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The map label for this gene is 103487338

Identifier: 103487338

GI number: 103487338

Start: 1948609

End: 1950126

Strand: Reverse

Name: 103487338

Synonym: Sala_1854

Alternate gene names: NA

Gene position: 1950126-1948609 (Counterclockwise)

Preceding gene: 103487341

Following gene: 103487337

Centisome position: 58.3

GC content: 68.12

Gene sequence:

>1518_bases
ATGAGCTGGAAAAAAGAAGTCGAGGAACTCGCCGCGCGCCGCGCGATGGCGGAGAAGATGGGCGGCAAGGAAAAAGTCGC
GCGCCAGCACAGTCGCGGCAAGATGGACGCGCGCGCGCGATTGAACGCGATCGTCGATCCGGGCAGTTTTCGCGAGATCG
GCAAGATCGCGGGGCGCGGCACCTACGGCGCCGGTGGCGAGCTGGAAGACCTCGCGCCAAGCAACTTCATTTTCGGCCGC
GCGAACATCGACGGGCGGCCGGTCGTCGCCTCGGCCGACGACTTCACCGTGCGCGGCGGCGCCGCCGATGCGGCGCTGCA
TCGCAAGTTCGTCCAGTGCGAGGCGATGGCGCACGAATATCGCCTGCCGCTCATTCGCATGATCGACGGCACCGGCGGCG
GCGGGTCGGTCAGGACGCTGGAGGATATGGGCTATACCTATATCCCGCATGTGCCGGGGTGGGACGAGGTCATCGCCAAT
CTCGACACGGTGCCGGTGGTCGCGCTCGCGCTGGGGCCGACCGCGGGGCTGGGCGCGGCGCGGGTTGTCGCCAGCCATTA
CAGCGTGATGGTGCGCGGGCTGTCGCAGCTGTTCGCGGCGGGACCGGCGGTGGCGGCGGCGATCGGCGATACATTGGACC
GCGAGGAGCTGGGCGGCAGCGACGTGCACACGCGCAACGGCGTCGTCGACGACGAGGTGGCGAGCGAGGCCGAAGCCTTC
GCCTCCGCGCGGCGGTTTTTGTCCTATCTGCCCTCGTCGATCCATGACCGGGCGGCGCGGACCGCTTGTAGCGATCCCGT
GGACCGGCGTGAGGAGTCGCTGCTGTCGGTGGTGCCGCGCGAGGCGAAGCAGGTCTATGCGATGCGGCGCATCGCCGACG
CGGTGTTCGACAAGGGCAGTTTTTTCGAGATGGGGGCCCGTTGGGGTCGCGCCGTCATCACCGCTTTCGCGCGGCTGGAC
GGCTGGCCGGTCGCGGTGCTCGCGAGCGATCCGTCCTACCTCGGCGGATCGTGGGACGCCAAGACGAGCGAAAAGGCCGA
GCGTTTTGTCAAGCTGGCCGACCAGTTCCGGCTGCCGATCGTTCATCTGGTCGATAACCCCGGCTTCATGATCGGCGGCG
AGGCCGAGCGGACGGGGACGATCCGTTACGGGGTACAGGCGATGAACGCGATCTACCGCGCCACCGTGCCGCTCGCGTCG
GTGGTGGTGCGCCGTGCCTATGGGATCGCGGGGAGCGCGATGTCGAACGCCGAGCGGTTCCAGTATCGCTTCGCCTGGCC
GTCGGGCGACTGGGGCAGCCTGCCGATCGAAGGCGGGGTCGAGGTCGCGTACAAGAGCGAGCTGGAAGCGGCGGCGGATC
CGGCAGCGCATCTGGAAGCGATCCGCGAGCGCCTCAATCGCGTGCGCTCGCCGTTCCGCACGGCAGAGCGGTTTGGAGTC
GAGGATATCATCGACCCACGCGATACGCGGCCTTTGCTGTGCGAGTTTGCGGAACTGGCGTGGCGGGTGGTGAAATAG

Upstream 100 bases:

>100_bases
GCGATGCGCCCCGCAAGATTCCTGTCGCTCATATGCCTCTCCCTTTCCGTTCGCGCGAATATGGCATGACGTTTCCGTCA
ACGTAAGCTAGCTTCGCGCC

Downstream 100 bases:

>100_bases
AGGGGAGGTGACGAGGGACGTAGTTGCATCGCGTGATCTGATCCCTGAGACGTTCCCTTGTTTCGTCCTACCGGTGGAGA
CCGGGATCTCGATCTTGCGC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSWKKEVEELAARRAMAEKMGGKEKVARQHSRGKMDARARLNAIVDPGSFREIGKIAGRGTYGAGGELEDLAPSNFIFGR
ANIDGRPVVASADDFTVRGGAADAALHRKFVQCEAMAHEYRLPLIRMIDGTGGGGSVRTLEDMGYTYIPHVPGWDEVIAN
LDTVPVVALALGPTAGLGAARVVASHYSVMVRGLSQLFAAGPAVAAAIGDTLDREELGGSDVHTRNGVVDDEVASEAEAF
ASARRFLSYLPSSIHDRAARTACSDPVDRREESLLSVVPREAKQVYAMRRIADAVFDKGSFFEMGARWGRAVITAFARLD
GWPVAVLASDPSYLGGSWDAKTSEKAERFVKLADQFRLPIVHLVDNPGFMIGGEAERTGTIRYGVQAMNAIYRATVPLAS
VVVRRAYGIAGSAMSNAERFQYRFAWPSGDWGSLPIEGGVEVAYKSELEAAADPAAHLEAIRERLNRVRSPFRTAERFGV
EDIIDPRDTRPLLCEFAELAWRVVK

Sequences:

>Translated_505_residues
MSWKKEVEELAARRAMAEKMGGKEKVARQHSRGKMDARARLNAIVDPGSFREIGKIAGRGTYGAGGELEDLAPSNFIFGR
ANIDGRPVVASADDFTVRGGAADAALHRKFVQCEAMAHEYRLPLIRMIDGTGGGGSVRTLEDMGYTYIPHVPGWDEVIAN
LDTVPVVALALGPTAGLGAARVVASHYSVMVRGLSQLFAAGPAVAAAIGDTLDREELGGSDVHTRNGVVDDEVASEAEAF
ASARRFLSYLPSSIHDRAARTACSDPVDRREESLLSVVPREAKQVYAMRRIADAVFDKGSFFEMGARWGRAVITAFARLD
GWPVAVLASDPSYLGGSWDAKTSEKAERFVKLADQFRLPIVHLVDNPGFMIGGEAERTGTIRYGVQAMNAIYRATVPLAS
VVVRRAYGIAGSAMSNAERFQYRFAWPSGDWGSLPIEGGVEVAYKSELEAAADPAAHLEAIRERLNRVRSPFRTAERFGV
EDIIDPRDTRPLLCEFAELAWRVVK
>Mature_504_residues
SWKKEVEELAARRAMAEKMGGKEKVARQHSRGKMDARARLNAIVDPGSFREIGKIAGRGTYGAGGELEDLAPSNFIFGRA
NIDGRPVVASADDFTVRGGAADAALHRKFVQCEAMAHEYRLPLIRMIDGTGGGGSVRTLEDMGYTYIPHVPGWDEVIANL
DTVPVVALALGPTAGLGAARVVASHYSVMVRGLSQLFAAGPAVAAAIGDTLDREELGGSDVHTRNGVVDDEVASEAEAFA
SARRFLSYLPSSIHDRAARTACSDPVDRREESLLSVVPREAKQVYAMRRIADAVFDKGSFFEMGARWGRAVITAFARLDG
WPVAVLASDPSYLGGSWDAKTSEKAERFVKLADQFRLPIVHLVDNPGFMIGGEAERTGTIRYGVQAMNAIYRATVPLASV
VVRRAYGIAGSAMSNAERFQYRFAWPSGDWGSLPIEGGVEVAYKSELEAAADPAAHLEAIRERLNRVRSPFRTAERFGVE
DIIDPRDTRPLLCEFAELAWRVVK

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=505, Percent_Identity=31.4851485148515, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI295821216, Length=525, Percent_Identity=30.8571428571429, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI11545863, Length=495, Percent_Identity=27.2727272727273, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI134142062, Length=271, Percent_Identity=25.4612546125461, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38679960, Length=271, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679974, Length=271, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679971, Length=271, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679977, Length=271, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=271, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=479, Percent_Identity=33.6116910229645, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI25147359, Length=479, Percent_Identity=33.6116910229645, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17552936, Length=500, Percent_Identity=28, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24586065, Length=511, Percent_Identity=26.4187866927593, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 54800; Mature: 54668

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWKKEVEELAARRAMAEKMGGKEKVARQHSRGKMDARARLNAIVDPGSFREIGKIAGRG
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEECCCCHHHHHHHHCCC
TYGAGGELEDLAPSNFIFGRANIDGRPVVASADDFTVRGGAADAALHRKFVQCEAMAHEY
CCCCCCCHHHCCCCCEEEEECCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHH
RLPLIRMIDGTGGGGSVRTLEDMGYTYIPHVPGWDEVIANLDTVPVVALALGPTAGLGAA
CCCEEEEEECCCCCCCCEEHHHCCCEECCCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHH
RVVASHYSVMVRGLSQLFAAGPAVAAAIGDTLDREELGGSDVHTRNGVVDDEVASEAEAF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHCHHHCCCCCCCCCCCCCCHHHHHHHHHH
ASARRFLSYLPSSIHDRAARTACSDPVDRREESLLSVVPREAKQVYAMRRIADAVFDKGS
HHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
FFEMGARWGRAVITAFARLDGWPVAVLASDPSYLGGSWDAKTSEKAERFVKLADQFRLPI
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VHLVDNPGFMIGGEAERTGTIRYGVQAMNAIYRATVPLASVVVRRAYGIAGSAMSNAERF
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHE
QYRFAWPSGDWGSLPIEGGVEVAYKSELEAAADPAAHLEAIRERLNRVRSPFRTAERFGV
EEEEECCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDIIDPRDTRPLLCEFAELAWRVVK
HHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWKKEVEELAARRAMAEKMGGKEKVARQHSRGKMDARARLNAIVDPGSFREIGKIAGRG
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEECCCCHHHHHHHHCCC
TYGAGGELEDLAPSNFIFGRANIDGRPVVASADDFTVRGGAADAALHRKFVQCEAMAHEY
CCCCCCCHHHCCCCCEEEEECCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHH
RLPLIRMIDGTGGGGSVRTLEDMGYTYIPHVPGWDEVIANLDTVPVVALALGPTAGLGAA
CCCEEEEEECCCCCCCCEEHHHCCCEECCCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHH
RVVASHYSVMVRGLSQLFAAGPAVAAAIGDTLDREELGGSDVHTRNGVVDDEVASEAEAF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHCHHHCCCCCCCCCCCCCCHHHHHHHHHH
ASARRFLSYLPSSIHDRAARTACSDPVDRREESLLSVVPREAKQVYAMRRIADAVFDKGS
HHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
FFEMGARWGRAVITAFARLDGWPVAVLASDPSYLGGSWDAKTSEKAERFVKLADQFRLPI
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VHLVDNPGFMIGGEAERTGTIRYGVQAMNAIYRATVPLASVVVRRAYGIAGSAMSNAERF
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHE
QYRFAWPSGDWGSLPIEGGVEVAYKSELEAAADPAAHLEAIRERLNRVRSPFRTAERFGV
EEEEECCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDIIDPRDTRPLLCEFAELAWRVVK
HHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]