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The map label for this gene is ribBA [H]

Identifier: 103488149

GI number: 103488149

Start: 2818357

End: 2819259

Strand: Direct

Name: ribBA [H]

Synonym: Sala_2672

Alternate gene names: 103488149

Gene position: 2818357-2819259 (Clockwise)

Preceding gene: 103488148

Following gene: 103488154

Centisome position: 84.25

GC content: 70.1

Gene sequence:

>903_bases
ATGCTGCTGTCGGGCGAGCGCGCGGTGACGCTGAAGCTCACCAACCAGCGCGCGGCCGCGACTCCCGGCCCCGTGCGGCT
CGCCAGCGCCGCCGACACGGTCGCGGCGGCGCTGGCGATCGCCGACCCCGCACTCGACCTTGCGAATCCATTGAAAGGCC
CCTTTCGTACCGTCGCGACGGGTGGCGACGCCGCGGCGGCAGCGGCAATGACGATGGCGCGCCACGCGGGGCTCCTGCCC
GCCTTCTTCGTGCGCGCGGCGGCGGGTGAGGCCGAAACGCAGTGTCGCGCCCACGATGTCGCGACGTTGCTCGACCCCGC
GCGGCTCGCCATCGCGGCGCGCGCGCGGCTGCCCGTGGCGGCGAGCGAGACGGCTGAAATCGTCGCCTTCCGCTCGCCCG
AGGAGGCGTCGGACCATGTCGCGCTCATCATCGGTCGGCGTGACGGCAATCCGCCCGTCGTCAGACTGCACAGCGAATGC
CTGACGGGCGACGTGCTCGGCAGCCTCAAATGCGATTGCGGCCCGCAACTCCACGCCGCGCTGCACGCGATGGCCGACGC
GCCGTGGGGCGTGCTGCTCTATCTGCGGCAGGAGGGGCGTGGGATCGGGCTGGTCAACAAGCTGCGTGCCTATGCGCTAC
AGGACCAGGGCTATGACACGGTCGATGCCAATCTGCGGCTCGGCTTCCCGGTCGAGGCGCGCGATTTCGCGATTGCGGCG
CGGATGCTGGACTTGCTGCGCATCCCGCGCATCCGGCTGATGACGAACAATCCCGAAAAGGTCGCGCGACTGGAAAAGGA
GGGCGTCGAGGTGATCGAGCGCCTGCCCCTCGCGCTGCCGACCAACCCGCACAACGAGCAGTATCTCGCGACGAAGCGCG
ACCGGACGGGGCATCAGCTTTAA

Upstream 100 bases:

>100_bases
CGGGTGGCCGCTGCGCGTCACCGGCGCCGACGGCTCGCTCGACCTGCTCGCGGTCGAAAGCGCGCGCGACGGGGCGCTCG
CGGAGTTTGCGAGCGACGAT

Downstream 100 bases:

>100_bases
CAATCGTCGCCCCCGCGAAGGCGGGGGCCGCTATCGGCGTAGCGCAAGGCTGCCAGCGGCCCCCGCCTTCGCGGGGGCGA
CGATTTGTTCAATGCACGAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MLLSGERAVTLKLTNQRAAATPGPVRLASAADTVAAALAIADPALDLANPLKGPFRTVATGGDAAAAAAMTMARHAGLLP
AFFVRAAAGEAETQCRAHDVATLLDPARLAIAARARLPVAASETAEIVAFRSPEEASDHVALIIGRRDGNPPVVRLHSEC
LTGDVLGSLKCDCGPQLHAALHAMADAPWGVLLYLRQEGRGIGLVNKLRAYALQDQGYDTVDANLRLGFPVEARDFAIAA
RMLDLLRIPRIRLMTNNPEKVARLEKEGVEVIERLPLALPTNPHNEQYLATKRDRTGHQL

Sequences:

>Translated_300_residues
MLLSGERAVTLKLTNQRAAATPGPVRLASAADTVAAALAIADPALDLANPLKGPFRTVATGGDAAAAAAMTMARHAGLLP
AFFVRAAAGEAETQCRAHDVATLLDPARLAIAARARLPVAASETAEIVAFRSPEEASDHVALIIGRRDGNPPVVRLHSEC
LTGDVLGSLKCDCGPQLHAALHAMADAPWGVLLYLRQEGRGIGLVNKLRAYALQDQGYDTVDANLRLGFPVEARDFAIAA
RMLDLLRIPRIRLMTNNPEKVARLEKEGVEVIERLPLALPTNPHNEQYLATKRDRTGHQL
>Mature_300_residues
MLLSGERAVTLKLTNQRAAATPGPVRLASAADTVAAALAIADPALDLANPLKGPFRTVATGGDAAAAAAMTMARHAGLLP
AFFVRAAAGEAETQCRAHDVATLLDPARLAIAARARLPVAASETAEIVAFRSPEEASDHVALIIGRRDGNPPVVRLHSEC
LTGDVLGSLKCDCGPQLHAALHAMADAPWGVLLYLRQEGRGIGLVNKLRAYALQDQGYDTVDANLRLGFPVEARDFAIAA
RMLDLLRIPRIRLMTNNPEKVARLEKEGVEVIERLPLALPTNPHNEQYLATKRDRTGHQL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=52.5773195876289, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=45.0867052023121, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 31961; Mature: 31961

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSGERAVTLKLTNQRAAATPGPVRLASAADTVAAALAIADPALDLANPLKGPFRTVAT
CCCCCCEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEC
GGDAAAAAAMTMARHAGLLPAFFVRAAAGEAETQCRAHDVATLLDPARLAIAARARLPVA
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
ASETAEIVAFRSPEEASDHVALIIGRRDGNPPVVRLHSECLTGDVLGSLKCDCGPQLHAA
CCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEHHHHCHHHHHCCCCCCCHHHHHH
LHAMADAPWGVLLYLRQEGRGIGLVNKLRAYALQDQGYDTVDANLRLGFPVEARDFAIAA
HHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCEECCCEEECCCCCHHHHHHHH
RMLDLLRIPRIRLMTNNPEKVARLEKEGVEVIERLPLALPTNPHNEQYLATKRDRTGHQL
HHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MLLSGERAVTLKLTNQRAAATPGPVRLASAADTVAAALAIADPALDLANPLKGPFRTVAT
CCCCCCEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEC
GGDAAAAAAMTMARHAGLLPAFFVRAAAGEAETQCRAHDVATLLDPARLAIAARARLPVA
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
ASETAEIVAFRSPEEASDHVALIIGRRDGNPPVVRLHSECLTGDVLGSLKCDCGPQLHAA
CCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEHHHHCHHHHHCCCCCCCHHHHHH
LHAMADAPWGVLLYLRQEGRGIGLVNKLRAYALQDQGYDTVDANLRLGFPVEARDFAIAA
HHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCEECCCEEECCCCCHHHHHHHH
RMLDLLRIPRIRLMTNNPEKVARLEKEGVEVIERLPLALPTNPHNEQYLATKRDRTGHQL
HHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA