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The map label for this gene is msrAB [H]

Identifier: 108562651

GI number: 108562651

Start: 229886

End: 230965

Strand: Direct

Name: msrAB [H]

Synonym: HPAG1_0226

Alternate gene names: 108562651

Gene position: 229886-230965 (Clockwise)

Preceding gene: 108562650

Following gene: 108562652

Centisome position: 14.4

GC content: 40.37

Gene sequence:

>1080_bases
ATGAAGGTATTATCTTATTTGAAAATTTTTTATCTTTTTTTAGCGATAGGAGCGATTATGCAAGCGAATGAAAACATGGG
ATCTAAACTTCCCAAAACCGATGAAAGAGTGATTTACTTGGCTGGGGGGTGCTTTTGGGGGCTAGAGGCGTATATGGAGA
GGATTTATGGCGTCATAGACGCAAGCTCTGGTTACGCTAACGGCAAGACTTCAAGCACGAATTATGAAAAATTGCATGAA
AGCGATCATGCTGAAAGCGTGAAAGTCGTTTATGATCCTAAAAAAATCAGTTTAGACAAGTTGTTGCGCTATTATTTTAA
GGTGGTTGATCCGGTGAGCGTGAACAAGCAGGGTAATGATGTGGGCAGGCAGTATCGCACAGGGATTTATTATGTCAATA
ACGCGGATAAAGAAGTGATAGACAACGCCTTAAAAGCATTACAAAAAGAAGTGAAAGGCAAAATCGCCATTGAGGTAGAG
CCGTTAAAAAATTATGTGAGGGCTGAAGAGTATCACCAGGATTATTTGAAAAAACACCCTGGTGGTTATTGCCATATTGA
TTTGAAAAAGGCGGATGAAGTGATTGTGGATGACGATAAATACACCAAACCCAGCGATGAAGTTTTAAAGAAAAAACTCA
CCAAACTCCAGTATGAAGTTACGCAAAACAAACACACTGAGAAACCCTTTGAAAACGAGTATTACAACAAAGAAGAAGAG
GGCATTTATGTGGATATTACCACAGGCGAGCCGTTATTTTCTTCAGCGGATAAATACGACTCCGGTTGCGGGTGGCCAAG
CTTTTCTAAGCCTATCAATAAAGATGTGGTGAAATACGAAGACGATGAGAGCCTTAACAGGAAACGCATTGAAGTGTTGA
GCCGTATTGGCAAGGCGCATTTAGGGCATGTGTTTAACGATGGGCCTAAAGAATTAGGGGGCTTAAGGTATTGCATCAAC
AGCGCGGCTTTAAGGTTTATCCCCTTAAAAGACATGGAAAAAGAGGGCTATGGCGAGTTTATCCCTTATATCAAAAGGGG
TGAATTGAAAAAATACATCCAAGATAAAAAAACGCATTAA

Upstream 100 bases:

>100_bases
AACAGAGTCTTATTAAAATTTAAACTCAATTTAAAGAACAACTACCATTTTTTTTAGTTATAATGGCAAACACCATTAAA
ATTAAAACAAAGGTTATTCA

Downstream 100 bases:

>100_bases
GAGGTAATGACTAAGCCCCCTAATGGGGGTTAAAGCGTTTGGTTATCTTATGGGTTATTTTAAAAAACGCTAAAATACGC
CCTAAATAATTCATTTTTTA

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKVLSYLKIFYLFLAIGAIMQANENMGSKLPKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHE
SDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVNNADKEVIDNALKALQKEVKGKIAIEVE
PLKNYVRAEEYHQDYLKKHPGGYCHIDLKKADEVIVDDDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEE
GIYVDITTGEPLFSSADKYDSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCIN
SAALRFIPLKDMEKEGYGEFIPYIKRGELKKYIQDKKTH

Sequences:

>Translated_359_residues
MKVLSYLKIFYLFLAIGAIMQANENMGSKLPKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHE
SDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVNNADKEVIDNALKALQKEVKGKIAIEVE
PLKNYVRAEEYHQDYLKKHPGGYCHIDLKKADEVIVDDDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEE
GIYVDITTGEPLFSSADKYDSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCIN
SAALRFIPLKDMEKEGYGEFIPYIKRGELKKYIQDKKTH
>Mature_359_residues
MKVLSYLKIFYLFLAIGAIMQANENMGSKLPKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHE
SDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVNNADKEVIDNALKALQKEVKGKIAIEVE
PLKNYVRAEEYHQDYLKKHPGGYCHIDLKKADEVIVDDDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEE
GIYVDITTGEPLFSSADKYDSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCIN
SAALRFIPLKDMEKEGYGEFIPYIKRGELKKYIQDKKTH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI117606353, Length=128, Percent_Identity=46.09375, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=34.3558282208589, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=36.6666666666667, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=36.2068965517241, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=48.8, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790665, Length=174, Percent_Identity=31.6091954022989, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=111, Percent_Identity=44.1441441441441, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=111, Percent_Identity=44.1441441441441, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=137, Percent_Identity=35.036496350365, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=40.625, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319816, Length=119, Percent_Identity=38.655462184874, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24645799, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356369, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645801, Length=133, Percent_Identity=44.3609022556391, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645804, Length=133, Percent_Identity=44.3609022556391, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=45.9016393442623, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=44.1860465116279, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45553131, Length=144, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 41262; Mature: 41262

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00191 CYTOCHROME_B5_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLSYLKIFYLFLAIGAIMQANENMGSKLPKTDERVIYLAGGCFWGLEAYMERIYGVID
CHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHC
ASSGYANGKTSSTNYEKLHESDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGND
CCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCH
VGRQYRTGIYYVNNADKEVIDNALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKHP
HHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
GGYCHIDLKKADEVIVDDDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEE
CCEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GIYVDITTGEPLFSSADKYDSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAH
CEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGHVFNDGPKELGGLRYCINSAALRFIPLKDMEKEGYGEFIPYIKRGELKKYIQDKKTH
HCHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLSYLKIFYLFLAIGAIMQANENMGSKLPKTDERVIYLAGGCFWGLEAYMERIYGVID
CHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHC
ASSGYANGKTSSTNYEKLHESDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGND
CCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCH
VGRQYRTGIYYVNNADKEVIDNALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKHP
HHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
GGYCHIDLKKADEVIVDDDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEE
CCEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GIYVDITTGEPLFSSADKYDSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAH
CEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGHVFNDGPKELGGLRYCINSAALRFIPLKDMEKEGYGEFIPYIKRGELKKYIQDKKTH
HCHHHCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]