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The map label for this gene is clpP

Identifier: 103488219

GI number: 103488219

Start: 2890513

End: 2891163

Strand: Direct

Name: clpP

Synonym: Sala_2742

Alternate gene names: 103488219

Gene position: 2890513-2891163 (Clockwise)

Preceding gene: 103488218

Following gene: 103488220

Centisome position: 86.41

GC content: 62.98

Gene sequence:

>651_bases
ATGATCGACCCGCTCGCCGCCCTTGTTCCCGTCGTCGTCGAGCAGACGAGCCGCGGCGAACGCAGCTTCGACATCTTTTC
GCGCCTGCTGCGCGAACGGATCGTCTTTGTAACGGGCGAGGTCGAGGACAATATGGCCTCGCTGATCGTCGCCCAGCTCC
TGTTCCTCGAATCGGAGAATCCGAAGAAGGACATCTATATGTACATCAACTCGCCGGGCGGCGTCGTCACGGCGGGCATG
GCGATCCACGACACGATGCAATATATCCGCCCGCGCGTCGGCACCGTGTGCATCGGCCAGGCGGCGTCGATGGGCAGCTT
CCTGCTCGCCGCGGGCGAGCCCGGAATGCGCGTTGCGCTGACCAATGCCCGCGTCATGGTCCACCAGCCGTCGGGCGGCG
CGCGCGGCATGGCATCGGACATCGAAATCCAGGCCAAGGAAATCCTGCGCATCCGCAAGCGGATGAACGATCTCTATGTC
AAATATACCGGCAAGTCGCTGAAAGATATTGAAAAAGCGATGGACCGCGACACGTTCCTCGAAGCCGACGAGGCCAAGGA
ATTCGGCATCGTCGATCATGTTTACGACCGCCGCCCCGCCCTGCCCGGCGACGACGCGCCGAGGGATGTGAGCGAAGGGC
CGACGCCCTGA

Upstream 100 bases:

>100_bases
CCTCTTGAAACCACTCCGCTTGGCGCCGATGTAGGGCGCCGGAGGGACAGCCCGCCGGTCCTCGGCCGGGTAACCCGATA
ATCGACAAGGACTCATTCGC

Downstream 100 bases:

>100_bases
GTCGATAAGATTGTCGCACCGGCCGGTTAGCCCAAGACAAGGCGCTTAACCGCGTTTGTTGACGGCCGCTTGGCGAGTTG
GCGTCAGGCGGGACATTGCG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MIDPLAALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGEVEDNMASLIVAQLLFLESENPKKDIYMYINSPGGVVTAGM
AIHDTMQYIRPRVGTVCIGQAASMGSFLLAAGEPGMRVALTNARVMVHQPSGGARGMASDIEIQAKEILRIRKRMNDLYV
KYTGKSLKDIEKAMDRDTFLEADEAKEFGIVDHVYDRRPALPGDDAPRDVSEGPTP

Sequences:

>Translated_216_residues
MIDPLAALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGEVEDNMASLIVAQLLFLESENPKKDIYMYINSPGGVVTAGM
AIHDTMQYIRPRVGTVCIGQAASMGSFLLAAGEPGMRVALTNARVMVHQPSGGARGMASDIEIQAKEILRIRKRMNDLYV
KYTGKSLKDIEKAMDRDTFLEADEAKEFGIVDHVYDRRPALPGDDAPRDVSEGPTP
>Mature_216_residues
MIDPLAALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGEVEDNMASLIVAQLLFLESENPKKDIYMYINSPGGVVTAGM
AIHDTMQYIRPRVGTVCIGQAASMGSFLLAAGEPGMRVALTNARVMVHQPSGGARGMASDIEIQAKEILRIRKRMNDLYV
KYTGKSLKDIEKAMDRDTFLEADEAKEFGIVDHVYDRRPALPGDDAPRDVSEGPTP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=205, Percent_Identity=60.9756097560976, Blast_Score=263, Evalue=7e-71,
Organism=Escherichia coli, GI1786641, Length=195, Percent_Identity=64.6153846153846, Blast_Score=277, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=196, Percent_Identity=56.6326530612245, Blast_Score=236, Evalue=8e-63,
Organism=Drosophila melanogaster, GI20129427, Length=200, Percent_Identity=56, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_SPHAL (Q1GPH5)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617780.1
- ProteinModelPortal:   Q1GPH5
- SMR:   Q1GPH5
- MEROPS:   S14.001
- GeneID:   4082481
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2742
- NMPDR:   fig|317655.9.peg.2607
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   SALA317655:SALA_2742-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23815; Mature: 23815

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 103-103 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPLAALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGEVEDNMASLIVAQLLFLESEN
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCC
PKKDIYMYINSPGGVVTAGMAIHDTMQYIRPRVGTVCIGQAASMGSFLLAAGEPGMRVAL
CCCEEEEEECCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEEEE
TNARVMVHQPSGGARGMASDIEIQAKEILRIRKRMNDLYVKYTGKSLKDIEKAMDRDTFL
ECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCHHHHC
EADEAKEFGIVDHVYDRRPALPGDDAPRDVSEGPTP
CCCCHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDPLAALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGEVEDNMASLIVAQLLFLESEN
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCC
PKKDIYMYINSPGGVVTAGMAIHDTMQYIRPRVGTVCIGQAASMGSFLLAAGEPGMRVAL
CCCEEEEEECCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEEEE
TNARVMVHQPSGGARGMASDIEIQAKEILRIRKRMNDLYVKYTGKSLKDIEKAMDRDTFL
ECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCHHHHC
EADEAKEFGIVDHVYDRRPALPGDDAPRDVSEGPTP
CCCCHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA