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The map label for this gene is hbd [H]

Identifier: 107023103

GI number: 107023103

Start: 1723917

End: 1724771

Strand: Reverse

Name: hbd [H]

Synonym: Bcen_1552

Alternate gene names: 107023103

Gene position: 1724771-1723917 (Counterclockwise)

Preceding gene: 107023104

Following gene: 107023101

Centisome position: 52.35

GC content: 67.37

Gene sequence:

>855_bases
ATGGCCATCGAAACCGTCGGCGTCGTGGGCGCCGGAACCATGGGTAACGGCATTGCGCAAACCGCCGCCGTTGCAGGACT
GAACGTCGTGATGATCGACGTCAGCGACGCCGCGCTCGACAAGGGCCTCGCGACGCTCAAGGGTAGCCTCGAGCGGCTCG
TGTCGAAGGACAAGCTCGCGGCCGACGCCCGCGATGCGGCGCTCGCGCGCATCACGACGTCGACCGACTACGCGAAGCTC
GCCGCCGTCGACATCGTGATCGAAGCCGCGACCGAGAACGTCGAGCTGAAGGGGCGCATCCTGAAGCAGATCGAGGCCGT
CGCGCGTCCGGACGCGATCATCGCGACCAACACGTCGTCGATCTCGATCACCGCGCTCGCGGCGCCGCTCGCCGATCCGT
CGCGTTTTCTCGGCATGCACTTCTTCAACCCGGTGCCGCTGATGCCGCTCGTCGAGATCATCCGCGGGCTGCAGACGAGC
GACGCGACCGCGTCGGCCGTGCGCGCGCTGACCGAGCGTTTCGACAAGTCGCCGATCGGCGTGCGCAACTCGCCGGGCTT
CGTCGTGAACCGGATCCTGGTGCCGATGATCAACGAAGCGTTCTTCGTGCTGGCCGAAGGCATCGCGTCGGCCGAGGAGA
TCGACGCGGGGATGAAGCTCGGCGCGAACCACCCGATCGGGCCGCTCGCGCTGGCCGACCTCGTTGGCCTCGACGTGTGC
CTCGCGGTGATGGACGTGTTCGTGAAGGACTTCGGCGATCCGAAGTATCGTGCGTGCCCGCTGCTGCGCGAGATGGTGTC
GGCCGGGCGGCTCGGGCGCAAGACCGGGCGTGGGGTGTACGACTACAGCAAGTAA

Upstream 100 bases:

>100_bases
CGCTCGTGACGATGTGCATCGGCGGCGGCCAGGGGATTGCGGCGATCTTCGAGAACATCTGATAATCGACCGCTCAGCCT
CCGAATACACAGGAATCGTC

Downstream 100 bases:

>100_bases
GCGGCACTTCATCCTACTTCGCGCGGCCGCGTGCTTTGTGCGGCACGCATGGCGCGATTACGCGTCGAGTACCGACAAGT
CGCGCGGCAGCATGCGCTTG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAIETVGVVGAGTMGNGIAQTAAVAGLNVVMIDVSDAALDKGLATLKGSLERLVSKDKLAADARDAALARITTSTDYAKL
AAVDIVIEAATENVELKGRILKQIEAVARPDAIIATNTSSISITALAAPLADPSRFLGMHFFNPVPLMPLVEIIRGLQTS
DATASAVRALTERFDKSPIGVRNSPGFVVNRILVPMINEAFFVLAEGIASAEEIDAGMKLGANHPIGPLALADLVGLDVC
LAVMDVFVKDFGDPKYRACPLLREMVSAGRLGRKTGRGVYDYSK

Sequences:

>Translated_284_residues
MAIETVGVVGAGTMGNGIAQTAAVAGLNVVMIDVSDAALDKGLATLKGSLERLVSKDKLAADARDAALARITTSTDYAKL
AAVDIVIEAATENVELKGRILKQIEAVARPDAIIATNTSSISITALAAPLADPSRFLGMHFFNPVPLMPLVEIIRGLQTS
DATASAVRALTERFDKSPIGVRNSPGFVVNRILVPMINEAFFVLAEGIASAEEIDAGMKLGANHPIGPLALADLVGLDVC
LAVMDVFVKDFGDPKYRACPLLREMVSAGRLGRKTGRGVYDYSK
>Mature_283_residues
AIETVGVVGAGTMGNGIAQTAAVAGLNVVMIDVSDAALDKGLATLKGSLERLVSKDKLAADARDAALARITTSTDYAKLA
AVDIVIEAATENVELKGRILKQIEAVARPDAIIATNTSSISITALAAPLADPSRFLGMHFFNPVPLMPLVEIIRGLQTSD
ATASAVRALTERFDKSPIGVRNSPGFVVNRILVPMINEAFFVLAEGIASAEEIDAGMKLGANHPIGPLALADLVGLDVCL
AVMDVFVKDFGDPKYRACPLLREMVSAGRLGRKTGRGVYDYSK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=39.5833333333333, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=37.3770491803279, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=37.1024734982332, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=33.1103678929766, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI68989263, Length=299, Percent_Identity=33.1103678929766, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=26.6949152542373, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=42.3487544483986, Blast_Score=230, Evalue=7e-62,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=38.4905660377359, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=42.3611111111111, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=41.6666666666667, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.4583333333333, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=36.6197183098592, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=36.6197183098592, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=36.6197183098592, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=34.8591549295775, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=31.8181818181818, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=288, Percent_Identity=30.9027777777778, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=27.4509803921569, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=27.4509803921569, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=38.6524822695035, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=38.6524822695035, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=38.6524822695035, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=30.379746835443, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20129993, Length=256, Percent_Identity=27.34375, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29774; Mature: 29643

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIETVGVVGAGTMGNGIAQTAAVAGLNVVMIDVSDAALDKGLATLKGSLERLVSKDKLA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ADARDAALARITTSTDYAKLAAVDIVIEAATENVELKGRILKQIEAVARPDAIIATNTSS
HHHHHHHHHEEECCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
ISITALAAPLADPSRFLGMHFFNPVPLMPLVEIIRGLQTSDATASAVRALTERFDKSPIG
EEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
VRNSPGFVVNRILVPMINEAFFVLAEGIASAEEIDAGMKLGANHPIGPLALADLVGLDVC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHH
LAVMDVFVKDFGDPKYRACPLLREMVSAGRLGRKTGRGVYDYSK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
AIETVGVVGAGTMGNGIAQTAAVAGLNVVMIDVSDAALDKGLATLKGSLERLVSKDKLA
CCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ADARDAALARITTSTDYAKLAAVDIVIEAATENVELKGRILKQIEAVARPDAIIATNTSS
HHHHHHHHHEEECCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
ISITALAAPLADPSRFLGMHFFNPVPLMPLVEIIRGLQTSDATASAVRALTERFDKSPIG
EEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
VRNSPGFVVNRILVPMINEAFFVLAEGIASAEEIDAGMKLGANHPIGPLALADLVGLDVC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHH
LAVMDVFVKDFGDPKYRACPLLREMVSAGRLGRKTGRGVYDYSK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA