Click here to switch to the map view.

The map label for this gene is accA1 [H]

Identifier: 103487018

GI number: 103487018

Start: 1599221

End: 1601059

Strand: Direct

Name: accA1 [H]

Synonym: Sala_1533

Alternate gene names: 103487018

Gene position: 1599221-1601059 (Clockwise)

Preceding gene: 103487017

Following gene: 103487019

Centisome position: 47.81

GC content: 67.21

Gene sequence:

>1839_bases
ATGATCCAGTCCCTCCTCATCGCCAATCGCGGCGAGATCGCCTGCCGCATCATCCGCACCGCACGCGAGATGGGCATTCG
CACCGTCGCGGTCTATTCGGACGCCGACGCCAAGGCGCTGCATGTCCGGCAGGCCGATGAGGCCGTGCATATCGGCCCGT
CGCCGGCGCGCGAATCCTATCTGGTGGGCGAGAAGATCGTTGCGGCCGCGAAGGCGACCGGGGCCGAGGCGATCCATCCG
GGTTATGGCTTCCTGTCGGAGAACGCCGCGTTCGCGCAGGCGGTCATTGACGCCGGGCTGGTCTGGGTGGGGCCAAACCC
CGCAAGCATCACCGCGATGGGGCTCAAGGATGCCGCGAAGAAGCTGATGGCCGAGGCCGGGGTTCCGGTGACGCCGGGCT
ATATGGGCGAGAACCAGGATCCCGCTTTCCTCGCCGAACGGGCCGCCGAGATCGGCTATCCCGTCCTCATCAAGGCCGTC
GCGGGCGGCGGCGGCAAGGGGATGCGCAAGGTGGATAGCCCGGCTGACTTCCTCGACGCGCTTGCCTCGTGCCAGCGCGA
GGCGGCGGCGTCGTTCGGCAACGACCATGTGCTGATCGAGAAATATATCCTCACCCCCCGCCATATCGAGGTGCAGATAT
TCGGCGACACGCACGGCAATGTCGTCCACCTGTTCGAACGCGACTGCTCGCTCCAGCGCCGCCACCAGAAGGTGATCGAG
GAAGCCCCCGCCCCCGGCATGGACGAGGCGACGCGCGCCGAGCTGTGCGCCGCCGCGGTGCGCGCCGCAAAGGCGGTCGA
TTATGTCGGCGCGGGGACGATCGAGTTCATCGCCGACGCGAGCGAGGGCCTGCGCGCCGACCGCATCTGGTTCATGGAAA
TGAACACGCGGTTGCAGGTCGAGCATCCGGTGACCGAGGAAATCACCGGCGTCGATCTGGTCGAATGGCAGCTGCGCGTC
GCGAGCGGCGAGCCATTGCCCCTGACGCAGGACCAGCTTGCAATCAACGGCTGGGCGATGGAAGCGCGGCTTTATGCCGA
AGACCCCGCCAAGGGCTTTCTGCCGAGCACGGGCACGCTCGAACTCTTCCAGCTTCCCGAGCATATCGGCCGCATCGACA
CCGGCGTCTATGAAGGCGCCGAGGTGTCGCCCTTCTATGACCCGATGATCGCCAAGGTCATCGCTTATGGCGAGAACCGC
GAAGAAGCGCGCGAGCTGCTTTCGGAGATGCTGGAGGACAGCGCGATCTGGCCGGTCAAAACCAATTCGGCCTTTCTGAT
CGCCGCGCTCGATCATCCTGATTTCGTCGCGGGCACCGTCGATACCGGCCTGATCGGTCGCGATGGCGATGCGATGACCG
CTGCGCCCGAACCTTCGGCGCAGGCACTGACCAATGCCGCAATGGCGATGGTGCCGCGCGCGTTACAGGCGGGGTTCCGC
CTCAACGCCCCCGAGGTGCGCACCGCGCCCTTCCTGCTCGACGGCAAGCGGGTCGACGTTGCGCTCCACGGCCCCGGCGC
CGAAGAACCCGCCCCCGCGATGCTCGTCGCCGAGGGTGGGTCGGTGTGGCAATTGGCACCCTGGCGCGCCGAGGGCAGCG
CGAGCGGCGCGGCGGGCGACGGCGCGATCCTGTCGCCCATGCCCGGCAAGATCATCGCGGTCGAGGTTGCCGCGGGCGAC
ACGGTGGCCAAGGGACAGAAGCTGCTCACGCTCGAAGCGATGAAGATGGAGCACAGCCTGGTTGCGCCGTTCGACGGCGT
GGTGGCGGAGCTTAACGCGGTGGCAGGCGGACAGGTGCAGGTCGAGGCATTGCTGGCGCGGATCGAGGCGGCGAAATGA

Upstream 100 bases:

>100_bases
ACCCCGCGCAGACGCGCGACGTGCTGGGGCTGGCCTTCACCGCAACGCTGAACGCCCCGGTAGAGGACCGCGGCTTCGGC
GTGTTCAGGATGTGATTACC

Downstream 100 bases:

>100_bases
GCAATCTTCTCCCGGCGGGAGAAGGATATGGAGCCTTATCGCGCAGCGATCAGGCGGAGTTGGATGAGGGGTTGCGAGCT
ATTGTGGGGGCACAACCCTC

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MIQSLLIANRGEIACRIIRTAREMGIRTVAVYSDADAKALHVRQADEAVHIGPSPARESYLVGEKIVAAAKATGAEAIHP
GYGFLSENAAFAQAVIDAGLVWVGPNPASITAMGLKDAAKKLMAEAGVPVTPGYMGENQDPAFLAERAAEIGYPVLIKAV
AGGGGKGMRKVDSPADFLDALASCQREAAASFGNDHVLIEKYILTPRHIEVQIFGDTHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATRAELCAAAVRAAKAVDYVGAGTIEFIADASEGLRADRIWFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPLPLTQDQLAINGWAMEARLYAEDPAKGFLPSTGTLELFQLPEHIGRIDTGVYEGAEVSPFYDPMIAKVIAYGENR
EEARELLSEMLEDSAIWPVKTNSAFLIAALDHPDFVAGTVDTGLIGRDGDAMTAAPEPSAQALTNAAMAMVPRALQAGFR
LNAPEVRTAPFLLDGKRVDVALHGPGAEEPAPAMLVAEGGSVWQLAPWRAEGSASGAAGDGAILSPMPGKIIAVEVAAGD
TVAKGQKLLTLEAMKMEHSLVAPFDGVVAELNAVAGGQVQVEALLARIEAAK

Sequences:

>Translated_612_residues
MIQSLLIANRGEIACRIIRTAREMGIRTVAVYSDADAKALHVRQADEAVHIGPSPARESYLVGEKIVAAAKATGAEAIHP
GYGFLSENAAFAQAVIDAGLVWVGPNPASITAMGLKDAAKKLMAEAGVPVTPGYMGENQDPAFLAERAAEIGYPVLIKAV
AGGGGKGMRKVDSPADFLDALASCQREAAASFGNDHVLIEKYILTPRHIEVQIFGDTHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATRAELCAAAVRAAKAVDYVGAGTIEFIADASEGLRADRIWFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPLPLTQDQLAINGWAMEARLYAEDPAKGFLPSTGTLELFQLPEHIGRIDTGVYEGAEVSPFYDPMIAKVIAYGENR
EEARELLSEMLEDSAIWPVKTNSAFLIAALDHPDFVAGTVDTGLIGRDGDAMTAAPEPSAQALTNAAMAMVPRALQAGFR
LNAPEVRTAPFLLDGKRVDVALHGPGAEEPAPAMLVAEGGSVWQLAPWRAEGSASGAAGDGAILSPMPGKIIAVEVAAGD
TVAKGQKLLTLEAMKMEHSLVAPFDGVVAELNAVAGGQVQVEALLARIEAAK
>Mature_612_residues
MIQSLLIANRGEIACRIIRTAREMGIRTVAVYSDADAKALHVRQADEAVHIGPSPARESYLVGEKIVAAAKATGAEAIHP
GYGFLSENAAFAQAVIDAGLVWVGPNPASITAMGLKDAAKKLMAEAGVPVTPGYMGENQDPAFLAERAAEIGYPVLIKAV
AGGGGKGMRKVDSPADFLDALASCQREAAASFGNDHVLIEKYILTPRHIEVQIFGDTHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATRAELCAAAVRAAKAVDYVGAGTIEFIADASEGLRADRIWFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPLPLTQDQLAINGWAMEARLYAEDPAKGFLPSTGTLELFQLPEHIGRIDTGVYEGAEVSPFYDPMIAKVIAYGENR
EEARELLSEMLEDSAIWPVKTNSAFLIAALDHPDFVAGTVDTGLIGRDGDAMTAAPEPSAQALTNAAMAMVPRALQAGFR
LNAPEVRTAPFLLDGKRVDVALHGPGAEEPAPAMLVAEGGSVWQLAPWRAEGSASGAAGDGAILSPMPGKIIAVEVAAGD
TVAKGQKLLTLEAMKMEHSLVAPFDGVVAELNAVAGGQVQVEALLARIEAAK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=674, Percent_Identity=44.6587537091988, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI295821183, Length=623, Percent_Identity=42.3756019261637, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=669, Percent_Identity=39.7608370702541, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=669, Percent_Identity=39.7608370702541, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=471, Percent_Identity=45.2229299363057, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=471, Percent_Identity=45.2229299363057, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=471, Percent_Identity=45.2229299363057, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=32.3586744639376, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=32.3586744639376, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=32.3586744639376, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=32.3586744639376, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=32.3586744639376, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=31.8271119842829, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=46.9662921348315, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71987519, Length=661, Percent_Identity=46.5960665658094, Blast_Score=518, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=49.2134831460674, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17562816, Length=471, Percent_Identity=42.8874734607219, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=28.3203125, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.5996055226824, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI133931226, Length=499, Percent_Identity=29.2585170340681, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=44.5190156599553, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=43.4589800443459, Blast_Score=342, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=43.8053097345133, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=705, Percent_Identity=28.5106382978723, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=30.406852248394, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24651757, Length=660, Percent_Identity=45.1515151515152, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24651759, Length=622, Percent_Identity=43.7299035369775, Blast_Score=474, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24652212, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=475, Percent_Identity=45.8947368421053, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076409, Length=693, Percent_Identity=28.8600288600289, Blast_Score=222, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24586458, Length=693, Percent_Identity=28.8600288600289, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI161076407, Length=693, Percent_Identity=28.8600288600289, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586460, Length=693, Percent_Identity=28.8600288600289, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 64762; Mature: 64762

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQSLLIANRGEIACRIIRTAREMGIRTVAVYSDADAKALHVRQADEAVHIGPSPARESY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCEEECCCCCCCCCC
LVGEKIVAAAKATGAEAIHPGYGFLSENAAFAQAVIDAGLVWVGPNPASITAMGLKDAAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCEEEECHHHHHH
KLMAEAGVPVTPGYMGENQDPAFLAERAAEIGYPVLIKAVAGGGGKGMRKVDSPADFLDA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
LASCQREAAASFGNDHVLIEKYILTPRHIEVQIFGDTHGNVVHLFERDCSLQRRHQKVIE
HHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHH
EAPAPGMDEATRAELCAAAVRAAKAVDYVGAGTIEFIADASEGLRADRIWFMEMNTRLQV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCEEEE
EHPVTEEITGVDLVEWQLRVASGEPLPLTQDQLAINGWAMEARLYAEDPAKGFLPSTGTL
CCCCCHHCCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCC
ELFQLPEHIGRIDTGVYEGAEVSPFYDPMIAKVIAYGENREEARELLSEMLEDSAIWPVK
HHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
TNSAFLIAALDHPDFVAGTVDTGLIGRDGDAMTAAPEPSAQALTNAAMAMVPRALQAGFR
CCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LNAPEVRTAPFLLDGKRVDVALHGPGAEEPAPAMLVAEGGSVWQLAPWRAEGSASGAAGD
CCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCC
GAILSPMPGKIIAVEVAAGDTVAKGQKLLTLEAMKMEHSLVAPFDGVVAELNAVAGGQVQ
CCEECCCCCCEEEEEEECCCCHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCEE
VEALLARIEAAK
HHHHHHHHHCCC
>Mature Secondary Structure
MIQSLLIANRGEIACRIIRTAREMGIRTVAVYSDADAKALHVRQADEAVHIGPSPARESY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCEEECCCCCCCCCC
LVGEKIVAAAKATGAEAIHPGYGFLSENAAFAQAVIDAGLVWVGPNPASITAMGLKDAAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCEEEECHHHHHH
KLMAEAGVPVTPGYMGENQDPAFLAERAAEIGYPVLIKAVAGGGGKGMRKVDSPADFLDA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
LASCQREAAASFGNDHVLIEKYILTPRHIEVQIFGDTHGNVVHLFERDCSLQRRHQKVIE
HHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHH
EAPAPGMDEATRAELCAAAVRAAKAVDYVGAGTIEFIADASEGLRADRIWFMEMNTRLQV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCEEEE
EHPVTEEITGVDLVEWQLRVASGEPLPLTQDQLAINGWAMEARLYAEDPAKGFLPSTGTL
CCCCCHHCCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCC
ELFQLPEHIGRIDTGVYEGAEVSPFYDPMIAKVIAYGENREEARELLSEMLEDSAIWPVK
HHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
TNSAFLIAALDHPDFVAGTVDTGLIGRDGDAMTAAPEPSAQALTNAAMAMVPRALQAGFR
CCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LNAPEVRTAPFLLDGKRVDVALHGPGAEEPAPAMLVAEGGSVWQLAPWRAEGSASGAAGD
CCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCC
GAILSPMPGKIIAVEVAAGDTVAKGQKLLTLEAMKMEHSLVAPFDGVVAELNAVAGGQVQ
CCEECCCCCCEEEEEEECCCCHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCEE
VEALLARIEAAK
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]