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The map label for this gene is lip2 [H]

Identifier: 103487034

GI number: 103487034

Start: 1616922

End: 1617869

Strand: Direct

Name: lip2 [H]

Synonym: Sala_1549

Alternate gene names: 103487034

Gene position: 1616922-1617869 (Clockwise)

Preceding gene: 103487028

Following gene: 103487035

Centisome position: 48.34

GC content: 65.3

Gene sequence:

>948_bases
ATGACCGACGGCACCCCCCATTATACGCGCCCCGATGTGGCGGCTTTTCTGGCCTTTCTGAATATGCAGGAAGGCCCGAA
GATGGAGGAGATGCCGCCAGAGGGCGCGCGGGAGATGTTCCGGGCGATGGGCCAGATCGCCGATGTTCCGCGCGGCGAGA
TAGCCCATGTCGAGGATCGCACCATCCCCGGACCCGCAGGCGCGCTTCCGATCCGGATCTACGATAATCGCCCCGATCGC
GAGCCCGGCCCGGTGATGGTCTTCTATCACGGTGGCGGCTGGGTGATCGGCGATCTCGACACGCACGATCCCTATTGCGC
CGAGGCGGCGCGGCAGCTCGACATGCCCGTGATCGCCGTCGATTACCGCCTCGCCCCCGAACATCCCTTTCCCGCGGCGC
CCGAAGATTGCGAAGCGGCAACGCGCTGGGTCGCCGACAATGTCCCCTGTACCGGTCTCGTGCTTTCGGGCGAGAGCGCG
GGCGGCAATCTGACGATCGCGACCGCGCTGACGTTGCGCGACAAGCCGGCGTCGAAACCGGTCATCGCCATCCATCCCAT
CTATCCCGCCGTGACGACGCGCGACGACTGGCAAAGCTATCGTGATTTCGGCGAGGGCCATTTGCTCACCAAAGGCGGCA
TGGCCTGGTTCGGCAATCATTATGCCGCGGATCCCGGAGACTATCGGGCTTCGCCGCTCGATTTCCCGGCGGAAGGCCTG
CCGCCGACGCTGCTGGTCACCGCGGGGCTCGACCCGCTGCGCGACCAGGGCCGCGCCTATGCCGCGAAGCTGATCGAGGC
GGGCGTGCCGACCAGCTTTCGCGAGGCAAAGGGCAATATCCACGGCTATATAAACCTGGCGCAAGGCATCCCCAGCGCAA
AGGACGATATTCGCGGCGCCCTCACCATATTGAAAGCAATCGTCGCCGACGCTAACGCCGCGGCATGA

Upstream 100 bases:

>100_bases
GCCGCAAAGGGTGACGCATGGGTGAGTTTCGATTTGCCATTGAATTTGCGGTGTCGATAGCGAATAGCCGGGCGACGATG
GCGATCAGGGAGAAACGCGA

Downstream 100 bases:

>100_bases
TCGACCACGACAAGCTTCCCTATCGCCCCTGCGCGGGCGTCATGCTCGCCAACCGCGACGGCCGCGTCTTCGTCGGCCAG
CGGCTCGATACGTCGAGCGA

Product: Alpha/beta hydrolase fold-3

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTDGTPHYTRPDVAAFLAFLNMQEGPKMEEMPPEGAREMFRAMGQIADVPRGEIAHVEDRTIPGPAGALPIRIYDNRPDR
EPGPVMVFYHGGGWVIGDLDTHDPYCAEAARQLDMPVIAVDYRLAPEHPFPAAPEDCEAATRWVADNVPCTGLVLSGESA
GGNLTIATALTLRDKPASKPVIAIHPIYPAVTTRDDWQSYRDFGEGHLLTKGGMAWFGNHYAADPGDYRASPLDFPAEGL
PPTLLVTAGLDPLRDQGRAYAAKLIEAGVPTSFREAKGNIHGYINLAQGIPSAKDDIRGALTILKAIVADANAAA

Sequences:

>Translated_315_residues
MTDGTPHYTRPDVAAFLAFLNMQEGPKMEEMPPEGAREMFRAMGQIADVPRGEIAHVEDRTIPGPAGALPIRIYDNRPDR
EPGPVMVFYHGGGWVIGDLDTHDPYCAEAARQLDMPVIAVDYRLAPEHPFPAAPEDCEAATRWVADNVPCTGLVLSGESA
GGNLTIATALTLRDKPASKPVIAIHPIYPAVTTRDDWQSYRDFGEGHLLTKGGMAWFGNHYAADPGDYRASPLDFPAEGL
PPTLLVTAGLDPLRDQGRAYAAKLIEAGVPTSFREAKGNIHGYINLAQGIPSAKDDIRGALTILKAIVADANAAA
>Mature_314_residues
TDGTPHYTRPDVAAFLAFLNMQEGPKMEEMPPEGAREMFRAMGQIADVPRGEIAHVEDRTIPGPAGALPIRIYDNRPDRE
PGPVMVFYHGGGWVIGDLDTHDPYCAEAARQLDMPVIAVDYRLAPEHPFPAAPEDCEAATRWVADNVPCTGLVLSGESAG
GNLTIATALTLRDKPASKPVIAIHPIYPAVTTRDDWQSYRDFGEGHLLTKGGMAWFGNHYAADPGDYRASPLDFPAEGLP
PTLLVTAGLDPLRDQGRAYAAKLIEAGVPTSFREAKGNIHGYINLAQGIPSAKDDIRGALTILKAIVADANAAA

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=101, Percent_Identity=40.5940594059406, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI68299767, Length=194, Percent_Identity=31.9587628865979, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI206597554, Length=288, Percent_Identity=25.6944444444444, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI157041239, Length=118, Percent_Identity=33.8983050847458, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786682, Length=258, Percent_Identity=28.6821705426357, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17567059, Length=129, Percent_Identity=35.6589147286822, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001146, Length=171, Percent_Identity=30.9941520467836, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533410, Length=97, Percent_Identity=37.1134020618557, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533412, Length=97, Percent_Identity=37.1134020618557, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17540028, Length=144, Percent_Identity=34.7222222222222, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996133, Length=143, Percent_Identity=30.0699300699301, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24656084, Length=105, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656076, Length=105, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130169, Length=105, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33829; Mature: 33697

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTPHYTRPDVAAFLAFLNMQEGPKMEEMPPEGAREMFRAMGQIADVPRGEIAHVEDR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
TIPGPAGALPIRIYDNRPDREPGPVMVFYHGGGWVIGDLDTHDPYCAEAARQLDMPVIAV
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCCEEEE
DYRLAPEHPFPAAPEDCEAATRWVADNVPCTGLVLSGESAGGNLTIATALTLRDKPASKP
EEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCC
VIAIHPIYPAVTTRDDWQSYRDFGEGHLLTKGGMAWFGNHYAADPGDYRASPLDFPAEGL
EEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPTLLVTAGLDPLRDQGRAYAAKLIEAGVPTSFREAKGNIHGYINLAQGIPSAKDDIRGA
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHH
LTILKAIVADANAAA
HHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDGTPHYTRPDVAAFLAFLNMQEGPKMEEMPPEGAREMFRAMGQIADVPRGEIAHVEDR
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
TIPGPAGALPIRIYDNRPDREPGPVMVFYHGGGWVIGDLDTHDPYCAEAARQLDMPVIAV
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCCEEEE
DYRLAPEHPFPAAPEDCEAATRWVADNVPCTGLVLSGESAGGNLTIATALTLRDKPASKP
EEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCC
VIAIHPIYPAVTTRDDWQSYRDFGEGHLLTKGGMAWFGNHYAADPGDYRASPLDFPAEGL
EEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPTLLVTAGLDPLRDQGRAYAAKLIEAGVPTSFREAKGNIHGYINLAQGIPSAKDDIRGA
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEECCCCCCCCHHHHHHH
LTILKAIVADANAAA
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]