Click here to switch to the map view.

The map label for this gene is ppi [H]

Identifier: 103487673

GI number: 103487673

Start: 2304518

End: 2305234

Strand: Reverse

Name: ppi [H]

Synonym: Sala_2192

Alternate gene names: 103487673

Gene position: 2305234-2304518 (Counterclockwise)

Preceding gene: 103487674

Following gene: 103487672

Centisome position: 68.91

GC content: 64.71

Gene sequence:

>717_bases
ATGACATTTTTTTTCCGCCCCATGGTTTTCACGGCGATGACGTTCGGTCTGGCGACTGCGGCCGTCGCGCAGGACGCGTC
GTCGGCCGTCGCGACGGGCGACGCGGCCGCCGCGGCGGAGACGCCCGCGGTTCCGGCGATGACTCCCGACCAATATCTGA
ACAACCCCGAATATATGCTCAACCTCGATCTTTCGACCGGCGGCCGTGTGGTGATCCAGCTTTATCCCCATGTCGCGCCG
AACCATGTCGAGCGGGTGAAGCAGCTCGCGCGCGCGGGTTTTTACGATGGCGTCAAGTTCCATCGCGTGATCGACGGTTT
CATGGCGCAGACGGGCGATCCGACCGCGACGGGGCAGGGTGGATCGCAGCTTCCCGACCTCAAGGCCGAGTTCAACGCGG
TTCCGCACCTGCGCGGCACCGTGTCGATGGCGCGCGCCCAGAGCGAGGACAGCGCGAACAGCCAGTTCTTCATCATGTTC
CAGCCGCGCTTCTCGCTAGACCGCCGCTACACGGTCTTCGGCCGCGTCGTGTCGGGGATGCAATATGTCGATGCGATCCA
GAAGGGCGAGCCGCCCGAAGTCATGTCGCGCATGGTCCAGGTGTCGGTCGCGGCCGACAACAAGCCGATGCCGCCGGCCG
CGATGCTCACCGAAGCGCAGCCCGCAGCATCCGCTGACGTGACGATCGACGAACTCAACGCGCCTATCGCGCAATAA

Upstream 100 bases:

>100_bases
CCAGGGCGAGCGTTGAGGCCAATCATTGAGCGTTCATATTTTTCCCGCTAGGGGACGCCCGACGGGGCGCAATTCCGATT
ATCCAAGAGGCCGATCCAGC

Downstream 100 bases:

>100_bases
TCGCGGAAAGCCGCGCGAACCAATATGCGCGTCGACGCCTTCGACTTCGATCTGCCCAGCGAGCGCATCGCGCTGCGCCC
GGCGCGACCGCGCGACGCGG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTFFFRPMVFTAMTFGLATAAVAQDASSAVATGDAAAAAETPAVPAMTPDQYLNNPEYMLNLDLSTGGRVVIQLYPHVAP
NHVERVKQLARAGFYDGVKFHRVIDGFMAQTGDPTATGQGGSQLPDLKAEFNAVPHLRGTVSMARAQSEDSANSQFFIMF
QPRFSLDRRYTVFGRVVSGMQYVDAIQKGEPPEVMSRMVQVSVAADNKPMPPAAMLTEAQPAASADVTIDELNAPIAQ

Sequences:

>Translated_238_residues
MTFFFRPMVFTAMTFGLATAAVAQDASSAVATGDAAAAAETPAVPAMTPDQYLNNPEYMLNLDLSTGGRVVIQLYPHVAP
NHVERVKQLARAGFYDGVKFHRVIDGFMAQTGDPTATGQGGSQLPDLKAEFNAVPHLRGTVSMARAQSEDSANSQFFIMF
QPRFSLDRRYTVFGRVVSGMQYVDAIQKGEPPEVMSRMVQVSVAADNKPMPPAAMLTEAQPAASADVTIDELNAPIAQ
>Mature_237_residues
TFFFRPMVFTAMTFGLATAAVAQDASSAVATGDAAAAAETPAVPAMTPDQYLNNPEYMLNLDLSTGGRVVIQLYPHVAPN
HVERVKQLARAGFYDGVKFHRVIDGFMAQTGDPTATGQGGSQLPDLKAEFNAVPHLRGTVSMARAQSEDSANSQFFIMFQ
PRFSLDRRYTVFGRVVSGMQYVDAIQKGEPPEVMSRMVQVSVAADNKPMPPAAMLTEAQPAASADVTIDELNAPIAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=131, Percent_Identity=40.4580152671756, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI19557636, Length=125, Percent_Identity=39.2, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI24308049, Length=123, Percent_Identity=44.7154471544715, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI64276486, Length=156, Percent_Identity=33.974358974359, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4505991, Length=130, Percent_Identity=42.3076923076923, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4758950, Length=161, Percent_Identity=35.4037267080745, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI22547212, Length=154, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI7657473, Length=154, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI22547215, Length=132, Percent_Identity=37.8787878787879, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=36.0248447204969, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786736, Length=130, Percent_Identity=36.9230769230769, Blast_Score=74, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=151, Percent_Identity=37.0860927152318, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=127, Percent_Identity=40.9448818897638, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532641, Length=130, Percent_Identity=40, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=127, Percent_Identity=40.9448818897638, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=123, Percent_Identity=39.0243902439024, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=135, Percent_Identity=36.2962962962963, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=172, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=161, Percent_Identity=35.4037267080745, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=131, Percent_Identity=39.6946564885496, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=133, Percent_Identity=35.3383458646617, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=133, Percent_Identity=35.3383458646617, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=172, Percent_Identity=36.046511627907, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=127, Percent_Identity=40.1574803149606, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=214, Percent_Identity=31.3084112149533, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=129, Percent_Identity=39.5348837209302, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=36.7741935483871, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24652460, Length=149, Percent_Identity=35.5704697986577, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=32.9268292682927, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130249, Length=178, Percent_Identity=35.3932584269663, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647301, Length=163, Percent_Identity=34.3558282208589, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21357249, Length=123, Percent_Identity=34.1463414634146, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922912, Length=125, Percent_Identity=46.4, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650807, Length=163, Percent_Identity=33.7423312883436, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25577; Mature: 25446

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFFRPMVFTAMTFGLATAAVAQDASSAVATGDAAAAAETPAVPAMTPDQYLNNPEYML
CCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCCCCCCCCCCCHHHCCCCCEEE
NLDLSTGGRVVIQLYPHVAPNHVERVKQLARAGFYDGVKFHRVIDGFMAQTGDPTATGQG
EEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GSQLPDLKAEFNAVPHLRGTVSMARAQSEDSANSQFFIMFQPRFSLDRRYTVFGRVVSGM
CCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
QYVDAIQKGEPPEVMSRMVQVSVAADNKPMPPAAMLTEAQPAASADVTIDELNAPIAQ
HHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TFFFRPMVFTAMTFGLATAAVAQDASSAVATGDAAAAAETPAVPAMTPDQYLNNPEYML
CEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCCCCCCCCCCCHHHCCCCCEEE
NLDLSTGGRVVIQLYPHVAPNHVERVKQLARAGFYDGVKFHRVIDGFMAQTGDPTATGQG
EEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GSQLPDLKAEFNAVPHLRGTVSMARAQSEDSANSQFFIMFQPRFSLDRRYTVFGRVVSGM
CCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
QYVDAIQKGEPPEVMSRMVQVSVAADNKPMPPAAMLTEAQPAASADVTIDELNAPIAQ
HHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA