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The map label for this gene is kefBC [H]

Identifier: 103487287

GI number: 103487287

Start: 1898481

End: 1900379

Strand: Reverse

Name: kefBC [H]

Synonym: Sala_1803

Alternate gene names: 103487287

Gene position: 1900379-1898481 (Counterclockwise)

Preceding gene: 103487288

Following gene: 103487286

Centisome position: 56.81

GC content: 66.46

Gene sequence:

>1899_bases
ATGATCCTGCCCGCGCTTGCGGCCGCAACCGCCCGGGTGGCGGAAAAAGCGGTCGAAACCGCTACCGATACCGCGCTGCT
CGAAGGCGCGATCCTGCTCGGTGTCGCAACGCTCTTCGTGCTGATTTTCCGCCGGCTCGGTTTGGGCGCGGTGCTCGGCT
ATCTCATCGCCGGCGCGATCGTCGGGCCGCACGGGCTGGCGCTGGTCGGCGGCGGCGAATCGAAGCTCGCGATTGCCGAA
CTTGGCATTGCCTTCCTGCTGTTCCTCGTCGGACTGGAGCTTCATCCGCGGCGGCTGTGGCAGCTGCGCCGCGCGATCTT
CGGGCTTGGCATGACGCAGGTGATCGTCACCGGGCTGATCCTCACAGCTCTTATCTACGTAGTGCTGGGGTTCAGTCCCG
CTGCCGCGATCGCGCTCGGCCTGCCGCTGGCACTTTCGTCGACCGCGCAGGTGCTGCCCGGCCTCAAAAGCTCGGGGCGC
ATCAACTCGCCGTTCGGAGAGAAGGCCTTTTCGATCCTGCTGTTTCAGGATCTGGCGATCGTACCGATGATTACGATCGT
CGCCGCGCTATCGCGCGCCCCCGCTGACCCGTCGGCGCCACCCGGCTGGATGCTCGCGCTCTATACGGTGGGTGCGATCG
TCGGGCTGGTGCTCGCGGGGCGGTTCATCCTCAACCCGCTGCTCCGGCTTATCGGCCGCTATGGCGAACGCGAGCTGTTC
GTCGTCGTCGGCCTGCTCGCGGTGCTCGCGAGCGCGGCGCTGATGCACAGCCTGCATCTGTCGACCGCGCTCGGGGCGTT
CATCGCGGGCGTGATGCTCGCCGATTCGCCCTATCGGCACGAAATCGAAGCCGATGTCGAACCCTTCCGCCTGATCCTGC
TCGGCCTCTTCTTCCTCGCAGTGGGAATGGTGCTCGACATCAATGTCGTGCTCGCCGACCCGCTGCGCGTTGTCGGGCTC
GCGGCGGCGCTGGTCGCGGTCAAGCTCGCCGTCCTGACAGCGATTGTCCGTGCATTCGGCAAATCGTGGAAGACAGCGCT
CGGTCTCGGCCTTCTGCTCAGCCAGGGCGGCGAGTTCGGTTTCCTGCTGTTCACGCAAGCTCAGCAGGCGCTGCTCATCG
CGCCCGAGGCGGCGAGCCTGTTCAGCGCGGTGGTGACGCTGTCGATGATCACGACGCCGTTCCTGATGCTGTTCGCGCGA
AACCTGGAGTTCGCACCCGACCGCGATGGCCCCGTCATGGACGGCCCTGAACATGCGCCGCGCGGGTCGGCGCTGGTGAT
CGGTCATGGCCGCTTCGGACAGACGGTGGCGCAGATGCTGCACGCAGTCGATTGTTCGGTCACCTTGATTGACAAGAAAC
CGAGCCAGATCGAACGGTCGGGGCGCTACGATAACAAAGTCTATTATGGTGATGGGCTGCGGATCGACCTGCTGCGGCGC
GCAGGCGCCGACGACGCAAAGCTCATCATCTATTGCATCGACGACGCCGCATTCGACGCAGCGACGATGCGCCCGATCGT
CGAGGCGTTTCCGCATGCGCGTGTGCTGGCGCGTGTGTTCGACCGCCGCCAGCTGATCGCGATCGACGGGGCGGGCGTGT
CGGCGGCGGTGCGCGAAGTGTTCGAAAGCTCGGTCGCGCTCGGCCGCAAGGCGCTCGAGGAACTCGACGTCGATCCGCGC
GAGATCGAGGATGTCGAGGCCGCCTTCCGCCAGCTCGACGCAACGCGGCTGGCGGCGCAGATCGATGAAGGCGACATCGG
CGCAGGCATGGACCATCGCTTCAGGCCCGGCGGCGGGCGCGAGGCCGACAGCGTGATCGAAACCTTCCGTCAACGCCGCC
GCGCGGCGAAGGCGGCGCGCGAAGAGAGCGATGCGAGCGGCGTGACAGTCGACACCTGA

Upstream 100 bases:

>100_bases
ACCTCCTCGCCCCCGCGCGTGACTATCCGGCGCGGCACGGGGCAATCCTGCTGCCCTTCGATGCGGCCATAGCGGCGCTC
GAGGCGCGGGCGGCGGCGGC

Downstream 100 bases:

>100_bases
TCGCTCCCGTGCGCGCTTCCTGATTGCAATCAAGGTCGGCGACGCCTCGCCGCGCGCAGCGGCGACGGCCCGCCTTCCGG
ATAATAGTCAATTACTCACT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MILPALAAATARVAEKAVETATDTALLEGAILLGVATLFVLIFRRLGLGAVLGYLIAGAIVGPHGLALVGGGESKLAIAE
LGIAFLLFLVGLELHPRRLWQLRRAIFGLGMTQVIVTGLILTALIYVVLGFSPAAAIALGLPLALSSTAQVLPGLKSSGR
INSPFGEKAFSILLFQDLAIVPMITIVAALSRAPADPSAPPGWMLALYTVGAIVGLVLAGRFILNPLLRLIGRYGERELF
VVVGLLAVLASAALMHSLHLSTALGAFIAGVMLADSPYRHEIEADVEPFRLILLGLFFLAVGMVLDINVVLADPLRVVGL
AAALVAVKLAVLTAIVRAFGKSWKTALGLGLLLSQGGEFGFLLFTQAQQALLIAPEAASLFSAVVTLSMITTPFLMLFAR
NLEFAPDRDGPVMDGPEHAPRGSALVIGHGRFGQTVAQMLHAVDCSVTLIDKKPSQIERSGRYDNKVYYGDGLRIDLLRR
AGADDAKLIIYCIDDAAFDAATMRPIVEAFPHARVLARVFDRRQLIAIDGAGVSAAVREVFESSVALGRKALEELDVDPR
EIEDVEAAFRQLDATRLAAQIDEGDIGAGMDHRFRPGGGREADSVIETFRQRRRAAKAAREESDASGVTVDT

Sequences:

>Translated_632_residues
MILPALAAATARVAEKAVETATDTALLEGAILLGVATLFVLIFRRLGLGAVLGYLIAGAIVGPHGLALVGGGESKLAIAE
LGIAFLLFLVGLELHPRRLWQLRRAIFGLGMTQVIVTGLILTALIYVVLGFSPAAAIALGLPLALSSTAQVLPGLKSSGR
INSPFGEKAFSILLFQDLAIVPMITIVAALSRAPADPSAPPGWMLALYTVGAIVGLVLAGRFILNPLLRLIGRYGERELF
VVVGLLAVLASAALMHSLHLSTALGAFIAGVMLADSPYRHEIEADVEPFRLILLGLFFLAVGMVLDINVVLADPLRVVGL
AAALVAVKLAVLTAIVRAFGKSWKTALGLGLLLSQGGEFGFLLFTQAQQALLIAPEAASLFSAVVTLSMITTPFLMLFAR
NLEFAPDRDGPVMDGPEHAPRGSALVIGHGRFGQTVAQMLHAVDCSVTLIDKKPSQIERSGRYDNKVYYGDGLRIDLLRR
AGADDAKLIIYCIDDAAFDAATMRPIVEAFPHARVLARVFDRRQLIAIDGAGVSAAVREVFESSVALGRKALEELDVDPR
EIEDVEAAFRQLDATRLAAQIDEGDIGAGMDHRFRPGGGREADSVIETFRQRRRAAKAAREESDASGVTVDT
>Mature_632_residues
MILPALAAATARVAEKAVETATDTALLEGAILLGVATLFVLIFRRLGLGAVLGYLIAGAIVGPHGLALVGGGESKLAIAE
LGIAFLLFLVGLELHPRRLWQLRRAIFGLGMTQVIVTGLILTALIYVVLGFSPAAAIALGLPLALSSTAQVLPGLKSSGR
INSPFGEKAFSILLFQDLAIVPMITIVAALSRAPADPSAPPGWMLALYTVGAIVGLVLAGRFILNPLLRLIGRYGERELF
VVVGLLAVLASAALMHSLHLSTALGAFIAGVMLADSPYRHEIEADVEPFRLILLGLFFLAVGMVLDINVVLADPLRVVGL
AAALVAVKLAVLTAIVRAFGKSWKTALGLGLLLSQGGEFGFLLFTQAQQALLIAPEAASLFSAVVTLSMITTPFLMLFAR
NLEFAPDRDGPVMDGPEHAPRGSALVIGHGRFGQTVAQMLHAVDCSVTLIDKKPSQIERSGRYDNKVYYGDGLRIDLLRR
AGADDAKLIIYCIDDAAFDAATMRPIVEAFPHARVLARVFDRRQLIAIDGAGVSAAVREVFESSVALGRKALEELDVDPR
EIEDVEAAFRQLDATRLAAQIDEGDIGAGMDHRFRPGGGREADSVIETFRQRRRAAKAAREESDASGVTVDT

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=382, Percent_Identity=26.9633507853403, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1786232, Length=549, Percent_Identity=40.0728597449909, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789749, Length=551, Percent_Identity=39.9274047186933, Blast_Score=344, Evalue=9e-96,
Organism=Escherichia coli, GI1786685, Length=543, Percent_Identity=27.4401473296501, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67016; Mature: 67016

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPALAAATARVAEKAVETATDTALLEGAILLGVATLFVLIFRRLGLGAVLGYLIAGAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGPHGLALVGGGESKLAIAELGIAFLLFLVGLELHPRRLWQLRRAIFGLGMTQVIVTGLI
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LTALIYVVLGFSPAAAIALGLPLALSSTAQVLPGLKSSGRINSPFGEKAFSILLFQDLAI
HHHHHHHHHCCCHHHHHHHHCCHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VPMITIVAALSRAPADPSAPPGWMLALYTVGAIVGLVLAGRFILNPLLRLIGRYGERELF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VVVGLLAVLASAALMHSLHLSTALGAFIAGVMLADSPYRHEIEADVEPFRLILLGLFFLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VGMVLDINVVLADPLRVVGLAAALVAVKLAVLTAIVRAFGKSWKTALGLGLLLSQGGEFG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FLLFTQAQQALLIAPEAASLFSAVVTLSMITTPFLMLFARNLEFAPDRDGPVMDGPEHAP
EEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
RGSALVIGHGRFGQTVAQMLHAVDCSVTLIDKKPSQIERSGRYDNKVYYGDGLRIDLLRR
CCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCCEEEECCCCEEHHHHH
AGADDAKLIIYCIDDAAFDAATMRPIVEAFPHARVLARVFDRRQLIAIDGAGVSAAVREV
CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
FESSVALGRKALEELDVDPREIEDVEAAFRQLDATRLAAQIDEGDIGAGMDHRFRPGGGR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
EADSVIETFRQRRRAAKAAREESDASGVTVDT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MILPALAAATARVAEKAVETATDTALLEGAILLGVATLFVLIFRRLGLGAVLGYLIAGAI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGPHGLALVGGGESKLAIAELGIAFLLFLVGLELHPRRLWQLRRAIFGLGMTQVIVTGLI
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LTALIYVVLGFSPAAAIALGLPLALSSTAQVLPGLKSSGRINSPFGEKAFSILLFQDLAI
HHHHHHHHHCCCHHHHHHHHCCHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VPMITIVAALSRAPADPSAPPGWMLALYTVGAIVGLVLAGRFILNPLLRLIGRYGERELF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VVVGLLAVLASAALMHSLHLSTALGAFIAGVMLADSPYRHEIEADVEPFRLILLGLFFLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VGMVLDINVVLADPLRVVGLAAALVAVKLAVLTAIVRAFGKSWKTALGLGLLLSQGGEFG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FLLFTQAQQALLIAPEAASLFSAVVTLSMITTPFLMLFARNLEFAPDRDGPVMDGPEHAP
EEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
RGSALVIGHGRFGQTVAQMLHAVDCSVTLIDKKPSQIERSGRYDNKVYYGDGLRIDLLRR
CCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCCEEEECCCCEEHHHHH
AGADDAKLIIYCIDDAAFDAATMRPIVEAFPHARVLARVFDRRQLIAIDGAGVSAAVREV
CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
FESSVALGRKALEELDVDPREIEDVEAAFRQLDATRLAAQIDEGDIGAGMDHRFRPGGGR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
EADSVIETFRQRRRAAKAAREESDASGVTVDT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]