Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 103487244

GI number: 103487244

Start: 1854284

End: 1854706

Strand: Reverse

Name: ndk [H]

Synonym: Sala_1759

Alternate gene names: 103487244

Gene position: 1854706-1854284 (Counterclockwise)

Preceding gene: 103487245

Following gene: 103487241

Centisome position: 55.44

GC content: 62.41

Gene sequence:

>423_bases
ATGGCGGTCACCCGCACCTTTTCGATCATCAAGCCCGACGCGACGCGCCGCAACCTGACCGGCGCCGTCACCAAGATGCT
GGAAGACGCGGGCCTCCGCGTCGTCGCGTCGAAGCGCATCCACATGACCCGCGAGCAGGCTGAAGGATTTTACGCGGTCC
ACAAGGAACGCCCTTTCTTCGGCGAACTCGTCGAGTTCATGATTTCGGGCCCGGTCGTCGTGCAGGTGCTCGAGGGTGAA
GACGCCGTGAAGCGCAACCGCGACGTGATGGGCGCGACCAACCCCGCCGACGCCGCCGAAGGCACGATCCGCAAGACTTT
CGCCGAAAGCATTGAGGCCAATTCGGTCCACGGGTCGGATAGCGACGAAAATGCCGCGACCGAAATCGCCTATTTCTTCA
AGCCCGAAGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
CCGAAGGGCCATAGGCCGTCCACGCTCTTTCCTTGCGGTCCCGTAAAAGCGCGGCTAGAGGCGCGCGCATCGCAAACCAT
AACATCGCAGGAGCTTTCCC

Downstream 100 bases:

>100_bases
CCCAGACGGCCGAACCGGAACGAAAAGGCCGCCGGAGCGATCCGGCGGCCTTTTTCATCAGAAATCCTCCGCCGCCGCCA
TCAGCCCCGCCAGCTTTTTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAVTRTFSIIKPDATRRNLTGAVTKMLEDAGLRVVASKRIHMTREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGE
DAVKRNRDVMGATNPADAAEGTIRKTFAESIEANSVHGSDSDENAATEIAYFFKPEEIVG

Sequences:

>Translated_140_residues
MAVTRTFSIIKPDATRRNLTGAVTKMLEDAGLRVVASKRIHMTREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGE
DAVKRNRDVMGATNPADAAEGTIRKTFAESIEANSVHGSDSDENAATEIAYFFKPEEIVG
>Mature_139_residues
AVTRTFSIIKPDATRRNLTGAVTKMLEDAGLRVVASKRIHMTREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGED
AVKRNRDVMGATNPADAAEGTIRKTFAESIEANSVHGSDSDENAATEIAYFFKPEEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.1851851851852, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=46.7153284671533, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=46.7153284671533, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=46.7153284671533, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=46.7153284671533, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=46.7153284671533, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=45.9259259259259, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=45.9259259259259, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.7777777777778, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=32.3308270676692, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.0294117647059, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.8467153284672, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=56.8345323741007, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=44.7761194029851, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.2222222222222, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=45.1851851851852, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15362; Mature: 15230

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTRTFSIIKPDATRRNLTGAVTKMLEDAGLRVVASKRIHMTREQAEGFYAVHKERPFF
CCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEECCCCCH
GELVEFMISGPVVVQVLEGEDAVKRNRDVMGATNPADAAEGTIRKTFAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SDENAATEIAYFFKPEEIVG
CCCCHHHHHHEEECCHHHCC
>Mature Secondary Structure 
AVTRTFSIIKPDATRRNLTGAVTKMLEDAGLRVVASKRIHMTREQAEGFYAVHKERPFF
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEECCCCCH
GELVEFMISGPVVVQVLEGEDAVKRNRDVMGATNPADAAEGTIRKTFAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SDENAATEIAYFFKPEEIVG
CCCCHHHHHHEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA