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The map label for this gene is yngE [H]

Identifier: 103487017

GI number: 103487017

Start: 1597617

End: 1599215

Strand: Direct

Name: yngE [H]

Synonym: Sala_1532

Alternate gene names: 103487017

Gene position: 1597617-1599215 (Clockwise)

Preceding gene: 103487016

Following gene: 103487018

Centisome position: 47.76

GC content: 64.73

Gene sequence:

>1599_bases
GTGAGCGCCCCTGTATTGGGAACGATGGTCGATCGCGACGGCGAGATGTTCCGCGCCAACGCCGCGCACAACCGCACGCT
GCGCGACGAACTCTACGCGCGCGTCGCCGAAGCGGCGCTGGGCGGCAATGAAAAGTCGCGCGAGCGGCATAGGAGCCGCG
GCAAGCTGCTGCCGCGTGAGCGCGTCGAGCGGTTGCTCGACCCCGGCTCGCCGTTCCTCGAAATCGGCCAGCTCGCCGCG
TGCGACATGTATGGCGGCGAGGTTCCGGGCGCAGGGATGATCGCGGGCATCGGCCGCGTGTCGGGGCGGCAGGCGATGAT
CGTCTGCAACGACGCGACGGTGAAGGGCGGCACCTATTATCCGATGACGGTGAAAAAGCATCTCCGCGCGCAGGAAATCG
CGCAGGAGAACCGCCTGCCGTGCATCTACCTTGTCGACAGCGGCGGCGCGAACCTGCCGCATCAGGATCAGGTCTTTCCC
GACCGCGACCATTTCGGGCGAATCTTCTTCAACCAGGCGAATATGAGCGCGCGGCGCATTCCGCAGATCGCCTGCGTGAT
GGGAAGCTGCACCGCGGGCGGCGCCTATGTGCCTGCGATGAGCGACGAGACGGTGATCGTCCGCGGTCAGGGCACGATCT
TCCTCGCCGGCCCGCCGCTGGTGAAAGCGGCAACGGGCGAGGAAATCAGCGCCGAGGATCTGGGCGGCGGCGATTTGCAC
GCAAAGAAGTCGGGCGTCGTCGATCATCTGGCCGAGAATGACGAACATGCGCTGACGATCGTCCGCGATATTATGTCGCA
CCTTGGCGCCGATGAAGGGTTCAAGGTTGAGCTGAAGGAACCGCGCCCGCCCAGATATGACGCCGAAGACCTATACGGCA
TCATCCCGCAGGACGTCCGCGCGCCCTATGACGTCCACGAAGTCATCGCGCGCCTGGTCGACGGCAGCGAGTTTCACGCG
TTCAAGGCGCAATATGGCAGCACGCTGGTGTGCGGCTTCGCGCATATCTGGGGCATCCCGGTCGCAATCCTCGCCAACAA
TGGCGTGCTGTTCAGCGAAAGCGCGGTCAAGGGCGCGCATTTCATCGAGCTCGCGCAGCAGCGGAGCATTCCCCTGCTCT
TCCTCCAGAATATCAGCGGCTTCATGGTCGGCGGGAAGTATGAGGCCGAAGGCATTGCAAAACATGGCGCAAAGCTGGTG
ACGGCGGTGGCAACCGCGACGGTACCGAAAATCACCGTCCTGATCGGCGGCAGCTTTGGCGCGGGCAATTACGGCATGTG
CGGGCGCGCCTATAGCCCACGCTTCCTGTTCACCTGGCCCAATGCGCGGATCAGCGTGATGGGCGGCGAACAGGCGGCAT
CGGTGCTGGCGACCGTCCACCGCGACGCCGACAAATGGACGGCGGAGGAGGCCGAAGCCTTCAAAGCCCCGATCCGCCAG
AAATATGAGGATGAGGGCAATCCCTATCACGCCACCGCGCGCCTGTGGGACGATGGCATCATCGACCCCGCGCAGACGCG
CGACGTGCTGGGGCTGGCCTTCACCGCAACGCTGAACGCCCCGGTAGAGGACCGCGGCTTCGGCGTGTTCAGGATGTGA

Upstream 100 bases:

>100_bases
CTGCGTCGGCGTTTATCGCCACCTTATCCGCAAGAAGCCGGGCGACCCCGCGGCCGCGCAGGAATAGCGACATGACAAGT
GCAAAGGGAGATTCGGCAAG

Downstream 100 bases:

>100_bases
TTACCATGATCCAGTCCCTCCTCATCGCCAATCGCGGCGAGATCGCCTGCCGCATCATCCGCACCGCACGCGAGATGGGC
ATTCGCACCGTCGCGGTCTA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSAPVLGTMVDRDGEMFRANAAHNRTLRDELYARVAEAALGGNEKSRERHRSRGKLLPRERVERLLDPGSPFLEIGQLAA
CDMYGGEVPGAGMIAGIGRVSGRQAMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQDQVFP
DRDHFGRIFFNQANMSARRIPQIACVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
AKKSGVVDHLAENDEHALTIVRDIMSHLGADEGFKVELKEPRPPRYDAEDLYGIIPQDVRAPYDVHEVIARLVDGSEFHA
FKAQYGSTLVCGFAHIWGIPVAILANNGVLFSESAVKGAHFIELAQQRSIPLLFLQNISGFMVGGKYEAEGIAKHGAKLV
TAVATATVPKITVLIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTAEEAEAFKAPIRQ
KYEDEGNPYHATARLWDDGIIDPAQTRDVLGLAFTATLNAPVEDRGFGVFRM

Sequences:

>Translated_532_residues
MSAPVLGTMVDRDGEMFRANAAHNRTLRDELYARVAEAALGGNEKSRERHRSRGKLLPRERVERLLDPGSPFLEIGQLAA
CDMYGGEVPGAGMIAGIGRVSGRQAMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQDQVFP
DRDHFGRIFFNQANMSARRIPQIACVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
AKKSGVVDHLAENDEHALTIVRDIMSHLGADEGFKVELKEPRPPRYDAEDLYGIIPQDVRAPYDVHEVIARLVDGSEFHA
FKAQYGSTLVCGFAHIWGIPVAILANNGVLFSESAVKGAHFIELAQQRSIPLLFLQNISGFMVGGKYEAEGIAKHGAKLV
TAVATATVPKITVLIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTAEEAEAFKAPIRQ
KYEDEGNPYHATARLWDDGIIDPAQTRDVLGLAFTATLNAPVEDRGFGVFRM
>Mature_531_residues
SAPVLGTMVDRDGEMFRANAAHNRTLRDELYARVAEAALGGNEKSRERHRSRGKLLPRERVERLLDPGSPFLEIGQLAAC
DMYGGEVPGAGMIAGIGRVSGRQAMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQDQVFPD
RDHFGRIFFNQANMSARRIPQIACVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEEISAEDLGGGDLHA
KKSGVVDHLAENDEHALTIVRDIMSHLGADEGFKVELKEPRPPRYDAEDLYGIIPQDVRAPYDVHEVIARLVDGSEFHAF
KAQYGSTLVCGFAHIWGIPVAILANNGVLFSESAVKGAHFIELAQQRSIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVT
AVATATVPKITVLIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTAEEAEAFKAPIRQK
YEDEGNPYHATARLWDDGIIDPAQTRDVLGLAFTATLNAPVEDRGFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=63.8733705772812, Blast_Score=689, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=31.8271119842829, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=30.812854442344, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI310133460, Length=147, Percent_Identity=57.8231292517007, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17552936, Length=536, Percent_Identity=62.1268656716418, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=501, Percent_Identity=32.7345309381238, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=501, Percent_Identity=32.7345309381238, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586065, Length=552, Percent_Identity=61.9565217391304, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57546; Mature: 57415

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVLGTMVDRDGEMFRANAAHNRTLRDELYARVAEAALGGNEKSRERHRSRGKLLPRE
CCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
RVERLLDPGSPFLEIGQLAACDMYGGEVPGAGMIAGIGRVSGRQAMIVCNDATVKGGTYY
HHHHHHCCCCCHHHHCCEEEECCCCCCCCCCCCEEECCCCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQDQVFPDRDHFGRIFFNQANMSARRI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHC
PQIACVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
CEEEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCCCCCCC
AKKSGVVDHLAENDEHALTIVRDIMSHLGADEGFKVELKEPRPPRYDAEDLYGIIPQDVR
CCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCHHHC
APYDVHEVIARLVDGSEFHAFKAQYGSTLVCGFAHIWGIPVAILANNGVLFSESAVKGAH
CCCCHHHHHHHHHCCCHHHHHHHHCCCEEEHHHHHHHCCCEEEEECCCEEEECCCCCCHH
FIELAQQRSIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTAVATATVPKITVLIGGSFG
HHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHCCHHHHHHHHHHCCCEEEEEEECCCC
AGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTAEEAEAFKAPIRQ
CCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KYEDEGNPYHATARLWDDGIIDPAQTRDVLGLAFTATLNAPVEDRGFGVFRM
HHCCCCCCEEEEEEECCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCEEECC
>Mature Secondary Structure 
SAPVLGTMVDRDGEMFRANAAHNRTLRDELYARVAEAALGGNEKSRERHRSRGKLLPRE
CCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
RVERLLDPGSPFLEIGQLAACDMYGGEVPGAGMIAGIGRVSGRQAMIVCNDATVKGGTYY
HHHHHHCCCCCHHHHCCEEEECCCCCCCCCCCCEEECCCCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQDQVFPDRDHFGRIFFNQANMSARRI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHC
PQIACVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
CEEEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCCCCCCC
AKKSGVVDHLAENDEHALTIVRDIMSHLGADEGFKVELKEPRPPRYDAEDLYGIIPQDVR
CCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCHHHC
APYDVHEVIARLVDGSEFHAFKAQYGSTLVCGFAHIWGIPVAILANNGVLFSESAVKGAH
CCCCHHHHHHHHHCCCHHHHHHHHCCCEEEHHHHHHHCCCEEEEECCCEEEECCCCCCHH
FIELAQQRSIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTAVATATVPKITVLIGGSFG
HHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHCCHHHHHHHHHHCCCEEEEEEECCCC
AGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTAEEAEAFKAPIRQ
CCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KYEDEGNPYHATARLWDDGIIDPAQTRDVLGLAFTATLNAPVEDRGFGVFRM
HHCCCCCCEEEEEEECCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]