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The map label for this gene is mutY [H]

Identifier: 108562565

GI number: 108562565

Start: 149377

End: 150363

Strand: Reverse

Name: mutY [H]

Synonym: HPAG1_0140

Alternate gene names: 108562565

Gene position: 150363-149377 (Counterclockwise)

Preceding gene: 108562566

Following gene: 108562562

Centisome position: 9.42

GC content: 36.88

Gene sequence:

>987_bases
CTGGAAACTTTACACAACGCCCTTTTAAAATGGTATGAAGAATTTGGGCGCAAAGGTTTACCTTTTAGGAATTTAAAGGG
CATTAACGCTCCTTATGAAGTCTATATCAGTGAAGTGATGAGCCAACAAACCCAAATCAACACGGTAATTGAGCGTTTCT
ATTCCCCTTTTTTAGAAGCTTTCCCCACTTTAAAAGACTTAGCAAACGCTCCATTAGAGGAGGTTTTATTGTTATGGCGA
GGGCTTGGTTATTATTCAAGGGCTAAAAATTTAAAAAAAAGCGCTGAAATTTGCGTTAAAGAACATAACTCACAATTACC
TAATGACTATCAAAGCCTGTTGAAACTCCCCGGTATTGGCGCATACACGGCTAATGCGATCTTGTGTTTTGGCTTTAGAG
AAAAGAGCGCATGCGTGGATGCTAATATCAAACGAACGCTTTTAAGGCTTTTTGGTTTGAATCCTAATATCACGGCTAAA
GACTTACAAATTAAAGCGAATGACTTTCTCAATCTTAATGAAAGCTTTAATCATAACCAAGCCCTAATTGATCTAGGGGC
TTTAATCTGCTCCCCTAAACCCAAATGCACGATTTGCCCTTTAAACCCTTATTGTTTAGGAAAAAATAACCCAGAAAAAC
ACACGCTTAAGAAAAAACAAGAAATCGTTCAAGAAGAGCGTTACTTGGGCGTTGTGATCCAAAATAACCAAATCGCTTTA
GAAAAAATAGAGCAAAAACTCTATTTGGGGATGCACCATTTCCCTGACTTAAAAGAAAATTTAGAATGCAAACTCCCCTT
TTTAGGCGCGATCAAACACAGCCACACTAAATTCAAGCTCCATTTAAACCTCTATTCAGCCGCAATAAAGGATCTAAAAA
ATCCCATTCGTTTTTATAGTCTTAAAGACTTAGAGACCTTACCCATAAGCTCTATGACGCTTAAAATCTTGCATTTTTTA
AAACAAAAAAATTTATTTGGGGGTTAA

Upstream 100 bases:

>100_bases
TTTTTGGAAATGGGGGTTTATTTTTGGCTTTTTGTATTTAATCGTGTTTTTAAGCGTGTGTGTGCCTTGGGTCAAATTCA
TCGCTTACAGGTGGTTGTAG

Downstream 100 bases:

>100_bases
ACCCTGCCAAATCTAAAATGGCTCTACTTTATCGCAGGCACCACTTCAGGGATCAAATACGCAATCGCGCTAATCACAAC
TCCCATGATCGCTACAAAAA

Product: DNA glycosylase MutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEAFPTLKDLANAPLEEVLLLWR
GLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRTLLRLFGLNPNITAK
DLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCTICPLNPYCLGKNNPEKHTLKKKQEIVQEERYLGVVIQNNQIAL
EKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPIRFYSLKDLETLPISSMTLKILHFL
KQKNLFGG

Sequences:

>Translated_328_residues
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEAFPTLKDLANAPLEEVLLLWR
GLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRTLLRLFGLNPNITAK
DLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCTICPLNPYCLGKNNPEKHTLKKKQEIVQEERYLGVVIQNNQIAL
EKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPIRFYSLKDLETLPISSMTLKILHFL
KQKNLFGG
>Mature_328_residues
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEAFPTLKDLANAPLEEVLLLWR
GLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRTLLRLFGLNPNITAK
DLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCTICPLNPYCLGKNNPEKHTLKKKQEIVQEERYLGVVIQNNQIAL
EKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPIRFYSLKDLETLPISSMTLKILHFL
KQKNLFGG

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI115298654, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI115298652, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI115298648, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI6912520, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI190358497, Length=227, Percent_Identity=37.0044052863436, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1789331, Length=302, Percent_Identity=35.0993377483444, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37546; Mature: 37546

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPTLKDLANAPLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIG
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
AYTANAILCFGFREKSACVDANIKRTLLRLFGLNPNITAKDLQIKANDFLNLNESFNHNQ
CHHHCEEEEEECCCCCHHHCCHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCCCCCH
ALIDLGALICSPKPKCTICPLNPYCLGKNNPEKHTLKKKQEIVQEERYLGVVIQNNQIAL
HHHHHHHHHCCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHH
EKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPIRFYS
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHCCCEEEEEEEHHHHHHHHHHHCHHHHEE
LKDLETLPISSMTLKILHFLKQKNLFGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
METLHNALLKWYEEFGRKGLPFRNLKGINAPYEVYISEVMSQQTQINTVIERFYSPFLEA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPTLKDLANAPLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIG
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
AYTANAILCFGFREKSACVDANIKRTLLRLFGLNPNITAKDLQIKANDFLNLNESFNHNQ
CHHHCEEEEEECCCCCHHHCCHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCCCCCH
ALIDLGALICSPKPKCTICPLNPYCLGKNNPEKHTLKKKQEIVQEERYLGVVIQNNQIAL
HHHHHHHHHCCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHH
EKIEQKLYLGMHHFPDLKENLECKLPFLGAIKHSHTKFKLHLNLYSAAIKDLKNPIRFYS
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHCCCEEEEEEEHHHHHHHHHHHCHHHHEE
LKDLETLPISSMTLKILHFLKQKNLFGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]