Click here to switch to the map view.

The map label for this gene is thlA [H]

Identifier: 107023104

GI number: 107023104

Start: 1724810

End: 1726003

Strand: Reverse

Name: thlA [H]

Synonym: Bcen_1553

Alternate gene names: 107023104

Gene position: 1726003-1724810 (Counterclockwise)

Preceding gene: 107023105

Following gene: 107023103

Centisome position: 52.39

GC content: 68.34

Gene sequence:

>1194_bases
ATGAGCAATGCAGCGAAGGAAGTCGTGGTGGTGAGCGGGGTCCGTACCGCGATCGGTGATTTCGGCGGCAGCCTGAAGGA
TTTCTCGCCGACCGACCTCGGCGCGAAGGTGGTCGCCGAAGTGCTGTCGCGCGCGAACGTGCCGGGCGACGCGGTCGGGC
ACGTCGTGTTCGGCCACGTCGTGAACACCGAGCCGAAGGACATGTATCTCGCGCGTGTCGCGGCGATCAACGGCGGCGTC
GCGCAGCACACGCCGGCGCTGACCGTGAACCGCCTGTGCGGCTCGGGCCTGCAGGCGATCGTATCGGCCGCGCAGACGAT
CATGCTCGGCGATGCCGACGTCGCGATCGGCGGCGGCTCGGAGAGCATGAGCCGCGCGCCGTACACCGTGCCGGCCGCGC
GCTTCGGCCAGCGCATGGGCGACGGCAAGCTCGTCGACATGATGCTCGGCGCGCTGCACGACCCGTTCCAGACGATCCAC
ATGGGCGTGACCGCCGAGAACGTCGCGAAGAAATACGACATCTCGCGTGACGCGCAGGATGCGCTGGCGCTCGAATCGCA
TCGTCGCGCGGCGCGCGCGATCGCGGAAGGGCGTTTCAAGGACCAGATCCTGCCGATCTCGATCCGCACGAAGAAGGGCG
AAGTGGCGTTCGATACCGACGAGCACGTGCGCCACGACGCGAGCGCGGACGATTTCACGAAGCTCAAGCCGGTGTTCGCG
AAGGAGAACGGCACCGTGACGGCCGGCAACGCGTCGGGCATCAACGACGCGGCCGCCGCCGTGCTGATGATGAGCGCGGA
CGCCGCACGCGCGCAGGGCGTGAAGCCGCTCGCCCGCCTCGTCGCGTATGCGCACGCAGGCGTCGATCCGGCGTACATGG
GCATCGGCCCGGTGCCGGCCACGCAGAAGGCGCTCGAACGCGCGGGCCTGAAGATCAGCGATCTCGACGTGATCGAAGCC
AACGAGGCATTCGCGGCCCAGGCGTGTGCGGTCACGCAGGAGCTCGGCCTCGATCCGGCCAAGGTCAACCCGAACGGCTC
GGGCATCTCGCTCGGTCACCCGATCGGTGCGACCGGCGCGCTGATCACGGTGAAGGCGCTGTACGAGCTGAAGCGCATCG
GCGGGCGTTACGCGCTCGTGACGATGTGCATCGGCGGCGGCCAGGGGATTGCGGCGATCTTCGAGAACATCTGA

Upstream 100 bases:

>100_bases
TCGTGTGGGTCACGCCCGAAGGCGGCGGCGGGCCGAATTACCCGAACATGTAACGCAACGCATCCCGCGCCCGCGGGCGC
GAACGAACCGGAGTGAGACG

Downstream 100 bases:

>100_bases
TAATCGACCGCTCAGCCTCCGAATACACAGGAATCGTCATGGCCATCGAAACCGTCGGCGTCGTGGGCGCCGGAACCATG
GGTAACGGCATTGCGCAAAC

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSNAAKEVVVVSGVRTAIGDFGGSLKDFSPTDLGAKVVAEVLSRANVPGDAVGHVVFGHVVNTEPKDMYLARVAAINGGV
AQHTPALTVNRLCGSGLQAIVSAAQTIMLGDADVAIGGGSESMSRAPYTVPAARFGQRMGDGKLVDMMLGALHDPFQTIH
MGVTAENVAKKYDISRDAQDALALESHRRAARAIAEGRFKDQILPISIRTKKGEVAFDTDEHVRHDASADDFTKLKPVFA
KENGTVTAGNASGINDAAAAVLMMSADAARAQGVKPLARLVAYAHAGVDPAYMGIGPVPATQKALERAGLKISDLDVIEA
NEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELKRIGGRYALVTMCIGGGQGIAAIFENI

Sequences:

>Translated_397_residues
MSNAAKEVVVVSGVRTAIGDFGGSLKDFSPTDLGAKVVAEVLSRANVPGDAVGHVVFGHVVNTEPKDMYLARVAAINGGV
AQHTPALTVNRLCGSGLQAIVSAAQTIMLGDADVAIGGGSESMSRAPYTVPAARFGQRMGDGKLVDMMLGALHDPFQTIH
MGVTAENVAKKYDISRDAQDALALESHRRAARAIAEGRFKDQILPISIRTKKGEVAFDTDEHVRHDASADDFTKLKPVFA
KENGTVTAGNASGINDAAAAVLMMSADAARAQGVKPLARLVAYAHAGVDPAYMGIGPVPATQKALERAGLKISDLDVIEA
NEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELKRIGGRYALVTMCIGGGQGIAAIFENI
>Mature_396_residues
SNAAKEVVVVSGVRTAIGDFGGSLKDFSPTDLGAKVVAEVLSRANVPGDAVGHVVFGHVVNTEPKDMYLARVAAINGGVA
QHTPALTVNRLCGSGLQAIVSAAQTIMLGDADVAIGGGSESMSRAPYTVPAARFGQRMGDGKLVDMMLGALHDPFQTIHM
GVTAENVAKKYDISRDAQDALALESHRRAARAIAEGRFKDQILPISIRTKKGEVAFDTDEHVRHDASADDFTKLKPVFAK
ENGTVTAGNASGINDAAAAVLMMSADAARAQGVKPLARLVAYAHAGVDPAYMGIGPVPATQKALERAGLKISDLDVIEAN
EAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELKRIGGRYALVTMCIGGGQGIAAIFENI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=47.1794871794872, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=43.3915211970075, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=41.6666666666667, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=41, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=36.2352941176471, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI194353979, Length=398, Percent_Identity=30.1507537688442, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=48.3375959079284, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=49.2462311557789, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.2970297029703, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.8496240601504, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=35.8536585365854, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=47.0886075949367, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=37.6923076923077, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=398, Percent_Identity=34.1708542713568, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=30.9692671394799, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=29, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=37.6237623762376, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=36.8811881188119, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.1734693877551, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI17648125, Length=399, Percent_Identity=44.1102756892231, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=41.044776119403, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.2206572769953, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41043; Mature: 40912

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAAKEVVVVSGVRTAIGDFGGSLKDFSPTDLGAKVVAEVLSRANVPGDAVGHVVFGHV
CCCCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHE
VNTEPKDMYLARVAAINGGVAQHTPALTVNRLCGSGLQAIVSAAQTIMLGDADVAIGGGS
ECCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHCHHHHHHHHHHHHEEECCCCEEECCCC
ESMSRAPYTVPAARFGQRMGDGKLVDMMLGALHDPFQTIHMGVTAENVAKKYDISRDAQD
HHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHEECCCHHHHHHHHCCCCCHHH
ALALESHRRAARAIAEGRFKDQILPISIRTKKGEVAFDTDEHVRHDASADDFTKLKPVFA
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCHHHHHCCCCCCHHHHCCCEEE
KENGTVTAGNASGINDAAAAVLMMSADAARAQGVKPLARLVAYAHAGVDPAYMGIGPVPA
CCCCEEEECCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCH
TQKALERAGLKISDLDVIEANEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGA
HHHHHHHCCCEEECCEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCHH
LITVKALYELKRIGGRYALVTMCIGGGQGIAAIFENI
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SNAAKEVVVVSGVRTAIGDFGGSLKDFSPTDLGAKVVAEVLSRANVPGDAVGHVVFGHV
CCCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHE
VNTEPKDMYLARVAAINGGVAQHTPALTVNRLCGSGLQAIVSAAQTIMLGDADVAIGGGS
ECCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHCHHHHHHHHHHHHEEECCCCEEECCCC
ESMSRAPYTVPAARFGQRMGDGKLVDMMLGALHDPFQTIHMGVTAENVAKKYDISRDAQD
HHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHEECCCHHHHHHHHCCCCCHHH
ALALESHRRAARAIAEGRFKDQILPISIRTKKGEVAFDTDEHVRHDASADDFTKLKPVFA
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCHHHHHCCCCCCHHHHCCCEEE
KENGTVTAGNASGINDAAAAVLMMSADAARAQGVKPLARLVAYAHAGVDPAYMGIGPVPA
CCCCEEEECCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCH
TQKALERAGLKISDLDVIEANEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGA
HHHHHHHCCCEEECCEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCHH
LITVKALYELKRIGGRYALVTMCIGGGQGIAAIFENI
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]