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The map label for this gene is clpX

Identifier: 103488220

GI number: 103488220

Start: 2891356

End: 2892627

Strand: Direct

Name: clpX

Synonym: Sala_2743

Alternate gene names: 103488220

Gene position: 2891356-2892627 (Clockwise)

Preceding gene: 103488219

Following gene: 103488221

Centisome position: 86.43

GC content: 63.76

Gene sequence:

>1272_bases
ATGACGAAATTGAGCGGCTCGGACAGCAAGAGCACTCTTTACTGCTCCTTCTGCGGCAAGTCGCAGCACGAAGTCCGCAA
GCTGATTGCCGGGCCCACCGTGTTCATCTGCGACGAATGCGTCGAGCTGTGCAACGACATCATCCGCGAAGAGATCAAGG
GCGGGGTCGCGGCGCGCAAGGATGGCGCGGTCCCGACGCCGCTCGAAATCTGCCAGCATCTCGACGCCTATGTCATCGGC
CAGAACAAGGCGAAGCGCGTCCTGTCGGTCGCGGTCCACAATCATTACAAGCGGCTTGCCAATTCGGGTCGCGGCGAGGA
CGTGGAGCTTGCCAAGTCGAACATCCTGCTCGTCGGCCCCACGGGCAGCGGCAAGACGCTGCTCGCGCAGACGCTCGCGC
GCTTCCTCGACGTGCCCTTCACCATGGCCGACGCGACGACGCTGACCGAGGCGGGCTATGTCGGCGAGGATGTCGAGAAT
ATCATCCTCAAGCTGCTGCAATCATCCGACTATAATGTCGAAAAGGCGCAGCGCGGCATCGTCTATATCGACGAAATCGA
CAAGATCAGCCGCAAGGCCGAAAATCCCTCGATCACCCGCGACGTGTCGGGCGAAGGCGTGCAGCAGGCGCTCCTGAAGC
TGATGGAGGGCACGACCGCGAGCGTGCCGCCGCAGGGCGGGCGCAAGCATCCCCAGCAGGAGTTCCTGCAGGTCGACACG
ACCAACATCCTGTTCATCGCGGGCGGCGCCTTCGCCGGCCTCGAAAAGATCATCGGCGACCGCCTGCAGGGCAAGTCGAT
CGGTTTCGGCGCGCATGTCGCCGGCCCCGACGAGCGCCGCGCGGGCGAAGTGCTGAAACAGATCGAGCCGGAGGATCTGC
TGAAGTTCGGGCTGATCCCCGAATTCGTCGGCCGCCTGCCGGTCATCGCGACGCTCGAGGATCTGGACGTCGACGCGCTG
GTCAAGATATTGGGCGAGCCCAAGAATGCGCTGGTCAAGCAGTATAAGAAGCTGTTCGACCTGGAGGAGGTCGCGCTGAC
CTTCACCGACGACGCGCTGGTCGCGGTCGCCAAAAAGGCGATCGAACGCAAGACCGGCGCGCGCGGGCTGCGCTCGATCG
TCGAGGCGATCCTGCTCGACACGATGTTCGACCTGCCCGACCTGACCGACGTGGTCGAGATCGTCGTCGACAAGGATGTC
GTCGAAGGACGCAAGGATCCCGTGCGCGTCTATGCCGACAAGGCGAAGGAAGCGGCGGGCGACGCCGCCTGA

Upstream 100 bases:

>100_bases
ACATTGCGCCCATGTCGCCCAATTGCCATATTGTAATTGGGTAGCCGGGGGCTAGGATAAGGATGGCACCGCCATTTCGG
CGCCTGCCAGAGGATGATTT

Downstream 100 bases:

>100_bases
TTCGAGTCGCCCGCGGCGTTCGCGCAAGCCCCTATGTTGCATCGCAGCAACAGTGGCCGCGAAAAATGCACCGGCGCCGG
TTCATGAAATCGGATGCGAT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTKLSGSDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREEIKGGVAARKDGAVPTPLEICQHLDAYVIG
QNKAKRVLSVAVHNHYKRLANSGRGEDVELAKSNILLVGPTGSGKTLLAQTLARFLDVPFTMADATTLTEAGYVGEDVEN
IILKLLQSSDYNVEKAQRGIVYIDEIDKISRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
TNILFIAGGAFAGLEKIIGDRLQGKSIGFGAHVAGPDERRAGEVLKQIEPEDLLKFGLIPEFVGRLPVIATLEDLDVDAL
VKILGEPKNALVKQYKKLFDLEEVALTFTDDALVAVAKKAIERKTGARGLRSIVEAILLDTMFDLPDLTDVVEIVVDKDV
VEGRKDPVRVYADKAKEAAGDAA

Sequences:

>Translated_423_residues
MTKLSGSDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREEIKGGVAARKDGAVPTPLEICQHLDAYVIG
QNKAKRVLSVAVHNHYKRLANSGRGEDVELAKSNILLVGPTGSGKTLLAQTLARFLDVPFTMADATTLTEAGYVGEDVEN
IILKLLQSSDYNVEKAQRGIVYIDEIDKISRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
TNILFIAGGAFAGLEKIIGDRLQGKSIGFGAHVAGPDERRAGEVLKQIEPEDLLKFGLIPEFVGRLPVIATLEDLDVDAL
VKILGEPKNALVKQYKKLFDLEEVALTFTDDALVAVAKKAIERKTGARGLRSIVEAILLDTMFDLPDLTDVVEIVVDKDV
VEGRKDPVRVYADKAKEAAGDAA
>Mature_422_residues
TKLSGSDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREEIKGGVAARKDGAVPTPLEICQHLDAYVIGQ
NKAKRVLSVAVHNHYKRLANSGRGEDVELAKSNILLVGPTGSGKTLLAQTLARFLDVPFTMADATTLTEAGYVGEDVENI
ILKLLQSSDYNVEKAQRGIVYIDEIDKISRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDTT
NILFIAGGAFAGLEKIIGDRLQGKSIGFGAHVAGPDERRAGEVLKQIEPEDLLKFGLIPEFVGRLPVIATLEDLDVDALV
KILGEPKNALVKQYKKLFDLEEVALTFTDDALVAVAKKAIERKTGARGLRSIVEAILLDTMFDLPDLTDVVEIVVDKDVV
EGRKDPVRVYADKAKEAAGDAA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=331, Percent_Identity=53.7764350453172, Blast_Score=332, Evalue=3e-91,
Organism=Escherichia coli, GI1786642, Length=424, Percent_Identity=70.5188679245283, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1790366, Length=100, Percent_Identity=43, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982905, Length=314, Percent_Identity=49.0445859872611, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI71982908, Length=314, Percent_Identity=49.0445859872611, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI71988663, Length=390, Percent_Identity=39.4871794871795, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71988660, Length=248, Percent_Identity=40.3225806451613, Blast_Score=171, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=436, Percent_Identity=37.8440366972477, Blast_Score=260, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24648291, Length=330, Percent_Identity=51.2121212121212, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24648289, Length=330, Percent_Identity=51.2121212121212, Blast_Score=319, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_SPHAL (Q1GPH4)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617781.1
- ProteinModelPortal:   Q1GPH4
- GeneID:   4080228
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2743
- NMPDR:   fig|317655.9.peg.2608
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   SALA317655:SALA_2743-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: 3.4.21.92

Molecular weight: Translated: 45804; Mature: 45673

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLSGSDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREEIKGGVAARK
CCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DGAVPTPLEICQHLDAYVIGQNKAKRVLSVAVHNHYKRLANSGRGEDVELAKSNILLVGP
CCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEC
TGSGKTLLAQTLARFLDVPFTMADATTLTEAGYVGEDVENIILKLLQSSDYNVEKAQRGI
CCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VYIDEIDKISRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEECC
TNILFIAGGAFAGLEKIIGDRLQGKSIGFGAHVAGPDERRAGEVLKQIEPEDLLKFGLIP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCH
EFVGRLPVIATLEDLDVDALVKILGEPKNALVKQYKKLFDLEEVALTFTDDALVAVAKKA
HHHCCCCEEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHEECCHHHHHHHHHH
IERKTGARGLRSIVEAILLDTMFDLPDLTDVVEIVVDKDVVEGRKDPVRVYADKAKEAAG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
DAA
CCC
>Mature Secondary Structure 
TKLSGSDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREEIKGGVAARK
CCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DGAVPTPLEICQHLDAYVIGQNKAKRVLSVAVHNHYKRLANSGRGEDVELAKSNILLVGP
CCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEC
TGSGKTLLAQTLARFLDVPFTMADATTLTEAGYVGEDVENIILKLLQSSDYNVEKAQRGI
CCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VYIDEIDKISRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEECC
TNILFIAGGAFAGLEKIIGDRLQGKSIGFGAHVAGPDERRAGEVLKQIEPEDLLKFGLIP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCH
EFVGRLPVIATLEDLDVDALVKILGEPKNALVKQYKKLFDLEEVALTFTDDALVAVAKKA
HHHCCCCEEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHEECCHHHHHHHHHH
IERKTGARGLRSIVEAILLDTMFDLPDLTDVVEIVVDKDVVEGRKDPVRVYADKAKEAAG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
DAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA