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The map label for this gene is cysG2 [H]

Identifier: 103486755

GI number: 103486755

Start: 1325020

End: 1325796

Strand: Direct

Name: cysG2 [H]

Synonym: Sala_1269

Alternate gene names: 103486755

Gene position: 1325020-1325796 (Clockwise)

Preceding gene: 103486754

Following gene: 103486756

Centisome position: 39.61

GC content: 67.31

Gene sequence:

>777_bases
ATGCAGCCTGATGATTTCGCCCCCGGCACGGTTTGGCTCGTCGGTGCAGGCCCCGGCGATCCCGACCTGCTGACGATGAA
GGCCGTGCGATTGATCAGCCGCGCCGATATCGTCTTTTACGACGCCTTGGTGAGCAAGCGCGTACGCGCCCTGATCCGCG
AAGGCACCAAAGGCGTGAACGTCGGGAAACGGTCGGGTCGTCATTCGAAAGATCAGTCCGCGATCAATGCGATGCTGGTA
GGCGCCGTCCGCGCGGGCAAGCGCGTCGTCCGGCTCAAGGGTGGCGACCCGATGGTTTTCGGCCGCGCGACCGAAGAAAT
TTCAGCGATCGAGGCGGCAGGTTTCCGGGTGTGCGTCTGCCCCGGAATAACGGCGGCCAGCGCAGCGGCGGCGTCGGCCG
GCTTGTCGCTCACGCTTCGCGGCGTTGCACGCGATGTACGGTTCGTGACCGCGCACAGCCGCCGCGGCGCCGCGCTCGAT
CTCGACTGGGCATCGCTGGCGCGGGGAGGTTCGACGCTTGCTTTCTACATGGGGCGCGACGTGGCGGGTCATATCGCAAG
GCGTTTGATCGAGGCCGGGATGTCCGGCGCCACGCCGGTGCTCGTCACCTGCAATGCCAGCCTGCCCGACGAACAGCGGC
TGGCGACGCGGCTTGACCTGCTCGACCTTGCGACGCGCGCGCTTGCAGGCTCGGCGCCGACCCTCATCCTCGTCGGACCC
GCAATGGCACTTGCCGAACGAGCCCGTTCGGGCGCGATGGCCGCCGAAGCAGACTGA

Upstream 100 bases:

>100_bases
CTCGCCGATGTTGCGGCGATCGGCGCTGCGCTGGGCGCGGGCACCAACTGCGGGTCGTGCCGCCCCGCGCTTGCCCGTAT
TCTGACCGAGGAGACCAGCA

Downstream 100 bases:

>100_bases
GTGCGGGTCTGCCCTCCACCCATATCGCTTGAGATGACATGATGTTGCGCTATGGCGGACGCGGCGCTGCTGCCGACATC
CAGGTCGAATCGGCTCTGCC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MQPDDFAPGTVWLVGAGPGDPDLLTMKAVRLISRADIVFYDALVSKRVRALIREGTKGVNVGKRSGRHSKDQSAINAMLV
GAVRAGKRVVRLKGGDPMVFGRATEEISAIEAAGFRVCVCPGITAASAAAASAGLSLTLRGVARDVRFVTAHSRRGAALD
LDWASLARGGSTLAFYMGRDVAGHIARRLIEAGMSGATPVLVTCNASLPDEQRLATRLDLLDLATRALAGSAPTLILVGP
AMALAERARSGAMAAEAD

Sequences:

>Translated_258_residues
MQPDDFAPGTVWLVGAGPGDPDLLTMKAVRLISRADIVFYDALVSKRVRALIREGTKGVNVGKRSGRHSKDQSAINAMLV
GAVRAGKRVVRLKGGDPMVFGRATEEISAIEAAGFRVCVCPGITAASAAAASAGLSLTLRGVARDVRFVTAHSRRGAALD
LDWASLARGGSTLAFYMGRDVAGHIARRLIEAGMSGATPVLVTCNASLPDEQRLATRLDLLDLATRALAGSAPTLILVGP
AMALAERARSGAMAAEAD
>Mature_258_residues
MQPDDFAPGTVWLVGAGPGDPDLLTMKAVRLISRADIVFYDALVSKRVRALIREGTKGVNVGKRSGRHSKDQSAINAMLV
GAVRAGKRVVRLKGGDPMVFGRATEEISAIEAAGFRVCVCPGITAASAAAASAGLSLTLRGVARDVRFVTAHSRRGAALD
LDWASLARGGSTLAFYMGRDVAGHIARRLIEAGMSGATPVLVTCNASLPDEQRLATRLDLLDLATRALAGSAPTLILVGP
AMALAERARSGAMAAEAD

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=43.75, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322922, Length=240, Percent_Identity=30.8333333333333, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26786; Mature: 26786

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPDDFAPGTVWLVGAGPGDPDLLTMKAVRLISRADIVFYDALVSKRVRALIREGTKGVN
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VGKRSGRHSKDQSAINAMLVGAVRAGKRVVRLKGGDPMVFGRATEEISAIEAAGFRVCVC
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCEEEEEC
PGITAASAAAASAGLSLTLRGVARDVRFVTAHSRRGAALDLDWASLARGGSTLAFYMGRD
CCCCHHHHHHHHCCCEEEEHHHHHHEEEEEECCCCCCEEECCHHHHHCCCCEEEEEECCC
VAGHIARRLIEAGMSGATPVLVTCNASLPDEQRLATRLDLLDLATRALAGSAPTLILVGP
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECH
AMALAERARSGAMAAEAD
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQPDDFAPGTVWLVGAGPGDPDLLTMKAVRLISRADIVFYDALVSKRVRALIREGTKGVN
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VGKRSGRHSKDQSAINAMLVGAVRAGKRVVRLKGGDPMVFGRATEEISAIEAAGFRVCVC
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCEEEEEC
PGITAASAAAASAGLSLTLRGVARDVRFVTAHSRRGAALDLDWASLARGGSTLAFYMGRD
CCCCHHHHHHHHCCCEEEEHHHHHHEEEEEECCCCCCEEECCHHHHHCCCCEEEEEECCC
VAGHIARRLIEAGMSGATPVLVTCNASLPDEQRLATRLDLLDLATRALAGSAPTLILVGP
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECH
AMALAERARSGAMAAEAD
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA