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The map label for this gene is thiD [H]

Identifier: 107021937

GI number: 107021937

Start: 419948

End: 420814

Strand: Reverse

Name: thiD [H]

Synonym: Bcen_0379

Alternate gene names: 107021937

Gene position: 420814-419948 (Counterclockwise)

Preceding gene: 107021946

Following gene: 107021928

Centisome position: 12.77

GC content: 68.86

Gene sequence:

>867_bases
ATGTCCAGCAACGCCCCTCCGATCGTCCTCACCTTCGGCCTGTCCGATCCCACCGGCGGCTCCGGCCTCCAAGCCGATCT
GATGACCCTGGCGAGCATGGGCTGTCACGGCGTGTCCGTCCTGACCGGCTATACCGTGCGCGACTCGGCCGCCTGCGATG
AAGTCACCGGCCTCGACCCCGATGTCGTCGCCGCGCAGGCGCGCATGCTGCTCGAAGACATGCCGGTTGCCGCGTTCAAG
ATCGGCGCGGCGACGCGCGCGGAAGTCGTCAGCGCGATCGCCGAAGTCGTCGCCGACTACGACGGCGTGCCGCTCGTGCT
CGCGCCGGACTTCACGCTCGACGATGAACACGTGCTCGCCGCCGACGACCTGCGCGAATCGATCGCCGACCTGCTGGCGC
CGCAAACCACGTTGCTGGTCGCCGACCACGCGACGCTGATCGCGCTCGCGCAACCGGACGGCGATGCCGAGGCGCCGAAT
CTCGACGCGGCCGTGTCGCATCTGCTGTCGCAGGGCTGCGAATACATCCTGTCGTCGGAAACCGGTTCGCACCGGCTCGT
CAATACGCTGTACGGCGAGGAAGGCCAGCTTCGCGAAGACATGTGGGATCGCTCGCCGCACCGGCTGATGGGCATCACCG
ATACGCTCGGCGCGGCCATCGCGGCGCTGCTCGCGAACGGTCAGGAGCCGCCCGAAGCCGTGCGCGAGGCACAGGAATAC
CTGTATCAGGCCGTGCGCGACGCGTTCCGGCCCGGCATGGGCGCGTACCTGCCTGACCGGTTCTTCTGGGCGCGCAGCAA
CGACGAGTCCGACACGCCGCCGGCCGTGAAGGCCGACCCGGTGCCGAGGACGTCGCATCGGCATTGA

Upstream 100 bases:

>100_bases
AAAAGTGCGGCCTGCCGGGCAACACAGGGCCGACCCCGCCCATTCGCCTCGCCGTCCGCATGTCCGTCGCTCGTCCGTTT
TTCTCTTGCCCCATTTTTAC

Downstream 100 bases:

>100_bases
GTTGCGCGCGGCGGGCAGGTCCCGCCGCCGCGAACAGCATGCCGAATTCCACGTGCAAATAAAAAAAGACCCGCATCGCT
GCGGGTCTTTTCTTTTGGCT

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAVRDAFRPGMGAYLPDRFFWARSNDESDTPPAVKADPVPRTSHRH

Sequences:

>Translated_288_residues
MSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAVRDAFRPGMGAYLPDRFFWARSNDESDTPPAVKADPVPRTSHRH
>Mature_287_residues
SSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDVVAAQARMLLEDMPVAAFKI
GAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNL
DAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYL
YQAVRDAFRPGMGAYLPDRFFWARSNDESDTPPAVKADPVPRTSHRH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=29.0983606557377, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30575; Mature: 30444

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEECCCCCHHHHCCCCH
DVVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSE
HHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAVRDAFRPGMGAYLPDRFFWARSNDESDTPPAVKADPVPRTSHRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEECCCCCHHHHCCCCH
DVVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSE
HHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TGSHRLVNTLYGEEGQLREDMWDRSPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCHHHHHHHHCCCCCHHHHHHCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAVRDAFRPGMGAYLPDRFFWARSNDESDTPPAVKADPVPRTSHRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]