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The map label for this gene is trpS [H]

Identifier: 103487496

GI number: 103487496

Start: 2123181

End: 2124179

Strand: Reverse

Name: trpS [H]

Synonym: Sala_2013

Alternate gene names: 103487496

Gene position: 2124179-2123181 (Counterclockwise)

Preceding gene: 103487497

Following gene: 103487495

Centisome position: 63.5

GC content: 66.37

Gene sequence:

>999_bases
ATGCGGACGCTATCGGGCATCCAGCCCACCGGAAACTTGCACCTCGGCAATTATCTGGGCGCGATCCGCAACTGGGTGCG
GATGCAGGACGCGATGGAGGGCGAGAAGCTCTATTTCCTCGCCGACCTGCACGCGATCACCGTCCATAACGACCCCGCCG
AGCTGACCGCGAACACGCGCGAGATGGCGGCGGCGCTGATGGCGGCGGGAATCGACCCCGCGAAGGCGATCCTGTTCAAT
CAGGCGCGCGTGCCCGCTCATGCCGAGCTGGCCTGGCTTCTGTTCTGCACCGCGCGCATCGGCTGGCTGAACCGGATGAC
GCAGTTCAAGGAAAAGTCGGGCAAGAACCGCGAGGGTGCGAGCGTCGGGCTCTTTGCCTATCCGGTGCTCCAGGCGGCCG
ATGTGCTGCTCTATCAGACGACGCATGTGCCCGTGGGCGACGACCAGAAACAGCATCTGGAGCTGGCGCGCGACATTGCG
ACCAAGTTCAACCTCGATACGGGGACCGACACCTTCACCCTGCCCGAACCGACGATCCCGGCGACCGCAGCGCGGATCAT
GAGCCTGCGCGACGGCAATGCCAAAATGTCGAAATCGGACCCGAGCGACATGAGCCGCATCAATCTGGTCGACGATCCCG
ACACGATCATGGCGAAGATCCGCAAGGCGAAGACCGACCCCGAACCGTTGCCGTCGGAGGCGGCGGGGCTGGAGGGGCGG
CCCGAGGCGAAGAATCTCGTGTCGATCTATGCCGCGATGGCCGACGAGAGCGTCGATCAGGTGCTCGCGCGCTTTGCCGG
CCAGGGATTTGGCGCGTTCAAGCCCGCGCTCGGCGAGCTGCTGGTCGAGACGTTGCGACCGATCGCCGCGCGCCTGACCG
AGCTGAAGGCCAATCCGGCGGCGATCGACGCCGCGCTGGAAGCGGGCGCAGCGCGGGCGTCGGCGCTGGCGAAACCGACG
CTCGACGCCGCCTATGCCGCGCTCGGGCTTTGCCGCTAA

Upstream 100 bases:

>100_bases
GACATTCTTTGGTTGCGCCTTGCTTTTCGGCGTGGTCAATCGCGACACCGTCGGCCAGTTGCGTCGACGGCAATTGTAAC
CAGCACACGGGATCATCGAC

Downstream 100 bases:

>100_bases
CCGGCTGGATGGGCTTGCGGATCGACCGTGGAGCACCATATCGTTCGATGACCAGGGTGCGACGAACCGGGTTCAACCAA
GGTTAAGTCGCATTGGCATA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRTLSGIQPTGNLHLGNYLGAIRNWVRMQDAMEGEKLYFLADLHAITVHNDPAELTANTREMAAALMAAGIDPAKAILFN
QARVPAHAELAWLLFCTARIGWLNRMTQFKEKSGKNREGASVGLFAYPVLQAADVLLYQTTHVPVGDDQKQHLELARDIA
TKFNLDTGTDTFTLPEPTIPATAARIMSLRDGNAKMSKSDPSDMSRINLVDDPDTIMAKIRKAKTDPEPLPSEAAGLEGR
PEAKNLVSIYAAMADESVDQVLARFAGQGFGAFKPALGELLVETLRPIAARLTELKANPAAIDAALEAGAARASALAKPT
LDAAYAALGLCR

Sequences:

>Translated_332_residues
MRTLSGIQPTGNLHLGNYLGAIRNWVRMQDAMEGEKLYFLADLHAITVHNDPAELTANTREMAAALMAAGIDPAKAILFN
QARVPAHAELAWLLFCTARIGWLNRMTQFKEKSGKNREGASVGLFAYPVLQAADVLLYQTTHVPVGDDQKQHLELARDIA
TKFNLDTGTDTFTLPEPTIPATAARIMSLRDGNAKMSKSDPSDMSRINLVDDPDTIMAKIRKAKTDPEPLPSEAAGLEGR
PEAKNLVSIYAAMADESVDQVLARFAGQGFGAFKPALGELLVETLRPIAARLTELKANPAAIDAALEAGAARASALAKPT
LDAAYAALGLCR
>Mature_332_residues
MRTLSGIQPTGNLHLGNYLGAIRNWVRMQDAMEGEKLYFLADLHAITVHNDPAELTANTREMAAALMAAGIDPAKAILFN
QARVPAHAELAWLLFCTARIGWLNRMTQFKEKSGKNREGASVGLFAYPVLQAADVLLYQTTHVPVGDDQKQHLELARDIA
TKFNLDTGTDTFTLPEPTIPATAARIMSLRDGNAKMSKSDPSDMSRINLVDDPDTIMAKIRKAKTDPEPLPSEAAGLEGR
PEAKNLVSIYAAMADESVDQVLARFAGQGFGAFKPALGELLVETLRPIAARLTELKANPAAIDAALEAGAARASALAKPT
LDAAYAALGLCR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=317, Percent_Identity=44.794952681388, Blast_Score=277, Evalue=9e-75,
Organism=Homo sapiens, GI41352700, Length=178, Percent_Identity=52.247191011236, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1789786, Length=328, Percent_Identity=42.6829268292683, Blast_Score=273, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI71982800, Length=336, Percent_Identity=36.3095238095238, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71982793, Length=331, Percent_Identity=36.2537764350453, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320474, Length=348, Percent_Identity=39.6551724137931, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24666151, Length=331, Percent_Identity=41.6918429003021, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 35686; Mature: 35686

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00141 ASP_PROTEASE ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLSGIQPTGNLHLGNYLGAIRNWVRMQDAMEGEKLYFLADLHAITVHNDPAELTANTR
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCHHHHHCCHH
EMAAALMAAGIDPAKAILFNQARVPAHAELAWLLFCTARIGWLNRMTQFKEKSGKNREGA
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SVGLFAYPVLQAADVLLYQTTHVPVGDDQKQHLELARDIATKFNLDTGTDTFTLPEPTIP
EEHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
ATAARIMSLRDGNAKMSKSDPSDMSRINLVDDPDTIMAKIRKAKTDPEPLPSEAAGLEGR
HHHHHHHHHCCCCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PEAKNLVSIYAAMADESVDQVLARFAGQGFGAFKPALGELLVETLRPIAARLTELKANPA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIDAALEAGAARASALAKPTLDAAYAALGLCR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRTLSGIQPTGNLHLGNYLGAIRNWVRMQDAMEGEKLYFLADLHAITVHNDPAELTANTR
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCHHHHHCCHH
EMAAALMAAGIDPAKAILFNQARVPAHAELAWLLFCTARIGWLNRMTQFKEKSGKNREGA
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SVGLFAYPVLQAADVLLYQTTHVPVGDDQKQHLELARDIATKFNLDTGTDTFTLPEPTIP
EEHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
ATAARIMSLRDGNAKMSKSDPSDMSRINLVDDPDTIMAKIRKAKTDPEPLPSEAAGLEGR
HHHHHHHHHCCCCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
PEAKNLVSIYAAMADESVDQVLARFAGQGFGAFKPALGELLVETLRPIAARLTELKANPA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIDAALEAGAARASALAKPTLDAAYAALGLCR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]