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The map label for this gene is fadH [H]

Identifier: 103486822

GI number: 103486822

Start: 1398541

End: 1399332

Strand: Reverse

Name: fadH [H]

Synonym: Sala_1336

Alternate gene names: 103486822

Gene position: 1399332-1398541 (Counterclockwise)

Preceding gene: 103486825

Following gene: 103486820

Centisome position: 41.83

GC content: 68.69

Gene sequence:

>792_bases
ATGACGACATTCCGCGACGGCCTGCTGGCCGGAAAGACCGCGTTCGTTGCCGGCGGGACGAGCGGTATCAACCTGGGCAT
CGCCAAACGCTTTGCCGAACTGGGCGCCAAAGTCGCGGTGGCGGGCCGCGATCCCGACAAGGCGGCACATGCCGCGGCCG
CGATCGGCGAGGGCGCTCTCGGCCTGTCGGGCGATGTGCGCGACTATGCCGCGATCCGCGGCGTGATGGAGCGGGTCGCG
GGCGAGCTGGGGCCGATGGATATCGTCGTTTCCGGTGCCGCGGGCAATTTTCTGGCCCCCGTTCTCGGCATGTCGGCGAA
CGCCTTTCGCACCGTTGTCGATATCGACCTCAACGGCACCTTCAATGTCTTTCGCGGCTGCCACGACCTGTTGGTGCGGC
CCGGCGCATCGCTGATCGCAATCACGGCGGGGCAGGCGGTCAACGCCTCCGCCTTGCAGGCGCACGCCTGTGCGGCGAAG
GCGGGGATCAACCAGCTGATCCGCGTGCTCGCGCTCGAATGGGGGCCGGAGGTGCGCGTCAACGGCATCTCGCCCGGCCC
GATCGCCGATACCGAAGGGATGAAGCGCCTCGCGCCCGATGCCGCCACGCGGCAGGCGCATTACGACCGCATCGCGATGA
AACGCTGGGGCCGGATCGAGGAGGTGGCCGAATCGGCGGTGTTCCTCTGCTCGCCCGCCGCGGGCTATATCACCGGGACG
ATCCTCGATTGCGACGGCGGCAGCCAGATCGGCGATGCGTCGCGCGGCGACCTGGCGAAGGGCATGGTCTGA

Upstream 100 bases:

>100_bases
CCTTGCTGTCTGTTCCAGTTTCAAAAGGCGACTGGTTTCGATCCGTCAACCCCCGGATCGCCTTCGCGCGATCAAGAAGA
AGTGAGGGAGAGAGAGAGAA

Downstream 100 bases:

>100_bases
AAGCAAAAACGCCGCCAACCCGGCGGGGCGGCGGCGTTTTGAATGGTGGGCGTGGCAAGGATTGAACTTGCGACCCCTGC
GATGTCAACACAGTGCTCTA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTTFRDGLLAGKTAFVAGGTSGINLGIAKRFAELGAKVAVAGRDPDKAAHAAAAIGEGALGLSGDVRDYAAIRGVMERVA
GELGPMDIVVSGAAGNFLAPVLGMSANAFRTVVDIDLNGTFNVFRGCHDLLVRPGASLIAITAGQAVNASALQAHACAAK
AGINQLIRVLALEWGPEVRVNGISPGPIADTEGMKRLAPDAATRQAHYDRIAMKRWGRIEEVAESAVFLCSPAAGYITGT
ILDCDGGSQIGDASRGDLAKGMV

Sequences:

>Translated_263_residues
MTTFRDGLLAGKTAFVAGGTSGINLGIAKRFAELGAKVAVAGRDPDKAAHAAAAIGEGALGLSGDVRDYAAIRGVMERVA
GELGPMDIVVSGAAGNFLAPVLGMSANAFRTVVDIDLNGTFNVFRGCHDLLVRPGASLIAITAGQAVNASALQAHACAAK
AGINQLIRVLALEWGPEVRVNGISPGPIADTEGMKRLAPDAATRQAHYDRIAMKRWGRIEEVAESAVFLCSPAAGYITGT
ILDCDGGSQIGDASRGDLAKGMV
>Mature_262_residues
TTFRDGLLAGKTAFVAGGTSGINLGIAKRFAELGAKVAVAGRDPDKAAHAAAAIGEGALGLSGDVRDYAAIRGVMERVAG
ELGPMDIVVSGAAGNFLAPVLGMSANAFRTVVDIDLNGTFNVFRGCHDLLVRPGASLIAITAGQAVNASALQAHACAAKA
GINQLIRVLALEWGPEVRVNGISPGPIADTEGMKRLAPDAATRQAHYDRIAMKRWGRIEEVAESAVFLCSPAAGYITGTI
LDCDGGSQIGDASRGDLAKGMV

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=40.7114624505929, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4503301, Length=249, Percent_Identity=33.7349397590361, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=28.6274509803922, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=26.8292682926829, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.968253968254, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI5031737, Length=240, Percent_Identity=27.5, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI15277342, Length=248, Percent_Identity=31.0483870967742, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=30.9803921568627, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=31.4741035856574, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=27.5720164609054, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=30, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=25.4980079681275, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788459, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=28.099173553719, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787545, Length=262, Percent_Identity=29.0076335877863, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=34.8837209302326, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=33.7209302325581, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17561272, Length=255, Percent_Identity=34.5098039215686, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=29.9610894941634, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=29.0441176470588, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=26.4227642276423, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=268, Percent_Identity=26.4925373134328, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=27.7153558052434, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=26.7924528301887, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=24.4094488188976, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=22.962962962963, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=38.7351778656126, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=26.953125, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=30.2040816326531, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=30.952380952381, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=25.1028806584362, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=26.3565891472868, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=24.5059288537549, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=25.2032520325203, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 26868; Mature: 26737

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFRDGLLAGKTAFVAGGTSGINLGIAKRFAELGAKVAVAGRDPDKAAHAAAAIGEGAL
CCCCCCCHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCC
GLSGDVRDYAAIRGVMERVAGELGPMDIVVSGAAGNFLAPVLGMSANAFRTVVDIDLNGT
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEEEECCCC
FNVFRGCHDLLVRPGASLIAITAGQAVNASALQAHACAAKAGINQLIRVLALEWGPEVRV
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
NGISPGPIADTEGMKRLAPDAATRQAHYDRIAMKRWGRIEEVAESAVFLCSPAAGYITGT
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCEEEE
ILDCDGGSQIGDASRGDLAKGMV
EEECCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
TTFRDGLLAGKTAFVAGGTSGINLGIAKRFAELGAKVAVAGRDPDKAAHAAAAIGEGAL
CCCCCCHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCC
GLSGDVRDYAAIRGVMERVAGELGPMDIVVSGAAGNFLAPVLGMSANAFRTVVDIDLNGT
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEEEECCCC
FNVFRGCHDLLVRPGASLIAITAGQAVNASALQAHACAAKAGINQLIRVLALEWGPEVRV
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
NGISPGPIADTEGMKRLAPDAATRQAHYDRIAMKRWGRIEEVAESAVFLCSPAAGYITGT
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCEEEE
ILDCDGGSQIGDASRGDLAKGMV
EEECCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]