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The map label for this gene is mazG [H]

Identifier: 103486756

GI number: 103486756

Start: 1325959

End: 1326732

Strand: Direct

Name: mazG [H]

Synonym: Sala_1270

Alternate gene names: 103486756

Gene position: 1325959-1326732 (Clockwise)

Preceding gene: 103486755

Following gene: 103486764

Centisome position: 39.64

GC content: 64.99

Gene sequence:

>774_bases
ATGACCGAGACCCTGGCCGCAGCCCCCATCGACCGCCTCCTTGCCATCATGCGGCAGCTCCGCGACCCCGACAGCGGCTG
CGAATGGGATCTCGCGCAGAGCTTTGCGACGATCGCGCCCTATACGATCGAGGAGGCCTATGAGGTTGCCGATGCCATTG
CAGGCGGCGACCCTGCGGCAATCTGCAACGAGCTTGGCGACCTGCTCCTTCAAGTCGTTTTTCATGCGCAGATTGCGGCC
GACAGCGGCCTTTTCACTTTTGATGATGTCGCCGATGCGATCAGCGACAAGATGGAACGGCGCCATCCGCATATCTTTGA
CGATGCGCCAACCGACGATGCGACTCGGCAATGGGAGGCGATCAAAGCCGAAGAGCGGGCGGCCGACGGGGCGCAGGGCG
CGCTCGCGGGGGTTGCCCTTTCGCTTCCCGCGCTGCTGCGCGCGCAGAAGCTTCAGGATCGCGCCGCGCGGGTCGGGTTT
GATTGGCCCGACATCGACGGTCCGCGTGAAAAAATTGTCGAGGAGCTGACGGAGGTTGCCGACGCCACCAATGCCGTCGA
GCGCCACGAAGAGATCGGCGACCTGCTCTTCGCCGTCGTCAACTATGCCCGCAAGATGGGCGTCGATGCCGAAAGCGCAC
TGCGCGACGCCAATCTGAAGTTCGCGCGGCGCTTTGCCGCAATGGAGGCGCGGGCGGGCGGTTCCCTGGCAGGACTGTCG
CTCGGCGCGCAGGAGGCGCACTGGAAAGCCGTCAAGGCGACGGAGGGCCGTTAG

Upstream 100 bases:

>100_bases
GGCGCTGCTGCCGACATCCAGGTCGAATCGGCTCTGCCGCGTCGTTCCCATGGCCGCCTCTCGCGGGCGCGCCAACCCCG
ATTGGAGTGGCGTGACGACT

Downstream 100 bases:

>100_bases
CGGGCCACAGCCTTTCAAAGCGGGCGCGATCCGCCGGATCGAGCCGAACGGTCAGCACATGCCCCTCGCCTTCAGCTTCG
TCCGCGAGCACTTCACCGCG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTETLAAAPIDRLLAIMRQLRDPDSGCEWDLAQSFATIAPYTIEEAYEVADAIAGGDPAAICNELGDLLLQVVFHAQIAA
DSGLFTFDDVADAISDKMERRHPHIFDDAPTDDATRQWEAIKAEERAADGAQGALAGVALSLPALLRAQKLQDRAARVGF
DWPDIDGPREKIVEELTEVADATNAVERHEEIGDLLFAVVNYARKMGVDAESALRDANLKFARRFAAMEARAGGSLAGLS
LGAQEAHWKAVKATEGR

Sequences:

>Translated_257_residues
MTETLAAAPIDRLLAIMRQLRDPDSGCEWDLAQSFATIAPYTIEEAYEVADAIAGGDPAAICNELGDLLLQVVFHAQIAA
DSGLFTFDDVADAISDKMERRHPHIFDDAPTDDATRQWEAIKAEERAADGAQGALAGVALSLPALLRAQKLQDRAARVGF
DWPDIDGPREKIVEELTEVADATNAVERHEEIGDLLFAVVNYARKMGVDAESALRDANLKFARRFAAMEARAGGSLAGLS
LGAQEAHWKAVKATEGR
>Mature_256_residues
TETLAAAPIDRLLAIMRQLRDPDSGCEWDLAQSFATIAPYTIEEAYEVADAIAGGDPAAICNELGDLLLQVVFHAQIAAD
SGLFTFDDVADAISDKMERRHPHIFDDAPTDDATRQWEAIKAEERAADGAQGALAGVALSLPALLRAQKLQDRAARVGFD
WPDIDGPREKIVEELTEVADATNAVERHEEIGDLLFAVVNYARKMGVDAESALRDANLKFARRFAAMEARAGGSLAGLSL
GAQEAHWKAVKATEGR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=51.7509727626459, Blast_Score=246, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 27741; Mature: 27610

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETLAAAPIDRLLAIMRQLRDPDSGCEWDLAQSFATIAPYTIEEAYEVADAIAGGDPAA
CCCCHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHH
ICNELGDLLLQVVFHAQIAADSGLFTFDDVADAISDKMERRHPHIFDDAPTDDATRQWEA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
IKAEERAADGAQGALAGVALSLPALLRAQKLQDRAARVGFDWPDIDGPREKIVEELTEVA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
DATNAVERHEEIGDLLFAVVNYARKMGVDAESALRDANLKFARRFAAMEARAGGSLAGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
LGAQEAHWKAVKATEGR
CCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TETLAAAPIDRLLAIMRQLRDPDSGCEWDLAQSFATIAPYTIEEAYEVADAIAGGDPAA
CCCHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHH
ICNELGDLLLQVVFHAQIAADSGLFTFDDVADAISDKMERRHPHIFDDAPTDDATRQWEA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
IKAEERAADGAQGALAGVALSLPALLRAQKLQDRAARVGFDWPDIDGPREKIVEELTEVA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
DATNAVERHEEIGDLLFAVVNYARKMGVDAESALRDANLKFARRFAAMEARAGGSLAGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHC
LGAQEAHWKAVKATEGR
CCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]