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The map label for this gene is dctA

Identifier: 103486941

GI number: 103486941

Start: 1508600

End: 1509940

Strand: Reverse

Name: dctA

Synonym: Sala_1456

Alternate gene names: 103486941

Gene position: 1509940-1508600 (Counterclockwise)

Preceding gene: 103486944

Following gene: 103486940

Centisome position: 45.14

GC content: 64.8

Gene sequence:

>1341_bases
GTGGCAGCCAACGTCAATGTTATGGCAGCGCCGACTCCTGCCCGGCCCCGCGCCTGGTGGTCGCATCTGTATGTACAGGT
ACTCGCAGCGATCGTTGCGGGTGTGCTGCTCGGCCATTTCTGGCCCGCCATCGGCACCGAACTCAAACCGCTCGGCGACG
GCTTCATCAAACTGGTGAAGATGATCATCGCGCCGGTCATCTTCCTGACCGTTGCGACCGGCATCGCCTCGATCGGTGGC
GAGACGAAAGCGCTCGGCCGCGTGGTCGGCAAGGCCTTTGCCTATTTTCTCTTTTTCTCGACGCTGGCGCTGATCGTCGG
GCTGGTGGTCGCCAACGTCGTTCAGCCCGGTGCGGGAATGAACATCGACCCCGCGACGCTCGACGCGGGCGCGGTCGCGC
AATATCAGGCGAAGGCACACGAGGCGACGCTCACCGCCTTCCTGCTCGACATCATTCCCGTCACCTTCGTTTCGGCGCTG
ACCGAGGGGTCGATATTGCAGGCGCTGTTCGTCGCGATCCTCTTTGGCCTCGCGCTGTCGCACGCGGGCGAACCGGGGCG
GCAGGTGCTGGGCCTGCTCGAAAAGGTCTCGACGGTGTTCTTCGGCCTTGTCGGGATGCTGATGAAGTTCGCGCCGATCG
GGGCGTTCGGCGCGATGGCCTTTACCATCGGCAAATATGGGGTCGAATCGCTCGCCAATCTCGGCCTGCTGATCGCGACC
TTCTATCTCACCTCGCTCTTTTTCGTGATCGTCATCCTGGGCGCCGTCGCGCATTTCTCAGGCTTTTCGATCTTTCGGCT
GATCGCCTATCTCAAGGCCGAACTGCTGCTCGTGCTCGGCACCTCCTCGTCCGAAGCCGCCTTGCCCAGCCTCATCGAAA
AGCTCGAAAAGGCGGGCTGCGCCAAGCCAATCGTCGGTCTCGTCGTGCCGACGGGCTACAGCTTCAACCTCGACGGCACC
AACATCTATATGACGCTCGCGGCGCTGTTCATTGCGCAGGCGGTCGGCGTCGACCTCAGCCTCGGCGATCAGATCGCGCT
GCTGCTCGTCGCGATGGTAAGCTCGAAGGGCGCGGCGGGAGTCACCGGCGCGGGGTTCATCACGCTGGCCGCGACGCTGT
CGATCGTGCCCTCGGTCCCCGTCGCGGGGCTCGCGCTGATCCTCGGCATCGACCGTTTCATGAGCGAGTGCCGCGCGCTC
ACCAATTTCATCGGCAACGCGCTCGCCGCGATCGTCGTCGCGGGCTGGGAAAAAGGCCTCGACCGCGAGGCGCTTGCCCG
CGCGCTCGCCGGCGAGCCCGCGCCGCTCGCCGCGGCGCCGATCGAAACCGACACCGACTGA

Upstream 100 bases:

>100_bases
GCCCGTTTGACCCCCGATCCGCCAACTCCCTAAACTCGCCAAAAGGCTGCCGAACGGCCGAAAGTCGCGCCGCATCGGCG
CACAACAAGGGGAGAGGCTG

Downstream 100 bases:

>100_bases
CCGGACAAATGGAAGAGAGATGGGGGACGATATGATCAAGACGACACAGAGCCGCTGGGTGCGCCAGAGCAGCCGGATCG
CGCTGATCGTCGCGGCCGGA

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAANVNVMAAPTPARPRAWWSHLYVQVLAAIVAGVLLGHFWPAIGTELKPLGDGFIKLVKMIIAPVIFLTVATGIASIGG
ETKALGRVVGKAFAYFLFFSTLALIVGLVVANVVQPGAGMNIDPATLDAGAVAQYQAKAHEATLTAFLLDIIPVTFVSAL
TEGSILQALFVAILFGLALSHAGEPGRQVLGLLEKVSTVFFGLVGMLMKFAPIGAFGAMAFTIGKYGVESLANLGLLIAT
FYLTSLFFVIVILGAVAHFSGFSIFRLIAYLKAELLLVLGTSSSEAALPSLIEKLEKAGCAKPIVGLVVPTGYSFNLDGT
NIYMTLAALFIAQAVGVDLSLGDQIALLLVAMVSSKGAAGVTGAGFITLAATLSIVPSVPVAGLALILGIDRFMSECRAL
TNFIGNALAAIVVAGWEKGLDREALARALAGEPAPLAAAPIETDTD

Sequences:

>Translated_446_residues
MAANVNVMAAPTPARPRAWWSHLYVQVLAAIVAGVLLGHFWPAIGTELKPLGDGFIKLVKMIIAPVIFLTVATGIASIGG
ETKALGRVVGKAFAYFLFFSTLALIVGLVVANVVQPGAGMNIDPATLDAGAVAQYQAKAHEATLTAFLLDIIPVTFVSAL
TEGSILQALFVAILFGLALSHAGEPGRQVLGLLEKVSTVFFGLVGMLMKFAPIGAFGAMAFTIGKYGVESLANLGLLIAT
FYLTSLFFVIVILGAVAHFSGFSIFRLIAYLKAELLLVLGTSSSEAALPSLIEKLEKAGCAKPIVGLVVPTGYSFNLDGT
NIYMTLAALFIAQAVGVDLSLGDQIALLLVAMVSSKGAAGVTGAGFITLAATLSIVPSVPVAGLALILGIDRFMSECRAL
TNFIGNALAAIVVAGWEKGLDREALARALAGEPAPLAAAPIETDTD
>Mature_445_residues
AANVNVMAAPTPARPRAWWSHLYVQVLAAIVAGVLLGHFWPAIGTELKPLGDGFIKLVKMIIAPVIFLTVATGIASIGGE
TKALGRVVGKAFAYFLFFSTLALIVGLVVANVVQPGAGMNIDPATLDAGAVAQYQAKAHEATLTAFLLDIIPVTFVSALT
EGSILQALFVAILFGLALSHAGEPGRQVLGLLEKVSTVFFGLVGMLMKFAPIGAFGAMAFTIGKYGVESLANLGLLIATF
YLTSLFFVIVILGAVAHFSGFSIFRLIAYLKAELLLVLGTSSSEAALPSLIEKLEKAGCAKPIVGLVVPTGYSFNLDGTN
IYMTLAALFIAQAVGVDLSLGDQIALLLVAMVSSKGAAGVTGAGFITLAATLSIVPSVPVAGLALILGIDRFMSECRALT
NFIGNALAAIVVAGWEKGLDREALARALAGEPAPLAAAPIETDTD

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI194239697, Length=497, Percent_Identity=25.1509054325956, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI21314632, Length=405, Percent_Identity=26.9135802469136, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI169790839, Length=423, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4827012, Length=248, Percent_Identity=31.4516129032258, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI40254478, Length=432, Percent_Identity=25.2314814814815, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI66773030, Length=468, Percent_Identity=26.0683760683761, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI5032093, Length=345, Percent_Identity=28.695652173913, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI223468566, Length=301, Percent_Identity=29.2358803986711, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223468564, Length=301, Percent_Identity=29.2358803986711, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI301601644, Length=152, Percent_Identity=32.8947368421053, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262359914, Length=377, Percent_Identity=23.342175066313, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=59.375, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=40.661938534279, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=23.3502538071066, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=443, Percent_Identity=27.0880361173815, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=469, Percent_Identity=26.226012793177, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=469, Percent_Identity=26.226012793177, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=414, Percent_Identity=24.6376811594203, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193206505, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=25.4945054945055, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17541374, Length=428, Percent_Identity=22.196261682243, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583025, Length=427, Percent_Identity=25.7611241217799, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137668, Length=427, Percent_Identity=25.7611241217799, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583023, Length=427, Percent_Identity=25.7611241217799, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360483, Length=470, Percent_Identity=24.468085106383, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137666, Length=470, Percent_Identity=24.468085106383, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360481, Length=470, Percent_Identity=24.468085106383, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCTA_SPHAL (Q1GT53)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616502.1
- ProteinModelPortal:   Q1GT53
- SMR:   Q1GT53
- GeneID:   4081267
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1456
- NMPDR:   fig|317655.9.peg.1388
- HOGENOM:   HBG739804
- BioCyc:   SALA317655:SALA_1456-MONOMER
- HAMAP:   MF_01300
- InterPro:   IPR001991
- InterPro:   IPR018107
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 46072; Mature: 45941

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1249cdac)-; HASH(0x11b5837c)-; HASH(0x1288a1a4)-; HASH(0x127d100c)-; HASH(0x1223bd70)-; HASH(0x118559b4)-; HASH(0xf64466c)-; HASH(0x10a034f8)-; HASH(0x11c34424)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANVNVMAAPTPARPRAWWSHLYVQVLAAIVAGVLLGHFWPAIGTELKPLGDGFIKLVK
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MIIAPVIFLTVATGIASIGGETKALGRVVGKAFAYFLFFSTLALIVGLVVANVVQPGAGM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIDPATLDAGAVAQYQAKAHEATLTAFLLDIIPVTFVSALTEGSILQALFVAILFGLALS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HAGEPGRQVLGLLEKVSTVFFGLVGMLMKFAPIGAFGAMAFTIGKYGVESLANLGLLIAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLTSLFFVIVILGAVAHFSGFSIFRLIAYLKAELLLVLGTSSSEAALPSLIEKLEKAGC
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCC
AKPIVGLVVPTGYSFNLDGTNIYMTLAALFIAQAVGVDLSLGDQIALLLVAMVSSKGAAG
CCCHHHEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
VTGAGFITLAATLSIVPSVPVAGLALILGIDRFMSECRALTNFIGNALAAIVVAGWEKGL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DREALARALAGEPAPLAAAPIETDTD
CHHHHHHHHCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
AANVNVMAAPTPARPRAWWSHLYVQVLAAIVAGVLLGHFWPAIGTELKPLGDGFIKLVK
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MIIAPVIFLTVATGIASIGGETKALGRVVGKAFAYFLFFSTLALIVGLVVANVVQPGAGM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIDPATLDAGAVAQYQAKAHEATLTAFLLDIIPVTFVSALTEGSILQALFVAILFGLALS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HAGEPGRQVLGLLEKVSTVFFGLVGMLMKFAPIGAFGAMAFTIGKYGVESLANLGLLIAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLTSLFFVIVILGAVAHFSGFSIFRLIAYLKAELLLVLGTSSSEAALPSLIEKLEKAGC
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCC
AKPIVGLVVPTGYSFNLDGTNIYMTLAALFIAQAVGVDLSLGDQIALLLVAMVSSKGAAG
CCCHHHEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
VTGAGFITLAATLSIVPSVPVAGLALILGIDRFMSECRALTNFIGNALAAIVVAGWEKGL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DREALARALAGEPAPLAAAPIETDTD
CHHHHHHHHCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA