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The map label for this gene is acsA [H]

Identifier: 107023152

GI number: 107023152

Start: 1777772

End: 1779439

Strand: Reverse

Name: acsA [H]

Synonym: Bcen_1601

Alternate gene names: 107023152

Gene position: 1779439-1777772 (Counterclockwise)

Preceding gene: 107023161

Following gene: 107023151

Centisome position: 54.01

GC content: 69.36

Gene sequence:

>1668_bases
ATGCCTGAAGGAGCTACCGCCCGGGCGGTGCCGGCCTACGCCGACGCCGTGGCCCGTTTCAGTATCGAGACCGCTGCCGC
GCAACTGAGCGGCGATCTGGAGCGCGGCCTGAACGCGTGTGTCGAATGTTGCGACCGGCACGCGAAGGCGGACGCGATCG
CGCTCGACTGGATCGACGCCGGCGGGCAGCACCACCGCTTCACGTTCGCGCAAATGCAGGCGTTGTCGGCCCGGGTTGCG
AACCTGCTCGTCGCGCAGGGCGTGAAGCCGGGCGACGTGGTGGCCGGCCTGCTGCCGCGCACGCCGGAGCTCGTCGCGAC
GATCCTCGGCACGTGGCGCGCGGGCGCCGTGTACCAGCCGCTGTTTACCGCGTTCGGCCCGAAGGCGATCGAGCACCGGC
TGCGCATGAGCGATGCGCGGCTCGTCGTGACCAACGTCGCGAATCGCGCGAAGCTCGACGAAATCGCCGATTGCCCGCCG
GTCGCGACGGTACGCGAAGCAGGCGAGGCGCTGCGGATGCGCGACATCGATTTCCGCACGGCGCTCGACGCGCAATCCGA
TACGTTCGAGCTCGTGCCGCGCAAGGGGTCGGACCTGTTCATGATGATGTCGACGTCGGGCACGACGGGCTTGCCGAAGG
GCGTGCCGGTGCCGCTGTACGCGCTGCTCGCGTTCAGCGCGTACATGCGCGAAGCGGTCGACCTGCGTGCCGGCGACCGG
TTCTGGAACATCGCCGATCCGGGCTGGGCGTACGGGCTCTATTACGCGATCACGGGCCCGCTGCTGCTCGGTCATGCGAC
GACGCTGTACGAGGGCAGCTTCACGGTCGACAGCACGTACGACGTGATCGACCGGCTCGGCATCACGAGCCTCGCGGGTT
CGCCGACCGCATTCCGGATGCTGATGGCGGCCGGGACGGAAGCGGCCGCGCGCGTGAAGGGCCGGCTGCGCGCGGTGAGC
AGCGCGGGCGAACCGTTGAACCCGGAGGTCGTGCGCTGGTTCCACGCGGCGCTCGGCGCGCCGATCCACGATCACTACGG
CCAGACCGAACTGGGCATGGTCGTGAACAACCATCACGGCCTCACGCACGTGGTGCACGTCGGTTCGGCCGGCTTCGCGA
TGCCGGGCTACCGCGTCGCGGTGCTCGACGAAGCGGGCCGCGAACTCGGCCCCGGCGAGCCCGGCAACCTCGCGATCGAC
ATCGCTCGCTCGCCGCTGCTGTGGTTCCGCGGCTACTGGCAGCAGGACACGCCGGCGATCGCGGGCGGCTATTACCGGAC
CGGCGACAACGTCGAGCTGGAGCCGGACGGCGCCGTGAGCTTCATCGGCCGCGCGGACGACGTGATCACGTCGTCCGGCT
ACCGGATCGGCCCGTTCGACGTGGAGAGCGCGCTGATCGAGCATCCGGCCGTCAGCGAGGCCGCCGTGATCGGCGTGCCC
GACCCGGAGCGCACGGAGATCGTGAAGGCGTTCGTCGTCCTGTCGAAGGGCTTCGACGGCACGCCCGAACTGGCCGAGGA
ATTGAGTCTGCACGTGAAGCGGCGGCTGTCCGCTCACGCTTATCCGCGCGCGATCGACTTCGTCGACGCGCTGCCGAAAA
CCCCGAGCGGCAAGATCCAGCGCTTCGTGTTGCGCAAGATGGAAGCCGAGAAGGTCGCTCAACCCTGA

Upstream 100 bases:

>100_bases
ATTCCGTTTGTCATTGATTGCAATGTAGGGGCTGTCTACTATCGATGTATCCCCGTCGCGCCTCTGGCGCGTCGGCGGCT
ATAACGCACAGGAGACACGC

Downstream 100 bases:

>100_bases
ATACGGACTGCCAATGAATATCAAGGATCGCGTTTTTCTGATTACGGGCGCCGGTTCCGGCCTCGGCGCCGCGGTGGCGC
GCATGGTCGTCGCGCAAGGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MPEGATARAVPAYADAVARFSIETAAAQLSGDLERGLNACVECCDRHAKADAIALDWIDAGGQHHRFTFAQMQALSARVA
NLLVAQGVKPGDVVAGLLPRTPELVATILGTWRAGAVYQPLFTAFGPKAIEHRLRMSDARLVVTNVANRAKLDEIADCPP
VATVREAGEALRMRDIDFRTALDAQSDTFELVPRKGSDLFMMMSTSGTTGLPKGVPVPLYALLAFSAYMREAVDLRAGDR
FWNIADPGWAYGLYYAITGPLLLGHATTLYEGSFTVDSTYDVIDRLGITSLAGSPTAFRMLMAAGTEAAARVKGRLRAVS
SAGEPLNPEVVRWFHAALGAPIHDHYGQTELGMVVNNHHGLTHVVHVGSAGFAMPGYRVAVLDEAGRELGPGEPGNLAID
IARSPLLWFRGYWQQDTPAIAGGYYRTGDNVELEPDGAVSFIGRADDVITSSGYRIGPFDVESALIEHPAVSEAAVIGVP
DPERTEIVKAFVVLSKGFDGTPELAEELSLHVKRRLSAHAYPRAIDFVDALPKTPSGKIQRFVLRKMEAEKVAQP

Sequences:

>Translated_555_residues
MPEGATARAVPAYADAVARFSIETAAAQLSGDLERGLNACVECCDRHAKADAIALDWIDAGGQHHRFTFAQMQALSARVA
NLLVAQGVKPGDVVAGLLPRTPELVATILGTWRAGAVYQPLFTAFGPKAIEHRLRMSDARLVVTNVANRAKLDEIADCPP
VATVREAGEALRMRDIDFRTALDAQSDTFELVPRKGSDLFMMMSTSGTTGLPKGVPVPLYALLAFSAYMREAVDLRAGDR
FWNIADPGWAYGLYYAITGPLLLGHATTLYEGSFTVDSTYDVIDRLGITSLAGSPTAFRMLMAAGTEAAARVKGRLRAVS
SAGEPLNPEVVRWFHAALGAPIHDHYGQTELGMVVNNHHGLTHVVHVGSAGFAMPGYRVAVLDEAGRELGPGEPGNLAID
IARSPLLWFRGYWQQDTPAIAGGYYRTGDNVELEPDGAVSFIGRADDVITSSGYRIGPFDVESALIEHPAVSEAAVIGVP
DPERTEIVKAFVVLSKGFDGTPELAEELSLHVKRRLSAHAYPRAIDFVDALPKTPSGKIQRFVLRKMEAEKVAQP
>Mature_554_residues
PEGATARAVPAYADAVARFSIETAAAQLSGDLERGLNACVECCDRHAKADAIALDWIDAGGQHHRFTFAQMQALSARVAN
LLVAQGVKPGDVVAGLLPRTPELVATILGTWRAGAVYQPLFTAFGPKAIEHRLRMSDARLVVTNVANRAKLDEIADCPPV
ATVREAGEALRMRDIDFRTALDAQSDTFELVPRKGSDLFMMMSTSGTTGLPKGVPVPLYALLAFSAYMREAVDLRAGDRF
WNIADPGWAYGLYYAITGPLLLGHATTLYEGSFTVDSTYDVIDRLGITSLAGSPTAFRMLMAAGTEAAARVKGRLRAVSS
AGEPLNPEVVRWFHAALGAPIHDHYGQTELGMVVNNHHGLTHVVHVGSAGFAMPGYRVAVLDEAGRELGPGEPGNLAIDI
ARSPLLWFRGYWQQDTPAIAGGYYRTGDNVELEPDGAVSFIGRADDVITSSGYRIGPFDVESALIEHPAVSEAAVIGVPD
PERTEIVKAFVVLSKGFDGTPELAEELSLHVKRRLSAHAYPRAIDFVDALPKTPSGKIQRFVLRKMEAEKVAQP

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI122937307, Length=506, Percent_Identity=36.5612648221344, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI38505220, Length=512, Percent_Identity=36.71875, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI42544132, Length=511, Percent_Identity=34.0508806262231, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI58082049, Length=507, Percent_Identity=36.094674556213, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI115511026, Length=506, Percent_Identity=33.00395256917, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI157311624, Length=505, Percent_Identity=35.8415841584158, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI157311622, Length=505, Percent_Identity=35.8415841584158, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI8923896, Length=605, Percent_Identity=31.2396694214876, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI253970489, Length=618, Percent_Identity=29.4498381877023, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI28416953, Length=553, Percent_Identity=30.5605786618445, Blast_Score=219, Evalue=8e-57,
Organism=Homo sapiens, GI13375727, Length=554, Percent_Identity=29.9638989169675, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI195947378, Length=411, Percent_Identity=28.4671532846715, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI42544134, Length=340, Percent_Identity=28.5294117647059, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI187761345, Length=543, Percent_Identity=26.1510128913444, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI187761343, Length=543, Percent_Identity=26.1510128913444, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI156151445, Length=520, Percent_Identity=26.7307692307692, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1790505, Length=548, Percent_Identity=32.2992700729927, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI145693145, Length=509, Percent_Identity=26.9155206286837, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1786529, Length=555, Percent_Identity=28.4684684684685, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788107, Length=520, Percent_Identity=27.6923076923077, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI221142682, Length=507, Percent_Identity=24.0631163708087, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786810, Length=530, Percent_Identity=23.3962264150943, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786801, Length=426, Percent_Identity=24.6478873239437, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=565, Percent_Identity=31.5044247787611, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982997, Length=568, Percent_Identity=30.9859154929577, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17557194, Length=547, Percent_Identity=27.0566727605119, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=546, Percent_Identity=25.0915750915751, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=511, Percent_Identity=25.8317025440313, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=22.5099601593625, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=548, Percent_Identity=23.5401459854015, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=495, Percent_Identity=23.4343434343434, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=524, Percent_Identity=24.8091603053435, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=524, Percent_Identity=24.8091603053435, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=524, Percent_Identity=24.8091603053435, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559526, Length=522, Percent_Identity=23.3716475095785, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=499, Percent_Identity=23.2464929859719, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=369, Percent_Identity=26.2872628726287, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI115534440, Length=524, Percent_Identity=23.4732824427481, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319264, Length=589, Percent_Identity=32.427843803056, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6323182, Length=579, Percent_Identity=30.3972366148532, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319699, Length=357, Percent_Identity=25.7703081232493, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24667955, Length=602, Percent_Identity=28.7375415282392, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62472339, Length=535, Percent_Identity=29.5327102803738, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24667959, Length=504, Percent_Identity=29.5634920634921, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355225, Length=562, Percent_Identity=27.7580071174377, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24581924, Length=508, Percent_Identity=26.1811023622047, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18859661, Length=508, Percent_Identity=27.5590551181102, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19922652, Length=513, Percent_Identity=25.5360623781676, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24656500, Length=493, Percent_Identity=24.7464503042596, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356947, Length=488, Percent_Identity=23.155737704918, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355181, Length=520, Percent_Identity=24.8076923076923, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24648260, Length=487, Percent_Identity=23.8193018480493, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648676, Length=523, Percent_Identity=26.0038240917782, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653035, Length=495, Percent_Identity=21.4141414141414, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20130357, Length=360, Percent_Identity=23.0555555555556, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI161076582, Length=506, Percent_Identity=20.5533596837945, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648257, Length=496, Percent_Identity=22.3790322580645, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648253, Length=435, Percent_Identity=21.8390804597701, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356441, Length=502, Percent_Identity=21.7131474103586, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648255, Length=432, Percent_Identity=21.5277777777778, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 59680; Mature: 59548

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGATARAVPAYADAVARFSIETAAAQLSGDLERGLNACVECCDRHAKADAIALDWIDA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
GGQHHRFTFAQMQALSARVANLLVAQGVKPGDVVAGLLPRTPELVATILGTWRAGAVYQP
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
LFTAFGPKAIEHRLRMSDARLVVTNVANRAKLDEIADCPPVATVREAGEALRMRDIDFRT
HHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
ALDAQSDTFELVPRKGSDLFMMMSTSGTTGLPKGVPVPLYALLAFSAYMREAVDLRAGDR
HCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
FWNIADPGWAYGLYYAITGPLLLGHATTLYEGSFTVDSTYDVIDRLGITSLAGSPTAFRM
EECCCCCCHHHHHHHHHHHHHHHCCHHEEECCCEEECCHHHHHHHCCCHHCCCCHHHHHH
LMAAGTEAAARVKGRLRAVSSAGEPLNPEVVRWFHAALGAPIHDHYGQTELGMVVNNHHG
HHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHCCCCEECEEEECCCC
LTHVVHVGSAGFAMPGYRVAVLDEAGRELGPGEPGNLAIDIARSPLLWFRGYWQQDTPAI
CEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCCC
AGGYYRTGDNVELEPDGAVSFIGRADDVITSSGYRIGPFDVESALIEHPAVSEAAVIGVP
CCCEEECCCCCEECCCCCEEECCCCCHHEECCCCEECCCCHHHHHHCCCCCCCEEEEECC
DPERTEIVKAFVVLSKGFDGTPELAEELSLHVKRRLSAHAYPRAIDFVDALPKTPSGKIQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
RFVLRKMEAEKVAQP
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
PEGATARAVPAYADAVARFSIETAAAQLSGDLERGLNACVECCDRHAKADAIALDWIDA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
GGQHHRFTFAQMQALSARVANLLVAQGVKPGDVVAGLLPRTPELVATILGTWRAGAVYQP
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
LFTAFGPKAIEHRLRMSDARLVVTNVANRAKLDEIADCPPVATVREAGEALRMRDIDFRT
HHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
ALDAQSDTFELVPRKGSDLFMMMSTSGTTGLPKGVPVPLYALLAFSAYMREAVDLRAGDR
HCCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
FWNIADPGWAYGLYYAITGPLLLGHATTLYEGSFTVDSTYDVIDRLGITSLAGSPTAFRM
EECCCCCCHHHHHHHHHHHHHHHCCHHEEECCCEEECCHHHHHHHCCCHHCCCCHHHHHH
LMAAGTEAAARVKGRLRAVSSAGEPLNPEVVRWFHAALGAPIHDHYGQTELGMVVNNHHG
HHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHCCCCEECEEEECCCC
LTHVVHVGSAGFAMPGYRVAVLDEAGRELGPGEPGNLAIDIARSPLLWFRGYWQQDTPAI
CEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCCC
AGGYYRTGDNVELEPDGAVSFIGRADDVITSSGYRIGPFDVESALIEHPAVSEAAVIGVP
CCCEEECCCCCEECCCCCEEECCCCCHHEECCCCEECCCCHHHHHHCCCCCCCEEEEECC
DPERTEIVKAFVVLSKGFDGTPELAEELSLHVKRRLSAHAYPRAIDFVDALPKTPSGKIQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
RFVLRKMEAEKVAQP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]