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The map label for this gene is yhdG [H]

Identifier: 103487189

GI number: 103487189

Start: 1793509

End: 1794906

Strand: Reverse

Name: yhdG [H]

Synonym: Sala_1704

Alternate gene names: 103487189

Gene position: 1794906-1793509 (Counterclockwise)

Preceding gene: 103487191

Following gene: 103487188

Centisome position: 53.66

GC content: 67.17

Gene sequence:

>1398_bases
ATGTCCGACAGCCTGTTGCGCCGCAAATCGATCGTCCCGGACCAGCCGGACGGGCGGGGATTGGCGCGCACATTGGGTTG
GCCGCACCTCGTTGCGCTGGGCGTCGGCGCGATCGTCGGCACGGGGATTTTGACGCTGATCGGCGTCGGCGCCGACAAAG
CGGGGCCGGCGGTGATCCTCTCCTTTGCCATCGCGGGGCTGATCTGCGCCTGCGCCGCGCTCGCCTATGCCGAAATGGCG
ACGATGATCCCGGCCTCGGGCAGCGCCTATACCTATAGCTATGTCGTGATCGGCGAAATCATCGCCTGGGTCGTCGGGTG
GAGCCTGATCCTGGAGTATTCATTGGTGGTCAGCGCGGTCGCGGTCGGCTGGTCGGGCTATGCCGCGCCGCTGCTGGAGG
CGTGGGCGGGGTTTCCGATGGCGCTGATGCAGGGACCGGAACTGGGCGGGATCGTCAATCTGCCGGCGATCGCGATCATC
GCCGCGGTCGCCGGGATGCTGCTCGTCGGCACGCGCGAAAGCGCCACGGTCAATGCCATCCTCGTGCTGGTGAAGATCGC
CGCGCTTGCGGTGTTCGTGGCGGTCGCGCTGCCTGCGTTCGACGCGGCGAACCTCGAACCCTTCAGCCCCTATGGCTTTG
CGAAGCATATGGGCCCCGACGGCGTCGAGCGCGGGGTGATGGCCGCCGCGGCGATCATCTTCTTCGCCTTTTACGGGTTC
GACGCGATCGCGACCGCGGCCGAGGAAGCGAAAAACCCCGACCGCGACCTCAAGATCGGCATCGTCGGGTCGATGCTCGC
CTGTGTCGCCATCTATATCGCCGTCGCGGTCGCCGCGGTCGGCGCGATCGCCTACACGCGCTTCGCCAACAGCCCCGAAC
CGCTCGCGCTGATCCTGCGCGAACTGGGCAGCCCGCTCGCGGCGCAATATCTTGCCGTCTCGGCGGTCGTCGCGCTGCCG
ACCGTGATCCTCGCCTTCTTCTATGGGCAGAGCCGCATCTTCTTCACCATGGCGCGCGACGGGCTGCTCCCCGCGAGCCT
GGCCAGGTTGTCGGCGCGCGGAACGCCGGTGCGCATCACCATCTTTACCGCGATCGTCGTTGCGATCCTCGCGGGTTTCA
TCCCCCTGGGCGAGCTGGCCGCGCTCGCCAATGCGGGAACGCTCGCCGCCTTTACCGCCGTGTCGATCTGTATGCTCATC
ATGCGCCGCCGCGCGCCGCAAGCGCCGCGCACCTTCCGCGCGCCGCTGCCGTGGCTGGTCGGAGGCATCGCGGTGTTCGG
CTGCATCTATCTTTTCTTCAGCCTGCCCGTGCAGACGCAGATCTGGTTCGGCATATGGAATATGGCGGGCCTTGCCGCCT
ATTTCCTCTATGCGCGCCGCCATGCGGTTGCCGACTGA

Upstream 100 bases:

>100_bases
GCTAGGTCGCCGCAGCCCATGCCCGGCTTGCGTTGCCGCCCGCCGTGCTTACAAGCGGCGCAGGGCGAAAAGCCATAATC
GATCAAAGGGGAGCCACTTT

Downstream 100 bases:

>100_bases
CGGGCGGTCGGCGGTGATGGCGACGCGCCGGGTCGACCGATGATCCGTTTCGACCGCTCGCAGCAGTGGCTCGCCGCCGC
GATATCGGCGCTCGCCGGTT

Product: amino acid permease-associated region

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSDSLLRRKSIVPDQPDGRGLARTLGWPHLVALGVGAIVGTGILTLIGVGADKAGPAVILSFAIAGLICACAALAYAEMA
TMIPASGSAYTYSYVVIGEIIAWVVGWSLILEYSLVVSAVAVGWSGYAAPLLEAWAGFPMALMQGPELGGIVNLPAIAII
AAVAGMLLVGTRESATVNAILVLVKIAALAVFVAVALPAFDAANLEPFSPYGFAKHMGPDGVERGVMAAAAIIFFAFYGF
DAIATAAEEAKNPDRDLKIGIVGSMLACVAIYIAVAVAAVGAIAYTRFANSPEPLALILRELGSPLAAQYLAVSAVVALP
TVILAFFYGQSRIFFTMARDGLLPASLARLSARGTPVRITIFTAIVVAILAGFIPLGELAALANAGTLAAFTAVSICMLI
MRRRAPQAPRTFRAPLPWLVGGIAVFGCIYLFFSLPVQTQIWFGIWNMAGLAAYFLYARRHAVAD

Sequences:

>Translated_465_residues
MSDSLLRRKSIVPDQPDGRGLARTLGWPHLVALGVGAIVGTGILTLIGVGADKAGPAVILSFAIAGLICACAALAYAEMA
TMIPASGSAYTYSYVVIGEIIAWVVGWSLILEYSLVVSAVAVGWSGYAAPLLEAWAGFPMALMQGPELGGIVNLPAIAII
AAVAGMLLVGTRESATVNAILVLVKIAALAVFVAVALPAFDAANLEPFSPYGFAKHMGPDGVERGVMAAAAIIFFAFYGF
DAIATAAEEAKNPDRDLKIGIVGSMLACVAIYIAVAVAAVGAIAYTRFANSPEPLALILRELGSPLAAQYLAVSAVVALP
TVILAFFYGQSRIFFTMARDGLLPASLARLSARGTPVRITIFTAIVVAILAGFIPLGELAALANAGTLAAFTAVSICMLI
MRRRAPQAPRTFRAPLPWLVGGIAVFGCIYLFFSLPVQTQIWFGIWNMAGLAAYFLYARRHAVAD
>Mature_464_residues
SDSLLRRKSIVPDQPDGRGLARTLGWPHLVALGVGAIVGTGILTLIGVGADKAGPAVILSFAIAGLICACAALAYAEMAT
MIPASGSAYTYSYVVIGEIIAWVVGWSLILEYSLVVSAVAVGWSGYAAPLLEAWAGFPMALMQGPELGGIVNLPAIAIIA
AVAGMLLVGTRESATVNAILVLVKIAALAVFVAVALPAFDAANLEPFSPYGFAKHMGPDGVERGVMAAAAIIFFAFYGFD
AIATAAEEAKNPDRDLKIGIVGSMLACVAIYIAVAVAAVGAIAYTRFANSPEPLALILRELGSPLAAQYLAVSAVVALPT
VILAFFYGQSRIFFTMARDGLLPASLARLSARGTPVRITIFTAIVVAILAGFIPLGELAALANAGTLAAFTAVSICMLIM
RRRAPQAPRTFRAPLPWLVGGIAVFGCIYLFFSLPVQTQIWFGIWNMAGLAAYFLYARRHAVAD

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=433, Percent_Identity=35.5658198614319, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI258614003, Length=434, Percent_Identity=34.331797235023, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI258614005, Length=434, Percent_Identity=34.331797235023, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI4507047, Length=442, Percent_Identity=34.3891402714932, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI114326544, Length=442, Percent_Identity=34.1628959276018, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI114326550, Length=442, Percent_Identity=34.1628959276018, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI181337167, Length=396, Percent_Identity=33.0808080808081, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI110347453, Length=407, Percent_Identity=32.6781326781327, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI187423910, Length=486, Percent_Identity=24.4855967078189, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI7657591, Length=486, Percent_Identity=24.4855967078189, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI115648063, Length=468, Percent_Identity=23.9316239316239, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=468, Percent_Identity=23.9316239316239, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI33286428, Length=435, Percent_Identity=25.5172413793103, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI7657683, Length=413, Percent_Identity=23.0024213075061, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786302, Length=417, Percent_Identity=24.7002398081535, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081708, Length=478, Percent_Identity=23.2217573221757, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786789, Length=400, Percent_Identity=24.5, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081915, Length=415, Percent_Identity=22.6506024096386, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789017, Length=435, Percent_Identity=23.6781609195402, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081869, Length=418, Percent_Identity=24.1626794258373, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=22.1709006928406, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790653, Length=445, Percent_Identity=20.8988764044944, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082250, Length=463, Percent_Identity=24.622030237581, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788480, Length=366, Percent_Identity=23.4972677595628, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994972, Length=348, Percent_Identity=22.1264367816092, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=425, Percent_Identity=32, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17533459, Length=414, Percent_Identity=31.6425120772947, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531343, Length=411, Percent_Identity=28.9537712895377, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17540018, Length=431, Percent_Identity=25.0580046403712, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=366, Percent_Identity=25.4098360655738, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568033, Length=421, Percent_Identity=24.7030878859857, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17537453, Length=399, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321053, Length=373, Percent_Identity=25.7372654155496, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24668806, Length=436, Percent_Identity=35.0917431192661, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21356285, Length=436, Percent_Identity=35.0917431192661, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24668802, Length=436, Percent_Identity=35.0917431192661, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24667468, Length=421, Percent_Identity=33.0166270783848, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI221512776, Length=412, Percent_Identity=33.0097087378641, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24666159, Length=412, Percent_Identity=33.0097087378641, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI281366235, Length=411, Percent_Identity=34.3065693430657, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI116007820, Length=411, Percent_Identity=34.3065693430657, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI116007818, Length=411, Percent_Identity=34.0632603406326, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI85725152, Length=411, Percent_Identity=34.0632603406326, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI161077963, Length=416, Percent_Identity=31.4903846153846, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221331183, Length=500, Percent_Identity=26.2, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17647653, Length=500, Percent_Identity=26.2, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664379, Length=500, Percent_Identity=26.2, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550968, Length=429, Percent_Identity=24.7086247086247, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921172, Length=429, Percent_Identity=24.7086247086247, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357367, Length=357, Percent_Identity=25.7703081232493, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48438; Mature: 48307

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLLRRKSIVPDQPDGRGLARTLGWPHLVALGVGAIVGTGILTLIGVGADKAGPAVIL
CCCHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SFAIAGLICACAALAYAEMATMIPASGSAYTYSYVVIGEIIAWVVGWSLILEYSLVVSAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGWSGYAAPLLEAWAGFPMALMQGPELGGIVNLPAIAIIAAVAGMLLVGTRESATVNAI
HHCCCCHHHHHHHHHCCCCHHHHCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVLVKIAALAVFVAVALPAFDAANLEPFSPYGFAKHMGPDGVERGVMAAAAIIFFAFYGF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
DAIATAAEEAKNPDRDLKIGIVGSMLACVAIYIAVAVAAVGAIAYTRFANSPEPLALILR
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELGSPLAAQYLAVSAVVALPTVILAFFYGQSRIFFTMARDGLLPASLARLSARGTPVRIT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEH
IFTAIVVAILAGFIPLGELAALANAGTLAAFTAVSICMLIMRRRAPQAPRTFRAPLPWLV
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GGIAVFGCIYLFFSLPVQTQIWFGIWNMAGLAAYFLYARRHAVAD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDSLLRRKSIVPDQPDGRGLARTLGWPHLVALGVGAIVGTGILTLIGVGADKAGPAVIL
CCHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SFAIAGLICACAALAYAEMATMIPASGSAYTYSYVVIGEIIAWVVGWSLILEYSLVVSAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGWSGYAAPLLEAWAGFPMALMQGPELGGIVNLPAIAIIAAVAGMLLVGTRESATVNAI
HHCCCCHHHHHHHHHCCCCHHHHCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVLVKIAALAVFVAVALPAFDAANLEPFSPYGFAKHMGPDGVERGVMAAAAIIFFAFYGF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
DAIATAAEEAKNPDRDLKIGIVGSMLACVAIYIAVAVAAVGAIAYTRFANSPEPLALILR
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELGSPLAAQYLAVSAVVALPTVILAFFYGQSRIFFTMARDGLLPASLARLSARGTPVRIT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEH
IFTAIVVAILAGFIPLGELAALANAGTLAAFTAVSICMLIMRRRAPQAPRTFRAPLPWLV
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GGIAVFGCIYLFFSLPVQTQIWFGIWNMAGLAAYFLYARRHAVAD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]