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The map label for this gene is murB

Identifier: 103487363

GI number: 103487363

Start: 1976289

End: 1977188

Strand: Reverse

Name: murB

Synonym: Sala_1879

Alternate gene names: 103487363

Gene position: 1977188-1976289 (Counterclockwise)

Preceding gene: 103487364

Following gene: 103487362

Centisome position: 59.11

GC content: 68.0

Gene sequence:

>900_bases
GTGAGCGCAACCGCCACCCTGCCGGCCGTTCGCGGCAAGCTCACCCCGCAAGCCCCGCTCGCCCCGCTCGTCTGGTTCAA
GTCGGGTGGCGCCGCCGACTGGCTGTTCGAGCCGAAGGACGTCGACGACCTCGCCGATTTCCTGCGCGACCTCGATCCGG
CGATCCCGGTGATGGCGCTCGGCCTCGGCTCGAACCTCATCGTCCGCGACGGCGGATTTCCCGGCGTCGTCGTCCGGCTG
GGCAAGGCTTTCGCCAAGGTGGAACCGATCGACGCCACCACATTGCGCTGCGGCGGCGGAGCGTCGGGCATTCTCGTTTC
CTCGACCGCGCGCGACGCGGGGATTGCGGGGATGGAGTTCCTGCGTTCGATTCCCGGCACCGTCGGCGGCTTCGTGCGCA
TGAACGGCGGCGCCTATGGCGGTGAGGTCAAGGATATATTGGTCGATTGCGACGTCGTGCTGCGCTCGGGCGAACGCAAG
ACGCTCGCACTTGCCGACCTCGGCTACACCTATCGCCACAGCGAACTGCCCGAGGGCGCGGTGGTCGTCGGCGCGACCTT
TCGTGGCCGGCCCGGCGCATCGGCGGCGATCCAGGCCGAGATGGACCGCATCTCGGCGAGCCGCGAGGCCTCGCAGCCGC
TGCGTTCGAGAACCGGCGGCTCGACCTTCAAGAACCCCGCCGGGCACAAGGCCTGGCAACTGGTCGACGCGGCCGGGTGC
CGCGGGCTGATGGTCGGCGGCGCGCAGGTCAGCGAGAAACACACCAATTTCCTGATCAATACCGGCGATGCGACGAGCGC
CGATATCGAGGCATTGGGCGAAGAAGTCCGCCGCCGGGTGAAGGACAAGAGCGGCATCGAATTGCAGTGGGAGATTCAGC
GCGTGGGTAAGGCCGAATGA

Upstream 100 bases:

>100_bases
TTCCGTTCGTGTCGAGCGAAGTCGAGACACCCCGCGGCATAGCGCCCAGCCCGATGGGCATCTCGACTTCGCTCGATGCG
AACGGGGAAGGGCTGGGGTC

Downstream 100 bases:

>100_bases
GCCGGGGTCCGTGGCATGTCGCCGTCCTGATGGGCGGCTGGTCGGCCGAGCGCGAGGTGTCGTTGATGAGCGGCAAGGGC
GTGGCCGACGCGCTCGAAAG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSATATLPAVRGKLTPQAPLAPLVWFKSGGAADWLFEPKDVDDLADFLRDLDPAIPVMALGLGSNLIVRDGGFPGVVVRL
GKAFAKVEPIDATTLRCGGGASGILVSSTARDAGIAGMEFLRSIPGTVGGFVRMNGGAYGGEVKDILVDCDVVLRSGERK
TLALADLGYTYRHSELPEGAVVVGATFRGRPGASAAIQAEMDRISASREASQPLRSRTGGSTFKNPAGHKAWQLVDAAGC
RGLMVGGAQVSEKHTNFLINTGDATSADIEALGEEVRRRVKDKSGIELQWEIQRVGKAE

Sequences:

>Translated_299_residues
MSATATLPAVRGKLTPQAPLAPLVWFKSGGAADWLFEPKDVDDLADFLRDLDPAIPVMALGLGSNLIVRDGGFPGVVVRL
GKAFAKVEPIDATTLRCGGGASGILVSSTARDAGIAGMEFLRSIPGTVGGFVRMNGGAYGGEVKDILVDCDVVLRSGERK
TLALADLGYTYRHSELPEGAVVVGATFRGRPGASAAIQAEMDRISASREASQPLRSRTGGSTFKNPAGHKAWQLVDAAGC
RGLMVGGAQVSEKHTNFLINTGDATSADIEALGEEVRRRVKDKSGIELQWEIQRVGKAE
>Mature_298_residues
SATATLPAVRGKLTPQAPLAPLVWFKSGGAADWLFEPKDVDDLADFLRDLDPAIPVMALGLGSNLIVRDGGFPGVVVRLG
KAFAKVEPIDATTLRCGGGASGILVSSTARDAGIAGMEFLRSIPGTVGGFVRMNGGAYGGEVKDILVDCDVVLRSGERKT
LALADLGYTYRHSELPEGAVVVGATFRGRPGASAAIQAEMDRISASREASQPLRSRTGGSTFKNPAGHKAWQLVDAAGCR
GLMVGGAQVSEKHTNFLINTGDATSADIEALGEEVRRRVKDKSGIELQWEIQRVGKAE

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_SPHAL (Q1GRY1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616924.1
- ProteinModelPortal:   Q1GRY1
- SMR:   Q1GRY1
- GeneID:   4082624
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1879
- NMPDR:   fig|317655.9.peg.1807
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   SALA317655:SALA_1879-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31358; Mature: 31227

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 221-221 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATATLPAVRGKLTPQAPLAPLVWFKSGGAADWLFEPKDVDDLADFLRDLDPAIPVMAL
CCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
GLGSNLIVRDGGFPGVVVRLGKAFAKVEPIDATTLRCGGGASGILVSSTARDAGIAGMEF
CCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCHHHHHH
LRSIPGTVGGFVRMNGGAYGGEVKDILVDCDVVLRSGERKTLALADLGYTYRHSELPEGA
HHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCE
VVVGATFRGRPGASAAIQAEMDRISASREASQPLRSRTGGSTFKNPAGHKAWQLVDAAGC
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
RGLMVGGAQVSEKHTNFLINTGDATSADIEALGEEVRRRVKDKSGIELQWEIQRVGKAE
CEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SATATLPAVRGKLTPQAPLAPLVWFKSGGAADWLFEPKDVDDLADFLRDLDPAIPVMAL
CCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
GLGSNLIVRDGGFPGVVVRLGKAFAKVEPIDATTLRCGGGASGILVSSTARDAGIAGMEF
CCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCCCCHHHHHH
LRSIPGTVGGFVRMNGGAYGGEVKDILVDCDVVLRSGERKTLALADLGYTYRHSELPEGA
HHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCE
VVVGATFRGRPGASAAIQAEMDRISASREASQPLRSRTGGSTFKNPAGHKAWQLVDAAGC
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
RGLMVGGAQVSEKHTNFLINTGDATSADIEALGEEVRRRVKDKSGIELQWEIQRVGKAE
CEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA