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The map label for this gene is pyrC [H]

Identifier: 103486413

GI number: 103486413

Start: 936265

End: 937488

Strand: Reverse

Name: pyrC [H]

Synonym: Sala_0923

Alternate gene names: 103486413

Gene position: 937488-936265 (Counterclockwise)

Preceding gene: 103486414

Following gene: 103486412

Centisome position: 28.03

GC content: 69.04

Gene sequence:

>1224_bases
ATGGAATTGAGGCCGCTCCATATCGCCAACGCGCTGCTGGTCGATGGCGATACGCCGCGTCCGGGCAGCCTGCTGGCGGT
CGACGGCCGCATCGCCGCGATCGACCCGGCTGACATCCCCGAAGGCGCCGAAACCGTCGATGCCAGGGGTCAGTGGCTCG
CGCCGGGAATCATCGACCTTGGCGTCTTTGCGACCGACAAGCCCGCCTTTCACTTCGGCGGCATCACGCGCGCCGCGCTG
ATGCCCGACAATGGTCCGCTCGACGGCGTCGGCCTTGTCGAGCGCGCGGCGAAGGGCGGCAAACCCGACCTCTGGGTCCA
TCCCCTCGCGGCCGCGACCAAGGGCCTCGAGGGCCGCGAGCTCGCGGAAATCGGCCTGATGAAACAGGCGGGTGCGCGTG
CCGTTGCCACCGGCCGCGCCCGCGTCGCCGACAGCGGAGTGATGCGCCGCGTGCTCGCCTATGCCGCCTCGTTGGGGCTC
GTGACGATCATCCATGCCGAGGATGAAGGGCTGACCGCCGGCGCCGTCGCAACCGACGGCGAGATGGCGACGCGGCTTGG
CCTGTCGTCGGCGCCCGCGATCGCCGAAGCGATGGCGATCGCGCGCGACCTGTCGCTCGTCGAGGAAACCGGCGCGCCGG
TGCATTTCCGCCAGGTCACGACCGCGCGCGGGCTCGACCTGATCCGCGCCGCCAAGGCAAAGGGACTGCCCGTGCTTTGC
GGCATCACCCCCGCGCATCTGTTCCTGTCGGATACGGCAATCGGCGATTTCCGGACCTTTGCGCGGCTTTCACCGCCGCT
GCGCAGCGAAGACGATCGCCGTGCCTGCCTTGCGGCGGTCGTCGACGGCACGATCGACGTTCTGTCTTCAGGCCACGACC
CGCGCGGCCCCGAGGACAAGCGCCTGCCATTTGCCGAAGCACTGCCCGGCATGGCGGGAGCCGAAACCTTGCTCGCCATG
GGCCTGAACCTCGTCCGCGACGGACATATCACGCCTGGCCGTCTGTTCGAGATGCTTGCCGCCATCCCAGCCTGCCTGCT
CGGTGTCGACGCGGGCCGCCTTGTAGCGGGCGGGGAAGCCGACCTCATCCTCGTCGACCCCGACATCCCGTGGCAGGTCG
ATGCAAAGAAGATGGCGACCTGGGCGGGCAACACTCCATTCGACGGCATGCCTGTCCAGGGCCGCGCCACCATGATGTGG
AAGGGCGGAAAGCGGATCCGCTGA

Upstream 100 bases:

>100_bases
ATCACGCGCGCTCGACGATCACCGAACAGGTCGAAATGGGGGTCGCGGTGCGCATGGCATGTCTCGACATATTGACGCGC
CGCCAGCGGGGAGTGCCGGG

Downstream 100 bases:

>100_bases
GCCGATCCGATCAACGGTGCGCCGACCCGAAACCGCTCGCGATCGACTTGCGATGCCGGGGAGGGACGCAGCCGAGCGAC
TGGAAACAGCGCCGGTAGAT

Product: amidohydrolase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MELRPLHIANALLVDGDTPRPGSLLAVDGRIAAIDPADIPEGAETVDARGQWLAPGIIDLGVFATDKPAFHFGGITRAAL
MPDNGPLDGVGLVERAAKGGKPDLWVHPLAAATKGLEGRELAEIGLMKQAGARAVATGRARVADSGVMRRVLAYAASLGL
VTIIHAEDEGLTAGAVATDGEMATRLGLSSAPAIAEAMAIARDLSLVEETGAPVHFRQVTTARGLDLIRAAKAKGLPVLC
GITPAHLFLSDTAIGDFRTFARLSPPLRSEDDRRACLAAVVDGTIDVLSSGHDPRGPEDKRLPFAEALPGMAGAETLLAM
GLNLVRDGHITPGRLFEMLAAIPACLLGVDAGRLVAGGEADLILVDPDIPWQVDAKKMATWAGNTPFDGMPVQGRATMMW
KGGKRIR

Sequences:

>Translated_407_residues
MELRPLHIANALLVDGDTPRPGSLLAVDGRIAAIDPADIPEGAETVDARGQWLAPGIIDLGVFATDKPAFHFGGITRAAL
MPDNGPLDGVGLVERAAKGGKPDLWVHPLAAATKGLEGRELAEIGLMKQAGARAVATGRARVADSGVMRRVLAYAASLGL
VTIIHAEDEGLTAGAVATDGEMATRLGLSSAPAIAEAMAIARDLSLVEETGAPVHFRQVTTARGLDLIRAAKAKGLPVLC
GITPAHLFLSDTAIGDFRTFARLSPPLRSEDDRRACLAAVVDGTIDVLSSGHDPRGPEDKRLPFAEALPGMAGAETLLAM
GLNLVRDGHITPGRLFEMLAAIPACLLGVDAGRLVAGGEADLILVDPDIPWQVDAKKMATWAGNTPFDGMPVQGRATMMW
KGGKRIR
>Mature_407_residues
MELRPLHIANALLVDGDTPRPGSLLAVDGRIAAIDPADIPEGAETVDARGQWLAPGIIDLGVFATDKPAFHFGGITRAAL
MPDNGPLDGVGLVERAAKGGKPDLWVHPLAAATKGLEGRELAEIGLMKQAGARAVATGRARVADSGVMRRVLAYAASLGL
VTIIHAEDEGLTAGAVATDGEMATRLGLSSAPAIAEAMAIARDLSLVEETGAPVHFRQVTTARGLDLIRAAKAKGLPVLC
GITPAHLFLSDTAIGDFRTFARLSPPLRSEDDRRACLAAVVDGTIDVLSSGHDPRGPEDKRLPFAEALPGMAGAETLLAM
GLNLVRDGHITPGRLFEMLAAIPACLLGVDAGRLVAGGEADLILVDPDIPWQVDAKKMATWAGNTPFDGMPVQGRATMMW
KGGKRIR

Specific function: Unknown

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI87082175, Length=437, Percent_Identity=26.3157894736842, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786722, Length=430, Percent_Identity=24.6511627906977, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193204318, Length=201, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=378, Percent_Identity=25.1322751322751, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642586, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 42416; Mature: 42416

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRPLHIANALLVDGDTPRPGSLLAVDGRIAAIDPADIPEGAETVDARGQWLAPGIIDL
CCCCCEEECCEEEECCCCCCCCCEEEECCEEEEECCCCCCCCCHHHCCCCCCCCCCCEEE
GVFATDKPAFHFGGITRAALMPDNGPLDGVGLVERAAKGGKPDLWVHPLAAATKGLEGRE
CEEECCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEECHHHHHCCCCCCH
LAEIGLMKQAGARAVATGRARVADSGVMRRVLAYAASLGLVTIIHAEDEGLTAGAVATDG
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEECEEECCC
EMATRLGLSSAPAIAEAMAIARDLSLVEETGAPVHFRQVTTARGLDLIRAAKAKGLPVLC
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCHHHHHHHHCCCCEEEE
GITPAHLFLSDTAIGDFRTFARLSPPLRSEDDRRACLAAVVDGTIDVLSSGHDPRGPEDK
CCCHHHEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RLPFAEALPGMAGAETLLAMGLNLVRDGHITPGRLFEMLAAIPACLLGVDAGRLVAGGEA
CCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCC
DLILVDPDIPWQVDAKKMATWAGNTPFDGMPVQGRATMMWKGGKRIR
CEEEECCCCCCEECHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MELRPLHIANALLVDGDTPRPGSLLAVDGRIAAIDPADIPEGAETVDARGQWLAPGIIDL
CCCCCEEECCEEEECCCCCCCCCEEEECCEEEEECCCCCCCCCHHHCCCCCCCCCCCEEE
GVFATDKPAFHFGGITRAALMPDNGPLDGVGLVERAAKGGKPDLWVHPLAAATKGLEGRE
CEEECCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEECHHHHHCCCCCCH
LAEIGLMKQAGARAVATGRARVADSGVMRRVLAYAASLGLVTIIHAEDEGLTAGAVATDG
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEECEEECCC
EMATRLGLSSAPAIAEAMAIARDLSLVEETGAPVHFRQVTTARGLDLIRAAKAKGLPVLC
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCHHHHHHHHCCCCEEEE
GITPAHLFLSDTAIGDFRTFARLSPPLRSEDDRRACLAAVVDGTIDVLSSGHDPRGPEDK
CCCHHHEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RLPFAEALPGMAGAETLLAMGLNLVRDGHITPGRLFEMLAAIPACLLGVDAGRLVAGGEA
CCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCC
DLILVDPDIPWQVDAKKMATWAGNTPFDGMPVQGRATMMWKGGKRIR
CEEEECCCCCCEECHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA