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The map label for this gene is tkt [H]

Identifier: 108562784

GI number: 108562784

Start: 371207

End: 373135

Strand: Reverse

Name: tkt [H]

Synonym: HPAG1_0359

Alternate gene names: 108562784

Gene position: 373135-371207 (Counterclockwise)

Preceding gene: 108562785

Following gene: 108562783

Centisome position: 23.37

GC content: 44.43

Gene sequence:

>1929_bases
TTGATGCGATTGAGTAACGCTGACTTAGAACGATTAAAAAGCATGGCCAATGTGCTTCGCTTTTTGTGCGCGGACATGAT
AGATAAGGCTAATAGCGGGCATCCGGGCGTGTGCTTGGGATTAGCCGATGTGATGGTGGTTTTAAGCTTGCACCTAAACC
TAAACCCCACTAACCCTAAATGGCTCAACAGAGACAGGTTGGTTTTTAGCGGAGGGCATGCGAGCGCGTTAGCGTATAGT
TTGTTGCATTTGTGGGGCTTTGATTTGAGCCTAGAAGATTTAAAGCGTTTCAGGCAATTACACTCTAAAACCCCAGGACA
CCCCGAATTGCACCACACCGAAGGCATTGAGATCACGACAGGCCCTTTGGGGCAAGGTTTTGCTAACGCTGTGGGCTTTA
GCATGGCGAGTCGATACGCTCAAAACCTTTTAGACAAAAAAGCCATTTCTCATAAAGTCTATTGCTTGTGTGGGGATGGG
GATTTGCAAGAAGGCATTAGCTATGAGAGCGCTTCTTTAGCCGGGCACTTTCGCCTTGATAACCTCATCGTGATTTATGA
CAGCAACCAGATCAGCATTGAAGGCGCTATTGATATTAGTTTTAGCGAACAGGTTAAAACGCGTTTTTTAGCGCAAAATT
GGGAAGTGCTAGAATGCGATGGGCATGACTATCAAGCGATTCATAACGCTTTAGAAGAAGCCAAAAAATCCCATAAACCC
ACGCTTTTAATCGCTCATACGATTATTGGTAAGGGGGCTGTTGGCTTAGAGGGGAGTGAAAAAACGCATGGCTCGCCTTT
AAATAAAGAAGTGTTAAAACAATCCAAAGAAAACGCTCAAATCAACCCTGATGAAAGCTTTATCATTAGCCCAAAAAACA
AAATGCATTTTGAAGAAGTGAAAGTTAGGGGCGTTAGTTTAGAGGCCTTATGGGAAAAATCCTTAAGCCCTAAAACAAAA
GAAAAAATCCATGCGTTAAAGGATTTTGATTTTAACGCCATCCATTACCCCACCTTTAAAAAAGGCGAATCTCTAGCCAC
AAGAGTGAGTAACGGCATGATTTTAAACGCTATCGCTAAAGAATGCGAGGGCTTTTTAGGGGGTAGCGCGGATCTAGCCC
CCTCTAACAACACGCAGTTAAAACACTCTGGCGATTTCCCTTTAGGGCAAAACTTGCATTTTGGGATCAGAGAGCATGCC
ATGGGGGCTATCACTAACGCTTTAGCGGCGTATGGCTTGTTTGTGCCTTTTTGCGCGACCTTTTTTGTGTTTAGCGATTA
CTTGATGCCCAGCATTCGTTTGAGCGCTTTAATGAAACTAAAAGCCCTTTTTATCTTCACGCATGACAGCATTGGCGTGG
GCGAAGACGGGGCGACGCACCAGCCCATAGAGCAATTGAGCCATTTACGCGCTTTGCCGCATTTTTACGCTTTCAGGCCC
AGCGACGCTTTTGAAAATAAGGCTTGCATGCAAGTAGCGTTAAGTTTGAACGCTCCTAGCGCTCTTATTTTATCGCGCCA
GAATTTGCCCGTGCTAGATGAAGTCTCTAAAGAGCAGGTTTTAAAAGGGGCGTATGTTAAACATGATGCTAAAGATCCCA
TTATCACGCTCGTTGCGAGCGGGAGCGAAGTCTCTTTAGCTTTAGAGAGCGCTAAAATGTTAGAGCGAGAAAATATTCCC
ACTCAAGTGGTGAGCGCACCATGTTTTGATTTATTGATAGAGCAAGATGAAAGCTATCTTAAAGAACTCTTTAAGGGTAA
AGTCTTAGTCATTGAAGCGAGCCGCGCGATAGAGTGGTATCGTTTTGCGGATAAAATCATTGGCATGGATTCTTTTGGGA
GCTCAGCAAAGGGCGATAAACTCTTTGAAAAATTCGGCTTCAGCGTTGAAAACATCACCGCTCAAGCTAAAAGATTACTC
AACGCATGA

Upstream 100 bases:

>100_bases
GAGCTTAAAAATCAGATCCAACAAGACATCTTAAGAGCCAAAGAGATTTTGAGATAATTTGTGTTAAAATGACTCTCAAA
AACCTTAAAAACGGAAAAAT

Downstream 100 bases:

>100_bases
ACTTAGAAAAACTTTTTTCACAAAAAAACCCCCTGTTTGTTTTTAGCTCCACCAGGCGTTTAAAACATTTCTATTTAGAG
CAAGGCGAAGGGTTTTTGCC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MMRLSNADLERLKSMANVLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYS
LLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASRYAQNLLDKKAISHKVYCLCGDG
DLQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAIDISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKP
TLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFIISPKNKMHFEEVKVRGVSLEALWEKSLSPKTK
EKIHALKDFDFNAIHYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHA
MGAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRP
SDAFENKACMQVALSLNAPSALILSRQNLPVLDEVSKEQVLKGAYVKHDAKDPIITLVASGSEVSLALESAKMLERENIP
TQVVSAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLL
NA

Sequences:

>Translated_642_residues
MMRLSNADLERLKSMANVLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYS
LLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASRYAQNLLDKKAISHKVYCLCGDG
DLQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAIDISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKP
TLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFIISPKNKMHFEEVKVRGVSLEALWEKSLSPKTK
EKIHALKDFDFNAIHYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHA
MGAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRP
SDAFENKACMQVALSLNAPSALILSRQNLPVLDEVSKEQVLKGAYVKHDAKDPIITLVASGSEVSLALESAKMLERENIP
TQVVSAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLL
NA
>Mature_642_residues
MMRLSNADLERLKSMANVLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYS
LLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASRYAQNLLDKKAISHKVYCLCGDG
DLQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAIDISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKP
TLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFIISPKNKMHFEEVKVRGVSLEALWEKSLSPKTK
EKIHALKDFDFNAIHYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHA
MGAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRP
SDAFENKACMQVALSLNAPSALILSRQNLPVLDEVSKEQVLKGAYVKHDAKDPIITLVASGSEVSLALESAKMLERENIP
TQVVSAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLL
NA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=591, Percent_Identity=26.9035532994924, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI4507521, Length=591, Percent_Identity=26.9035532994924, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI133778974, Length=649, Percent_Identity=25.57781201849, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI225637459, Length=569, Percent_Identity=23.1985940246046, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI225637463, Length=480, Percent_Identity=23.75, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI225637461, Length=480, Percent_Identity=23.75, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=42.3600605143722, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=39.8791540785499, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17539652, Length=571, Percent_Identity=27.84588441331, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=42.3192771084337, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=40.990990990991, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551847, Length=596, Percent_Identity=27.5167785234899, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI45550715, Length=596, Percent_Identity=27.5167785234899, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24666278, Length=655, Percent_Identity=27.175572519084, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24645119, Length=558, Percent_Identity=27.0609318996416, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70803; Mature: 70803

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRLSNADLERLKSMANVLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
WLNRDRLVFSGGHASALAYSLLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITT
CCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GPLGQGFANAVGFSMASRYAQNLLDKKAISHKVYCLCGDGDLQEGISYESASLAGHFRLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCCEEEEEEC
NLIVIYDSNQISIEGAIDISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKP
CEEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCC
TLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFIISPKNKMHFEEV
EEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHH
KVRGVSLEALWEKSLSPKTKEKIHALKDFDFNAIHYPTFKKGESLATRVSNGMILNAIAK
HEECCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHCCCHHHHHHH
ECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCAT
HHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRP
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHEECC
SDAFENKACMQVALSLNAPSALILSRQNLPVLDEVSKEQVLKGAYVKHDAKDPIITLVAS
CCHHCCHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSEVSLALESAKMLERENIPTQVVSAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWY
CCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHH
RFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
HHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMRLSNADLERLKSMANVLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCC
WLNRDRLVFSGGHASALAYSLLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITT
CCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GPLGQGFANAVGFSMASRYAQNLLDKKAISHKVYCLCGDGDLQEGISYESASLAGHFRLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCCEEEEEEC
NLIVIYDSNQISIEGAIDISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKP
CEEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCC
TLLIAHTIIGKGAVGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFIISPKNKMHFEEV
EEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHH
KVRGVSLEALWEKSLSPKTKEKIHALKDFDFNAIHYPTFKKGESLATRVSNGMILNAIAK
HEECCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHCCCHHHHHHH
ECEGFLGGSADLAPSNNTQLKHSGDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCAT
HHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRP
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHEECC
SDAFENKACMQVALSLNAPSALILSRQNLPVLDEVSKEQVLKGAYVKHDAKDPIITLVAS
CCHHCCHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSEVSLALESAKMLERENIPTQVVSAPCFDLLIEQDESYLKELFKGKVLVIEASRAIEWY
CCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHH
RFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
HHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]