Click here to switch to the map view.

The map label for this gene is lspA

Identifier: 103487837

GI number: 103487837

Start: 2480257

End: 2480778

Strand: Reverse

Name: lspA

Synonym: Sala_2356

Alternate gene names: 103487837

Gene position: 2480778-2480257 (Counterclockwise)

Preceding gene: 103487838

Following gene: 103487836

Centisome position: 74.16

GC content: 63.22

Gene sequence:

>522_bases
ATGAGCAGCGCCCGTTCCCCCTATCTGCGCTTCGGCCTGATTTTCGCCGCGGTCGCCTTCCTTCTCGATCAGGTGACCAA
ATGGATCGTCACCGTTCCGCTGTCGCTCGAGCCCAAGGGGCAGATCGAGCTCACCAGCTTCTTCAACCTGACCTGGGCCG
AAAATTGCGGCATCTCGCTGTCGATGTTCGCGAGCTGCACCGACACGACGCGCTGGACGCTCGTCGCGGTCACCGGGATC
GTCGCCGCCGCGGTCGCCTTCTGGATGACGCGCGAACAGGCGAAGGGCGACGTCATCGCGCTCGCGCTGATCCTCGGCGG
CGCGCTCGGCAATATCGTCGATCGGGTGCGTTTCGGCTATGTCGTCGACTTCGCCGACCTGCACATCGGCGATTTCCGTC
CCTTCATGATCTTCAACGTCGCCGATGCGTGCATCACCATCGGCGTGCTTTTGCTGGTTGCGCGCGCGCTGCTCTTGGGC
GAAAAGGCGGGCCAAGCAGACGCCAAGCCGTCTGTCGATTAA

Upstream 100 bases:

>100_bases
CCACCTCCCACCACAAATGCGGCCGCTGCTGGCGCCACCTGCCCGAAGTCACCGCCGACGGCGCCTTGTGCAATCGGTGC
GAGACGGTATTGGGGGCGGG

Downstream 100 bases:

>100_bases
TTGGGGCACCGCGTAAACGGGGCGCATAGGAGAGTATTTTAGTGAACCGGACCACCGCCATCCTGGCTGCCTCGATCGTC
GCCACCACTTTGTCGGCCTG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSSARSPYLRFGLIFAAVAFLLDQVTKWIVTVPLSLEPKGQIELTSFFNLTWAENCGISLSMFASCTDTTRWTLVAVTGI
VAAAVAFWMTREQAKGDVIALALILGGALGNIVDRVRFGYVVDFADLHIGDFRPFMIFNVADACITIGVLLLVARALLLG
EKAGQADAKPSVD

Sequences:

>Translated_173_residues
MSSARSPYLRFGLIFAAVAFLLDQVTKWIVTVPLSLEPKGQIELTSFFNLTWAENCGISLSMFASCTDTTRWTLVAVTGI
VAAAVAFWMTREQAKGDVIALALILGGALGNIVDRVRFGYVVDFADLHIGDFRPFMIFNVADACITIGVLLLVARALLLG
EKAGQADAKPSVD
>Mature_172_residues
SSARSPYLRFGLIFAAVAFLLDQVTKWIVTVPLSLEPKGQIELTSFFNLTWAENCGISLSMFASCTDTTRWTLVAVTGIV
AAAVAFWMTREQAKGDVIALALILGGALGNIVDRVRFGYVVDFADLHIGDFRPFMIFNVADACITIGVLLLVARALLLGE
KAGQADAKPSVD

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=150, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SPHAL (Q1GQK7)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617398.1
- MEROPS:   A08.001
- GeneID:   4080757
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2356
- NMPDR:   fig|317655.9.peg.2279
- HOGENOM:   HBG724422
- OMA:   ADACITI
- ProtClustDB:   CLSK835121
- BioCyc:   SALA317655:SALA_2356-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18660; Mature: 18529

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

HASH(0x13d51fb0)-; HASH(0xf8cb618)-; HASH(0x13f12ae4)-; HASH(0x1439bb24)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSARSPYLRFGLIFAAVAFLLDQVTKWIVTVPLSLEPKGQIELTSFFNLTWAENCGISL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEEECCCCCCCH
SMFASCTDTTRWTLVAVTGIVAAAVAFWMTREQAKGDVIALALILGGALGNIVDRVRFGY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVDFADLHIGDFRPFMIFNVADACITIGVLLLVARALLLGEKAGQADAKPSVD
EEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure 
SSARSPYLRFGLIFAAVAFLLDQVTKWIVTVPLSLEPKGQIELTSFFNLTWAENCGISL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEEECCCCCCCH
SMFASCTDTTRWTLVAVTGIVAAAVAFWMTREQAKGDVIALALILGGALGNIVDRVRFGY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVDFADLHIGDFRPFMIFNVADACITIGVLLLVARALLLGEKAGQADAKPSVD
EEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA