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The map label for this gene is murC

Identifier: 103487364

GI number: 103487364

Start: 1977319

End: 1978752

Strand: Reverse

Name: murC

Synonym: Sala_1880

Alternate gene names: 103487364

Gene position: 1978752-1977319 (Counterclockwise)

Preceding gene: 103487365

Following gene: 103487363

Centisome position: 59.15

GC content: 65.97

Gene sequence:

>1434_bases
ATGCGCGGCGTCGCGACCGACATCGGAACCATCCACTTCATCGGCATCGGCGGCATCGGCATGTCGGGGATCGCCGAGGT
GATGCATAATCTGGGTTATCGGGTACAGGGCAGCGACATTGCCGACAGCTATGTCGTCGAAGGGCTGAGGAAGCGCGGGA
TCAAGGTCGCGATCGGCCATGCGCCGGAGAATGTCGACGGCGTTGCGGTCGTCGTCACCTCGACCGCGGTGAAACGCGGC
AATCCCGAGGTGGAAGCCGCGCTGGCGCAGCGCATCCCGATCGTCCGCCGCGCCGAAATGCTCGCCGAACTGATGCGGCT
GAAATCGACCGTCGCCATCGCCGGGACGCACGGCAAGACGACGACGACCAGCCTTGTCGCCGCGCTGCTCGATGCCGGCG
GGATCGACCCGACGGTGATCAACGGCGGCATCATCAACAATTATGGCTCGAACGCGCGGCTCGGCGCGTCGGACTGGATG
GTGGTCGAGGCCGACGAGAGCGACGGCAGCTTTCTGCGACTCGACGGCACGATCGCGGTCGTCACCAATATCGACCCCGA
ACATCTCGACCATTATGGCAGCTTCGACGCGATCAAGGACGCGTTCGTCGAGTTTATCGAAAATGTGCCCTTTTACGGCG
CGGCGATGCTCTGCCTCGACCATCCGGAGGTGCAGGCGATCATCCCGCGTATCCGCGACCGGCGGATTATCACCTATGGC
TTTTCTGCCCAGGCCGACGTGCGCGGCACCAATGTGACCCCCGGCCCCGACGGCAACCGCTTCGACGTCGTCGTGCGCGA
CCGCGACGGGAACAGCCGGACGATCGAGGGCATCCATCTGCCGATGTCGGGGCGCCACAATGTCCAGAATGCGCTCGCCG
CGGTCGCGGTCGCGCTGCACATGGGGGTGCCGGACGAAAAGATCGTGTCGGGTTTCAACGGTTTTGCCGGGGTCAAGCGG
CGCTTCACCAAGGTTGGCGAGATTGTGACCGATGAGGGCGTTGTCACCGTGATCGACGATTATGCGCACCACCCGGTCGA
GATTCGCGCGGTGCTGTCGGCGGCGCGTGAAGGCGCGGGGGCGGGGCGCGTCGTCGCCGTCGTCCAGCCGCACCGCTTCA
CGCGCCTTCGCGATCATATGGACGATTTCCAGCAGGCGTTTAACGACGCCGACATGGTGTTGGCGCTGCCGGTCTATGCG
GCGGGTGAAAGCCCGATCGAGGGCGTGTCGTCGGATGCGCTGGTGCGGGGCCTGCGCGACCGCGGGCATCGGCAGGCGAA
TGTCGTCGCCGACGCCGACGCACTGGCCGCAAGCCTTGCCGCGAGTATCAAGGCGGGCGACCTCGGCGCGGGCGATATGA
TCATCTGCCTCGGCGCGGGCGACATCACCAAGATGGCGGCTGGGCTGGCGAGCGCGGTGGAGGGTGCGGCGTGA

Upstream 100 bases:

>100_bases
AATCCTTTGCCGCGCCGCCGATGATGGACGTGATCCGTGTTGGCGCTTCGCTGCCGCGCGCGGCATCGGGTATCGCGGCT
GCGCGCCGGGAGGCGAAGTG

Downstream 100 bases:

>100_bases
CACCCTTCTCGTCCCGGATACTGCTTATTTTTCCGTTCGTGTCGAGCGAAGTCGAGACACCCCGCGGCATAGCGCCCAGC
CCGATGGGCATCTCGACTTC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MRGVATDIGTIHFIGIGGIGMSGIAEVMHNLGYRVQGSDIADSYVVEGLRKRGIKVAIGHAPENVDGVAVVVTSTAVKRG
NPEVEAALAQRIPIVRRAEMLAELMRLKSTVAIAGTHGKTTTTSLVAALLDAGGIDPTVINGGIINNYGSNARLGASDWM
VVEADESDGSFLRLDGTIAVVTNIDPEHLDHYGSFDAIKDAFVEFIENVPFYGAAMLCLDHPEVQAIIPRIRDRRIITYG
FSAQADVRGTNVTPGPDGNRFDVVVRDRDGNSRTIEGIHLPMSGRHNVQNALAAVAVALHMGVPDEKIVSGFNGFAGVKR
RFTKVGEIVTDEGVVTVIDDYAHHPVEIRAVLSAAREGAGAGRVVAVVQPHRFTRLRDHMDDFQQAFNDADMVLALPVYA
AGESPIEGVSSDALVRGLRDRGHRQANVVADADALAASLAASIKAGDLGAGDMIICLGAGDITKMAAGLASAVEGAA

Sequences:

>Translated_477_residues
MRGVATDIGTIHFIGIGGIGMSGIAEVMHNLGYRVQGSDIADSYVVEGLRKRGIKVAIGHAPENVDGVAVVVTSTAVKRG
NPEVEAALAQRIPIVRRAEMLAELMRLKSTVAIAGTHGKTTTTSLVAALLDAGGIDPTVINGGIINNYGSNARLGASDWM
VVEADESDGSFLRLDGTIAVVTNIDPEHLDHYGSFDAIKDAFVEFIENVPFYGAAMLCLDHPEVQAIIPRIRDRRIITYG
FSAQADVRGTNVTPGPDGNRFDVVVRDRDGNSRTIEGIHLPMSGRHNVQNALAAVAVALHMGVPDEKIVSGFNGFAGVKR
RFTKVGEIVTDEGVVTVIDDYAHHPVEIRAVLSAAREGAGAGRVVAVVQPHRFTRLRDHMDDFQQAFNDADMVLALPVYA
AGESPIEGVSSDALVRGLRDRGHRQANVVADADALAASLAASIKAGDLGAGDMIICLGAGDITKMAAGLASAVEGAA
>Mature_477_residues
MRGVATDIGTIHFIGIGGIGMSGIAEVMHNLGYRVQGSDIADSYVVEGLRKRGIKVAIGHAPENVDGVAVVVTSTAVKRG
NPEVEAALAQRIPIVRRAEMLAELMRLKSTVAIAGTHGKTTTTSLVAALLDAGGIDPTVINGGIINNYGSNARLGASDWM
VVEADESDGSFLRLDGTIAVVTNIDPEHLDHYGSFDAIKDAFVEFIENVPFYGAAMLCLDHPEVQAIIPRIRDRRIITYG
FSAQADVRGTNVTPGPDGNRFDVVVRDRDGNSRTIEGIHLPMSGRHNVQNALAAVAVALHMGVPDEKIVSGFNGFAGVKR
RFTKVGEIVTDEGVVTVIDDYAHHPVEIRAVLSAAREGAGAGRVVAVVQPHRFTRLRDHMDDFQQAFNDADMVLALPVYA
AGESPIEGVSSDALVRGLRDRGHRQANVVADADALAASLAASIKAGDLGAGDMIICLGAGDITKMAAGLASAVEGAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=468, Percent_Identity=44.8717948717949, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790680, Length=404, Percent_Identity=30.4455445544554, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SPHAL (Q1GRY0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616925.1
- ProteinModelPortal:   Q1GRY0
- SMR:   Q1GRY0
- GeneID:   4082625
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1880
- NMPDR:   fig|317655.9.peg.1808
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   SALA317655:SALA_1880-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50172; Mature: 50172

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVATDIGTIHFIGIGGIGMSGIAEVMHNLGYRVQGSDIADSYVVEGLRKRGIKVAIGH
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEECC
APENVDGVAVVVTSTAVKRGNPEVEAALAQRIPIVRRAEMLAELMRLKSTVAIAGTHGKT
CCCCCCCEEEEEEEHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCC
TTTSLVAALLDAGGIDPTVINGGIINNYGSNARLGASDWMVVEADESDGSFLRLDGTIAV
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEECCCCEEEEEECCCCCCEEEECCEEEE
VTNIDPEHLDHYGSFDAIKDAFVEFIENVPFYGAAMLCLDHPEVQAIIPRIRDRRIITYG
EECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEC
FSAQADVRGTNVTPGPDGNRFDVVVRDRDGNSRTIEGIHLPMSGRHNVQNALAAVAVALH
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
MGVPDEKIVSGFNGFAGVKRRFTKVGEIVTDEGVVTVIDDYAHHPVEIRAVLSAAREGAG
CCCCHHHHHHCCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
AGRVVAVVQPHRFTRLRDHMDDFQQAFNDADMVLALPVYAAGESPIEGVSSDALVRGLRD
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHH
RGHRQANVVADADALAASLAASIKAGDLGAGDMIICLGAGDITKMAAGLASAVEGAA
CCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGVATDIGTIHFIGIGGIGMSGIAEVMHNLGYRVQGSDIADSYVVEGLRKRGIKVAIGH
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEEECC
APENVDGVAVVVTSTAVKRGNPEVEAALAQRIPIVRRAEMLAELMRLKSTVAIAGTHGKT
CCCCCCCEEEEEEEHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCC
TTTSLVAALLDAGGIDPTVINGGIINNYGSNARLGASDWMVVEADESDGSFLRLDGTIAV
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEECCCCEEEEEECCCCCCEEEECCEEEE
VTNIDPEHLDHYGSFDAIKDAFVEFIENVPFYGAAMLCLDHPEVQAIIPRIRDRRIITYG
EECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEC
FSAQADVRGTNVTPGPDGNRFDVVVRDRDGNSRTIEGIHLPMSGRHNVQNALAAVAVALH
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
MGVPDEKIVSGFNGFAGVKRRFTKVGEIVTDEGVVTVIDDYAHHPVEIRAVLSAAREGAG
CCCCHHHHHHCCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
AGRVVAVVQPHRFTRLRDHMDDFQQAFNDADMVLALPVYAAGESPIEGVSSDALVRGLRD
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHH
RGHRQANVVADADALAASLAASIKAGDLGAGDMIICLGAGDITKMAAGLASAVEGAA
CCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA