTACTGGGGAAAGGTTTTT

Downstream 100 bases:

>100_bases
TGGCGTAAAAACCAAATGATAAGTTTGCTTGTATTGTCAGTGTTATGTTAAAATACAAGCGTATTTTAACTCCAAATTGA
TATAAAAAGGGATTTCATGA

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTLISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIAGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK

Sequences:

>Translated_416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTLISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIAGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK
>Mature_416_residues
MENSTLYIVIAGLWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDIGEFGIVFLMFMIGIEFNFDKLKSI
KQEVLVFGLLQVVLCALIAFLLGYFVLGLSPIFSLVLGMGLSLSSTAIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIP
MLLILTILGSKDSNVNLLILKTLISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMS
LGAFIAGMAISKSRYKINVQEEFAQLKNLFLALFFITIGMQINVSFFMEKFFVVIFLLILVMGFKTAIIYALLRFFRDAK
TAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKYLESIA
QFILHQKSQENEPAKK

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=359, Percent_Identity=28.9693593314763, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786232, Length=395, Percent_Identity=29.3670886075949, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789749, Length=392, Percent_Identity=27.2959183673469, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786685, Length=369, Percent_Identity=26.8292682926829, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 46035; Mature: 46035

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]