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The map label for this gene is sdcS [H]

Identifier: 108562640

GI number: 108562640

Start: 219623

End: 221281

Strand: Direct

Name: sdcS [H]

Synonym: HPAG1_0215

Alternate gene names: 108562640

Gene position: 219623-221281 (Clockwise)

Preceding gene: 108562636

Following gene: 108562641

Centisome position: 13.76

GC content: 43.04

Gene sequence:

>1659_bases
ATGGAAAATCATTCGCATGCCAATACGCATACCGATACGCGCACCGATGATAAAAGCACTAAGATCGTGCGCTTGTTGGG
GTTAATAGGGGGATCGTTAATCGCGCTTGTTATCTACTATGCGCTCAATTCTCAAATGCCTCATATTGTAGAAGAAATCC
CCAAGCTCAGTTCTTTGAATTATAAGGCGATGCCTGTTGTGGCAGGGGTGGCTGTTTTAATGGGGATATGGTGGATGACT
GAAGCCATTGACTTGCCTGCAACCGCACTTTTACCTTTGGTGCTTTTTAGCGTCTTTAGCGTGGATCAATTCGCTAGCGT
TAGCTCTTCTTACGCATCGCCCATTATCTTTCTTTTTATGGGAGGGTTTATTTTAGCTTTAAGCATGCAAAAATGGAATT
TGCACACGCGCATCGCTTTAAGCATTATTTTATTAGTAGGCACAAGCCCTAGGAGGTTGATTTTAGGTTTCATGATCGCT
ACAGGCTTTTTGTCTATGTGGGTGAGCAATACCGCAACGGCGGTGATGATGTTTCCTGTTGGCATGAGCGTTTTGCAATT
AGTCGCTAAACTGGTGGGTAAAGAAAACGCCTCTAATTCATGGTATCAAAAAGAAGAAATCACCAAAGCGCATGGGGGTA
TTATGAGTAATATCGTGCATAAGGGCAAAGACATTACTCAAGTCATTCAAGAAAAGACTACTATCTATCGCACGAATTTC
AGTATTTGCTTGATGCTTGGCATCGCTTATTCTGCTTCTATTGGCTCTTTAGGCACTTTAATTGGCACGCCGCCTAACGC
TTTATTAGCCGGCTATATGAAAACCGCTTTCAATATTGAAATTGATTTCGCTCAGTGGATGGTGTTTGGGACGCCGTTAG
CCTTTATCATGCTCATTTTAGCGTGGCTCTTGCTCACTTATGTGATTTTCCCTTTAAAGATTAAAGAAATCCCGGGGGGT
AAGGAAGTCGTTAGATTAGAGTTAAACAAATTAGGCCGCTTGAGTCAAGCGGAAATCTCTGTGGGGATTATTTTTATTTT
GGCGTCTTTAGGGTGGATTTTTTTAGATACGATTTTAAAATCTTGGGGCATTAAGATAGATAAAATTGATTCAGTGATCG
CTATGGGGGTTTCTGCACTTTTATTCATTTTGCCCGCTAACCATCAGGGCGATAGGCTCATTGATTGGGGTGTTGCCAAA
AAACTCCCTTGGGATGTGTTGCTTTTATTTGGCGGCGGGTTAGCCTTGAGCGCGCAATTTTCTAAAACCGGGTTGAGTTT
GTGGATCGGGCATTTAGTTTCTGGCTTTTCGCATTTACCGATTTTATTCATCATTGTCATGGTCACTTTAATGGTCATTT
TCTTAACCGAAATCACTTCTAACACCGCCACCGCTGCGGCGTTTTTGCCGGTGATTGGAGGGGTTGCGATGGGCATGGGT
TATGAAAACCATCAGAGCTTGTTATTGACCATTCCTGTAGCCTTGAGCGCGACTTGTGCGTTCATGCTCCCTGTGGCCAC
CCCACCCAATGCGATAGCTTATGGCTCTGGGTATGTTAAAATAACGGATATGATTAAAGCCGGTTTGTGGCTTAATTTGG
TGGGCGTTGTTTTGATTAGCGCGTTTAGCTATTGTTTAGTTTCGCTGGTATTTAATTGA

Upstream 100 bases:

>100_bases
ACCACTCTTTTTCCTATTTTGATATGATTTTTCTAAAATCTTAGTTTTGAAAAAGTTTTATTGTAGCATGGAGGTTAGTA
ATTTTAAAGGGTAAAATAAA

Downstream 100 bases:

>100_bases
TTAAGGAAAAAAGTGAAAGAAGAGTTATTTAAAGAAAAATCTCGTTACATTACAGGGTTTGTTTTAATCATTGCGGCAGG
CTTGATTTTATATGCGGACA

Product: sodium-dependent transporter

Products: tartrate [Cytoplasm]; succinate [Periplasm] [C]

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MENHSHANTHTDTRTDDKSTKIVRLLGLIGGSLIALVIYYALNSQMPHIVEEIPKLSSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMFPVGMSVLQLVAKLVGKENASNSWYQKEEITKAHGGIMSNIVHKGKDITQVIQEKTTIYRTNF
SICLMLGIAYSASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVVRLELNKLGRLSQAEISVGIIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHQGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIVMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLVFN

Sequences:

>Translated_552_residues
MENHSHANTHTDTRTDDKSTKIVRLLGLIGGSLIALVIYYALNSQMPHIVEEIPKLSSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMFPVGMSVLQLVAKLVGKENASNSWYQKEEITKAHGGIMSNIVHKGKDITQVIQEKTTIYRTNF
SICLMLGIAYSASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVVRLELNKLGRLSQAEISVGIIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHQGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIVMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLVFN
>Mature_552_residues
MENHSHANTHTDTRTDDKSTKIVRLLGLIGGSLIALVIYYALNSQMPHIVEEIPKLSSLNYKAMPVVAGVAVLMGIWWMT
EAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMFPVGMSVLQLVAKLVGKENASNSWYQKEEITKAHGGIMSNIVHKGKDITQVIQEKTTIYRTNF
SICLMLGIAYSASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVVRLELNKLGRLSQAEISVGIIFILASLGWIFLDTILKSWGIKIDKIDSVIAMGVSALLFILPANHQGDRLIDWGVAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILFIIVMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLVFN

Specific function: Mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI29171306, Length=513, Percent_Identity=36.2573099415205, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI31377715, Length=525, Percent_Identity=34.0952380952381, Blast_Score=273, Evalue=4e-73,
Organism=Homo sapiens, GI58761541, Length=521, Percent_Identity=33.9731285988484, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI301069349, Length=507, Percent_Identity=33.1360946745562, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI19923838, Length=529, Percent_Identity=33.648393194707, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI4506979, Length=517, Percent_Identity=33.6557059961315, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI301069353, Length=470, Percent_Identity=33.1914893617021, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI225637549, Length=566, Percent_Identity=31.2720848056537, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI31795546, Length=567, Percent_Identity=29.1005291005291, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI301069346, Length=506, Percent_Identity=32.2134387351779, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI225637552, Length=484, Percent_Identity=33.0578512396694, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI219802232, Length=449, Percent_Identity=35.1893095768374, Blast_Score=219, Evalue=5e-57,
Organism=Escherichia coli, GI1789444, Length=449, Percent_Identity=24.0534521158129, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786829, Length=443, Percent_Identity=24.3792325056433, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989118, Length=492, Percent_Identity=33.5365853658537, Blast_Score=245, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71988385, Length=484, Percent_Identity=33.2644628099174, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565804, Length=472, Percent_Identity=33.6864406779661, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17551790, Length=511, Percent_Identity=27.3972602739726, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32564681, Length=502, Percent_Identity=28.0876494023904, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324340, Length=500, Percent_Identity=22.8, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322263, Length=511, Percent_Identity=22.3091976516634, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281366409, Length=496, Percent_Identity=31.6532258064516, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI17737623, Length=496, Percent_Identity=31.6532258064516, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24666468, Length=496, Percent_Identity=31.6532258064516, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI45551633, Length=496, Percent_Identity=31.6532258064516, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281362116, Length=522, Percent_Identity=30.4597701149425, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI281362114, Length=522, Percent_Identity=30.2681992337165, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281362112, Length=522, Percent_Identity=30.2681992337165, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI78706796, Length=505, Percent_Identity=29.5049504950495, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI78706798, Length=505, Percent_Identity=29.5049504950495, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 59920; Mature: 59920

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENHSHANTHTDTRTDDKSTKIVRLLGLIGGSLIALVIYYALNSQMPHIVEEIPKLSSLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCC
YKAMPVVAGVAVLMGIWWMTEAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMFPV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHC
GMSVLQLVAKLVGKENASNSWYQKEEITKAHGGIMSNIVHKGKDITQVIQEKTTIYRTNF
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHEEECCH
SICLMLGIAYSASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHCCHHHHHHHHH
AWLLLTYVIFPLKIKEIPGGKEVVRLELNKLGRLSQAEISVGIIFILASLGWIFLDTILK
HHHHHHHHHHHHHEEECCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANHQGDRLIDWGVAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCCCCHHHHEEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILFIIVMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCEEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYCLVSLVFN
HHHHHHHHHHCC
>Mature Secondary Structure
MENHSHANTHTDTRTDDKSTKIVRLLGLIGGSLIALVIYYALNSQMPHIVEEIPKLSSLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCC
YKAMPVVAGVAVLMGIWWMTEAIDLPATALLPLVLFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMFPV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHC
GMSVLQLVAKLVGKENASNSWYQKEEITKAHGGIMSNIVHKGKDITQVIQEKTTIYRTNF
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHEEECCH
SICLMLGIAYSASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHCCHHHHHHHHH
AWLLLTYVIFPLKIKEIPGGKEVVRLELNKLGRLSQAEISVGIIFILASLGWIFLDTILK
HHHHHHHHHHHHHEEECCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANHQGDRLIDWGVAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCCCCHHHHEEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILFIIVMVTLMVIFLTEITSNTATAAAFLPVIGGVAMGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
YENHQSLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCEEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYCLVSLVFN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: tartrate [Periplasm]; succinate [Cytoplasm] [C]

Specific reaction: tartrate [Periplasm] + succinate [Cytoplasm] = tartrate [Cytoplasm] + succinate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA