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The map label for this gene is gyrA [H]

Identifier: 103486652

GI number: 103486652

Start: 1196355

End: 1199060

Strand: Reverse

Name: gyrA [H]

Synonym: Sala_1164

Alternate gene names: 103486652

Gene position: 1199060-1196355 (Counterclockwise)

Preceding gene: 103486653

Following gene: 103486651

Centisome position: 35.84

GC content: 65.04

Gene sequence:

>2706_bases
GTGCAGCCGTCCGAGGACGGCGTTTCGCCGATCAACATCGTCGACGAAATGAAGACCAGCTACCTCGATTACGCGATGAG
CGTGATCGTCAGCCGCGCGCTGCCCGACGTGCGCGACGGGCTGAAGCCCGTCCACCGCCGCATCCTCTATGCGGCGCAGG
AAGGCGGCTTCATCCCCGGTCGTCCGTACAAGAAATCGGCGAAGATCGTCGGCGACGTCATGGGTAATTATCACCCGCAC
GGCGACAGCGCGATCTATGACGCGCTGGCGCGGATGACGCAGGACTGGTCGCTGCGCGTGCCCTTGATCGACGGTCAGGG
CAATTTCGGCTCGATGGACCCCGACCCGCCGGCGTCGATGCGCTACACCGAGGCGCGCCTTGCCAAGACCGCGATGGTGC
TGCTGAACGATCTCGACAAGGATACGGTCGACTTCCAGCCCAATTATGACGCGAGCCGTGAGGAGCCGACCGTGCTTCCG
GCGCGCTTCCCGAATCTGCTCGTCAACGGCGCGGGCGGGATCGCGGTCGGCATGGCGACCAATATCCCGCCGCACAACCT
TGGCGAAATCATCGACGCGACGCTCGCGATGATCGACAATCCGGCGATCACGCTTGAAGAATTGATGGCGATCGTCCCCG
GCCCCGATTTCCCGACGGGCGCGATGATGCTCGGCCAGGGTGGCGCACGCAGCGCCTATGCAACCGGCCGCGGCTCGATC
ATGATGCGCTCCACCCATGTAATAGAGGAAGGCAGGAACGATCGACAATCCATTGTATTAACGTCGATTCCGTTCCAGGT
CGGCAAGTCGGGCCTTGTCGAGAAGATCGCCGAGGCGGCGCGCGACAAGCGGATCGAGGGCGTCGCCGATATCCGCGACG
AATCGAACCGCGAGGGCGTGCGCGTCGTCATCGAGCTGAAGCGCGACGCGACGGCAGAGGTGGTGCTCAACCAGCTGTGG
CGTCACACGCCCGCGCAGTCGAGCTTTCCCGCGAACATGCTCGCGATCCGCGGCGGCCGCCCCGAAATGATGGGGCTGAA
GGATATTCTCTCGGCCTTCATCATCTTCCGCGAAGAGGTCATCACCCGCCGCTGCAAGTTCGAACTCGCCAAGGCACGCG
ACCGCGCGCATATCTTGCTCGGCCTCGTCGTCGCGGTCAGCAACCTCGACGAAGTCGTGCGCATCATTCGCGGTTCGTCC
TCGCCCGCCGCCGCGCGCGAAGCCCTGCTCGCGCGCGAATGGCCGATCGGCGACATCGCCCCCTATATCCGCCTCGTCGA
AGCAATCGAGGGCGAGATGGAGGAAGCCGCAACCTATCGGCTGTCCGAAGTGCAGGTGAAGGCGATCCTCGACCTCCGCC
TCCACCGGCTGACGGCACTGGGTCGCGACGAAATCGGCAAGGAACTCGGTGAGTTGGCAGCCGAAATTGAGGAACTGCTT
TCGATCCTCGCCGACCGCGTCAAGCTATATGGCGTGATGCGCGAGGAACTGGTTGCGGTGCGCGACGAATTTGCGACCCC
GCGCCGCACCCTCCTCGCCCCCGCCGCCGACGGCATCGACGACGAAGATCTGATCGAGCGCGAGGAGATGGTCGTCACCG
TCACGATGGACGGCTATATCAAGCGGACGCCCCTGGCCACCTTTCGCGCACAGCGACGCGGCGGCAAGGGCCGCGCAGGC
ATGGCGACGAAGGACGAGGATGTCGTCACCGAACTGTTCGTCACCTCGACGCACACGCCGGTGCTCTTCTTCTCGACCGC
GGGCAAGGTCTATCGCATGAAGGTGTGGCGCCTGCCCGAGGGCGGCCCTGCGACGCGCGGCCGTCCGATGATCAACCTGC
TCCCGCTTGCCCAGGGCGAAACCATCTCGACCGTGCTGCCGCTGCCCGAGGACGAGAGCGAATGGGGCAAGCTGCACGTC
ATGTTCGCAACCGCGAAGGGCAGCGTGCGCCGCAACAGCATGGACGCCTTCACCAACGTCCCCTCGAACGGCAAGATCGC
GATGAAGTTCGAGGGCGATGACGAGGACGACCGGCTGATCGGCGTCGCGCTGCTCGACGAAAGCGACGATGTGCTGCTCG
CGACGCGGCAGGGCAAGGCGATCCGCTTTGCCGGCGACGATGTCCGCGAGTTTCAGAGCCGCAATTCGACCGGGGTGCGC
GGGATGCGCCTGGCCGAGGGGGATGAGGTTATTTCGCTCTCGATCCTCCACCGCGTCGGCACCACCGGCGACGAACGCGA
AGCCTATCTGCGCGCCGCGCCGTGGAAGGATAACGAGAATGAACCGACCTTGCCCGCCGAACGCATGGCCGAACTGGCGG
CGCGCGAACAGTTCATCCTGACCGTTTGTGCCAATGGCTATGGCAAGCTGTCGTCGGCCTATGAATATCGCCGCACGGGC
CGCGGCGGTCAGGGGATTACCAATATCGACAATATCGCGCGCAACGGCCCGGTGGTCGCCAGCTTCCCCGCCACGCAGGC
GCACCAGCTGATGCTCGTCACCGATCAGGCCAAACTCATCCGCATGGGGCTCGACAGCTTGCGCATCATCGGCCGCGGCA
GCGCGGGCGTGCGCCTGTTCGATGTCGCCGAGGGCGAGCATGTCGTGTCGGCCGCGCTGATCGAAGATGGCGACGAAGAC
GCGGATGACGGCCGCGACGTCGAGGTGGCGAGCGACAATCCGGTGAGCGAAGCCCCCACCGAATGA

Upstream 100 bases:

>100_bases
TCGCCCGAATCACTGGCAATTCGCCGCGCCTTGGGCTAGGCCAAATCCATCTCCCGATAAGCAGAAAAAAGGCCGGGTCT
TGACCGAAGAAAATACGCCT

Downstream 100 bases:

>100_bases
CGACGCCGACGACTGCCTTCAAGGTGCTTACCGCGCAGCAGTGGACCGATTTCGAGCGCGAGCGCGTCTTCCGCGGCGCG
CCGGTCGACATCGAGGATGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 901; Mature: 901

Protein sequence:

>901_residues
MQPSEDGVSPINIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAAQEGGFIPGRPYKKSAKIVGDVMGNYHPH
GDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKTAMVLLNDLDKDTVDFQPNYDASREEPTVLP
ARFPNLLVNGAGGIAVGMATNIPPHNLGEIIDATLAMIDNPAITLEELMAIVPGPDFPTGAMMLGQGGARSAYATGRGSI
MMRSTHVIEEGRNDRQSIVLTSIPFQVGKSGLVEKIAEAARDKRIEGVADIRDESNREGVRVVIELKRDATAEVVLNQLW
RHTPAQSSFPANMLAIRGGRPEMMGLKDILSAFIIFREEVITRRCKFELAKARDRAHILLGLVVAVSNLDEVVRIIRGSS
SPAAAREALLAREWPIGDIAPYIRLVEAIEGEMEEAATYRLSEVQVKAILDLRLHRLTALGRDEIGKELGELAAEIEELL
SILADRVKLYGVMREELVAVRDEFATPRRTLLAPAADGIDDEDLIEREEMVVTVTMDGYIKRTPLATFRAQRRGGKGRAG
MATKDEDVVTELFVTSTHTPVLFFSTAGKVYRMKVWRLPEGGPATRGRPMINLLPLAQGETISTVLPLPEDESEWGKLHV
MFATAKGSVRRNSMDAFTNVPSNGKIAMKFEGDDEDDRLIGVALLDESDDVLLATRQGKAIRFAGDDVREFQSRNSTGVR
GMRLAEGDEVISLSILHRVGTTGDEREAYLRAAPWKDNENEPTLPAERMAELAAREQFILTVCANGYGKLSSAYEYRRTG
RGGQGITNIDNIARNGPVVASFPATQAHQLMLVTDQAKLIRMGLDSLRIIGRGSAGVRLFDVAEGEHVVSAALIEDGDED
ADDGRDVEVASDNPVSEAPTE

Sequences:

>Translated_901_residues
MQPSEDGVSPINIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAAQEGGFIPGRPYKKSAKIVGDVMGNYHPH
GDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKTAMVLLNDLDKDTVDFQPNYDASREEPTVLP
ARFPNLLVNGAGGIAVGMATNIPPHNLGEIIDATLAMIDNPAITLEELMAIVPGPDFPTGAMMLGQGGARSAYATGRGSI
MMRSTHVIEEGRNDRQSIVLTSIPFQVGKSGLVEKIAEAARDKRIEGVADIRDESNREGVRVVIELKRDATAEVVLNQLW
RHTPAQSSFPANMLAIRGGRPEMMGLKDILSAFIIFREEVITRRCKFELAKARDRAHILLGLVVAVSNLDEVVRIIRGSS
SPAAAREALLAREWPIGDIAPYIRLVEAIEGEMEEAATYRLSEVQVKAILDLRLHRLTALGRDEIGKELGELAAEIEELL
SILADRVKLYGVMREELVAVRDEFATPRRTLLAPAADGIDDEDLIEREEMVVTVTMDGYIKRTPLATFRAQRRGGKGRAG
MATKDEDVVTELFVTSTHTPVLFFSTAGKVYRMKVWRLPEGGPATRGRPMINLLPLAQGETISTVLPLPEDESEWGKLHV
MFATAKGSVRRNSMDAFTNVPSNGKIAMKFEGDDEDDRLIGVALLDESDDVLLATRQGKAIRFAGDDVREFQSRNSTGVR
GMRLAEGDEVISLSILHRVGTTGDEREAYLRAAPWKDNENEPTLPAERMAELAAREQFILTVCANGYGKLSSAYEYRRTG
RGGQGITNIDNIARNGPVVASFPATQAHQLMLVTDQAKLIRMGLDSLRIIGRGSAGVRLFDVAEGEHVVSAALIEDGDED
ADDGRDVEVASDNPVSEAPTE
>Mature_901_residues
MQPSEDGVSPINIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAAQEGGFIPGRPYKKSAKIVGDVMGNYHPH
GDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKTAMVLLNDLDKDTVDFQPNYDASREEPTVLP
ARFPNLLVNGAGGIAVGMATNIPPHNLGEIIDATLAMIDNPAITLEELMAIVPGPDFPTGAMMLGQGGARSAYATGRGSI
MMRSTHVIEEGRNDRQSIVLTSIPFQVGKSGLVEKIAEAARDKRIEGVADIRDESNREGVRVVIELKRDATAEVVLNQLW
RHTPAQSSFPANMLAIRGGRPEMMGLKDILSAFIIFREEVITRRCKFELAKARDRAHILLGLVVAVSNLDEVVRIIRGSS
SPAAAREALLAREWPIGDIAPYIRLVEAIEGEMEEAATYRLSEVQVKAILDLRLHRLTALGRDEIGKELGELAAEIEELL
SILADRVKLYGVMREELVAVRDEFATPRRTLLAPAADGIDDEDLIEREEMVVTVTMDGYIKRTPLATFRAQRRGGKGRAG
MATKDEDVVTELFVTSTHTPVLFFSTAGKVYRMKVWRLPEGGPATRGRPMINLLPLAQGETISTVLPLPEDESEWGKLHV
MFATAKGSVRRNSMDAFTNVPSNGKIAMKFEGDDEDDRLIGVALLDESDDVLLATRQGKAIRFAGDDVREFQSRNSTGVR
GMRLAEGDEVISLSILHRVGTTGDEREAYLRAAPWKDNENEPTLPAERMAELAAREQFILTVCANGYGKLSSAYEYRRTG
RGGQGITNIDNIARNGPVVASFPATQAHQLMLVTDQAKLIRMGLDSLRIIGRGSAGVRLFDVAEGEHVVSAALIEDGDED
ADDGRDVEVASDNPVSEAPTE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=340, Percent_Identity=23.8235294117647, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=911, Percent_Identity=45.8836443468716, Blast_Score=772, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=711, Percent_Identity=35.4430379746835, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=209, Percent_Identity=30.1435406698565, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98595; Mature: 98595

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSEDGVSPINIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAAQEGGFIPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
RPYKKSAKIVGDVMGNYHPHGDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASM
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
RYTEARLAKTAMVLLNDLDKDTVDFQPNYDASREEPTVLPARFPNLLVNGAGGIAVGMAT
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEIIDATLAMIDNPAITLEELMAIVPGPDFPTGAMMLGQGGARSAYATGRGSI
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCCEEECCCCCCCCEECCCCCE
MMRSTHVIEEGRNDRQSIVLTSIPFQVGKSGLVEKIAEAARDKRIEGVADIRDESNREGV
EEEEHHHHHCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCE
RVVIELKRDATAEVVLNQLWRHTPAQSSFPANMLAIRGGRPEMMGLKDILSAFIIFREEV
EEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCHHHHHHHHHHHHHHH
ITRRCKFELAKARDRAHILLGLVVAVSNLDEVVRIIRGSSSPAAAREALLAREWPIGDIA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
PYIRLVEAIEGEMEEAATYRLSEVQVKAILDLRLHRLTALGRDEIGKELGELAAEIEELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SILADRVKLYGVMREELVAVRDEFATPRRTLLAPAADGIDDEDLIEREEMVVTVTMDGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCHHHHHCCCCEEEEEEECCCE
KRTPLATFRAQRRGGKGRAGMATKDEDVVTELFVTSTHTPVLFFSTAGKVYRMKVWRLPE
ECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCC
GGPATRGRPMINLLPLAQGETISTVLPLPEDESEWGKLHVMFATAKGSVRRNSMDAFTNV
CCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCC
PSNGKIAMKFEGDDEDDRLIGVALLDESDDVLLATRQGKAIRFAGDDVREFQSRNSTGVR
CCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCEEEECCCHHHHHHCCCCCCCC
GMRLAEGDEVISLSILHRVGTTGDEREAYLRAAPWKDNENEPTLPAERMAELAAREQFIL
CEEECCCCCEEEHHHHHHHCCCCCCCHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHEEE
TVCANGYGKLSSAYEYRRTGRGGQGITNIDNIARNGPVVASFPATQAHQLMLVTDQAKLI
EEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHH
RMGLDSLRIIGRGSAGVRLFDVAEGEHVVSAALIEDGDEDADDGRDVEVASDNPVSEAPT
HHCHHHEEEEECCCCCEEEEEECCCCHHEEEHHHCCCCCCCCCCCEEEECCCCCCCCCCC
E
C
>Mature Secondary Structure
MQPSEDGVSPINIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAAQEGGFIPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
RPYKKSAKIVGDVMGNYHPHGDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASM
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
RYTEARLAKTAMVLLNDLDKDTVDFQPNYDASREEPTVLPARFPNLLVNGAGGIAVGMAT
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEIIDATLAMIDNPAITLEELMAIVPGPDFPTGAMMLGQGGARSAYATGRGSI
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCCEEECCCCCCCCEECCCCCE
MMRSTHVIEEGRNDRQSIVLTSIPFQVGKSGLVEKIAEAARDKRIEGVADIRDESNREGV
EEEEHHHHHCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCE
RVVIELKRDATAEVVLNQLWRHTPAQSSFPANMLAIRGGRPEMMGLKDILSAFIIFREEV
EEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCHHHHHHHHHHHHHHH
ITRRCKFELAKARDRAHILLGLVVAVSNLDEVVRIIRGSSSPAAAREALLAREWPIGDIA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHH
PYIRLVEAIEGEMEEAATYRLSEVQVKAILDLRLHRLTALGRDEIGKELGELAAEIEELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SILADRVKLYGVMREELVAVRDEFATPRRTLLAPAADGIDDEDLIEREEMVVTVTMDGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCHHHHHCCCCEEEEEEECCCE
KRTPLATFRAQRRGGKGRAGMATKDEDVVTELFVTSTHTPVLFFSTAGKVYRMKVWRLPE
ECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEECCC
GGPATRGRPMINLLPLAQGETISTVLPLPEDESEWGKLHVMFATAKGSVRRNSMDAFTNV
CCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCC
PSNGKIAMKFEGDDEDDRLIGVALLDESDDVLLATRQGKAIRFAGDDVREFQSRNSTGVR
CCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCEEEECCCHHHHHHCCCCCCCC
GMRLAEGDEVISLSILHRVGTTGDEREAYLRAAPWKDNENEPTLPAERMAELAAREQFIL
CEEECCCCCEEEHHHHHHHCCCCCCCHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHEEE
TVCANGYGKLSSAYEYRRTGRGGQGITNIDNIARNGPVVASFPATQAHQLMLVTDQAKLI
EEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHH
RMGLDSLRIIGRGSAGVRLFDVAEGEHVVSAALIEDGDEDADDGRDVEVASDNPVSEAPT
HHCHHHEEEEECCCCCEEEEEECCCCHHEEEHHHCCCCCCCCCCCEEEECCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA