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The map label for this gene is kynU [H]

Identifier: 103486875

GI number: 103486875

Start: 1444604

End: 1445845

Strand: Reverse

Name: kynU [H]

Synonym: Sala_1389

Alternate gene names: 103486875

Gene position: 1445845-1444604 (Counterclockwise)

Preceding gene: 103486876

Following gene: 103486874

Centisome position: 43.22

GC content: 66.67

Gene sequence:

>1242_bases
ATGACCGGCACGATGGCCGTCGCCGATGTGGTGTCGCTCGACGCGGGCGACCCGCTCGCGCCTTTTCGCGACCGCTTTCA
TCTGCGCGAAGGGCTGATCTATCTCGACGGCAATTCGCTCGGTGCGTTGCCCAGGGCGACGGGCGACCGGCTCGCCGAAG
TCATCGGCGACGAGTGGGGCGAGGGGCTGATCACCTCGTGGCTCGGCGCCTCATGGTCGACCGCCCCGCGGCGGATCGGC
GACAAGATCGCCCGGCTGGTCGGCGCCCACCCCGGCGAGATCGTCGCGACCGATTCCACCTCGGTCAATATCTTCAAGGC
GTTGACCGCCGCGCTTTCCTTGCGGCGCGAACGCCCGGTGATCCTGTCGGAAGCCACCAACTTTCCGACCGACGTATATA
TGATGCAGGGGATCGAGGCTTTTTCGGGCGGGCGTGTGAAGGCGGTCACGGTGGCGCCCGATGCCATCGTCGATGCGCTG
AGCGATGAGGTGGCGGTGCTGCTGCTGACGCAGGTGCACTACAAGTCGGGCCGCGTTCGCGACATGGCGGCGATCACGCG
CGCCGCGCACGAAGCGGGCGCGCTGATCGTCTGGGATCTGAGCCACAGCGCGGGGGCGATTCCGGTCGATCTCAACGGTG
CGAACGCCGATTTTGCGATCGGTTGCGGCTACAAGTTTCTCAACGGTGGCCCCGGTGCGCCGGCCTATCTCTTTGCCGCT
GCGCGGCACCATGGCGCCACGCCGATCTTGTCGGGCTGGTTCGGTCACGCGCGGCCGTTCGATTTCGAGGAGGATTATGA
TCCCGCCGCCGGGATCGCACGCTTCCAGTGCGGCACGCCGCCGGTGCTGGGTCTTGCGGCGCTCGAAGTCGGCGTCGACC
TGATGCTCGAAGCCGATATGGCCGAGGTGCGCCGCAAGTCGCTGGCGCTTGGCGATCTACTCATCGCGCGGATGCAGCCC
TTGTGCGATGCCTATGGCTTTGCTCTGGCAAGCCCGCGCGATCATGCGCTGCGCGGCAGCCAGGTCGCCTATGCGCACCG
CCAGGGCTATCAGATCGCGCAGGCGCTCAGGGAACTGGATGTCATTGCGGACTTCCGCGCCCCCGACATTTTGCGCTTCG
GGCTGACGCCGCTTTACCTGCGGTACAGCGACATCGTCGAGACGGTCGAACGGCTCGAAAGGGTCTGCGCCACCCGCGCG
TGGGACAAGCCGCAATATCACCAGCGGGCGGCGGTGACATGA

Upstream 100 bases:

>100_bases
TCGATGATGTGCCGCCCGGCCGCTACGAACTGATTGCCCTGCCGCTGCGCATCGTCGGCGCCGATGCCAGCCCGGTGCGC
GCCATTCTGAGGGAAATCGC

Downstream 100 bases:

>100_bases
GCGATACGTCGGCCTCCCTCCTGCCCAAATCGCGCGTCGCCGCAGTGCAGGCGGCGCCGGTGTTCCTCGATCCGGCAGCG
ACGGTCGACAAGGCGTGTGC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTGTMAVADVVSLDAGDPLAPFRDRFHLREGLIYLDGNSLGALPRATGDRLAEVIGDEWGEGLITSWLGASWSTAPRRIG
DKIARLVGAHPGEIVATDSTSVNIFKALTAALSLRRERPVILSEATNFPTDVYMMQGIEAFSGGRVKAVTVAPDAIVDAL
SDEVAVLLLTQVHYKSGRVRDMAAITRAAHEAGALIVWDLSHSAGAIPVDLNGANADFAIGCGYKFLNGGPGAPAYLFAA
ARHHGATPILSGWFGHARPFDFEEDYDPAAGIARFQCGTPPVLGLAALEVGVDLMLEADMAEVRRKSLALGDLLIARMQP
LCDAYGFALASPRDHALRGSQVAYAHRQGYQIAQALRELDVIADFRAPDILRFGLTPLYLRYSDIVETVERLERVCATRA
WDKPQYHQRAAVT

Sequences:

>Translated_413_residues
MTGTMAVADVVSLDAGDPLAPFRDRFHLREGLIYLDGNSLGALPRATGDRLAEVIGDEWGEGLITSWLGASWSTAPRRIG
DKIARLVGAHPGEIVATDSTSVNIFKALTAALSLRRERPVILSEATNFPTDVYMMQGIEAFSGGRVKAVTVAPDAIVDAL
SDEVAVLLLTQVHYKSGRVRDMAAITRAAHEAGALIVWDLSHSAGAIPVDLNGANADFAIGCGYKFLNGGPGAPAYLFAA
ARHHGATPILSGWFGHARPFDFEEDYDPAAGIARFQCGTPPVLGLAALEVGVDLMLEADMAEVRRKSLALGDLLIARMQP
LCDAYGFALASPRDHALRGSQVAYAHRQGYQIAQALRELDVIADFRAPDILRFGLTPLYLRYSDIVETVERLERVCATRA
WDKPQYHQRAAVT
>Mature_412_residues
TGTMAVADVVSLDAGDPLAPFRDRFHLREGLIYLDGNSLGALPRATGDRLAEVIGDEWGEGLITSWLGASWSTAPRRIGD
KIARLVGAHPGEIVATDSTSVNIFKALTAALSLRRERPVILSEATNFPTDVYMMQGIEAFSGGRVKAVTVAPDAIVDALS
DEVAVLLLTQVHYKSGRVRDMAAITRAAHEAGALIVWDLSHSAGAIPVDLNGANADFAIGCGYKFLNGGPGAPAYLFAAA
RHHGATPILSGWFGHARPFDFEEDYDPAAGIARFQCGTPPVLGLAALEVGVDLMLEADMAEVRRKSLALGDLLIARMQPL
CDAYGFALASPRDHALRGSQVAYAHRQGYQIAQALRELDVIADFRAPDILRFGLTPLYLRYSDIVETVERLERVCATRAW
DKPQYHQRAAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=433, Percent_Identity=25.8660508083141, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI74101437, Length=280, Percent_Identity=27.5, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550466, Length=427, Percent_Identity=26.2295081967213, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323261, Length=415, Percent_Identity=26.7469879518072, Blast_Score=140, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 44473; Mature: 44342

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTMAVADVVSLDAGDPLAPFRDRFHLREGLIYLDGNSLGALPRATGDRLAEVIGDEWG
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
EGLITSWLGASWSTAPRRIGDKIARLVGAHPGEIVATDSTSVNIFKALTAALSLRRERPV
CHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCE
ILSEATNFPTDVYMMQGIEAFSGGRVKAVTVAPDAIVDALSDEVAVLLLTQVHYKSGRVR
EEECCCCCCHHHHHHHCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHH
DMAAITRAAHEAGALIVWDLSHSAGAIPVDLNGANADFAIGCGYKFLNGGPGAPAYLFAA
HHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHH
ARHHGATPILSGWFGHARPFDFEEDYDPAAGIARFQCGTPPVLGLAALEVGVDLMLEADM
HHHCCCCCHHHCCCCCCCCCCCCCCCCCHHCEEEEECCCCCHHHHHHHHHCHHHEEECCH
AEVRRKSLALGDLLIARMQPLCDAYGFALASPRDHALRGSQVAYAHRQGYQIAQALRELD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
VIADFRAPDILRFGLTPLYLRYSDIVETVERLERVCATRAWDKPQYHQRAAVT
HHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
>Mature Secondary Structure 
TGTMAVADVVSLDAGDPLAPFRDRFHLREGLIYLDGNSLGALPRATGDRLAEVIGDEWG
CCCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
EGLITSWLGASWSTAPRRIGDKIARLVGAHPGEIVATDSTSVNIFKALTAALSLRRERPV
CHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCE
ILSEATNFPTDVYMMQGIEAFSGGRVKAVTVAPDAIVDALSDEVAVLLLTQVHYKSGRVR
EEECCCCCCHHHHHHHCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHH
DMAAITRAAHEAGALIVWDLSHSAGAIPVDLNGANADFAIGCGYKFLNGGPGAPAYLFAA
HHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHH
ARHHGATPILSGWFGHARPFDFEEDYDPAAGIARFQCGTPPVLGLAALEVGVDLMLEADM
HHHCCCCCHHHCCCCCCCCCCCCCCCCCHHCEEEEECCCCCHHHHHHHHHCHHHEEECCH
AEVRRKSLALGDLLIARMQPLCDAYGFALASPRDHALRGSQVAYAHRQGYQIAQALRELD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
VIADFRAPDILRFGLTPLYLRYSDIVETVERLERVCATRAWDKPQYHQRAAVT
HHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA