Click here to switch to the map view.

The map label for this gene is rppH

Identifier: 103487035

GI number: 103487035

Start: 1617866

End: 1618342

Strand: Direct

Name: rppH

Synonym: Sala_1550

Alternate gene names: 103487035

Gene position: 1617866-1618342 (Clockwise)

Preceding gene: 103487034

Following gene: 103487037

Centisome position: 48.36

GC content: 64.15

Gene sequence:

>477_bases
ATGATCGACCACGACAAGCTTCCCTATCGCCCCTGCGCGGGCGTCATGCTCGCCAACCGCGACGGCCGCGTCTTCGTCGG
CCAGCGGCTCGATACGTCGAGCGAGGCATGGCAGATGCCGCAGGGCGGCATCGACGAGGGGGAGGATGCCGAAAAGGCCG
CGATCCGCGAACTTGGCGAGGAAACCGGCATCCACGGCGGGCTGGTCGACATCATCGCGCGCAGCCGCGAGGAGTATTTC
TATGACCTGCCCGACCATCTGATCGGCAAGATGTGGGGCGGCAAATATCGCGGCCAGCGCCAGCACTGGTTCCTGATGCG
CTTCATGGGCGAGGACAGCGACATCGACATCCACACCAGGCATCAGGAGTTTCGTGCGTGGCGCTGGGTCGATCTCGGCG
AGATCGAGAAACTGATCGTCCCGTTCAAACGCGCGCTCTACCGCGGGCTGATCGAGGAGTTCGGTCCGCTGGTCTGA

Upstream 100 bases:

>100_bases
GCTATATAAACCTGGCGCAAGGCATCCCCAGCGCAAAGGACGATATTCGCGGCGCCCTCACCATATTGAAAGCAATCGTC
GCCGACGCTAACGCCGCGGC

Downstream 100 bases:

>100_bases
CCTCAGCCGTCATTGCGAGCGAAGCGACGCAATCTCCCGCCATCCACCTTAGGGAAGGTCGATGGCTGAGGATTGCCGCG
TCGCCTTCGGCTCCTCGCAA

Product: NUDIX hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MIDHDKLPYRPCAGVMLANRDGRVFVGQRLDTSSEAWQMPQGGIDEGEDAEKAAIRELGEETGIHGGLVDIIARSREEYF
YDLPDHLIGKMWGGKYRGQRQHWFLMRFMGEDSDIDIHTRHQEFRAWRWVDLGEIEKLIVPFKRALYRGLIEEFGPLV

Sequences:

>Translated_158_residues
MIDHDKLPYRPCAGVMLANRDGRVFVGQRLDTSSEAWQMPQGGIDEGEDAEKAAIRELGEETGIHGGLVDIIARSREEYF
YDLPDHLIGKMWGGKYRGQRQHWFLMRFMGEDSDIDIHTRHQEFRAWRWVDLGEIEKLIVPFKRALYRGLIEEFGPLV
>Mature_158_residues
MIDHDKLPYRPCAGVMLANRDGRVFVGQRLDTSSEAWQMPQGGIDEGEDAEKAAIRELGEETGIHGGLVDIIARSREEYF
YDLPDHLIGKMWGGKYRGQRQHWFLMRFMGEDSDIDIHTRHQEFRAWRWVDLGEIEKLIVPFKRALYRGLIEEFGPLV

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=40.9937888198758, Blast_Score=111, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_SPHAL (Q1GSV9)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616596.1
- ProteinModelPortal:   Q1GSV9
- SMR:   Q1GSV9
- GeneID:   4082719
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1550
- NMPDR:   fig|317655.9.peg.1482
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   CLSK753557
- BioCyc:   SALA317655:SALA_1550-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18360; Mature: 18360

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDHDKLPYRPCAGVMLANRDGRVFVGQRLDTSSEAWQMPQGGIDEGEDAEKAAIRELGE
CCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHH
ETGIHGGLVDIIARSREEYFYDLPDHLIGKMWGGKYRGQRQHWFLMRFMGEDSDIDIHTR
HCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEC
HQEFRAWRWVDLGEIEKLIVPFKRALYRGLIEEFGPLV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDHDKLPYRPCAGVMLANRDGRVFVGQRLDTSSEAWQMPQGGIDEGEDAEKAAIRELGE
CCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHH
ETGIHGGLVDIIARSREEYFYDLPDHLIGKMWGGKYRGQRQHWFLMRFMGEDSDIDIHTR
HCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEC
HQEFRAWRWVDLGEIEKLIVPFKRALYRGLIEEFGPLV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA