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The map label for this gene is mutL

Identifier: 103487111

GI number: 103487111

Start: 1705394

End: 1707205

Strand: Reverse

Name: mutL

Synonym: Sala_1626

Alternate gene names: 103487111

Gene position: 1707205-1705394 (Counterclockwise)

Preceding gene: 103487117

Following gene: 103487108

Centisome position: 51.03

GC content: 70.75

Gene sequence:

>1812_bases
ATGTCAATACGCCGCCTGCCGGAAACGCTCGTAAATCGGATCGCCGCCGGTGAAGTGGTCGAAAGACCCGCCGCGGCGCT
CAAGGAACTGGTCGAAAATGCCATCGACGCGGGGGCGACTCGCATCGCGGTGCGAATCGCCGAAGGCGGCATAGCGCGGC
TGGAGGTCGAGGATGACGGCTGCGGCATGACCGCCGCCGACATGGTACTCGCGCTCGAACGCCATGCGACTTCGAAGCTG
CCCGACGACGCGATCGAGGCGGTGACGACGCTGGGCTTCCGGGGCGAGGCGCTGCCCTCGATCGCCAGCGTCGCGCGGTT
GACGCTCGAAAGCCGGACGGCGGGCGGCGACGGCTGGCGGCGCGTCGTCGACAATGGCGCTGTCGTCGCCGAAGGCCCGG
CGGCGCTTGGCCAGGGCACGCGCGTGATCGTCGAGCATCTGTTCGCGCGCGTCCCCGCGCGGCGCAAGTTCCTGCGCAGC
GCGCGCAGCGAATATGCCGCCTGCCTCGATGTCGTGCGGCGGCTCGCGATGGCGCGCCCCGACGTCGGCTTCACGCTTGA
GCATGACGGCCGCCGCGTGCTCGACGTGCAGGGCGGGCAGGACCGCGTCGGGCGTGTCGCCGCGCTCACCAGTCGCGACC
TTGCCGCGAACAGCATCGGCGTCGACCTCGACCGCGGCGAGGTGCATCTGGGCGGCGTCATCAGCCTGCCGACCTACAAT
CGCGGCATTGCCGACCATCAATATCTGTTCGTCAACGGCCGCCCGGTGAAGGACCGGCTGCTCGTCGGCGCGCTGCGCGG
CGCCTATGCCGACCTGCTCGCGCGCGACCGGCACCCGGTCGTCGCGCTGTTTCTCGACGTGCCGACGGGCGAGGTCGATG
TGAATGTCCATCCCGCAAAGACCGAGGTGCGCTTTCGCGATCCGCAGCTCATTCGCGGGATGATCGTCGGGGGCCTCCGG
CGCGCGCTCGACGAACATGGCTTTCGCAGCGTGCAGAAGCCCGCCGAGGCGGCGCTCGCGGCGTGGCAGCAGGAACCCGT
CGCGCCGCCGCCGGCGACGGGATTCCTCTTCGACCGGCGCGCCGGCGCGGCGGTGCATCCCTTCGCCGCCGAGGTATCGT
TGCCCGCGGCCGACGTTGCGCGCGTCTATGACCGGCTGATGCCCTTCACCGCGCCCGCGCCGCTCGCCGGGCGCGCCGAG
GTCGCGGCGACGCCGCCGCCCGCCGCCGAGGCGCATCCGCTGGGCATCGCGCGCGGCCAGATCGCGAAAACCTATATTGT
CGCCGAGGCCGAGGACGGGCTGGTCATCGTCGACCAGCATGCGGCGCACGAGCGGCTGGTGCTCGAAACGCTGAAGCGCG
GCATGGCGGGGCAGGCGGTCCCGTCGCAGGGCCTGCTGATCCCCGAAGTCGTCGAACTCGACGAACCCGCGTGCGACCGG
CTGGAGGCCGCGGCGGATGGGCTCGCCGCGCTCGGTGTCGAGCTCGAACGCTTCGGCCCCGGTGCGGTAATGGTGCGCGC
GACCCCGGCGATGCTGGGGGCGATTGATTGCCACAGGCTCGTCACCGACATCGCCGACGATCTGGCGGGCTATGACGCCG
CGCTCGGCCTCAACGAACGGCTCGAACTGGTCGCCGCGACGATGGCGTGCCATGGGTCGGTGCGCGCGGGGCGCACATTG
AGCGTCGCGGAGATGAACGCGCTGCTCCGCCAGATGGAGGTCACGCCGCATTCGGGCCAGTGCAACCATGGCCGCCCGAC
TTGGGTAAAGCTGGCGATGGGCGATGTCGAACGGTTGTTCGGCCGAAAATGA

Upstream 100 bases:

>100_bases
GGGGAAGACTCCGGCTCGGCCGAGGGCGGCGGGCTGGACGGGAAGATCGGGCTGTGCGGGTGGGTCGCGATTTGCGTCCG
ACTGCGCTAGGACAGGCCCC

Downstream 100 bases:

>100_bases
GGCCCGCCGGGCGGCTTACGCCATCTTCACGCCCGCAACGCCGCGTTCGACCACGCCCGTCGCGCGTTTCGACAGGCTGT
TCACCGGCGTCGAGACCTTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSIRRLPETLVNRIAAGEVVERPAAALKELVENAIDAGATRIAVRIAEGGIARLEVEDDGCGMTAADMVLALERHATSKL
PDDAIEAVTTLGFRGEALPSIASVARLTLESRTAGGDGWRRVVDNGAVVAEGPAALGQGTRVIVEHLFARVPARRKFLRS
ARSEYAACLDVVRRLAMARPDVGFTLEHDGRRVLDVQGGQDRVGRVAALTSRDLAANSIGVDLDRGEVHLGGVISLPTYN
RGIADHQYLFVNGRPVKDRLLVGALRGAYADLLARDRHPVVALFLDVPTGEVDVNVHPAKTEVRFRDPQLIRGMIVGGLR
RALDEHGFRSVQKPAEAALAAWQQEPVAPPPATGFLFDRRAGAAVHPFAAEVSLPAADVARVYDRLMPFTAPAPLAGRAE
VAATPPPAAEAHPLGIARGQIAKTYIVAEAEDGLVIVDQHAAHERLVLETLKRGMAGQAVPSQGLLIPEVVELDEPACDR
LEAAADGLAALGVELERFGPGAVMVRATPAMLGAIDCHRLVTDIADDLAGYDAALGLNERLELVAATMACHGSVRAGRTL
SVAEMNALLRQMEVTPHSGQCNHGRPTWVKLAMGDVERLFGRK

Sequences:

>Translated_603_residues
MSIRRLPETLVNRIAAGEVVERPAAALKELVENAIDAGATRIAVRIAEGGIARLEVEDDGCGMTAADMVLALERHATSKL
PDDAIEAVTTLGFRGEALPSIASVARLTLESRTAGGDGWRRVVDNGAVVAEGPAALGQGTRVIVEHLFARVPARRKFLRS
ARSEYAACLDVVRRLAMARPDVGFTLEHDGRRVLDVQGGQDRVGRVAALTSRDLAANSIGVDLDRGEVHLGGVISLPTYN
RGIADHQYLFVNGRPVKDRLLVGALRGAYADLLARDRHPVVALFLDVPTGEVDVNVHPAKTEVRFRDPQLIRGMIVGGLR
RALDEHGFRSVQKPAEAALAAWQQEPVAPPPATGFLFDRRAGAAVHPFAAEVSLPAADVARVYDRLMPFTAPAPLAGRAE
VAATPPPAAEAHPLGIARGQIAKTYIVAEAEDGLVIVDQHAAHERLVLETLKRGMAGQAVPSQGLLIPEVVELDEPACDR
LEAAADGLAALGVELERFGPGAVMVRATPAMLGAIDCHRLVTDIADDLAGYDAALGLNERLELVAATMACHGSVRAGRTL
SVAEMNALLRQMEVTPHSGQCNHGRPTWVKLAMGDVERLFGRK
>Mature_602_residues
SIRRLPETLVNRIAAGEVVERPAAALKELVENAIDAGATRIAVRIAEGGIARLEVEDDGCGMTAADMVLALERHATSKLP
DDAIEAVTTLGFRGEALPSIASVARLTLESRTAGGDGWRRVVDNGAVVAEGPAALGQGTRVIVEHLFARVPARRKFLRSA
RSEYAACLDVVRRLAMARPDVGFTLEHDGRRVLDVQGGQDRVGRVAALTSRDLAANSIGVDLDRGEVHLGGVISLPTYNR
GIADHQYLFVNGRPVKDRLLVGALRGAYADLLARDRHPVVALFLDVPTGEVDVNVHPAKTEVRFRDPQLIRGMIVGGLRR
ALDEHGFRSVQKPAEAALAAWQQEPVAPPPATGFLFDRRAGAAVHPFAAEVSLPAADVARVYDRLMPFTAPAPLAGRAEV
AATPPPAAEAHPLGIARGQIAKTYIVAEAEDGLVIVDQHAAHERLVLETLKRGMAGQAVPSQGLLIPEVVELDEPACDRL
EAAADGLAALGVELERFGPGAVMVRATPAMLGAIDCHRLVTDIADDLAGYDAALGLNERLELVAATMACHGSVRAGRTLS
VAEMNALLRQMEVTPHSGQCNHGRPTWVKLAMGDVERLFGRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=38.1410256410256, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=28.3536585365854, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458898, Length=330, Percent_Identity=28.1818181818182, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=27.8481012658228, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=29.4797687861272, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=29.4797687861272, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=33.4862385321101, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128480, Length=303, Percent_Identity=27.3927392739274, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI91992160, Length=346, Percent_Identity=25.1445086705202, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI91992162, Length=346, Percent_Identity=25.1445086705202, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790612, Length=611, Percent_Identity=33.8788870703764, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=36.1635220125786, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=339, Percent_Identity=28.6135693215339, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323819, Length=315, Percent_Identity=36.5079365079365, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=332, Percent_Identity=27.710843373494, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=713, Percent_Identity=21.0378681626928, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=462, Percent_Identity=24.025974025974, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=37.0481927710843, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=26.2857142857143, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SPHAL (Q1GSN3)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616672.1
- ProteinModelPortal:   Q1GSN3
- GeneID:   4081899
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1626
- NMPDR:   fig|317655.9.peg.1559
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   SALA317655:SALA_1626-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64189; Mature: 64058

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRRLPETLVNRIAAGEVVERPAAALKELVENAIDAGATRIAVRIAEGGIARLEVEDDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCC
CGMTAADMVLALERHATSKLPDDAIEAVTTLGFRGEALPSIASVARLTLESRTAGGDGWR
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
RVVDNGAVVAEGPAALGQGTRVIVEHLFARVPARRKFLRSARSEYAACLDVVRRLAMARP
HHHCCCCEEECCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVGFTLEHDGRRVLDVQGGQDRVGRVAALTSRDLAANSIGVDLDRGEVHLGGVISLPTYN
CCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEECCCCC
RGIADHQYLFVNGRPVKDRLLVGALRGAYADLLARDRHPVVALFLDVPTGEVDVNVHPAK
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
TEVRFRDPQLIRGMIVGGLRRALDEHGFRSVQKPAEAALAAWQQEPVAPPPATGFLFDRR
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECC
AGAAVHPFAAEVSLPAADVARVYDRLMPFTAPAPLAGRAEVAATPPPAAEAHPLGIARGQ
CCCEECCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IAKTYIVAEAEDGLVIVDQHAAHERLVLETLKRGMAGQAVPSQGLLIPEVVELDEPACDR
EEEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHH
LEAAADGLAALGVELERFGPGAVMVRATPAMLGAIDCHRLVTDIADDLAGYDAALGLNER
HHHHHCCHHHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHH
LELVAATMACHGSVRAGRTLSVAEMNALLRQMEVTPHSGQCNHGRPTWVKLAMGDVERLF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHH
GRK
CCC
>Mature Secondary Structure 
SIRRLPETLVNRIAAGEVVERPAAALKELVENAIDAGATRIAVRIAEGGIARLEVEDDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCC
CGMTAADMVLALERHATSKLPDDAIEAVTTLGFRGEALPSIASVARLTLESRTAGGDGWR
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
RVVDNGAVVAEGPAALGQGTRVIVEHLFARVPARRKFLRSARSEYAACLDVVRRLAMARP
HHHCCCCEEECCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVGFTLEHDGRRVLDVQGGQDRVGRVAALTSRDLAANSIGVDLDRGEVHLGGVISLPTYN
CCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEECCCCC
RGIADHQYLFVNGRPVKDRLLVGALRGAYADLLARDRHPVVALFLDVPTGEVDVNVHPAK
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
TEVRFRDPQLIRGMIVGGLRRALDEHGFRSVQKPAEAALAAWQQEPVAPPPATGFLFDRR
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECC
AGAAVHPFAAEVSLPAADVARVYDRLMPFTAPAPLAGRAEVAATPPPAAEAHPLGIARGQ
CCCEECCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IAKTYIVAEAEDGLVIVDQHAAHERLVLETLKRGMAGQAVPSQGLLIPEVVELDEPACDR
EEEEEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHH
LEAAADGLAALGVELERFGPGAVMVRATPAMLGAIDCHRLVTDIADDLAGYDAALGLNER
HHHHHCCHHHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHH
LELVAATMACHGSVRAGRTLSVAEMNALLRQMEVTPHSGQCNHGRPTWVKLAMGDVERLF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHH
GRK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA