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The map label for this gene is fghA [H]

Identifier: 103487318

GI number: 103487318

Start: 1929863

End: 1930711

Strand: Reverse

Name: fghA [H]

Synonym: Sala_1834

Alternate gene names: 103487318

Gene position: 1930711-1929863 (Counterclockwise)

Preceding gene: 103487319

Following gene: 103487313

Centisome position: 57.72

GC content: 64.78

Gene sequence:

>849_bases
ATGACCCTCGAAACCCTCTCCACCATCCGCAGCCATGGCGGCACCCAGGGCGTGTACAGCCACGCCAGCACGACGACCGG
CACCGACATGACCTTTGCGCTGTTCGTGCCCGACCACGCGCCGGGGACCAAGCTGCCGGTGCTCTGGTATCTGTCGGGGC
TGACCTGCACCCACGCCAATGTGATGGAAAAGGGCGAATATCGCGCCGCCTGCGCCGAGCATGGCGTGATCTTTGTCGCG
CCCGACACATCCCCACGCGGCGAAGATGTGCCCGACGATCCCGACGGGGCCTGGGATTTCGGGCTGGGCGCGGGCTTTTA
TGTCGATGCGACCGTCGAGCCGTGGGCGAAGCATTACCGGATGCGGTCCTATATCGAGGACGAATTGCCTTCGCTGGTGC
TGCGCAATTTCGCGAGCGCCGACCTGACGCGACAGGCGATCACGGGGCATTCGATGGGCGGGCATGGCGCTTTGACCATT
GGCCTCCGCAATCCGGATCGCTTCCGCTCGGTGTCGGCTTTTTCGCCGATCGTTGCGCCGATCCGCTGCCCGTGGGGCGA
AAAGGCGTTCGGTCACTATCTCGGCGACGACCGCGAGGCGTGGCGCGCCTATGACGCCTGCGCATTGCTCGACGACGGGC
TTCGCCTGCCCGACCTGCTCGTCGATCAGGGCGATGCGGACACTTTCCTGGCTGAACAGCTCAGGACCGACCTGCTCGTC
GAAGCCTGCGAGCGGAACGGGCAGAAGGCCGCGATCCGGATGCAGCCGGGATATGACCACAGCTATTTTTTCATCTCGAC
CTTCATGGCCGAGCATGTCGCGTGGCACGCCGAGCGGTTGAAGGCGTAG

Upstream 100 bases:

>100_bases
ACACGGGCACGCTGGGGCTTTCGGGCGGATCGATCCTCGACCTGCTGCGTCATTGGGGGCATGATCCGGTGATCGCCCCC
ATTCCCGTTCAGGAAAGCGC

Downstream 100 bases:

>100_bases
CCGTCGCCCCCGCGAAGGCGGGGGCCGCTGTCGGCATTGATCTTCCTCGCTGCGTAAACCTCCGGCGGCCCCCGCCTTCG
CGGGGGTCACGGTTTGTCAG

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTLETLSTIRSHGGTQGVYSHASTTTGTDMTFALFVPDHAPGTKLPVLWYLSGLTCTHANVMEKGEYRAACAEHGVIFVA
PDTSPRGEDVPDDPDGAWDFGLGAGFYVDATVEPWAKHYRMRSYIEDELPSLVLRNFASADLTRQAITGHSMGGHGALTI
GLRNPDRFRSVSAFSPIVAPIRCPWGEKAFGHYLGDDREAWRAYDACALLDDGLRLPDLLVDQGDADTFLAEQLRTDLLV
EACERNGQKAAIRMQPGYDHSYFFISTFMAEHVAWHAERLKA

Sequences:

>Translated_282_residues
MTLETLSTIRSHGGTQGVYSHASTTTGTDMTFALFVPDHAPGTKLPVLWYLSGLTCTHANVMEKGEYRAACAEHGVIFVA
PDTSPRGEDVPDDPDGAWDFGLGAGFYVDATVEPWAKHYRMRSYIEDELPSLVLRNFASADLTRQAITGHSMGGHGALTI
GLRNPDRFRSVSAFSPIVAPIRCPWGEKAFGHYLGDDREAWRAYDACALLDDGLRLPDLLVDQGDADTFLAEQLRTDLLV
EACERNGQKAAIRMQPGYDHSYFFISTFMAEHVAWHAERLKA
>Mature_281_residues
TLETLSTIRSHGGTQGVYSHASTTTGTDMTFALFVPDHAPGTKLPVLWYLSGLTCTHANVMEKGEYRAACAEHGVIFVAP
DTSPRGEDVPDDPDGAWDFGLGAGFYVDATVEPWAKHYRMRSYIEDELPSLVLRNFASADLTRQAITGHSMGGHGALTIG
LRNPDRFRSVSAFSPIVAPIRCPWGEKAFGHYLGDDREAWRAYDACALLDDGLRLPDLLVDQGDADTFLAEQLRTDLLVE
ACERNGQKAAIRMQPGYDHSYFFISTFMAEHVAWHAERLKA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=285, Percent_Identity=48.4210526315789, Blast_Score=284, Evalue=8e-77,
Organism=Escherichia coli, GI1786551, Length=279, Percent_Identity=47.3118279569892, Blast_Score=281, Evalue=3e-77,
Organism=Escherichia coli, GI1788477, Length=280, Percent_Identity=48.9285714285714, Blast_Score=262, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=52.4647887323944, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322393, Length=286, Percent_Identity=42.6573426573427, Blast_Score=235, Evalue=5e-63,
Organism=Drosophila melanogaster, GI45551932, Length=286, Percent_Identity=49.3006993006993, Blast_Score=263, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24648347, Length=286, Percent_Identity=49.6503496503497, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31083; Mature: 30952

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLETLSTIRSHGGTQGVYSHASTTTGTDMTFALFVPDHAPGTKLPVLWYLSGLTCTHAN
CCHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEECHHH
VMEKGEYRAACAEHGVIFVAPDTSPRGEDVPDDPDGAWDFGLGAGFYVDATVEPWAKHYR
HHHCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCHHHHHHH
MRSYIEDELPSLVLRNFASADLTRQAITGHSMGGHGALTIGLRNPDRFRSVSAFSPIVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCE
IRCPWGEKAFGHYLGDDREAWRAYDACALLDDGLRLPDLLVDQGDADTFLAEQLRTDLLV
EECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
EACERNGQKAAIRMQPGYDHSYFFISTFMAEHVAWHAERLKA
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLETLSTIRSHGGTQGVYSHASTTTGTDMTFALFVPDHAPGTKLPVLWYLSGLTCTHAN
CHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEECHHH
VMEKGEYRAACAEHGVIFVAPDTSPRGEDVPDDPDGAWDFGLGAGFYVDATVEPWAKHYR
HHHCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCHHHHHHH
MRSYIEDELPSLVLRNFASADLTRQAITGHSMGGHGALTIGLRNPDRFRSVSAFSPIVAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCE
IRCPWGEKAFGHYLGDDREAWRAYDACALLDDGLRLPDLLVDQGDADTFLAEQLRTDLLV
EECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
EACERNGQKAAIRMQPGYDHSYFFISTFMAEHVAWHAERLKA
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]