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The map label for this gene is hbdA [H]

Identifier: 103488565

GI number: 103488565

Start: 3240724

End: 3241590

Strand: Direct

Name: hbdA [H]

Synonym: Sala_3089

Alternate gene names: 103488565

Gene position: 3240724-3241590 (Clockwise)

Preceding gene: 103488564

Following gene: 103488566

Centisome position: 96.88

GC content: 67.7

Gene sequence:

>867_bases
ATGATCGTCGGCGTTATCGGGGCAGGGCAGATGGGCGCGGGCATCGCGCAGGTGTCGGCGGGGGCTGGGCACGACGTGCT
GCTGGCCGACATTGACCTCGCGCGCGCCGAAGCCGGCAAGGCGGGCATTGCCAAGGCGCTCGGCCGCCTCGTCGCCAGGG
AGAAGATGGCGCAGAGCGACGCCGATATGCTGCTGGCCCGCATCACCCCCGTCGCCGACCATGCGGCTTTCGCCCCCTCC
GATCTGGTGATCGAGGCGGCGACCGAGCGCGAAGAGATCAAACGCGCCATCTTCGCCAGCGTCGGCGAGCATCTTTCGGC
CACCGCGATCCTCGCGAGCAACACCAGCTCGATCCCGATCACCCGCCTCGCGCAGGCGGCGCCCGATCCGGCACGCTTCA
TCGGCGTCCATTTCTTCAACCCGGTACCCGTCATGGGCCTGATCGAACTGATCCGCGGGCTCGCGACGAGCGACGACACG
CTGGCGACGGTCGAGGCCTATGGCCGCGGGCTCGGCAAACAGATCGTCCACGCCAACGATGCGCCGGGCTTCATCGTCAA
CCGCGTGCTGATGCCGCTGATCAACGAAGCGATTTTCGCGCTGGGCGAGGGCGTCGCGACGATGCAGGATATCGACGCCG
GTTGCCGCCTCGGCCTCAATCACCCGATGGGGCCGATCACGCTCGCCGATTTCATCGGCCTCGACACCTGCCTCGAAATC
ATCCGCGTGCTGCAATCGGGCACCGGCGACCCCAAGTTCCGCCCCGCGCCGCTGCTCGTCCAATATGTCGAGGCCGGCTG
GGTCGGCAAAAAGGCCGGGCGCGGCTTTTACGACTGGACCGGTGACAAACCCGTGCCGACGCGCTGA

Upstream 100 bases:

>100_bases
AGGCCGGGATCCCGCCGTTTCCGTAAGACGCACGGGCGAGATTCCGGCCTTCGCCGGGATGATGGATAGGGTCTCGGGAT
TTCTATTGGAGAATAAGGGC

Downstream 100 bases:

>100_bases
GGGCGGCCCCGCGACCACGGAGCCGAAATGCGTTTGCTGCGTTGGAACCTTGAGAAAGCAGGGAATCGACATGAGAAAAG
GTAACAAGGCGCTGTTCGTT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIVGVIGAGQMGAGIAQVSAGAGHDVLLADIDLARAEAGKAGIAKALGRLVAREKMAQSDADMLLARITPVADHAAFAPS
DLVIEAATEREEIKRAIFASVGEHLSATAILASNTSSIPITRLAQAAPDPARFIGVHFFNPVPVMGLIELIRGLATSDDT
LATVEAYGRGLGKQIVHANDAPGFIVNRVLMPLINEAIFALGEGVATMQDIDAGCRLGLNHPMGPITLADFIGLDTCLEI
IRVLQSGTGDPKFRPAPLLVQYVEAGWVGKKAGRGFYDWTGDKPVPTR

Sequences:

>Translated_288_residues
MIVGVIGAGQMGAGIAQVSAGAGHDVLLADIDLARAEAGKAGIAKALGRLVAREKMAQSDADMLLARITPVADHAAFAPS
DLVIEAATEREEIKRAIFASVGEHLSATAILASNTSSIPITRLAQAAPDPARFIGVHFFNPVPVMGLIELIRGLATSDDT
LATVEAYGRGLGKQIVHANDAPGFIVNRVLMPLINEAIFALGEGVATMQDIDAGCRLGLNHPMGPITLADFIGLDTCLEI
IRVLQSGTGDPKFRPAPLLVQYVEAGWVGKKAGRGFYDWTGDKPVPTR
>Mature_288_residues
MIVGVIGAGQMGAGIAQVSAGAGHDVLLADIDLARAEAGKAGIAKALGRLVAREKMAQSDADMLLARITPVADHAAFAPS
DLVIEAATEREEIKRAIFASVGEHLSATAILASNTSSIPITRLAQAAPDPARFIGVHFFNPVPVMGLIELIRGLATSDDT
LATVEAYGRGLGKQIVHANDAPGFIVNRVLMPLINEAIFALGEGVATMQDIDAGCRLGLNHPMGPITLADFIGLDTCLEI
IRVLQSGTGDPKFRPAPLLVQYVEAGWVGKKAGRGFYDWTGDKPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=41.0526315789474, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=39.2739273927393, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=34.6289752650177, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=30.8474576271186, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=30.8474576271186, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=42.9078014184397, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI1788682, Length=229, Percent_Identity=40.174672489083, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=35.9550561797753, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=283, Percent_Identity=40.9893992932862, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=41.6083916083916, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=293, Percent_Identity=35.8361774744027, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=35.84229390681, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=35.84229390681, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=35.84229390681, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17558304, Length=279, Percent_Identity=34.7670250896057, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=277, Percent_Identity=27.0758122743682, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=26.6903914590747, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=35.6890459363958, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=35.6890459363958, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=35.6890459363958, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30132; Mature: 30132

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGVIGAGQMGAGIAQVSAGAGHDVLLADIDLARAEAGKAGIAKALGRLVAREKMAQSD
CEEEEECCCCCCCCHHHHCCCCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ADMLLARITPVADHAAFAPSDLVIEAATEREEIKRAIFASVGEHLSATAILASNTSSIPI
HHHHHHHHCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
TRLAQAAPDPARFIGVHFFNPVPVMGLIELIRGLATSDDTLATVEAYGRGLGKQIVHAND
HHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHEECCC
APGFIVNRVLMPLINEAIFALGEGVATMQDIDAGCRLGLNHPMGPITLADFIGLDTCLEI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHEECCCCCCCCHHHHHHHCHHHHHHH
IRVLQSGTGDPKFRPAPLLVQYVEAGWVGKKAGRGFYDWTGDKPVPTR
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVGVIGAGQMGAGIAQVSAGAGHDVLLADIDLARAEAGKAGIAKALGRLVAREKMAQSD
CEEEEECCCCCCCCHHHHCCCCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ADMLLARITPVADHAAFAPSDLVIEAATEREEIKRAIFASVGEHLSATAILASNTSSIPI
HHHHHHHHCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCH
TRLAQAAPDPARFIGVHFFNPVPVMGLIELIRGLATSDDTLATVEAYGRGLGKQIVHAND
HHHHHCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHEECCC
APGFIVNRVLMPLINEAIFALGEGVATMQDIDAGCRLGLNHPMGPITLADFIGLDTCLEI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHEECCCCCCCCHHHHHHHCHHHHHHH
IRVLQSGTGDPKFRPAPLLVQYVEAGWVGKKAGRGFYDWTGDKPVPTR
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]