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The map label for this gene is hemH [H]

Identifier: 103487734

GI number: 103487734

Start: 2367158

End: 2368153

Strand: Direct

Name: hemH [H]

Synonym: Sala_2253

Alternate gene names: 103487734

Gene position: 2367158-2368153 (Clockwise)

Preceding gene: 103487733

Following gene: 103487735

Centisome position: 70.76

GC content: 69.08

Gene sequence:

>996_bases
ATGACCCTGCCCCCCGATCATCCTCCCGTTCGGCCGCCCCGCGTCGCCGTGCTGCTCGTCAACCTCGGCACCCCCGACGC
GCCCGATCCGCCGTCGGTGCGCCGCTATCTCAGACAATTTCTGTCCGACCGGCGTGTCGTCGAAATCCCGCCAATCCTGT
GGCAGCCGATCCTGCGCGGCATCATCCTGACGACACGGCCGAAAAAATCGGCGCACGCCTATGCGCAGGTGTGGACCGGG
GACGGTTCGCCGCTCGCCGCGATCACCCGCGCACAGGCGGCGGCGCTGCAAGGCGCGCTCGGCGAAGGCGTCGCGGTCGC
TTATGCGATGCGTTACGGCGAACCGGCGATCGGCCGCGCGATCGACGCGCTGACTGCCGCGGGGTGCCGCCGCATCCTCG
TCGCGCCGCTCTATCCGCAATATTGCGCGGCGACGACCGCGACCGTCGTCGATGCCGCCGCCGACCATCTGAAGACGCTG
CGCTGGCAGCCCGCGCTGCGTTTCCTGCCGCCTTACCACGACGATCCCGCCTATCTGGCGGCGCTGAAGGCCTCGGTCGA
AGCGGGGCTTGCGACGCTCGATTTCATCCCCGACGTGCTGCTCGCGAGCTTTCACGGGATGCCCGAGCGCACGCTCCATC
TCGGCGATCCCTATCATTGCCAGTGCCAAAAGACCGCGCGCCTGCTTTCGGACATGCTCGGTCGCCCCGTCGAGGTCGCC
TTCCAGTCGCGCTTCGGCCGCGCCAAATGGCTCGAACCCGCGACCGATACGCGGCTCGAAGCGCTGGGCGCGGCGGGCAA
GAGCGTTGCGGTCTTTGCGCCGGGCTTTGCCGCCGACTGCCTCGAAACGCTCGAGGAGCTGGCGATGCGCGGCAAGGAAC
AGTTCATGGCGGCGGGGGGCAAGCAATTCGCCTACCTCCCCTGCCTCAACGCCGACGCTCCCGGCATGGCGATGATCGAG
GCGCTCGTCCGCCGCGAGCTGGCGGGCTGGATCTGA

Upstream 100 bases:

>100_bases
GCGAAATCGGCGTGCCCGTCGTCGCCCCCGCGATCGCCAACGCAATGTTCGCCGCGACGGGCCGCCGCATTCGCCGCATC
CCGCTGTCGGGGCACCCGCT

Downstream 100 bases:

>100_bases
CGCGCCGTCGCTTACCAACTGTTTAGGTCGATGCGCTAAATTACTCCATCGTGGCGCCGATCCGGCGCGGCGTCGCCCGT
TGGAGTGATGCAATGAACGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTLPPDHPPVRPPRVAVLLVNLGTPDAPDPPSVRRYLRQFLSDRRVVEIPPILWQPILRGIILTTRPKKSAHAYAQVWTG
DGSPLAAITRAQAAALQGALGEGVAVAYAMRYGEPAIGRAIDALTAAGCRRILVAPLYPQYCAATTATVVDAAADHLKTL
RWQPALRFLPPYHDDPAYLAALKASVEAGLATLDFIPDVLLASFHGMPERTLHLGDPYHCQCQKTARLLSDMLGRPVEVA
FQSRFGRAKWLEPATDTRLEALGAAGKSVAVFAPGFAADCLETLEELAMRGKEQFMAAGGKQFAYLPCLNADAPGMAMIE
ALVRRELAGWI

Sequences:

>Translated_331_residues
MTLPPDHPPVRPPRVAVLLVNLGTPDAPDPPSVRRYLRQFLSDRRVVEIPPILWQPILRGIILTTRPKKSAHAYAQVWTG
DGSPLAAITRAQAAALQGALGEGVAVAYAMRYGEPAIGRAIDALTAAGCRRILVAPLYPQYCAATTATVVDAAADHLKTL
RWQPALRFLPPYHDDPAYLAALKASVEAGLATLDFIPDVLLASFHGMPERTLHLGDPYHCQCQKTARLLSDMLGRPVEVA
FQSRFGRAKWLEPATDTRLEALGAAGKSVAVFAPGFAADCLETLEELAMRGKEQFMAAGGKQFAYLPCLNADAPGMAMIE
ALVRRELAGWI
>Mature_330_residues
TLPPDHPPVRPPRVAVLLVNLGTPDAPDPPSVRRYLRQFLSDRRVVEIPPILWQPILRGIILTTRPKKSAHAYAQVWTGD
GSPLAAITRAQAAALQGALGEGVAVAYAMRYGEPAIGRAIDALTAAGCRRILVAPLYPQYCAATTATVVDAAADHLKTLR
WQPALRFLPPYHDDPAYLAALKASVEAGLATLDFIPDVLLASFHGMPERTLHLGDPYHCQCQKTARLLSDMLGRPVEVAF
QSRFGRAKWLEPATDTRLEALGAAGKSVAVFAPGFAADCLETLEELAMRGKEQFMAAGGKQFAYLPCLNADAPGMAMIEA
LVRRELAGWI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=307, Percent_Identity=25.7328990228013, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI60499025, Length=301, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=46.2264150943396, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35774; Mature: 35643

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPPDHPPVRPPRVAVLLVNLGTPDAPDPPSVRRYLRQFLSDRRVVEIPPILWQPILRG
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHCC
IILTTRPKKSAHAYAQVWTGDGSPLAAITRAQAAALQGALGEGVAVAYAMRYGEPAIGRA
EEEECCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHH
IDALTAAGCRRILVAPLYPQYCAATTATVVDAAADHLKTLRWQPALRFLPPYHDDPAYLA
HHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHH
ALKASVEAGLATLDFIPDVLLASFHGMPERTLHLGDPYHCQCQKTARLLSDMLGRPVEVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
FQSRFGRAKWLEPATDTRLEALGAAGKSVAVFAPGFAADCLETLEELAMRGKEQFMAAGG
HHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCC
KQFAYLPCLNADAPGMAMIEALVRRELAGWI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLPPDHPPVRPPRVAVLLVNLGTPDAPDPPSVRRYLRQFLSDRRVVEIPPILWQPILRG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHCC
IILTTRPKKSAHAYAQVWTGDGSPLAAITRAQAAALQGALGEGVAVAYAMRYGEPAIGRA
EEEECCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHH
IDALTAAGCRRILVAPLYPQYCAATTATVVDAAADHLKTLRWQPALRFLPPYHDDPAYLA
HHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHH
ALKASVEAGLATLDFIPDVLLASFHGMPERTLHLGDPYHCQCQKTARLLSDMLGRPVEVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
FQSRFGRAKWLEPATDTRLEALGAAGKSVAVFAPGFAADCLETLEELAMRGKEQFMAAGG
HHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHCCC
KQFAYLPCLNADAPGMAMIEALVRRELAGWI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA