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The map label for this gene is pepA [H]

Identifier: 103487870

GI number: 103487870

Start: 2521467

End: 2523137

Strand: Direct

Name: pepA [H]

Synonym: Sala_2389

Alternate gene names: 103487870

Gene position: 2521467-2523137 (Clockwise)

Preceding gene: 103487865

Following gene: 103487872

Centisome position: 75.38

GC content: 69.96

Gene sequence:

>1671_bases
ATGGCAAGCCGATGTCGTTCGTCGAGCCCGATTTGCGGACGGGCTGGAGGCAGCTATGCAGGACGCAGGTCGTCAAACAA
CGGGGATTATCGAACGATGCGCATGAAAACACTGCTTCTTTCCGCTTGCCTGTCGCTCGCCTTCACGCCCGGCGCGATGG
CGCAAACCGTGATCGGGTCGGGCGTTGTCCCGGCGAACGCCGCGAACAGCGCCGAACGCGCGATCGGCTTCGCATCGCGC
GCGCCGACGGGCGCCGCGCTCGTCATTGTGATGACCGACGCCGCGCTGCCGCCGCTCGATGGCGTCGCGCTCTCCGCGCC
CGAGCGGCAGGCAGTCGAGGCCGCGATCGCCGCCGCGAGCTTCGACGGCAAGGCGGAATCGACGCTGTCGCTGCGCGGCA
TCGGCGCGCATCCGCGCATCCTGCTCGTCGGCGCCGGGCCGGCGCCCTCGTCGCTCGCGCTCGCCGAAGCGGGCGGCAAG
GCGGCGCAGGAGATGAAGGGCGAGGCGCATCCCGTGGCGATCGCCGGCGCCTTTGGCGACACCTCCGCCGCCGAGGTCGC
TTATGGCTTCGCGCTCGGCCAATATCGTTTCGACCGCTACAAGACGGTCGACCGCAAGACGCCGCCCTCCGCCGCGGTCA
CGCTCGTCGGCGCCAATCCCTCGACCGCCGAGACCGCCTTTGCGACGCGCTGGCAGCCGCTCGTCGACGGCGTGCGCCTG
TCGCGCGATCTGGCCAACGAGCCCGCGAACGTCATCTACCCCGAAAGCTTCGTTGCGCGCGTGCGTGCGGCGTTCGCGGG
CGTTCCGGGCGTCAGCATCGAGGTGCTCGACGAAGCGGCGATGCGGCGGCTCGGCATGGGCACGCTCGTCGGCGTGGGCC
AGGGCAGCCCGCGCGGCTCGCGCCTGCTCGCGGTGCGCTACCGCGGCGTGGGTGCGCCCGCCGCACCGCTGGCGTTCGTC
GGCAAGGGCATCACCTTCGATTCGGGCGGCATTTCGCTCAAACCCGGCACGGGCATGTGGAACATGAAGGGCGACATGTC
GGGCGCCGCGTCGGTCGTCGGCGCGGCGCTGTCGCTCGCCAAGTCGCGCGTGCCGGTGCATGTCGTCGCGGTCGCGGCGC
TTGCCGAGAATATGCCCGACGGCAACGCGCAGCGTCCGGGCGACGTCGTGCGCACCCTGTCGGGCAAGACGATCGAGATG
CTGAACAGCGACGCCGAGGGCCGCCTCGTCCTCGCCGACGCTAATGAATATGTCGCGCGCGAATATAAGCCGCGCGCGAT
CGTCAATATCGCGACGCTCACCGGGTCGATCGTCGGTGCACTCGACGACCGATATGCGGGCCTCTTTTCGCGCGATGACG
AGCTTGCCGCCGCGCTGCTCGCCGCCGGAACCGCCAGCGGCGAGGAGCTGTGGCGGATGCCGCTGCACCGGGATTATGCC
GACAAGCTCAAATCGGACATCGCCGACATCCGCAACATCGCGGCGGGCCAGGGGCCGGGCGCGAGCCTCGGCGCGCATTT
CATCGGCTTCTTCGTCGATGAGGACATGCCATGGGCGCATCTCGACATCGCAGGCGTCAACCGCAGCGAATCGGCAAGCC
CGCTCGTGCCTAGGGGGATGACGGGCTTCGGCGTGCGTCTGCTCGACCAGCTGGCGCGCGGCGGGGAGTAG

Upstream 100 bases:

>100_bases
CAACAAGCAGAAGCAACAGGAATCCCGGAAAAATCCGTCGCAACATCACTGGTCCTCTTCGCTTCGGCTCCCGCGGCATC
TGTGGCGGCCATGTCGTCCA

Downstream 100 bases:

>100_bases
GCCGGCCTGTCAGAAAAGGTCCAGCCGCTGTTACGTCAGGGACTGGGCCTTTCGTTCGTTCGGGACGGGCATGGGAACCG
CGGCGAACAGACGGTTCATG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MASRCRSSSPICGRAGGSYAGRRSSNNGDYRTMRMKTLLLSACLSLAFTPGAMAQTVIGSGVVPANAANSAERAIGFASR
APTGAALVIVMTDAALPPLDGVALSAPERQAVEAAIAAASFDGKAESTLSLRGIGAHPRILLVGAGPAPSSLALAEAGGK
AAQEMKGEAHPVAIAGAFGDTSAAEVAYGFALGQYRFDRYKTVDRKTPPSAAVTLVGANPSTAETAFATRWQPLVDGVRL
SRDLANEPANVIYPESFVARVRAAFAGVPGVSIEVLDEAAMRRLGMGTLVGVGQGSPRGSRLLAVRYRGVGAPAAPLAFV
GKGITFDSGGISLKPGTGMWNMKGDMSGAASVVGAALSLAKSRVPVHVVAVAALAENMPDGNAQRPGDVVRTLSGKTIEM
LNSDAEGRLVLADANEYVAREYKPRAIVNIATLTGSIVGALDDRYAGLFSRDDELAAALLAAGTASGEELWRMPLHRDYA
DKLKSDIADIRNIAAGQGPGASLGAHFIGFFVDEDMPWAHLDIAGVNRSESASPLVPRGMTGFGVRLLDQLARGGE

Sequences:

>Translated_556_residues
MASRCRSSSPICGRAGGSYAGRRSSNNGDYRTMRMKTLLLSACLSLAFTPGAMAQTVIGSGVVPANAANSAERAIGFASR
APTGAALVIVMTDAALPPLDGVALSAPERQAVEAAIAAASFDGKAESTLSLRGIGAHPRILLVGAGPAPSSLALAEAGGK
AAQEMKGEAHPVAIAGAFGDTSAAEVAYGFALGQYRFDRYKTVDRKTPPSAAVTLVGANPSTAETAFATRWQPLVDGVRL
SRDLANEPANVIYPESFVARVRAAFAGVPGVSIEVLDEAAMRRLGMGTLVGVGQGSPRGSRLLAVRYRGVGAPAAPLAFV
GKGITFDSGGISLKPGTGMWNMKGDMSGAASVVGAALSLAKSRVPVHVVAVAALAENMPDGNAQRPGDVVRTLSGKTIEM
LNSDAEGRLVLADANEYVAREYKPRAIVNIATLTGSIVGALDDRYAGLFSRDDELAAALLAAGTASGEELWRMPLHRDYA
DKLKSDIADIRNIAAGQGPGASLGAHFIGFFVDEDMPWAHLDIAGVNRSESASPLVPRGMTGFGVRLLDQLARGGE
>Mature_555_residues
ASRCRSSSPICGRAGGSYAGRRSSNNGDYRTMRMKTLLLSACLSLAFTPGAMAQTVIGSGVVPANAANSAERAIGFASRA
PTGAALVIVMTDAALPPLDGVALSAPERQAVEAAIAAASFDGKAESTLSLRGIGAHPRILLVGAGPAPSSLALAEAGGKA
AQEMKGEAHPVAIAGAFGDTSAAEVAYGFALGQYRFDRYKTVDRKTPPSAAVTLVGANPSTAETAFATRWQPLVDGVRLS
RDLANEPANVIYPESFVARVRAAFAGVPGVSIEVLDEAAMRRLGMGTLVGVGQGSPRGSRLLAVRYRGVGAPAAPLAFVG
KGITFDSGGISLKPGTGMWNMKGDMSGAASVVGAALSLAKSRVPVHVVAVAALAENMPDGNAQRPGDVVRTLSGKTIEML
NSDAEGRLVLADANEYVAREYKPRAIVNIATLTGSIVGALDDRYAGLFSRDDELAAALLAAGTASGEELWRMPLHRDYAD
KLKSDIADIRNIAAGQGPGASLGAHFIGFFVDEDMPWAHLDIAGVNRSESASPLVPRGMTGFGVRLLDQLARGGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=489, Percent_Identity=33.7423312883436, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI47155554, Length=372, Percent_Identity=32.258064516129, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790710, Length=464, Percent_Identity=36.2068965517241, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=38.7692307692308, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=33.445945945946, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=223, Percent_Identity=28.2511210762332, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355725, Length=314, Percent_Identity=33.4394904458599, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24661038, Length=288, Percent_Identity=33.6805555555556, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI161077148, Length=316, Percent_Identity=32.2784810126582, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI20130057, Length=316, Percent_Identity=32.2784810126582, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21355645, Length=317, Percent_Identity=31.8611987381703, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24662223, Length=317, Percent_Identity=31.8611987381703, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129963, Length=318, Percent_Identity=34.2767295597484, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662227, Length=316, Percent_Identity=30.379746835443, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19922386, Length=341, Percent_Identity=32.258064516129, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=32.6018808777429, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=32.6018808777429, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=32.6018808777429, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646701, Length=183, Percent_Identity=32.2404371584699, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646703, Length=183, Percent_Identity=32.2404371584699, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358201, Length=183, Percent_Identity=32.2404371584699, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 57181; Mature: 57049

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRCRSSSPICGRAGGSYAGRRSSNNGDYRTMRMKTLLLSACLSLAFTPGAMAQTVIGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
GVVPANAANSAERAIGFASRAPTGAALVIVMTDAALPPLDGVALSAPERQAVEAAIAAAS
CCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHC
FDGKAESTLSLRGIGAHPRILLVGAGPAPSSLALAEAGGKAAQEMKGEAHPVAIAGAFGD
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEHHHCCCHHHHHHCCCCCCEEEEECCCC
TSAAEVAYGFALGQYRFDRYKTVDRKTPPSAAVTLVGANPSTAETAFATRWQPLVDGVRL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHH
SRDLANEPANVIYPESFVARVRAAFAGVPGVSIEVLDEAAMRRLGMGTLVGVGQGSPRGS
HHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
RLLAVRYRGVGAPAAPLAFVGKGITFDSGGISLKPGTGMWNMKGDMSGAASVVGAALSLA
EEEEEEEECCCCCCCCHHHHCCCCEECCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHH
KSRVPVHVVAVAALAENMPDGNAQRPGDVVRTLSGKTIEMLNSDAEGRLVLADANEYVAR
HCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEEECCCHHHHH
EYKPRAIVNIATLTGSIVGALDDRYAGLFSRDDELAAALLAAGTASGEELWRMPLHRDYA
HCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHH
DKLKSDIADIRNIAAGQGPGASLGAHFIGFFVDEDMPWAHLDIAGVNRSESASPLVPRGM
HHHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
TGFGVRLLDQLARGGE
CHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASRCRSSSPICGRAGGSYAGRRSSNNGDYRTMRMKTLLLSACLSLAFTPGAMAQTVIGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
GVVPANAANSAERAIGFASRAPTGAALVIVMTDAALPPLDGVALSAPERQAVEAAIAAAS
CCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHC
FDGKAESTLSLRGIGAHPRILLVGAGPAPSSLALAEAGGKAAQEMKGEAHPVAIAGAFGD
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEHHHCCCHHHHHHCCCCCCEEEEECCCC
TSAAEVAYGFALGQYRFDRYKTVDRKTPPSAAVTLVGANPSTAETAFATRWQPLVDGVRL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHH
SRDLANEPANVIYPESFVARVRAAFAGVPGVSIEVLDEAAMRRLGMGTLVGVGQGSPRGS
HHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
RLLAVRYRGVGAPAAPLAFVGKGITFDSGGISLKPGTGMWNMKGDMSGAASVVGAALSLA
EEEEEEEECCCCCCCCHHHHCCCCEECCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHH
KSRVPVHVVAVAALAENMPDGNAQRPGDVVRTLSGKTIEMLNSDAEGRLVLADANEYVAR
HCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEEECCCHHHHH
EYKPRAIVNIATLTGSIVGALDDRYAGLFSRDDELAAALLAAGTASGEELWRMPLHRDYA
HCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHH
DKLKSDIADIRNIAAGQGPGASLGAHFIGFFVDEDMPWAHLDIAGVNRSESASPLVPRGM
HHHHHHHHHHHHHHCCCCCCCHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
TGFGVRLLDQLARGGE
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA