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The map label for this gene is merR [H]

Identifier: 103487108

GI number: 103487108

Start: 1702552

End: 1702953

Strand: Reverse

Name: merR [H]

Synonym: Sala_1623

Alternate gene names: 103487108

Gene position: 1702953-1702552 (Counterclockwise)

Preceding gene: 103487111

Following gene: 103487105

Centisome position: 50.91

GC content: 70.15

Gene sequence:

>402_bases
ATGCAGATGACGATCGGCAAACTGGCCGCCGCGGGCGATGTCGGGGTAGAGACGATACGCTATTATCAGCGCCGCGGCCT
GATGGGCACGCCCGCGCGCAGCGGCGGCGACGGCTGGGGCGGCGGCGTGCGCCGCTATGGCGATGATGATCTCAGACGGC
TTAGATTTATCCGCGCGGCGCAGGCAGCGGGCTTCACGCTCGACGAGATCGGCGAATTGCTCGCGCTCGACCAGAGCGAC
GACCGCGCCCGTGTCCGCGCCCTCGCGCGCCAGCGCATCGACGCGCTCGACGCCAAGATCGCCCAGATGACCGCAACGCG
CGCCGCTCTCGCGCGCCTCGCCGATCAATGCGCCGCGAGCGAGACGGGGCCGTGCCCGATTATGGCGGCGTTCGAGCCCT
GA

Upstream 100 bases:

>100_bases
CCATAGGGGCAGATGTGCCCCGGCATGACCATGCGATGAAGGATTGCCTGTTTTGTCATGCCCCTCCTATAGCATCCGTA
CCATGGTACGGAGTCAAGCG

Downstream 100 bases:

>100_bases
AGCATCCGTCATTGCCAGGAGCAGAGCGACGAAGCAATCTCCAGCTATCAGCCTATTCTCCGGTTAGTTCAGGAAACAGG
TCCCGCCACTCTGGATTGCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MQMTIGKLAAAGDVGVETIRYYQRRGLMGTPARSGGDGWGGGVRRYGDDDLRRLRFIRAAQAAGFTLDEIGELLALDQSD
DRARVRALARQRIDALDAKIAQMTATRAALARLADQCAASETGPCPIMAAFEP

Sequences:

>Translated_133_residues
MQMTIGKLAAAGDVGVETIRYYQRRGLMGTPARSGGDGWGGGVRRYGDDDLRRLRFIRAAQAAGFTLDEIGELLALDQSD
DRARVRALARQRIDALDAKIAQMTATRAALARLADQCAASETGPCPIMAAFEP
>Mature_133_residues
MQMTIGKLAAAGDVGVETIRYYQRRGLMGTPARSGGDGWGGGVRRYGDDDLRRLRFIRAAQAAGFTLDEIGELLALDQSD
DRARVRALARQRIDALDAKIAQMTATRAALARLADQCAASETGPCPIMAAFEP

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=133, Percent_Identity=33.8345864661654, Blast_Score=82, Evalue=9e-18,
Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=29.6875, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14298; Mature: 14298

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMTIGKLAAAGDVGVETIRYYQRRGLMGTPARSGGDGWGGGVRRYGDDDLRRLRFIRAA
CCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QAAGFTLDEIGELLALDQSDDRARVRALARQRIDALDAKIAQMTATRAALARLADQCAAS
HHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETGPCPIMAAFEP
CCCCCCEEECCCC
>Mature Secondary Structure
MQMTIGKLAAAGDVGVETIRYYQRRGLMGTPARSGGDGWGGGVRRYGDDDLRRLRFIRAA
CCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QAAGFTLDEIGELLALDQSDDRARVRALARQRIDALDAKIAQMTATRAALARLADQCAAS
HHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETGPCPIMAAFEP
CCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]