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The map label for this gene is nuoH

Identifier: 103486788

GI number: 103486788

Start: 1361460

End: 1362503

Strand: Reverse

Name: nuoH

Synonym: Sala_1302

Alternate gene names: 103486788

Gene position: 1362503-1361460 (Counterclockwise)

Preceding gene: 103486789

Following gene: 103486787

Centisome position: 40.73

GC content: 60.25

Gene sequence:

>1044_bases
ATGACCGATTTTTTCCAATCGCTCGGCATGTCCTATGAATGGGCTTGGGGGCTTGCGACCGTCGCGGGCATCCTGCTCAT
CGCGCTGCCATTGATGCTCGCGGTCGCGATGATCATTTATGCCGACCGCAAGATCTGGGCGGCGATCGCGCTGCGCCGGG
GTCCGAACGTCGTCGGGCCGTTCGGCCTGCTCCAGTCGTTCGCCGACGGCCTCAAAGTGTTTCTGCAGGAAACGATCATC
CCGTCGGGCGCCAATCGGGGCCTGTTCCTGATCGCGCCGATCATCACCTTTACCGTCGCGCTGCTCGCCTGGGCGGTGAT
TCCGTTCAATTCGGGCGCGGTGCTCGCCGACATCAATGTCGGCCTGCTCTATATCCTCGCGATTTCGTCGCTCGGCGTTT
ATGGCGTGATCCTGTCGGGCTGGGCGTCGAACTCGAAATATCCCTTCTTTTCCGCGCTCCGCGCCTCGGCGCAGATGATC
AGCTATGAAGTGTCGATCGGCTTCATCCTGATCGGCGTCGTGCTGTTTGCCGACAGTTTCAACATGAACGAGATCGTCAA
GGCGCAGCAGGGCCACGGGCTCGGCATCGTCAACGCCTTCGGCTTCAACCTGCTGCTGTTCCCGCTCGCGGTGATGTTCC
TGATCTCGTCGCTCGCCGAAACCGCGCGCGCGCCGTTCGATCTGACCGAAGCCGAAAGCGAGCTCGTCGCGGGCTATCAG
ACCGAATATTCGTCGATGAGCTTCGCGCTCTTCTGGCTCGGCGAATATGCTAACGTCCTTCTGATGTGCACACTCAACGC
GGTGCTGTTCTGGGGCGGCTGGCTGCCTCCGATCGACTGGGCGCCGCTCTATGCCGTCCCCGGCATCATCTGGCTGTTCG
CGAAGATCCTGTTCTTCTTCTTCGTCTTCAGCTGGGTCAAGGCGACCGTTCCGCGCTACCGCTATGACCAGCTCATGCGG
CTGGGCTGGAAAATCTTCCTGCCGATTTCGCTGATCTGGATCTTCCTGATCTCCGGCTATCTGATGCTGACGAGGTATTC
ATGA

Upstream 100 bases:

>100_bases
CGCGACCGCATACCCCTCACCCAGCTTCGACTAGGCGACCGAGCCGCCAAGTCTTCGCAACCCTCTCCCGCAAGGGGAGA
GGGGAAGGGGTTGTGTATCA

Downstream 100 bases:

>100_bases
GTTACGTAGGCCATCTCGTCAAAAGCTTCACCTTGTGGGAGTTTGTGAAGGCGCACGCCCTCACGCTGAAGTATTTCTTC
AAGCCGAAGGCGACGATCAA

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTDFFQSLGMSYEWAWGLATVAGILLIALPLMLAVAMIIYADRKIWAAIALRRGPNVVGPFGLLQSFADGLKVFLQETII
PSGANRGLFLIAPIITFTVALLAWAVIPFNSGAVLADINVGLLYILAISSLGVYGVILSGWASNSKYPFFSALRASAQMI
SYEVSIGFILIGVVLFADSFNMNEIVKAQQGHGLGIVNAFGFNLLLFPLAVMFLISSLAETARAPFDLTEAESELVAGYQ
TEYSSMSFALFWLGEYANVLLMCTLNAVLFWGGWLPPIDWAPLYAVPGIIWLFAKILFFFFVFSWVKATVPRYRYDQLMR
LGWKIFLPISLIWIFLISGYLMLTRYS

Sequences:

>Translated_347_residues
MTDFFQSLGMSYEWAWGLATVAGILLIALPLMLAVAMIIYADRKIWAAIALRRGPNVVGPFGLLQSFADGLKVFLQETII
PSGANRGLFLIAPIITFTVALLAWAVIPFNSGAVLADINVGLLYILAISSLGVYGVILSGWASNSKYPFFSALRASAQMI
SYEVSIGFILIGVVLFADSFNMNEIVKAQQGHGLGIVNAFGFNLLLFPLAVMFLISSLAETARAPFDLTEAESELVAGYQ
TEYSSMSFALFWLGEYANVLLMCTLNAVLFWGGWLPPIDWAPLYAVPGIIWLFAKILFFFFVFSWVKATVPRYRYDQLMR
LGWKIFLPISLIWIFLISGYLMLTRYS
>Mature_346_residues
TDFFQSLGMSYEWAWGLATVAGILLIALPLMLAVAMIIYADRKIWAAIALRRGPNVVGPFGLLQSFADGLKVFLQETIIP
SGANRGLFLIAPIITFTVALLAWAVIPFNSGAVLADINVGLLYILAISSLGVYGVILSGWASNSKYPFFSALRASAQMIS
YEVSIGFILIGVVLFADSFNMNEIVKAQQGHGLGIVNAFGFNLLLFPLAVMFLISSLAETARAPFDLTEAESELVAGYQT
EYSSMSFALFWLGEYANVLLMCTLNAVLFWGGWLPPIDWAPLYAVPGIIWLFAKILFFFFVFSWVKATVPRYRYDQLMRL
GWKIFLPISLIWIFLISGYLMLTRYS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=298, Percent_Identity=43.6241610738255, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1788618, Length=315, Percent_Identity=42.2222222222222, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_SPHAL (Q1GTK6)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616349.1
- GeneID:   4082594
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1302
- NMPDR:   fig|317655.9.peg.1238
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   CLSK843948
- BioCyc:   SALA317655:SALA_1302-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38456; Mature: 38325

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11ac1f38)-; HASH(0x120f4de8)-; HASH(0x1258e808)-; HASH(0x12520188)-; HASH(0x10e3947c)-; HASH(0x1258e85c)-; HASH(0x12591624)-; HASH(0x10e8305c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFFQSLGMSYEWAWGLATVAGILLIALPLMLAVAMIIYADRKIWAAIALRRGPNVVGP
CCCHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
FGLLQSFADGLKVFLQETIIPSGANRGLFLIAPIITFTVALLAWAVIPFNSGAVLADINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECHH
GLLYILAISSLGVYGVILSGWASNSKYPFFSALRASAQMISYEVSIGFILIGVVLFADSF
HHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NMNEIVKAQQGHGLGIVNAFGFNLLLFPLAVMFLISSLAETARAPFDLTEAESELVAGYQ
CHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TEYSSMSFALFWLGEYANVLLMCTLNAVLFWGGWLPPIDWAPLYAVPGIIWLFAKILFFF
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVFSWVKATVPRYRYDQLMRLGWKIFLPISLIWIFLISGYLMLTRYS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
>Mature Secondary Structure 
TDFFQSLGMSYEWAWGLATVAGILLIALPLMLAVAMIIYADRKIWAAIALRRGPNVVGP
CCHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
FGLLQSFADGLKVFLQETIIPSGANRGLFLIAPIITFTVALLAWAVIPFNSGAVLADINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECHH
GLLYILAISSLGVYGVILSGWASNSKYPFFSALRASAQMISYEVSIGFILIGVVLFADSF
HHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NMNEIVKAQQGHGLGIVNAFGFNLLLFPLAVMFLISSLAETARAPFDLTEAESELVAGYQ
CHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TEYSSMSFALFWLGEYANVLLMCTLNAVLFWGGWLPPIDWAPLYAVPGIIWLFAKILFFF
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVFSWVKATVPRYRYDQLMRLGWKIFLPISLIWIFLISGYLMLTRYS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA