| Definition | Burkholderia cenocepacia AU 1054 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008060 |
| Length | 3,294,563 |
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The map label for this gene is fabG2 [H]
Identifier: 107023151
GI number: 107023151
Start: 1776991
End: 1777758
Strand: Reverse
Name: fabG2 [H]
Synonym: Bcen_1600
Alternate gene names: 107023151
Gene position: 1777758-1776991 (Counterclockwise)
Preceding gene: 107023152
Following gene: 107023150
Centisome position: 53.96
GC content: 69.01
Gene sequence:
>768_bases ATGAATATCAAGGATCGCGTTTTTCTGATTACGGGCGCCGGTTCCGGCCTCGGCGCCGCGGTGGCGCGCATGGTCGTCGC GCAAGGCGGCAAGGCCGTGCTGCTGGACGTCAATGACGAGGCGGGCGCGGGTCTCGCGAACGAACTCGGCGCGGCCGCGC GCTTCGTGAAGACCGACGTGACGAGCGAAGCCGACGGTCAGGCGGCCGTTGCGGCCGCGCGCGACGCGTTTGGCCGCGTC GATGCGCTCGTCAACTGCGCGGGCGTCGCGCCGGGCGAGAAGGTCGTCGGCCGCGATGGCCTGCACTCGCTCGACCGCTT CGCGCGGGCGGTGTCGATCAACCTCGTCGGCACGTTCAACATGATTCGGCTGGCTGCTGAAGCGATGTCGAAGCAGGACG CCGATGCGGAAGGCGAGCGCGGCGTGATCATCAACACCGCGTCGGTCGCGGCGTTCGACGGACAGATCGGACAGGCCGCG TATGCGGCGTCGAAGAGCGGCGTGGTGGGCATGACGCTGCCGATCGCGCGCGAACTCGCGCGCTTCGGCATTCGCGTCGT GACGGTCGCGCCCGGTATCTTCGCGACGCCGATGATGGCCGGCATGCCGCAGGACGTGCAGGACGCGCTCGGCAAGAGCG TGCCGTTTCCGCCGCGGCTCGGCCGCCCGGAAGAATTTGCGGCGCTGGTGCGCCACATCGCCGAGAACACGATGCTGAAC GGCGAAGTCATCCGTCTCGATGGCGCGTTGCGCATGGCACCGCGCTGA
Upstream 100 bases:
>100_bases GTCGACGCGCTGCCGAAAACCCCGAGCGGCAAGATCCAGCGCTTCGTGTTGCGCAAGATGGAAGCCGAGAAGGTCGCTCA ACCCTGAATACGGACTGCCA
Downstream 100 bases:
>100_bases CACTGGAGGAAGCGAATCATGACGACTCAGGATCCGATCGTAATCGTGGGCGCGGCGCGCACGCCGATGGGTGGTTTTCA GGGCGACCTGGCGGCGGCGA
Product: short-chain dehydrogenase/reductase SDR
Products: 3-oxoacyl-CoA; NADH; H+
Alternate protein names: NA
Number of amino acids: Translated: 255; Mature: 255
Protein sequence:
>255_residues MNIKDRVFLITGAGSGLGAAVARMVVAQGGKAVLLDVNDEAGAGLANELGAAARFVKTDVTSEADGQAAVAAARDAFGRV DALVNCAGVAPGEKVVGRDGLHSLDRFARAVSINLVGTFNMIRLAAEAMSKQDADAEGERGVIINTASVAAFDGQIGQAA YAASKSGVVGMTLPIARELARFGIRVVTVAPGIFATPMMAGMPQDVQDALGKSVPFPPRLGRPEEFAALVRHIAENTMLN GEVIRLDGALRMAPR
Sequences:
>Translated_255_residues MNIKDRVFLITGAGSGLGAAVARMVVAQGGKAVLLDVNDEAGAGLANELGAAARFVKTDVTSEADGQAAVAAARDAFGRV DALVNCAGVAPGEKVVGRDGLHSLDRFARAVSINLVGTFNMIRLAAEAMSKQDADAEGERGVIINTASVAAFDGQIGQAA YAASKSGVVGMTLPIARELARFGIRVVTVAPGIFATPMMAGMPQDVQDALGKSVPFPPRLGRPEEFAALVRHIAENTMLN GEVIRLDGALRMAPR >Mature_255_residues MNIKDRVFLITGAGSGLGAAVARMVVAQGGKAVLLDVNDEAGAGLANELGAAARFVKTDVTSEADGQAAVAAARDAFGRV DALVNCAGVAPGEKVVGRDGLHSLDRFARAVSINLVGTFNMIRLAAEAMSKQDADAEGERGVIINTASVAAFDGQIGQAA YAASKSGVVGMTLPIARELARFGIRVVTVAPGIFATPMMAGMPQDVQDALGKSVPFPPRLGRPEEFAALVRHIAENTMLN GEVIRLDGALRMAPR
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=55.2941176470588, Blast_Score=274, Evalue=7e-74, Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=52.5490196078431, Blast_Score=251, Evalue=6e-67, Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=34.469696969697, Blast_Score=118, Evalue=6e-27, Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=31.8725099601594, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=27.8625954198473, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI4504505, Length=244, Percent_Identity=31.9672131147541, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI59889578, Length=211, Percent_Identity=30.3317535545024, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=34.4632768361582, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI22507405, Length=231, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=7e-13, Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=30.1960784313725, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=26.7716535433071, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=24.9056603773585, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=31.5175097276265, Blast_Score=107, Evalue=1e-24, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=32.1705426356589, Blast_Score=89, Evalue=2e-19, Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=30.7086614173228, Blast_Score=85, Evalue=4e-18, Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=29.5019157088123, Blast_Score=82, Evalue=2e-17, Organism=Escherichia coli, GI1789057, Length=210, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=28.9156626506024, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1789378, Length=252, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=29.5275590551181, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=31.6, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=27.6264591439689, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=27.8225806451613, Blast_Score=62, Evalue=5e-11, Organism=Escherichia coli, GI1787820, Length=187, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=9e-11, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=47.0355731225296, Blast_Score=232, Evalue=1e-61, Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=29.4820717131474, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=31.8897637795276, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=27.2373540856031, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.5092936802974, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=27.363184079602, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17568967, Length=242, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=26.7924528301887, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI193203115, Length=207, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203117, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17563726, Length=242, Percent_Identity=26.0330578512397, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17508895, Length=215, Percent_Identity=28.3720930232558, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=26.3358778625954, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI72000259, Length=204, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17538480, Length=248, Percent_Identity=26.6129032258064, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=260, Percent_Identity=30.3846153846154, Blast_Score=97, Evalue=2e-21, Organism=Saccharomyces cerevisiae, GI6322227, Length=231, Percent_Identity=26.4069264069264, Blast_Score=68, Evalue=1e-12, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=55.5118110236221, Blast_Score=278, Evalue=3e-75, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=35.1778656126482, Blast_Score=127, Evalue=8e-30, Organism=Drosophila melanogaster, GI28571526, Length=266, Percent_Identity=31.203007518797, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=30.8270676691729, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI24644339, Length=267, Percent_Identity=31.4606741573034, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI23397609, Length=266, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI18859837, Length=210, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI221331218, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24665243, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI221331216, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24665247, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.35
Molecular weight: Translated: 26252; Mature: 26252
Theoretical pI: Translated: 6.55; Mature: 6.55
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.9 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.9 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIKDRVFLITGAGSGLGAAVARMVVAQGGKAVLLDVNDEAGAGLANELGAAARFVKTDV CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCC TSEADGQAAVAAARDAFGRVDALVNCAGVAPGEKVVGRDGLHSLDRFARAVSINLVGTFN CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHEEEEEEEHHH MIRLAAEAMSKQDADAEGERGVIINTASVAAFDGQIGQAAYAASKSGVVGMTLPIARELA HHHHHHHHHHHCCCCCCCCCCEEEEECEEEEECCCCCHHHHHHCCCCEEEEEHHHHHHHH RFGIRVVTVAPGIFATPMMAGMPQDVQDALGKSVPFPPRLGRPEEFAALVRHIAENTMLN HCCEEEEEECCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC GEVIRLDGALRMAPR CEEEEECCCEECCCC >Mature Secondary Structure MNIKDRVFLITGAGSGLGAAVARMVVAQGGKAVLLDVNDEAGAGLANELGAAARFVKTDV CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCC TSEADGQAAVAAARDAFGRVDALVNCAGVAPGEKVVGRDGLHSLDRFARAVSINLVGTFN CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHEEEEEEEHHH MIRLAAEAMSKQDADAEGERGVIINTASVAAFDGQIGQAAYAASKSGVVGMTLPIARELA HHHHHHHHHHHCCCCCCCCCCEEEEECEEEEECCCCCHHHHHHCCCCEEEEEHHHHHHHH RFGIRVVTVAPGIFATPMMAGMPQDVQDALGKSVPFPPRLGRPEEFAALVRHIAENTMLN HCCEEEEEECCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC GEVIRLDGALRMAPR CEEEEECCCEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (S)-3-hydroxyacyl-CoA; NAD+
Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9634230; 12218036 [H]