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The map label for this gene is folC [H]

Identifier: 103486550

GI number: 103486550

Start: 1093797

End: 1095128

Strand: Reverse

Name: folC [H]

Synonym: Sala_1061

Alternate gene names: 103486550

Gene position: 1095128-1093797 (Counterclockwise)

Preceding gene: 103486551

Following gene: 103486547

Centisome position: 32.74

GC content: 71.02

Gene sequence:

>1332_bases
ATGCCCGACCACGCGCACAGCACCGACCCCGCCGTCCAGGCCCAGCTCGACCGCCTCGCCGCGCTGTCGCCGGGGCGCGA
CATCCTCGGCCTCGAACGCATCACCGAGCTTTGCCACCGCCTCGGCGATCCGCAGCACCGGCTGCCGCCCGTCTTCCACG
TCGCGGGAACCAACGGCAAGGGTTCGACCTGCGCCTTCCTGCGCGCCGCAATCGAGGCGCAGGGCCTGACCGCACATGTT
TACTCCAGCCCGCACCTCGTCCGCTTCAACGAGCGCATCCGTCTTGCCGGAGCGCTGATCGACGACGCGCTGCTCGCCGC
GCTGCTCGCCGAAGTGCTCGACGTCGCAGAAGACCTGCAAGCGAGCTTTTTCGAGGTCACGACCGCCTCCGCCTTCCTCG
CCTTTGCGCGCACGCCCGCCGACGCCTGCATCGTCGAGGTCGGGCTGGGCGGGCGGCTCGACGCGACGAACATCATCGCC
GCACCGACCGTCTGCGGCATCGCCTCGCTCGGCATCGACCATGAGGCGTTCCTGCTCGCGCCCGAGGCCGATGTGCCCGC
GCCGCCGCACGACCGCATCGCCTTTGAAAAGGTCGGAATCGCCAAGCCGGGCGCACCGCTGGTGACACAGGCCTATCCGG
CGTCGATGCGCGCGGTGATCGCCGCGCGCGCCGCCGCCGTCGGCGCCCCGCTCATCGAACGCGGCGCGGCATGGGATGCC
GCCATCGCCGACGGGTGCCTTGCCTATCGCGACGCGCGCGGCGCCCTCGACCTGCCCCTGCCCGCAATGGCCGGCGCGCA
TCAGGCCGACAATGCCGCGCTCGCAGTCGCGATGCTCCGCCATCAGGACGCCGTCCGCATCGACCAGGCCGCTTTCGCCG
CCGCCATGACGCATGCGACCTGGCCCGCCCGAATGCAGCGGCTCGGCGCAGGGCCGCTGACCGACCTGCTGCCACAGGGC
ACCGCCGTCTGGCTCGACGGCGGTCACAACCCCGACGCGGGCATCGCCCTTTCCCGCGCGCTGGAAGGCGTGGCGCCGCT
CCACATCGTCTGCGGCCTGCTCGCGAACAAGAATGCGATGGGGTTCCTGCGTCCCTTCGCGGACCGCATTGCCTCGTTCA
GCGCGGTTCCGATCCCGGGCCACGAGCATCATGACCCCAAGGATCTGTGCTGGTGGGTGCAGGACGGGCTTGGCATTGTC
GATGCCCGCCCGTGCGACAATGTGCCGACCGCGCTGCGCCAGCTTGCGGACGCGCGCGGCGACGTCCTCATCTGCGGCTC
GCTCTATCTCGCGGGCGAAGTCCTTGCCGCGAATGGCGAGGTGCCCGAATGA

Upstream 100 bases:

>100_bases
GTTAGGGAGAGGGGGACTCTCTCGAATGTTGATCAAGGCCGGTCTTTCGGAGACGCCCCCTCTCCCCGGCCCTCTCCCCT
GAAGGGGAGAGGGAGAATCC

Downstream 100 bases:

>100_bases
ATCATCAGGCGGCCGGCTCTTTCGCAGCGCTTCCTGCCCTGCCCGCCGTGCCCACCGACAGGTCGACCAGCCCGCTGCGC
ATCATCAGCCAGAAAAGGAT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPDHAHSTDPAVQAQLDRLAALSPGRDILGLERITELCHRLGDPQHRLPPVFHVAGTNGKGSTCAFLRAAIEAQGLTAHV
YSSPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQASFFEVTTASAFLAFARTPADACIVEVGLGGRLDATNIIA
APTVCGIASLGIDHEAFLLAPEADVPAPPHDRIAFEKVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPLIERGAAWDA
AIADGCLAYRDARGALDLPLPAMAGAHQADNAALAVAMLRHQDAVRIDQAAFAAAMTHATWPARMQRLGAGPLTDLLPQG
TAVWLDGGHNPDAGIALSRALEGVAPLHIVCGLLANKNAMGFLRPFADRIASFSAVPIPGHEHHDPKDLCWWVQDGLGIV
DARPCDNVPTALRQLADARGDVLICGSLYLAGEVLAANGEVPE

Sequences:

>Translated_443_residues
MPDHAHSTDPAVQAQLDRLAALSPGRDILGLERITELCHRLGDPQHRLPPVFHVAGTNGKGSTCAFLRAAIEAQGLTAHV
YSSPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQASFFEVTTASAFLAFARTPADACIVEVGLGGRLDATNIIA
APTVCGIASLGIDHEAFLLAPEADVPAPPHDRIAFEKVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPLIERGAAWDA
AIADGCLAYRDARGALDLPLPAMAGAHQADNAALAVAMLRHQDAVRIDQAAFAAAMTHATWPARMQRLGAGPLTDLLPQG
TAVWLDGGHNPDAGIALSRALEGVAPLHIVCGLLANKNAMGFLRPFADRIASFSAVPIPGHEHHDPKDLCWWVQDGLGIV
DARPCDNVPTALRQLADARGDVLICGSLYLAGEVLAANGEVPE
>Mature_442_residues
PDHAHSTDPAVQAQLDRLAALSPGRDILGLERITELCHRLGDPQHRLPPVFHVAGTNGKGSTCAFLRAAIEAQGLTAHVY
SSPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQASFFEVTTASAFLAFARTPADACIVEVGLGGRLDATNIIAA
PTVCGIASLGIDHEAFLLAPEADVPAPPHDRIAFEKVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPLIERGAAWDAA
IADGCLAYRDARGALDLPLPAMAGAHQADNAALAVAMLRHQDAVRIDQAAFAAAMTHATWPARMQRLGAGPLTDLLPQGT
AVWLDGGHNPDAGIALSRALEGVAPLHIVCGLLANKNAMGFLRPFADRIASFSAVPIPGHEHHDPKDLCWWVQDGLGIVD
ARPCDNVPTALRQLADARGDVLICGSLYLAGEVLAANGEVPE

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=329, Percent_Identity=32.2188449848024, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI66932984, Length=329, Percent_Identity=32.2188449848024, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI1788654, Length=416, Percent_Identity=32.9326923076923, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71984923, Length=309, Percent_Identity=30.0970873786408, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17553148, Length=309, Percent_Identity=30.0970873786408, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17553150, Length=309, Percent_Identity=30.0970873786408, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323760, Length=429, Percent_Identity=30.5361305361305, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324815, Length=356, Percent_Identity=27.8089887640449, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322718, Length=443, Percent_Identity=26.1851015801354, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24641571, Length=189, Percent_Identity=34.3915343915344, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24581568, Length=205, Percent_Identity=32.1951219512195, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 46269; Mature: 46138

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHAHSTDPAVQAQLDRLAALSPGRDILGLERITELCHRLGDPQHRLPPVFHVAGTNGK
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
GSTCAFLRAAIEAQGLTAHVYSSPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQ
CCHHHHHHHHHHHCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFFEVTTASAFLAFARTPADACIVEVGLGGRLDATNIIAAPTVCGIASLGIDHEAFLLA
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCHHHHHHHCCCCCCEEEEE
PEADVPAPPHDRIAFEKVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPLIERGAAWDA
CCCCCCCCCCCCCHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCHH
AIADGCLAYRDARGALDLPLPAMAGAHQADNAALAVAMLRHQDAVRIDQAAFAAAMTHAT
HHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
WPARMQRLGAGPLTDLLPQGTAVWLDGGHNPDAGIALSRALEGVAPLHIVCGLLANKNAM
CHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
GFLRPFADRIASFSAVPIPGHEHHDPKDLCWWVQDGLGIVDARPCDNVPTALRQLADARG
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCC
DVLICGSLYLAGEVLAANGEVPE
CEEEEECHHHHCEEEECCCCCCC
>Mature Secondary Structure 
PDHAHSTDPAVQAQLDRLAALSPGRDILGLERITELCHRLGDPQHRLPPVFHVAGTNGK
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
GSTCAFLRAAIEAQGLTAHVYSSPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQ
CCHHHHHHHHHHHCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFFEVTTASAFLAFARTPADACIVEVGLGGRLDATNIIAAPTVCGIASLGIDHEAFLLA
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCHHHHHHHCCCCCCEEEEE
PEADVPAPPHDRIAFEKVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPLIERGAAWDA
CCCCCCCCCCCCCHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCHH
AIADGCLAYRDARGALDLPLPAMAGAHQADNAALAVAMLRHQDAVRIDQAAFAAAMTHAT
HHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
WPARMQRLGAGPLTDLLPQGTAVWLDGGHNPDAGIALSRALEGVAPLHIVCGLLANKNAM
CHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
GFLRPFADRIASFSAVPIPGHEHHDPKDLCWWVQDGLGIVDARPCDNVPTALRQLADARG
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCC
DVLICGSLYLAGEVLAANGEVPE
CEEEEECHHHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]