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The map label for this gene is pcoA [H]

Identifier: 103487935

GI number: 103487935

Start: 2597575

End: 2599269

Strand: Direct

Name: pcoA [H]

Synonym: Sala_2456

Alternate gene names: 103487935

Gene position: 2597575-2599269 (Clockwise)

Preceding gene: 103487934

Following gene: 103487936

Centisome position: 77.65

GC content: 64.42

Gene sequence:

>1695_bases
ATGCCCCTCCTTCATAGCTTGCCGATCGCACGGCGCCACTTCGTTCAGGGGCTGGCGATTGGCGGAGCCGTCGCGGGCTT
CGTCCCGGCACTGCAGGCGAAATCCCTCTCCGCATCGACGGCTGAATTGAGCGGGACCGAATTCGACCTCGAGATCGCCG
AGATCCCGGTCAACTATACCGGCAAGCGCCGGGTCGCGACGGCAGTGAACGGCGCCGTACCCGCGCCGGTCCTGCGCCTG
CGCGAGGGCGACACCGTCACGCTGCGCGTTCGCAACAGCCTCAAGGAGATGTCCAGCATCCACTGGCACGGGATCATCCT
GCCCGCAGAAATGGACGGCGTTCCGGGCATCAGCTTCGCCGGTATCGCGCCGGGCGAGACCTTCACCTATCGATTCGAAG
TACGCCAAGTGGGCACCTACTGGTACCACGCTCATACGCTTGCCGAGCAGACCGGACTTTATGGAGCGATTGTCGTCGAG
CCGAGAGTGCCGATGGGTCCCGTTCCCCACCGCGACTATACCATCATGCTGAGCGACTGGTCGGACGAACCACCGCTCCA
GATCTTCACGAACCTCAAGAAGCTGAGCAGCTATTATAACTTCGCGCAGCCGACCGCCGGCGACTTTCTAGAGGATGTGA
GCGAGTTGGGCCTCGCCAAAGCCCTCGAACGGCGGCGGATGTGGAACGGGTCGCGGATGAATCCGACCGACTACAGCGAC
CTTTCCGCAGCGACCTACACTTATCTTATGAACGGGACGACGCCTGCGGGCAACTGGACCGCCGTCGCCGCGCCCGGCGA
GCATGTGCGCCTGCGCTTTGTGGGCGCGGGAACGGCGACCTTCTTCGACGTACGGATTCCCGGTGTGGAGCTGACAATCG
TTTCGACCGACGGGCAGCCGGTGGTGCCGGTGACGGTCGAGGAGTTCCGGATCGGCCCGGGGGAAACCTATGATGTCGAG
TTCACCATGCCCGATGGCAATGCGCGCACGATCTTCGCCCAGGCGATCGATCGGACCGGCTTTGCCCGCGGCACGATCGC
GCCTGCTCCCGGCATGTCGGCACCGGTCCCCACCCTCGATGCGCGGCCCTGGCTCGATCCCGTCGACATGATGGGGGCGA
TGATGACGATGGGCGGCGGCGAGCACGCCGGGCACGGCCTGACGGAGATGCCGCCGAAGGCCCGGCATGCCCGCACCGAA
TATGGTGCGAACACCGATATGCGCGTCGACTATCCCCGCGCCAATCTCGATGATCCCGGCGCCGGCCTGCGCGACCGCTC
ATGGCGTGTCCTGACGCTGGCGGACTTGCGGACACCCAATGGCGATCCCGATCCGCGCGAGCCCGAACGCGAGATCGAGC
TCCACCTCAACGGCAATATGGAGCGCTTCATCTGGGCGCTCGACGGAATCAAGCTCAATGACTCGCGGCCGCTCCACTTC
AAGCCGAACGAGCGACTGCGCATCATCTTGGTCAACGACACGATGATGTCCCATCCGATGCACCTCCACGGCATGTGGAG
CGATGTCGAAGGATCCGATGGCGCCTTCCAGGTCCGCAAGCATACGGTGGTGGTCCAGCCTGCCCAGAGGGTGAGCTTCC
GCGTCACCGCCGATGCTATGGGTCGATGGGCGTTTCACTGCCATCTGCTCTACCATATGGCGGCCGGCATGTTCCGGGAG
GTCGTCGTCGCATGA

Upstream 100 bases:

>100_bases
AGAACATCAACGACGTCTTTGCGCGCATGCGCCGCGGCGACATTGACGGGCGGATCGTTCTCGATCTGGCCTGACCATCT
TCTGGCGAAAGAAACATTCA

Downstream 100 bases:

>100_bases
TCCGCATGGCCCGCCCCCGCCCCGCGCCGTTCCTGGTTGTCCTCCTCTTCTCGACTGCGATTGCATCAACCGCCTCGGCG
CAAGAGCCATCTTCCACGGC

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MPLLHSLPIARRHFVQGLAIGGAVAGFVPALQAKSLSASTAELSGTEFDLEIAEIPVNYTGKRRVATAVNGAVPAPVLRL
REGDTVTLRVRNSLKEMSSIHWHGIILPAEMDGVPGISFAGIAPGETFTYRFEVRQVGTYWYHAHTLAEQTGLYGAIVVE
PRVPMGPVPHRDYTIMLSDWSDEPPLQIFTNLKKLSSYYNFAQPTAGDFLEDVSELGLAKALERRRMWNGSRMNPTDYSD
LSAATYTYLMNGTTPAGNWTAVAAPGEHVRLRFVGAGTATFFDVRIPGVELTIVSTDGQPVVPVTVEEFRIGPGETYDVE
FTMPDGNARTIFAQAIDRTGFARGTIAPAPGMSAPVPTLDARPWLDPVDMMGAMMTMGGGEHAGHGLTEMPPKARHARTE
YGANTDMRVDYPRANLDDPGAGLRDRSWRVLTLADLRTPNGDPDPREPEREIELHLNGNMERFIWALDGIKLNDSRPLHF
KPNERLRIILVNDTMMSHPMHLHGMWSDVEGSDGAFQVRKHTVVVQPAQRVSFRVTADAMGRWAFHCHLLYHMAAGMFRE
VVVA

Sequences:

>Translated_564_residues
MPLLHSLPIARRHFVQGLAIGGAVAGFVPALQAKSLSASTAELSGTEFDLEIAEIPVNYTGKRRVATAVNGAVPAPVLRL
REGDTVTLRVRNSLKEMSSIHWHGIILPAEMDGVPGISFAGIAPGETFTYRFEVRQVGTYWYHAHTLAEQTGLYGAIVVE
PRVPMGPVPHRDYTIMLSDWSDEPPLQIFTNLKKLSSYYNFAQPTAGDFLEDVSELGLAKALERRRMWNGSRMNPTDYSD
LSAATYTYLMNGTTPAGNWTAVAAPGEHVRLRFVGAGTATFFDVRIPGVELTIVSTDGQPVVPVTVEEFRIGPGETYDVE
FTMPDGNARTIFAQAIDRTGFARGTIAPAPGMSAPVPTLDARPWLDPVDMMGAMMTMGGGEHAGHGLTEMPPKARHARTE
YGANTDMRVDYPRANLDDPGAGLRDRSWRVLTLADLRTPNGDPDPREPEREIELHLNGNMERFIWALDGIKLNDSRPLHF
KPNERLRIILVNDTMMSHPMHLHGMWSDVEGSDGAFQVRKHTVVVQPAQRVSFRVTADAMGRWAFHCHLLYHMAAGMFRE
VVVA
>Mature_563_residues
PLLHSLPIARRHFVQGLAIGGAVAGFVPALQAKSLSASTAELSGTEFDLEIAEIPVNYTGKRRVATAVNGAVPAPVLRLR
EGDTVTLRVRNSLKEMSSIHWHGIILPAEMDGVPGISFAGIAPGETFTYRFEVRQVGTYWYHAHTLAEQTGLYGAIVVEP
RVPMGPVPHRDYTIMLSDWSDEPPLQIFTNLKKLSSYYNFAQPTAGDFLEDVSELGLAKALERRRMWNGSRMNPTDYSDL
SAATYTYLMNGTTPAGNWTAVAAPGEHVRLRFVGAGTATFFDVRIPGVELTIVSTDGQPVVPVTVEEFRIGPGETYDVEF
TMPDGNARTIFAQAIDRTGFARGTIAPAPGMSAPVPTLDARPWLDPVDMMGAMMTMGGGEHAGHGLTEMPPKARHARTEY
GANTDMRVDYPRANLDDPGAGLRDRSWRVLTLADLRTPNGDPDPREPEREIELHLNGNMERFIWALDGIKLNDSRPLHFK
PNERLRIILVNDTMMSHPMHLHGMWSDVEGSDGAFQVRKHTVVVQPAQRVSFRVTADAMGRWAFHCHLLYHMAAGMFREV
VVA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320714, Length=287, Percent_Identity=24.0418118466899, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=148, Percent_Identity=33.1081081081081, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=318, Percent_Identity=25.7861635220126, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221329998, Length=592, Percent_Identity=25, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859919, Length=535, Percent_Identity=22.4299065420561, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28574104, Length=142, Percent_Identity=33.8028169014084, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585842, Length=268, Percent_Identity=29.4776119402985, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281360167, Length=268, Percent_Identity=29.4776119402985, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221330000, Length=268, Percent_Identity=29.4776119402985, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650186, Length=263, Percent_Identity=26.615969581749, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 62158; Mature: 62026

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLHSLPIARRHFVQGLAIGGAVAGFVPALQAKSLSASTAELSGTEFDLEIAEIPVNYT
CCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCC
GKRRVATAVNGAVPAPVLRLREGDTVTLRVRNSLKEMSSIHWHGIILPAEMDGVPGISFA
CCEEEEEECCCCCCCCEEEECCCCEEEEEEHHHHHHHHCCCEEEEEEEECCCCCCCCEEE
GIAPGETFTYRFEVRQVGTYWYHAHTLAEQTGLYGAIVVEPRVPMGPVPHRDYTIMLSDW
CCCCCCEEEEEEEEEEECEEEEEHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECC
SDEPPLQIFTNLKKLSSYYNFAQPTAGDFLEDVSELGLAKALERRRMWNGSRMNPTDYSD
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LSAATYTYLMNGTTPAGNWTAVAAPGEHVRLRFVGAGTATFFDVRIPGVELTIVSTDGQP
CCCEEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCEEEEEEEECCEEEEEEECCCCE
VVPVTVEEFRIGPGETYDVEFTMPDGNARTIFAQAIDRTGFARGTIAPAPGMSAPVPTLD
EEEEEHHHEECCCCCEEEEEEECCCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCC
ARPWLDPVDMMGAMMTMGGGEHAGHGLTEMPPKARHARTEYGANTDMRVDYPRANLDDPG
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCC
AGLRDRSWRVLTLADLRTPNGDPDPREPEREIELHLNGNMERFIWALDGIKLNDSRPLHF
CCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCEEECCCCCEEE
KPNERLRIILVNDTMMSHPMHLHGMWSDVEGSDGAFQVRKHTVVVQPAQRVSFRVTADAM
CCCCCEEEEEEECHHHHCCEEEEEEECCCCCCCCEEEEEEEEEEECCHHHEEEEEEHHHH
GRWAFHCHLLYHMAAGMFREVVVA
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLLHSLPIARRHFVQGLAIGGAVAGFVPALQAKSLSASTAELSGTEFDLEIAEIPVNYT
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCC
GKRRVATAVNGAVPAPVLRLREGDTVTLRVRNSLKEMSSIHWHGIILPAEMDGVPGISFA
CCEEEEEECCCCCCCCEEEECCCCEEEEEEHHHHHHHHCCCEEEEEEEECCCCCCCCEEE
GIAPGETFTYRFEVRQVGTYWYHAHTLAEQTGLYGAIVVEPRVPMGPVPHRDYTIMLSDW
CCCCCCEEEEEEEEEEECEEEEEHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECC
SDEPPLQIFTNLKKLSSYYNFAQPTAGDFLEDVSELGLAKALERRRMWNGSRMNPTDYSD
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LSAATYTYLMNGTTPAGNWTAVAAPGEHVRLRFVGAGTATFFDVRIPGVELTIVSTDGQP
CCCEEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCEEEEEEEECCEEEEEEECCCCE
VVPVTVEEFRIGPGETYDVEFTMPDGNARTIFAQAIDRTGFARGTIAPAPGMSAPVPTLD
EEEEEHHHEECCCCCEEEEEEECCCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCC
ARPWLDPVDMMGAMMTMGGGEHAGHGLTEMPPKARHARTEYGANTDMRVDYPRANLDDPG
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCC
AGLRDRSWRVLTLADLRTPNGDPDPREPEREIELHLNGNMERFIWALDGIKLNDSRPLHF
CCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCEEECCCCCEEE
KPNERLRIILVNDTMMSHPMHLHGMWSDVEGSDGAFQVRKHTVVVQPAQRVSFRVTADAM
CCCCCEEEEEEECHHHHCCEEEEEEECCCCCCCCEEEEEEEEEEECCHHHEEEEEEHHHH
GRWAFHCHLLYHMAAGMFREVVVA
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]